CN105440135A - 用于治疗肿瘤的抗-pd-l1结合物 - Google Patents

用于治疗肿瘤的抗-pd-l1结合物 Download PDF

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Publication number
CN105440135A
CN105440135A CN201410440824.0A CN201410440824A CN105440135A CN 105440135 A CN105440135 A CN 105440135A CN 201410440824 A CN201410440824 A CN 201410440824A CN 105440135 A CN105440135 A CN 105440135A
Authority
CN
China
Prior art keywords
imidazo
amino
alkyl
quinolin
ethoxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410440824.0A
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English (en)
Chinese (zh)
Inventor
李立新
刘华涛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Birdie Biopharmaceuticals Inc Cayman Islands
Original Assignee
Birdie Biopharmaceuticals Inc Cayman Islands
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Birdie Biopharmaceuticals Inc Cayman Islands filed Critical Birdie Biopharmaceuticals Inc Cayman Islands
Priority to CN201410440824.0A priority Critical patent/CN105440135A/zh
Priority to CN202011353067.5A priority patent/CN112546238A/zh
Priority to CN202011360594.9A priority patent/CN112587672A/zh
Priority to ES15819519T priority patent/ES2910446T3/es
Priority to PCT/CN2015/083585 priority patent/WO2016004876A1/en
Priority to EP15819519.8A priority patent/EP3166976B1/en
Priority to KR1020177003560A priority patent/KR102462743B1/ko
Priority to AU2015286043A priority patent/AU2015286043B2/en
Priority to CA2954446A priority patent/CA2954446A1/en
Priority to TW104122202A priority patent/TWI691335B/zh
Priority to DK15819519.8T priority patent/DK3166976T3/da
Priority to TW108134121A priority patent/TWI727427B/zh
Priority to CN201580036993.0A priority patent/CN107074958A/zh
Priority to EP22151690.9A priority patent/EP4001311B1/en
Priority to JP2017500812A priority patent/JP6760919B2/ja
Priority to JP2017530389A priority patent/JP6921745B2/ja
Priority to PCT/CN2015/088456 priority patent/WO2016034085A1/en
Priority to DK15839010.4T priority patent/DK3189082T3/da
Priority to CA2959564A priority patent/CA2959564A1/en
Priority to KR1020177008631A priority patent/KR20170072192A/ko
Priority to ES15839010T priority patent/ES2822560T3/es
Priority to EP15839010.4A priority patent/EP3189082B1/en
Priority to CN201580037746.2A priority patent/CN107074959A/zh
Priority to US15/508,033 priority patent/US11130812B2/en
Priority to AU2015311400A priority patent/AU2015311400B2/en
Priority to EP20191420.7A priority patent/EP3763742B1/en
Priority to EP22199269.6A priority patent/EP4148069A1/en
Publication of CN105440135A publication Critical patent/CN105440135A/zh
Priority to US15/401,843 priority patent/US20170114137A1/en
Priority to US16/029,352 priority patent/US11279761B2/en
Priority to US16/053,540 priority patent/US20190048084A1/en
Priority to JP2020147949A priority patent/JP7252644B2/ja
Priority to AU2020267157A priority patent/AU2020267157B2/en
Priority to AU2021201166A priority patent/AU2021201166A1/en
Priority to US17/405,680 priority patent/US20220033503A1/en
Priority to US17/669,177 priority patent/US20220251212A1/en
Priority to AU2022211790A priority patent/AU2022211790B2/en
Priority to JP2023041774A priority patent/JP7636820B2/ja
Priority to ARP240101137A priority patent/AR132604A2/es
Priority to JP2025018420A priority patent/JP2025065346A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN201410440824.0A 2014-07-09 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物 Pending CN105440135A (zh)

Priority Applications (39)

