CN105518005B - 作为rock抑制剂的三环吡啶-甲酰胺衍生物 - Google Patents

作为rock抑制剂的三环吡啶-甲酰胺衍生物 Download PDF

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CN105518005B
CN105518005B CN201480047826.1A CN201480047826A CN105518005B CN 105518005 B CN105518005 B CN 105518005B CN 201480047826 A CN201480047826 A CN 201480047826A CN 105518005 B CN105518005 B CN 105518005B
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pyridine
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CN105518005A (zh
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陈丽芬
胡子伦
王彩兰
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Bristol Myers Squibb Co
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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CN201480047826.1A 2013-07-02 2014-07-01 作为rock抑制剂的三环吡啶-甲酰胺衍生物 Expired - Fee Related CN105518005B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361842084P 2013-07-02 2013-07-02
US61/842,084 2013-07-02
PCT/US2014/045008 WO2015002926A1 (en) 2013-07-02 2014-07-01 Tricyclic pyrido-carboxamide derivatives as rock inhibitors

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CN105518005A CN105518005A (zh) 2016-04-20
CN105518005B true CN105518005B (zh) 2018-07-20

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US (1) US9663529B2 (cg-RX-API-DMAC7.html)
EP (1) EP3016950B1 (cg-RX-API-DMAC7.html)
JP (1) JP6522602B2 (cg-RX-API-DMAC7.html)
CN (1) CN105518005B (cg-RX-API-DMAC7.html)
ES (1) ES2634628T3 (cg-RX-API-DMAC7.html)
WO (1) WO2015002926A1 (cg-RX-API-DMAC7.html)

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TW201506024A (zh) 2013-07-02 2015-02-16 必治妥美雅史谷比公司 作為有效ｒｏｃｋ抑制劑的三環甲醯胺衍生物
CN105979950A (zh) 2013-10-11 2016-09-28 百时美施贵宝公司 吡咯并三嗪激酶抑制剂
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JP7191826B2 (ja) * 2016-11-30 2022-12-19 ブリストル－マイヤーズ スクイブ カンパニー 三環式ｒｈｏキナーゼ阻害剤
TW201908293A (zh) 2017-07-12 2019-03-01 美商必治妥美雅史谷比公司 作為rock抑制劑之5員及雙環雜環醯胺
JP7313331B2 (ja) 2017-07-12 2023-07-24 ブリストル－マイヤーズ スクイブ カンパニー Ｒｏｃｋ阻害剤としてのスピロヘプタニルヒダントイン
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