CN105492429A - Sumo活化酶的杂芳基抑制剂 - Google Patents
Sumo活化酶的杂芳基抑制剂 Download PDFInfo
- Publication number
- CN105492429A CN105492429A CN201480046426.9A CN201480046426A CN105492429A CN 105492429 A CN105492429 A CN 105492429A CN 201480046426 A CN201480046426 A CN 201480046426A CN 105492429 A CN105492429 A CN 105492429A
- Authority
- CN
- China
- Prior art keywords
- amino
- carbonyl
- methyl ester
- sulfamic acid
- pyrimidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC(*)(CC(COS(N)(=O)=O)C1)C1N(*)c1ncnc(*)c1C(C(C(*)=C(*)N*(C1)(C2C1(*)*2[Re])[Re])=*)=O Chemical compound CC(*)(CC(COS(N)(=O)=O)C1)C1N(*)c1ncnc(*)c1C(C(C(*)=C(*)N*(C1)(C2C1(*)*2[Re])[Re])=*)=O 0.000 description 13
- UYNOXTHSDFPJQC-UHFFFAOYSA-N C=NNCc1cccc(Cl)c1 Chemical compound C=NNCc1cccc(Cl)c1 UYNOXTHSDFPJQC-UHFFFAOYSA-N 0.000 description 2
- JZQLJHIDFDVMDY-UHFFFAOYSA-N C/[I]=C(\CCN)/CO Chemical compound C/[I]=C(\CCN)/CO JZQLJHIDFDVMDY-UHFFFAOYSA-N 0.000 description 1
- FUPCHIJVCBGZEK-JWWFHCCTSA-N CC(Cc1cncnc1N[C@@H](C[C@@H]1OC(C)(C)O)CC1(C1)C1=O)[OH3+2] Chemical compound CC(Cc1cncnc1N[C@@H](C[C@@H]1OC(C)(C)O)CC1(C1)C1=O)[OH3+2] FUPCHIJVCBGZEK-JWWFHCCTSA-N 0.000 description 1
- MWOVFCCILWBHLM-UHFFFAOYSA-N CC1(C)OB(C=C)OC1 Chemical compound CC1(C)OB(C=C)OC1 MWOVFCCILWBHLM-UHFFFAOYSA-N 0.000 description 1
- FLXMCYGUCUWNSA-QPJJXVBHSA-N CCC(C)/C=C(/N=C\N)\Cl Chemical compound CCC(C)/C=C(/N=C\N)\Cl FLXMCYGUCUWNSA-QPJJXVBHSA-N 0.000 description 1
- CZJHCMBIBAZWCE-JAMMHHFISA-N C[C@@H](CCC=N1)C(C)C=C1Cl Chemical compound C[C@@H](CCC=N1)C(C)C=C1Cl CZJHCMBIBAZWCE-JAMMHHFISA-N 0.000 description 1
- XJPZKYIHCLDXST-UHFFFAOYSA-N Clc1ncnc(Cl)c1 Chemical compound Clc1ncnc(Cl)c1 XJPZKYIHCLDXST-UHFFFAOYSA-N 0.000 description 1
- MXOIIXRYAPGBEN-CKRUTQJISA-N NS(CC[C@@H](C[C@H](C1)Nc2ncnc(Cl)c2C(c2n[n](Cc3cccc(Cl)c3)cc2)=O)[C@H]1O)(=O)=[U] Chemical compound NS(CC[C@@H](C[C@H](C1)Nc2ncnc(Cl)c2C(c2n[n](Cc3cccc(Cl)c3)cc2)=O)[C@H]1O)(=O)=[U] MXOIIXRYAPGBEN-CKRUTQJISA-N 0.000 description 1
- ROQIWOPSUUICIF-UHFFFAOYSA-N O=Cc1n[n](Cc2cccc(Cl)c2)cc1 Chemical compound O=Cc1n[n](Cc2cccc(Cl)c2)cc1 ROQIWOPSUUICIF-UHFFFAOYSA-N 0.000 description 1
- AESIVDWDYMOZGZ-UHFFFAOYSA-N OC1(COC1)C#CCBr Chemical compound OC1(COC1)C#CCBr AESIVDWDYMOZGZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361842097P | 2013-07-02 | 2013-07-02 | |
| US61/842,097 | 2013-07-02 | ||
| PCT/US2014/045129 WO2015002994A2 (en) | 2013-07-02 | 2014-07-01 | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105492429A true CN105492429A (zh) | 2016-04-13 |
Family
ID=52144279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480046426.9A Pending CN105492429A (zh) | 2013-07-02 | 2014-07-01 | Sumo活化酶的杂芳基抑制剂 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9695154B2 (https=) |
| EP (1) | EP3016934B1 (https=) |
| JP (1) | JP6378759B2 (https=) |
| CN (1) | CN105492429A (https=) |
| BR (1) | BR112015032902A8 (https=) |
| CA (1) | CA2916468C (https=) |
