CN105473144A - 用于加速斑块消退的组合物和治疗方法 - Google Patents

用于加速斑块消退的组合物和治疗方法 Download PDF

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Publication number
CN105473144A
CN105473144A CN201480046366.0A CN201480046366A CN105473144A CN 105473144 A CN105473144 A CN 105473144A CN 201480046366 A CN201480046366 A CN 201480046366A CN 105473144 A CN105473144 A CN 105473144A
Authority
CN
China
Prior art keywords
pharmaceutically acceptable
acceptable salt
rosuvastatin
dimethoxyquinazoline
oxethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480046366.0A
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English (en)
Chinese (zh)
Inventor
K·E·莱贝达
J·O·约翰逊
F·A·戈登
F·S·齐亚科齐亚
C·R·A·哈利迪
E·B·库利科夫斯基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Resverlogix Corp
Original Assignee
Resverlogix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resverlogix Corp filed Critical Resverlogix Corp
Publication of CN105473144A publication Critical patent/CN105473144A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CN201480046366.0A 2013-08-21 2014-08-21 用于加速斑块消退的组合物和治疗方法 Pending CN105473144A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361868386P 2013-08-21 2013-08-21
US61/868,386 2013-08-21
PCT/IB2014/002546 WO2015025226A2 (en) 2013-08-21 2014-08-21 Compositions and therapeutic methods for accelerated plaque regression

Publications (1)

Publication Number Publication Date
CN105473144A true CN105473144A (zh) 2016-04-06

Family

ID=52484226

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480046366.0A Pending CN105473144A (zh) 2013-08-21 2014-08-21 用于加速斑块消退的组合物和治疗方法

Country Status (14)

Country Link
US (1) US20160206617A1 (pt)
EP (1) EP3035934A4 (pt)
JP (1) JP2016528275A (pt)
KR (1) KR20160043117A (pt)
CN (1) CN105473144A (pt)
AU (1) AU2014310369A1 (pt)
BR (1) BR112016003584A8 (pt)
CA (1) CA2921985A1 (pt)
CL (1) CL2016000379A1 (pt)
EA (1) EA201690284A1 (pt)
HK (1) HK1219434A1 (pt)
IL (1) IL244166A0 (pt)
MX (1) MX2016002302A (pt)
WO (1) WO2015025226A2 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115003306A (zh) * 2020-01-08 2022-09-02 雷斯韦洛吉克斯公司 用bet溴结构域抑制剂和二肽基肽酶4抑制剂的组合治疗和/或预防主要不良心血管事件(mace)的方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101641339B (zh) 2007-02-01 2013-07-17 雷斯韦洛吉克斯公司 用于预防和治疗心血管疾病的化合物
MX2021012876A (es) 2009-03-18 2022-06-23 Resverlogix Corp Nuevos agentes anti-inflamatorios.
ES2821018T3 (es) 2009-04-22 2021-04-23 Resverlogix Corp Nuevos agentes antiinflamatorios
PT2773354T (pt) 2011-11-01 2019-07-17 Resverlogix Corp Formulações orais de libertação imediata para quinazolinonas substituídas
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
KR20160043118A (ko) * 2013-08-21 2016-04-20 리스버로직스 코퍼레이션 가속화된 경화반 퇴행을 위한 조성물 및 치료방법
US10111885B2 (en) 2015-03-13 2018-10-30 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
MX2022005029A (es) * 2019-11-05 2022-07-12 Resverlogix Corp Metodos de tratamiento y/o prevencion de acontecimientos cardiovasculares adversos graves (mace) con una combinacion de un inhibidor de bromodominio y extraterminal (bet) y un inhibidor de transporte de glucosa dependiente de sodio 2.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101641339A (zh) * 2007-02-01 2010-02-03 雷斯韦洛吉克斯公司 用于预防和治疗心血管疾病的化合物

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NZ556545A (en) * 2002-03-22 2009-03-31 Novartis Ag Combination comprising a beta-hydroxy-beta-methylglutaryl-co-enzyme-A reductase inhibitor and a glucagon-like peptide-1 agonist
US20080085911A1 (en) * 2006-10-10 2008-04-10 Reliant Pharmaceuticals, Inc. Statin and omega-3 fatty acids for reduction of apo-b levels
EP2675445A1 (en) * 2011-02-16 2013-12-25 Pivotal Therapeutics, Inc. Statin and omega 3 fatty acids (epa, dha and dpa) for use in cardiovascular diseases
AU2014205553A1 (en) * 2013-01-08 2015-07-09 Volant Holdings Gmbh Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems
KR20160043118A (ko) * 2013-08-21 2016-04-20 리스버로직스 코퍼레이션 가속화된 경화반 퇴행을 위한 조성물 및 치료방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
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CN101641339A (zh) * 2007-02-01 2010-02-03 雷斯韦洛吉克斯公司 用于预防和治疗心血管疾病的化合物

Non-Patent Citations (4)

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Title
DANA BAILEY等: "RVX-208，A Small Molecule That Increases Apolipoprotein A-I and High-Density Lipoprotein Cholesterol In Vitro and In Vivo", 《JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY》 *
STEPHEN J. NICHOLLS等: "ApoA-I Induction as a Potential Cardioprotective Strategy: Rationale for the SUSTAIN and ASSURE Studies", 《CARDIOVASCULAR DRUGS AND THERAPY》 *
STEPHEN J. NICHOLLS等: "Efficacy and Safety of a Novel Oral Inducer of Apolipoprotein A-I Synthesis in Statin-Treated Patients With Stable Coronary Artery Disease", 《JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY》 *
无: "SUCCESSFUL ASSERT TRIAL RESULT IN RESVERLOGIX FILING NEW RVX-208 PATENT", 《HTTPS://WWW.RESVERLOGIX.COM/INVESTORS/NEWS?ARTICLE=453》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115003306A (zh) * 2020-01-08 2022-09-02 雷斯韦洛吉克斯公司 用bet溴结构域抑制剂和二肽基肽酶4抑制剂的组合治疗和/或预防主要不良心血管事件(mace)的方法

Also Published As

Publication number Publication date
EA201690284A1 (ru) 2016-08-31
HK1219434A1 (zh) 2017-04-07
EP3035934A4 (en) 2017-04-26
BR112016003584A8 (pt) 2018-01-30
KR20160043117A (ko) 2016-04-20
WO2015025226A2 (en) 2015-02-26
CA2921985A1 (en) 2015-02-26
US20160206617A1 (en) 2016-07-21
WO2015025226A9 (en) 2015-12-03
MX2016002302A (es) 2016-06-15
EP3035934A2 (en) 2016-06-29
IL244166A0 (en) 2016-04-21
CL2016000379A1 (es) 2016-08-26
AU2014310369A1 (en) 2016-03-10
JP2016528275A (ja) 2016-09-15
AU2014310369A2 (en) 2016-04-21
WO2015025226A3 (en) 2015-06-25

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