CN105473573B - 用作激酶抑制剂的咔唑甲酰胺化合物 - Google Patents

用作激酶抑制剂的咔唑甲酰胺化合物 Download PDF

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Publication number
CN105473573B
CN105473573B CN201480046669.2A CN201480046669A CN105473573B CN 105473573 B CN105473573 B CN 105473573B CN 201480046669 A CN201480046669 A CN 201480046669A CN 105473573 B CN105473573 B CN 105473573B
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China
Prior art keywords
carbazole
carboxamide
methylphenyl
dioxo
methyl
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Expired - Fee Related
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CN201480046669.2A
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English (en)
Chinese (zh)
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CN105473573A (zh
Inventor
S·S·科
D·G·巴特
M·B·贝特朗
G·V·德卢卡
C·M·兰格文
Q·刘
A·S·斯里瓦斯塔瓦
S·H·沃特森
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201480046669.2A 2013-06-25 2014-06-25 用作激酶抑制剂的咔唑甲酰胺化合物 Expired - Fee Related CN105473573B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361839130P 2013-06-25 2013-06-25
US61/839,130 2013-06-25
PCT/US2014/043980 WO2014210087A1 (en) 2013-06-25 2014-06-25 Carbazole carboxamide compounds useful as kinase inhibitors

Publications (2)

Publication Number Publication Date
CN105473573A CN105473573A (zh) 2016-04-06
CN105473573B true CN105473573B (zh) 2018-03-16

Family

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CN201480046669.2A Expired - Fee Related CN105473573B (zh) 2013-06-25 2014-06-25 用作激酶抑制剂的咔唑甲酰胺化合物

Country Status (13)

Country Link
US (1) US9714234B2 (OSRAM)
EP (1) EP3013815B1 (OSRAM)
JP (1) JP6353530B2 (OSRAM)
KR (1) KR102345381B1 (OSRAM)
CN (1) CN105473573B (OSRAM)
AU (1) AU2014302550A1 (OSRAM)
BR (1) BR112015031432A2 (OSRAM)
CA (1) CA2916504A1 (OSRAM)
EA (1) EA025863B1 (OSRAM)
IL (1) IL243295A0 (OSRAM)
MX (1) MX2015016771A (OSRAM)
SG (1) SG11201510028PA (OSRAM)
WO (1) WO2014210087A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110511209B (zh) 2014-10-24 2022-07-05 百时美施贵宝公司 可用作激酶抑制剂的吲哚甲酰胺化合物
SG10201903621SA (en) 2014-10-24 2019-05-30 Bristol Myers Squibb Co Tricyclic atropisomer compounds
HRP20192197T2 (hr) 2014-10-24 2020-11-13 Bristol-Myers Squibb Company Derivati karbazola
CN105802100A (zh) * 2016-04-22 2016-07-27 宁波硫华聚合物有限公司 橡胶促进剂粘合剂六甲氧基甲基蜜胺预分散母胶粒及其制备方法
CN105670057A (zh) * 2016-04-25 2016-06-15 无锡智谷锐拓技术服务有限公司 一种耐油橡胶的制备方法
CN105694150A (zh) * 2016-04-25 2016-06-22 无锡智谷锐拓技术服务有限公司 一种耐油橡胶
CN106084903A (zh) * 2016-06-02 2016-11-09 扬州兰都塑料科技有限公司 一种电缆外部涂覆的水性防火涂料的制备方法
CN105907150A (zh) * 2016-06-02 2016-08-31 扬州兰都塑料科技有限公司 一种电缆涂料用阻燃剂
CN106045972B (zh) * 2016-06-03 2018-11-16 中山大学 咔唑-利凡斯的明二联体及其药物组合物和应用
CN115335380B (zh) 2020-02-03 2024-08-02 百时美施贵宝公司 可用作irak4抑制剂的三环杂芳基化合物
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
CN115232061B (zh) * 2021-09-18 2024-01-30 山西紫罗蓝新材料科技有限公司 一种3-硝基-9-乙基咔唑粗产物的提取工艺

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CN102325753A (zh) * 2008-12-19 2012-01-18 百时美施贵宝公司 用作激酶抑制剂的咔唑甲酰胺化合物

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Also Published As

Publication number Publication date
EA025863B1 (ru) 2017-02-28
EA201690012A1 (ru) 2016-05-31
US9714234B2 (en) 2017-07-25
MX2015016771A (es) 2016-03-31
WO2014210087A1 (en) 2014-12-31
EP3013815A1 (en) 2016-05-04
IL243295A0 (en) 2016-02-29
SG11201510028PA (en) 2016-01-28
BR112015031432A2 (pt) 2017-07-25
KR20160022890A (ko) 2016-03-02
JP2016523908A (ja) 2016-08-12
EP3013815B1 (en) 2017-05-03
CA2916504A1 (en) 2014-12-31
US20160200710A1 (en) 2016-07-14
CN105473573A (zh) 2016-04-06
AU2014302550A1 (en) 2016-02-11
KR102345381B1 (ko) 2021-12-29
JP6353530B2 (ja) 2018-07-04

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