CN105463439B - 铑配合物修饰的钛金属材料及其制备方法和用途 - Google Patents
铑配合物修饰的钛金属材料及其制备方法和用途 Download PDFInfo
- Publication number
- CN105463439B CN105463439B CN201510793931.6A CN201510793931A CN105463439B CN 105463439 B CN105463439 B CN 105463439B CN 201510793931 A CN201510793931 A CN 201510793931A CN 105463439 B CN105463439 B CN 105463439B
- Authority
- CN
- China
- Prior art keywords
- rhodium complex
- metal material
- added
- titanium
- milliliter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229910052703 rhodium Inorganic materials 0.000 title claims abstract description 70
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 title claims abstract description 70
- 239000010948 rhodium Substances 0.000 title claims abstract description 69
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 title claims abstract description 64
- 239000010936 titanium Substances 0.000 title claims abstract description 64
- 229910052719 titanium Inorganic materials 0.000 title claims abstract description 64
- 239000007769 metal material Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000012986 modification Methods 0.000 title claims abstract description 6
- 230000004048 modification Effects 0.000 title claims abstract description 6
- 244000309466 calf Species 0.000 claims abstract description 22
- 210000001541 thymus gland Anatomy 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 12
- 229910052751 metal Inorganic materials 0.000 claims abstract description 6
- 239000002184 metal Substances 0.000 claims abstract description 6
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 5
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 claims description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Natural products C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 claims description 24
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 21
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 21
- 125000005577 anthracene group Chemical group 0.000 claims description 21
- 108020004414 DNA Proteins 0.000 claims description 20
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 20
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 19
- BRWIZMBXBAOCCF-UHFFFAOYSA-N hydrazinecarbothioamide Chemical compound NNC(N)=S BRWIZMBXBAOCCF-UHFFFAOYSA-N 0.000 claims description 18
- 125000002252 acyl group Chemical group 0.000 claims description 17
- 235000019441 ethanol Nutrition 0.000 claims description 17
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 claims description 17
- 239000012141 concentrate Substances 0.000 claims description 15
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 10
- LULWASAYMJSAPB-UHFFFAOYSA-N 6-(oxomethylidene)cyclohexa-2,4-diene-1-carbaldehyde Chemical compound O=CC1C=CC=CC1=C=O LULWASAYMJSAPB-UHFFFAOYSA-N 0.000 claims description 9
- 150000002118 epoxides Chemical class 0.000 claims description 9
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 9
- DYNFCHNNOHNJFG-UHFFFAOYSA-N 2-formylbenzoic acid Chemical class OC(=O)C1=CC=CC=C1C=O DYNFCHNNOHNJFG-UHFFFAOYSA-N 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 125000003963 dichloro group Chemical group Cl* 0.000 claims description 7
- PZSJYEAHAINDJI-UHFFFAOYSA-N rhodium(3+) Chemical class [Rh+3] PZSJYEAHAINDJI-UHFFFAOYSA-N 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
- DQMGZCOKSYOUNY-UHFFFAOYSA-N [O].C1=CC=CC2=CC3=CC=CC=C3C=C21 Chemical compound [O].C1=CC=CC2=CC3=CC=CC=C3C=C21 DQMGZCOKSYOUNY-UHFFFAOYSA-N 0.000 claims description 5
- 239000000460 chlorine Substances 0.000 claims description 5
- 229910052801 chlorine Inorganic materials 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 238000003810 ethyl acetate extraction Methods 0.000 claims description 4
