CN105518014A - C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 - Google Patents
C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 Download PDFInfo
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- CN105518014A CN105518014A CN201480048856.4A CN201480048856A CN105518014A CN 105518014 A CN105518014 A CN 105518014A CN 201480048856 A CN201480048856 A CN 201480048856A CN 105518014 A CN105518014 A CN 105518014A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
Abstract
本发明涉及C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用。具体而言,本发明涉及如通式I所示的化合物以及它们的互变异构体、对映体、非对映体、消旋体和可药用的盐,其制备方法或含有该化合物的药物组合物,以及作为治疗剂特别是作为钠依赖性葡糖转运蛋白(SGLT)抑制剂的用途。
Description
PCT国内申请,说明书已公开。
Claims (1)
- PCT国内申请,权利要求书已公开。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201480048856.4A CN105518014B (zh) | 2013-09-09 | 2014-08-19 | C‑芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
CN201710378637.8A CN107311992B (zh) | 2013-09-09 | 2014-08-19 | C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2013104083579 | 2013-09-09 | ||
CN201310408357 | 2013-09-09 | ||
PCT/CN2014/084717 WO2015032272A1 (zh) | 2013-09-09 | 2014-08-19 | C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
CN201480048856.4A CN105518014B (zh) | 2013-09-09 | 2014-08-19 | C‑芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710378637.8A Division CN107311992B (zh) | 2013-09-09 | 2014-08-19 | C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105518014A true CN105518014A (zh) | 2016-04-20 |
CN105518014B CN105518014B (zh) | 2018-03-23 |
Family
ID=52627785
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710378637.8A Expired - Fee Related CN107311992B (zh) | 2013-09-09 | 2014-08-19 | C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
CN201480048856.4A Active CN105518014B (zh) | 2013-09-09 | 2014-08-19 | C‑芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710378637.8A Expired - Fee Related CN107311992B (zh) | 2013-09-09 | 2014-08-19 | C-芳基葡糖苷衍生物、其制备方法及其在医药上的应用 |
Country Status (9)
Country | Link |
---|---|
US (1) | US10011627B2 (zh) |
EP (1) | EP3056507B1 (zh) |
JP (1) | JP6353054B2 (zh) |
CN (2) | CN107311992B (zh) |
AU (1) | AU2014317663B2 (zh) |
CA (1) | CA2923522C (zh) |
ES (1) | ES2828548T3 (zh) |
TW (1) | TWI652272B (zh) |
WO (1) | WO2015032272A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2605886T3 (es) | 2013-09-27 | 2017-03-16 | Sunshine Lake Pharma Co., Ltd. | Derivados de glucopiranosilo y sus usos en medicina |
AU2017205545B2 (en) * | 2016-01-04 | 2019-11-21 | Je Il Pharmaceutical Co., Ltd. | C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same |
RU2710230C1 (ru) * | 2016-05-04 | 2019-12-25 | Юнджин Терапьютикс Ко., Лтд. | Аминный сольват ингибитора натрий-глюкозного котранспортера и способ его получения и его применение |
US10815210B2 (en) | 2016-11-10 | 2020-10-27 | Janssen Pharmaceutica Nv | Benzocyclobutane derivatives useful as dual SGLT1 / SGLT2 modulators |
CN108203432B (zh) * | 2016-12-20 | 2021-03-02 | 宜昌东阳光长江药业股份有限公司 | 吡喃葡萄糖基衍生物及其在医药上的应用 |
US10696662B2 (en) | 2017-08-21 | 2020-06-30 | Janssen Pharmaceutica Nv | 5-fluoro-C-(aryl or heterocyclyl)-glycoside derivatives useful as dual SGLT1 / SGLT2 modulators |
WO2019134667A1 (zh) * | 2018-01-05 | 2019-07-11 | 南京明德新药研发股份有限公司 | 一种SGLTs抑制剂及其应用 |
CA3098428A1 (en) | 2018-04-18 | 2019-10-24 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
BR112021002523A2 (pt) | 2018-08-13 | 2021-05-04 | Daewoong Pharmaceutical Co., Ltd. | método para preparar um composto |
CN113330017B (zh) * | 2019-12-19 | 2023-01-31 | 上海研健新药研发有限公司 | 一种SGLTs抑制剂的纯化方法及其应用 |
CN113004349A (zh) * | 2019-12-19 | 2021-06-22 | 上海研健新药研发有限公司 | 一种SGLTs抑制剂的制备方法及其关键中间体 |
Citations (7)
