CN105473573B - 用作激酶抑制剂的咔唑甲酰胺化合物 - Google Patents

用作激酶抑制剂的咔唑甲酰胺化合物 Download PDF

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Publication number
CN105473573B
CN105473573B CN201480046669.2A CN201480046669A CN105473573B CN 105473573 B CN105473573 B CN 105473573B CN 201480046669 A CN201480046669 A CN 201480046669A CN 105473573 B CN105473573 B CN 105473573B
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CN
China
Prior art keywords
carbazole
carboxamide
methylphenyl
dioxo
methyl
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Expired - Fee Related
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CN201480046669.2A
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English (en)
Chinese (zh)
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CN105473573A (zh
Inventor
S·S·科
D·G·巴特
M·B·贝特朗
G·V·德卢卡
C·M·兰格文
Q·刘
A·S·斯里瓦斯塔瓦
S·H·沃特森
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CN105473573A publication Critical patent/CN105473573A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201480046669.2A 2013-06-25 2014-06-25 用作激酶抑制剂的咔唑甲酰胺化合物 Expired - Fee Related CN105473573B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361839130P 2013-06-25 2013-06-25
US61/839,130 2013-06-25
PCT/US2014/043980 WO2014210087A1 (en) 2013-06-25 2014-06-25 Carbazole carboxamide compounds useful as kinase inhibitors

Publications (2)

Publication Number Publication Date
CN105473573A CN105473573A (zh) 2016-04-06
CN105473573B true CN105473573B (zh) 2018-03-16

Family

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CN201480046669.2A Expired - Fee Related CN105473573B (zh) 2013-06-25 2014-06-25 用作激酶抑制剂的咔唑甲酰胺化合物

Country Status (13)

Country Link
US (1) US9714234B2 (https=)
EP (1) EP3013815B1 (https=)
JP (1) JP6353530B2 (https=)
KR (1) KR102345381B1 (https=)
CN (1) CN105473573B (https=)
AU (1) AU2014302550A1 (https=)
BR (1) BR112015031432A2 (https=)
CA (1) CA2916504A1 (https=)
EA (1) EA025863B1 (https=)
IL (1) IL243295A0 (https=)
MX (1) MX2015016771A (https=)
SG (1) SG11201510028PA (https=)
WO (1) WO2014210087A1 (https=)

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EA034931B1 (ru) 2014-10-24 2020-04-08 Бристол-Майерс Сквибб Компани Индолкарбоксамидные соединения
SI3209651T1 (sl) 2014-10-24 2019-12-31 Bristol-Myers Squibb Company Derivati karbazola
JP6592512B2 (ja) 2014-10-24 2019-10-16 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 三環式アトロプ異性体の化合物
CN105802100A (zh) * 2016-04-22 2016-07-27 宁波硫华聚合物有限公司 橡胶促进剂粘合剂六甲氧基甲基蜜胺预分散母胶粒及其制备方法
CN105670057A (zh) * 2016-04-25 2016-06-15 无锡智谷锐拓技术服务有限公司 一种耐油橡胶的制备方法
CN105694150A (zh) * 2016-04-25 2016-06-22 无锡智谷锐拓技术服务有限公司 一种耐油橡胶
CN105907150A (zh) * 2016-06-02 2016-08-31 扬州兰都塑料科技有限公司 一种电缆涂料用阻燃剂
CN106084903A (zh) * 2016-06-02 2016-11-09 扬州兰都塑料科技有限公司 一种电缆外部涂覆的水性防火涂料的制备方法
CN106045972B (zh) * 2016-06-03 2018-11-16 中山大学 咔唑-利凡斯的明二联体及其药物组合物和应用
EP4100408B1 (en) 2020-02-03 2024-02-28 Bristol-Myers Squibb Company Tricyclic heteroaryl compounds useful as irak4 inhibitors
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
CN115232061B (zh) * 2021-09-18 2024-01-30 山西紫罗蓝新材料科技有限公司 一种3-硝基-9-乙基咔唑粗产物的提取工艺

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CN102325753A (zh) * 2008-12-19 2012-01-18 百时美施贵宝公司 用作激酶抑制剂的咔唑甲酰胺化合物

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Also Published As

Publication number Publication date
KR102345381B1 (ko) 2021-12-29
JP2016523908A (ja) 2016-08-12
EP3013815B1 (en) 2017-05-03
BR112015031432A2 (pt) 2017-07-25
WO2014210087A1 (en) 2014-12-31
KR20160022890A (ko) 2016-03-02
AU2014302550A1 (en) 2016-02-11
EA025863B1 (ru) 2017-02-28
MX2015016771A (es) 2016-03-31
US9714234B2 (en) 2017-07-25
EP3013815A1 (en) 2016-05-04
JP6353530B2 (ja) 2018-07-04
CN105473573A (zh) 2016-04-06
EA201690012A1 (ru) 2016-05-31
IL243295A0 (en) 2016-02-29
SG11201510028PA (en) 2016-01-28
CA2916504A1 (en) 2014-12-31
US20160200710A1 (en) 2016-07-14

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