- 102000053602 DNA Human genes 0.000 claims description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 150000001335 aliphatic alkanes Chemical class 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- WQIQNKQYEUMPBM-UHFFFAOYSA-N pentamethylcyclopentadiene Chemical compound CC1C(C)=C(C)C(C)=C1C WQIQNKQYEUMPBM-UHFFFAOYSA-N 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 6
- 230000001093 anti-cancer Effects 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 25
- -1 Pentadienyl Chemical group 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 7
- 230000008901 benefit Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
- 229910021529 ammonia Inorganic materials 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 description 3
- 125000005909 ethyl alcohol group Chemical group 0.000 description 3
- 235000011181 potassium carbonates Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 150000003583 thiosemicarbazides Chemical class 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical class O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 238000012565 NMR experiment Methods 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002189 fluorescence spectrum Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
- C23C22/05—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions
- C23C22/68—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using aqueous solutions using aqueous solutions with pH between 6 and 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C22/00—Chemical surface treatment of metallic material by reaction of the surface with a reactive liquid, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
- C23C22/78—Pretreatment of the material to be coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
细胞株 | U2-OS | CNE-1 |
IC50(umol/mL) | 13.6 | 20.2 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510793931.6A CN105463439B (zh) | 2015-11-17 | 2015-11-17 | 铑配合物修饰的钛金属材料及其制备方法和用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510793931.6A CN105463439B (zh) | 2015-11-17 | 2015-11-17 | 铑配合物修饰的钛金属材料及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105463439A CN105463439A (zh) | 2016-04-06 |
CN105463439B true CN105463439B (zh) | 2018-09-04 |
Family
ID=55601588
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510793931.6A Active CN105463439B (zh) | 2015-11-17 | 2015-11-17 | 铑配合物修饰的钛金属材料及其制备方法和用途 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105463439B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109232662B (zh) * | 2018-11-07 | 2020-08-14 | 广西中医药大学 | 抗肿瘤作用的化合物及其制备方法和应用 |
CN109438525B (zh) * | 2018-11-07 | 2020-08-14 | 广西中医药大学 | 具有化疗和光疗抗肿瘤作用的化合物及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102964387A (zh) * | 2012-11-30 | 2013-03-13 | 广西师范学院 | 一种有机金属钌离子对化合物及其制备方法和用途 |
CN103113414A (zh) * | 2013-03-06 | 2013-05-22 | 广西中医药大学 | 一种芳基钌配合物及其制备方法和用途 |
CN104402940A (zh) * | 2014-11-18 | 2015-03-11 | 广西中医药大学 | 一种铑配合物及其制备方法和用途 |
-
2015
- 2015-11-17 CN CN201510793931.6A patent/CN105463439B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102964387A (zh) * | 2012-11-30 | 2013-03-13 | 广西师范学院 | 一种有机金属钌离子对化合物及其制备方法和用途 |
CN103113414A (zh) * | 2013-03-06 | 2013-05-22 | 广西中医药大学 | 一种芳基钌配合物及其制备方法和用途 |
CN104402940A (zh) * | 2014-11-18 | 2015-03-11 | 广西中医药大学 | 一种铑配合物及其制备方法和用途 |
Non-Patent Citations (1)
Title |
---|
Synthesis, crystal and electronic structure,anticancer activity of ruthenium(II) arene,complexes with thiosemicarbazones;Wei Su et al.;《Appl. Organometal. Chem.》;20130411;第27卷;第307-312页 * |
Also Published As
Publication number | Publication date |