| EA (1) | EA032577B1 (https=) |
| WO (1) | WO2015002994A2 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105670066A (zh) * | 2016-04-22 | 2016-06-15 | 宁波硫华聚合物有限公司 | 橡胶促进剂活性剂氧化镁母胶粒及其制备方法 |
| CN107586315A (zh) * | 2016-07-08 | 2018-01-16 | 成都海创药业有限公司 | 一种嵌合分子 |
| WO2024067676A1 (zh) * | 2022-09-30 | 2024-04-04 | 微境生物医药科技(上海)有限公司 | 作为sumo活化酶抑制剂的化合物 |
| WO2024099438A1 (zh) * | 2022-11-11 | 2024-05-16 | 微境生物医药科技(上海)有限公司 | 作为sumo活化酶抑制剂的化合物 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| CN104136399B (zh) | 2012-02-17 | 2018-08-07 | 米伦纽姆医药公司 | 泛素活化酶的吡唑并嘧啶基抑制剂 |
| JP2015524442A (ja) | 2012-08-03 | 2015-08-24 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｕｂａ６のインドール置換ピロロピリミジニル阻害剤 |
| CN105492429A (zh) | 2013-07-02 | 2016-04-13 | 米伦纽姆医药公司 | Sumo活化酶的杂芳基抑制剂 |
| BR112016030787B1 (pt) * | 2014-07-01 | 2022-12-20 | Takeda Pharmaceutical Company Limited | Entidade química, composição farmacêutica e seu uso |
| KR101927375B1 (ko) | 2016-04-20 | 2018-12-11 | 한국화학연구원 | 신규한 헤테로고리 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물 |
| EP3490980A4 (en) | 2016-07-22 | 2020-04-15 | Virginia Commonwealth University | Prodrug and protected forms of 5-hydroxymethylfurfuranal (5-hmf) and its derivatives |
| MX2021000349A (es) | 2018-07-09 | 2021-05-14 | Takeda Pharmaceuticals Co | Administracion de un inhibidor de la enzima activadora de sumo y anticuerpos anti-cd20. |
| PL3829581T3 (pl) | 2018-07-27 | 2024-07-01 | Arcus Biosciences, Inc. | Antagoniści pirydonu a2r |
| WO2020028525A1 (en) * | 2018-07-31 | 2020-02-06 | City Of Hope | Sumo inhibitor compounds and uses thereof |
| CA3128521A1 (en) | 2019-02-27 | 2020-09-03 | Millennium Pharmaceuticals, Inc. | Administration of sumo-activating enzyme inhibitor and checkpoint inhibitors |
| WO2022159980A1 (en) * | 2021-01-25 | 2022-07-28 | Athos Therapeutics, Inc. | Pharmaceutical compounds and methods of making and using the same |
| WO2023073645A1 (en) | 2021-10-29 | 2023-05-04 | Takeda Pharmaceutical Company Limited | Therapy comprising anti-cd19 antibody and sumo-activating enzyme inhibitor |
| WO2024097736A1 (en) * | 2022-11-02 | 2024-05-10 | Arcus Biosciences, Inc. | Processes for preparing azolopyrimidine compounds |
| CN116640068A (zh) * | 2023-05-26 | 2023-08-25 | 康化（上海）新药研发有限公司 | 一种（3-环丙基-2-炔-1-基）甘氨酸苄酯的合成方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101516850A (zh) * | 2006-08-08 | 2009-08-26 | 米伦纽姆医药公司 | 适用作e1活化酶抑制剂的杂芳基化合物 |
| US20120258927A1 (en) * | 2006-02-02 | 2012-10-11 | Millenium Pharmaceuticals, Inc. | Inhibitors of e1 activating enzymes |
| US20130150388A1 (en) * | 2011-08-24 | 2013-06-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of nedd8-activating enzyme |
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| US5194446A (en) | 1989-06-12 | 1993-03-16 | A. H. Robins Company, Incorporated | Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals |