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CN1407990A (zh) * | 1999-10-12 | 2003-04-02 | 布里斯托尔-迈尔斯斯奎布公司 | C-芳基葡糖苷sglt2抑制剂 |
JP2004359630A (ja) * | 2003-06-06 | 2004-12-24 | Yamanouchi Pharmaceut Co Ltd | ジフルオロジフェニルメタン誘導体及びその塩 |
CN1784415A (zh) * | 2003-03-31 | 2006-06-07 | 橘生药品工业株式会社 | 稠合杂环衍生物、含该衍生物的医药组合物及其医药用途 |
WO2011048112A1 (en) * | 2009-10-20 | 2011-04-28 | Novartis Ag | Glycoside derivatives and uses thereof |
WO2012019496A1 (zh) * | 2010-08-10 | 2012-02-16 | 上海恒瑞医药有限公司 | C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用 |
WO2012140597A1 (en) * | 2011-04-14 | 2012-10-18 | Novartis Ag | Glycoside derivatives and their uses for the treatment of diabetes |
WO2012165914A2 (en) * | 2011-06-01 | 2012-12-06 | Green Cross Corporation | Novel diphenylmethane derivatives as sglt2 inhibitors |
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US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
TWI254635B (en) | 2002-08-05 | 2006-05-11 | Yamanouchi Pharma Co Ltd | Azulene derivative and salt thereof |
TW200637839A (en) * | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
US8115017B2 (en) * | 2006-06-29 | 2012-02-14 | Taisho Pharmaceutical Co., Ltd | C-phenyl 1-thioglucitol compound |
CN101611023A (zh) * | 2006-12-14 | 2009-12-23 | 大正制药株式会社 | 1-苯基1-硫代-d-山梨醇衍生物 |
WO2010074219A1 (ja) * | 2008-12-26 | 2010-07-01 | アステラス製薬株式会社 | ベンゾチオフェン化合物 |
EP2491050A2 (en) | 2009-10-20 | 2012-08-29 | Novartis AG | Glycoside derivative and uses thereof |
-
2014
- 2014-08-19 WO PCT/CN2014/084717 patent/WO2015032272A1/zh active Application Filing
- 2014-08-19 JP JP2016539403A patent/JP6353054B2/ja active Active
- 2014-08-19 CA CA2923522A patent/CA2923522C/en active Active
- 2014-08-19 US US14/917,792 patent/US10011627B2/en active Active
- 2014-08-19 CN CN201710378637.8A patent/CN107311992B/zh not_active Expired - Fee Related
- 2014-08-19 EP EP14841970.8A patent/EP3056507B1/en active Active
- 2014-08-19 AU AU2014317663A patent/AU2014317663B2/en active Active
- 2014-08-19 ES ES14841970T patent/ES2828548T3/es active Active
- 2014-08-19 CN CN201480048856.4A patent/CN105518014B/zh active Active
- 2014-09-09 TW TW103130957A patent/TWI652272B/zh active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1407990A (zh) * | 1999-10-12 | 2003-04-02 | 布里斯托尔-迈尔斯斯奎布公司 | C-芳基葡糖苷sglt2抑制剂 |
CN1784415A (zh) * | 2003-03-31 | 2006-06-07 | 橘生药品工业株式会社 | 稠合杂环衍生物、含该衍生物的医药组合物及其医药用途 |
JP2004359630A (ja) * | 2003-06-06 | 2004-12-24 | Yamanouchi Pharmaceut Co Ltd | ジフルオロジフェニルメタン誘導体及びその塩 |
WO2011048112A1 (en) * | 2009-10-20 | 2011-04-28 | Novartis Ag | Glycoside derivatives and uses thereof |
WO2012019496A1 (zh) * | 2010-08-10 | 2012-02-16 | 上海恒瑞医药有限公司 | C-芳基葡萄糖苷衍生物、其制备方法及其在医药上的应用 |
WO2012140597A1 (en) * | 2011-04-14 | 2012-10-18 | Novartis Ag | Glycoside derivatives and their uses for the treatment of diabetes |
WO2012165914A2 (en) * | 2011-06-01 | 2012-12-06 | Green Cross Corporation | Novel diphenylmethane derivatives as sglt2 inhibitors |
Also Published As
Publication number | Publication date |
---|---|
WO2015032272A1 (zh) | 2015-03-12 |
CA2923522A1 (en) | 2015-03-12 |
US20160222047A1 (en) | 2016-08-04 |
AU2014317663B2 (en) | 2018-02-08 |
CN105518014B (zh) | 2018-03-23 |
US10011627B2 (en) | 2018-07-03 |
JP6353054B2 (ja) | 2018-07-04 |
CN107311992B (zh) | 2020-08-18 |
ES2828548T3 (es) | 2021-05-26 |
EP3056507B1 (en) | 2020-09-23 |
TWI652272B (zh) | 2019-03-01 |
AU2014317663A1 (en) | 2016-04-28 |
CA2923522C (en) | 2018-11-06 |
EP3056507A1 (en) | 2016-08-17 |
CN107311992A (zh) | 2017-11-03 |
TW201512205A (zh) | 2015-04-01 |
EP3056507A4 (en) | 2017-04-19 |
JP2016529298A (ja) | 2016-09-23 |
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