---|---|
CN105463439A (zh) | 2016-04-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104892543B (zh) | 噻唑类化合物及其合成方法和应用 | |
Swetha et al. | Synthesis, characterization and antimicrobial evaluation of ferrocene–oxime ether benzyl 1 H-1, 2, 3-triazole hybrids | |
CN102101847B (zh) | N-甲基-n′-(2-氯乙基)哌嗪的制备方法 | |
CN103923034B (zh) | 一种蒎烷基-3-[4-(取代基)-2-噻唑]腙类化合物及其合成方法和应用 | |
CN105463439B (zh) | 铑配合物修饰的钛金属材料及其制备方法和用途 | |
CN106588945B (zh) | 阿司匹林抗癌药物偶联物、合成方法及其应用 | |
CN105288727B (zh) | 利用铑配合物制备具有抗菌抗癌的二氧化钛纳米管的方法 | |
CN108997229B (zh) | 1,2,3,4-四氢喹喔啉-6-羧酸甲酯及其制备方法 | |
CN105457087B (zh) | 铱配合物修饰的钛金属材料及其制备方法和用途 | |
CN113121458B (zh) | 一种超声波辐射催化快速合成2,3-二氨基吩嗪的方法 | |
CN106588826B (zh) | 阿司匹林紫杉醇抗癌药物偶联物、合成方法及其应用 | |
CN105457091B (zh) | 铑配合物修饰的聚乙烯材料及其制备方法与用途 | |
CN111848537B (zh) | 一种绿原酸衍生物的合成方法及抗菌活性测定方法 | |
CN105288726B (zh) | 钌配合物修饰的钛金属材料及其制备方法和用途 | |
CN105288753B (zh) | 姜黄素衍生物修饰的钛金属材料及其制备方法和用途 | |
CN106188089A (zh) | 倒捻子素衍生物a,其制备方法及其抗肿瘤的用途 | |
CN105777773B (zh) | 噻吩[2,3‑b]喹啉衍生物及其合成方法和应用 | |
CN105420718B (zh) | 铱配合物修饰的不锈钢材料及其制备方法与用途 | |
CN102584670B (zh) | 一种吲哚-3-甲醛缩苯二胺双席夫碱及其制备方法 | |
CN109704925B (zh) | 一种吉马酮衍生物及其制备方法与应用 | |
CN105693705B (zh) | 基于香豆素的唑醇类化合物及其制备方法和应用 | |
CN101215263B (zh) | 用于生物降解聚合物合成的催化剂苯甲酸肌酐胍的制备 | |
CN105239068A (zh) | 钌配合物修饰的不锈钢材料及其制备方法与用途 | |
CN107536835A (zh) | 1,3‑二氨基‑7H‑吡咯[3,2‑f]喹唑啉衍生物作为抗菌药物的应用以及药物 | |
CN111217795B (zh) | 一种抗菌药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210119 Address after: 710000 Shaanxi Xi'an economic and Technological Development Zone, Fengcheng four road, Ming Guang road, southeast corner of the new business building 1808 Patentee after: SHAANXI ZHUANYI INTELLECTUAL PROPERTY OPERATION Co.,Ltd. Address before: 530213 No. 13 Wuhe Avenue, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region Patentee before: Guangxi University of Chinese Medicine |
|
TR01 | Transfer of patent right |
Effective date of registration: 20211125 Address after: 257091 room 419, building a, Dongying Economic and Technological Development Zone Management Committee, No. 59, Fuqian street, Dongying District, Dongying City, Shandong Province Patentee after: Dongying dongkai New Material Industrial Park Co.,Ltd. Address before: 710000 Shaanxi Xi'an economic and Technological Development Zone, Fengcheng four road, Ming Guang road, southeast corner of the new business building 1808 Patentee before: SHAANXI ZHUANYI INTELLECTUAL PROPERTY OPERATION CO.,LTD. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20221230 Address after: 257091 Room 101, Building 5, Science and Technology Enterprise Accelerator, No. 17, Xinghuahe Road, Dongying Development Zone, Shandong Province Patentee after: Dongying Dongkai New Material Technology Research and Development Co.,Ltd. Address before: 257091 room 419, building a, Dongying Economic and Technological Development Zone Management Committee, No. 59, Fuqian street, Dongying District, Dongying City, Shandong Province Patentee before: Dongying dongkai New Material Industrial Park Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240126 Address after: Room 405, Building A, Technology Enterprise Accelerator, No. 17 Xinghuahe Road, Development Zone, Dongying City, Shandong Province, 257091 Patentee after: Dongying Dongkai Industrial Park Operation Management Co.,Ltd. Country or region after: China Address before: 257091 Room 101, Building 5, Science and Technology Enterprise Accelerator, No. 17, Xinghuahe Road, Dongying Development Zone, Shandong Province Patentee before: Dongying Dongkai New Material Technology Research and Development Co.,Ltd. Country or region before: China |
|
TR01 | Transfer of patent right |