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| DE60313872T2 (de) | 2002-09-04 | 2008-01-17 | Schering Corp. | Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen |
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| JP2015502137A (ja) * | 2011-10-07 | 2015-01-22 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｅ１酵素変異体およびその用途 |
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| WO2013151975A1 (en) | 2012-04-02 | 2013-10-10 | Northeastern University | Compositions and methods for the inhibition of methyltransferases |
| CN105492429A (zh) | 2013-07-02 | 2016-04-13 | 米伦纽姆医药公司 | Sumo活化酶的杂芳基抑制剂 |
| US20150087673A1 (en) | 2013-09-26 | 2015-03-26 | Rigel Pharmaceuticals, Inc. | Methods for using and biomarkers for ampk-activating compounds |
| BR112016008632A8 (pt) | 2013-10-21 | 2020-03-17 | Merck Patent Gmbh | compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica |
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-
2014
- 2014-07-01 CN CN201480046426.9A patent/CN105492429A/zh active Pending
- 2014-07-01 JP JP2016524326A patent/JP6378759B2/ja not_active Expired - Fee Related
- 2014-07-01 BR BR112015032902A patent/BR112015032902A8/pt not_active Application Discontinuation
- 2014-07-01 US US14/901,809 patent/US9695154B2/en active Active
- 2014-07-01 CA CA2916468A patent/CA2916468C/en not_active Expired - Fee Related
- 2014-07-01 WO PCT/US2014/045129 patent/WO2015002994A2/en not_active Ceased
- 2014-07-01 EP EP14819587.8A patent/EP3016934B1/en active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120258927A1 (en) * | 2006-02-02 | 2012-10-11 | Millenium Pharmaceuticals, Inc. | Inhibitors of e1 activating enzymes |
| CN101516850A (zh) * | 2006-08-08 | 2009-08-26 | 米伦纽姆医药公司 | 适用作e1活化酶抑制剂的杂芳基化合物 |
| US20130150388A1 (en) * | 2011-08-24 | 2013-06-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of nedd8-activating enzyme |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105670066A (zh) * | 2016-04-22 | 2016-06-15 | 宁波硫华聚合物有限公司 | 橡胶促进剂活性剂氧化镁母胶粒及其制备方法 |
| CN107586315A (zh) * | 2016-07-08 | 2018-01-16 | 成都海创药业有限公司 | 一种嵌合分子 |
| CN107586315B (zh) * | 2016-07-08 | 2020-03-31 | 成都海创药业有限公司 | 一种嵌合分子 |
| WO2024067676A1 (zh) * | 2022-09-30 | 2024-04-04 | 微境生物医药科技(上海)有限公司 | 作为sumo活化酶抑制剂的化合物 |
| WO2024099438A1 (zh) * | 2022-11-11 | 2024-05-16 | 微境生物医药科技(上海)有限公司 | 作为sumo活化酶抑制剂的化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3016934A4 (en) | 2016-12-14 |
| CA2916468A1 (en) | 2015-01-08 |
| CA2916468C (en) | 2019-07-23 |
| BR112015032902A8 (pt) | 2019-12-24 |
| EA032577B1 (ru) | 2019-06-28 |
| WO2015002994A2 (en) | 2015-01-08 |
| EA201690129A1 (ru) | 2016-06-30 |
| US20160355504A1 (en) | 2016-12-08 |
| JP6378759B2 (ja) | 2018-08-22 |
| JP2016523925A (ja) | 2016-08-12 |
| EP3016934B1 (en) | 2018-01-10 |
| EP3016934A2 (en) | 2016-05-11 |
| WO2015002994A3 (en) | 2015-05-28 |
| US9695154B2 (en) | 2017-07-04 |
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