Application Number Priority Date Filing Date Title
CN201410440824.0A CN105440135A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
CN202011353067.5A CN112546238A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
CN202011360594.9A CN112587672A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
ES15819519T ES2910446T3 (es) 2014-07-09 2015-07-08 Combinaciones anti-PD-L1 para tratar tumores
PCT/CN2015/083585 WO2016004876A1 (en) 2014-07-09 2015-07-08 Anti-pd-l1 combinations for treating tumors
EP15819519.8A EP3166976B1 (en) 2014-07-09 2015-07-08 Anti-pd-l1 combinations for treating tumors
KR1020177003560A KR102462743B1 (ko) 2014-07-09 2015-07-08 종양 치료용 항-pd-l1 조합
AU2015286043A AU2015286043B2 (en) 2014-07-09 2015-07-08 Anti-PD-L1 combinations for treating tumors
CA2954446A CA2954446A1 (en) 2014-07-09 2015-07-08 Anti-pd-l1 combinations for treating tumors
TW104122202A TWI691335B (zh) 2014-07-09 2015-07-08 用於治療腫瘤的抗pd-l1組合
DK15819519.8T DK3166976T3 (da) 2014-07-09 2015-07-08 Anti-pd-l1-kombinationer til behandling af tumorer
TW108134121A TWI727427B (zh) 2014-07-09 2015-07-08 用於治療腫瘤的抗pd-1組合
CN201580036993.0A CN107074958A (zh) 2014-07-09 2015-07-08 用于治疗肿瘤的抗‑pd‑l1组合
EP22151690.9A EP4001311B1 (en) 2014-07-09 2015-07-08 Anti-pd-l1/pd-1 combinations for treating tumors
JP2017500812A JP6760919B2 (ja) 2014-07-09 2015-07-08 腫瘍を治療するための抗ｐｄ−ｌ１組み合わせ
KR1020177008631A KR20170072192A (ko) 2014-09-01 2015-08-29 종양 치료용 항-pd-l1 접합체
CN201580037746.2A CN107074959A (zh) 2014-09-01 2015-08-29 用于治疗肿瘤的抗‑pd‑l1结合物
DK15839010.4T DK3189082T3 (da) 2014-09-01 2015-08-29 Anti-pd-l1-konjugater til behandling af tumorer
CA2959564A CA2959564A1 (en) 2014-09-01 2015-08-29 Anti-pd-l1 conjugates for treating tumors
JP2017530389A JP6921745B2 (ja) 2014-09-01 2015-08-29 腫瘍を治療するための抗ｐｄ−ｌ１コンジュゲート
ES15839010T ES2822560T3 (es) 2014-09-01 2015-08-29 Conjugados anti-PD-L1 para tratar tumores
EP15839010.4A EP3189082B1 (en) 2014-09-01 2015-08-29 Anti-pd-l1 conjugates for treating tumors
PCT/CN2015/088456 WO2016034085A1 (en) 2014-09-01 2015-08-29 Anti-pd-l1 conjugates for treating tumors
US15/508,033 US11130812B2 (en) 2014-09-01 2015-08-29 Anti PD-L1 conjugates for treating tumors
AU2015311400A AU2015311400B2 (en) 2014-09-01 2015-08-29 Anti-PD-L1 conjugates for treating tumors
EP20191420.7A EP3763742B1 (en) 2014-09-01 2015-08-29 Anti-pd-l1 conjugates for treating tumors
EP22199269.6A EP4148069A1 (en) 2014-09-01 2015-08-29 Anti-pd-l1 conjugates for treating tumors
US15/401,843 US20170114137A1 (en) 2014-07-09 2017-01-09 Anti-pd-l1 combinations for treating tumors
US16/029,352 US11279761B2 (en) 2014-07-09 2018-07-06 Anti-PD-L1 combinations for treating tumors
US16/053,540 US20190048084A1 (en) 2014-07-09 2018-08-02 Anti-pd-l1 combinations for treating tumors
JP2020147949A JP7252644B2 (ja) 2014-07-09 2020-09-03 腫瘍を治療するための組み合わせ物およびキット
AU2020267157A AU2020267157B2 (en) 2014-07-09 2020-11-09 Anti-pd-l1 combinations for treating tumors
AU2021201166A AU2021201166A1 (en) 2014-09-01 2021-02-23 Anti-pd-l1 conjugates for treating tumors
US17/405,680 US20220033503A1 (en) 2014-09-01 2021-08-18 Anti PD-L1 Conjugates for Treating Tumors
US17/669,177 US20220251212A1 (en) 2014-07-09 2022-02-10 Anti-pd-l1 combinations for treating tumors
AU2022211790A AU2022211790B2 (en) 2014-07-09 2022-08-01 Anti-pd-l1 combinations for treating tumours
JP2023041774A JP7636820B2 (ja) 2014-07-09 2023-03-16 腫瘍を治療するための組み合わせ物
ARP240101137A AR132604A2 (es) 2014-07-09 2024-05-03 Kit que comprende anti-pd-l1
JP2025018420A JP2025065346A (ja) 2014-07-09 2025-02-06 腫瘍を治療するための抗ｐｄ－ｌ１組み合わせ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410440824.0A CN105440135A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202011360594.9A Division CN112587672A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
CN202011353067.5A Division CN112546238A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物

Publications (1)

Publication Number Publication Date
CN105440135A true CN105440135A (zh) 2016-03-30

Family

ID=55439131

Family Applications (4)

Application Number Title Priority Date Filing Date
CN202011353067.5A Pending CN112546238A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
CN201410440824.0A Pending CN105440135A (zh) 2014-07-09 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
CN202011360594.9A Pending CN112587672A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
CN201580037746.2A Pending CN107074959A (zh) 2014-09-01 2015-08-29 用于治疗肿瘤的抗‑pd‑l1结合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN202011353067.5A Pending CN112546238A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN202011360594.9A Pending CN112587672A (zh) 2014-09-01 2014-09-01 用于治疗肿瘤的抗-pd-l1结合物
CN201580037746.2A Pending CN107074959A (zh) 2014-09-01 2015-08-29 用于治疗肿瘤的抗‑pd‑l1结合物

Country Status (10)

Country Link
US (2) US11130812B2 (enExample)
EP (3) EP3763742B1 (enExample)
JP (1) JP6921745B2 (enExample)
KR (1) KR20170072192A (enExample)
CN (4) CN112546238A (enExample)
AU (2) AU2015311400B2 (enExample)
CA (1) CA2959564A1 (enExample)
DK (1) DK3189082T3 (enExample)
ES (1) ES2822560T3 (enExample)
WO (1) WO2016034085A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107574149A (zh) * 2016-07-05 2018-01-12 上海细胞治疗研究院 一种树突状细胞的高效促成熟方法及其用途
CN107750166A (zh) * 2015-06-16 2018-03-02 默克专利股份有限公司 Pd‑l1 拮抗剂组合治疗
CN109476648A (zh) * 2016-06-06 2019-03-15 豪夫迈·罗氏有限公司 司维司群抗体-药物缀合物和使用方法
CN109897036A (zh) * 2019-03-15 2019-06-18 沈阳药科大学 三唑并吡啶类化合物及其制备方法和用途
CN112041346A (zh) * 2018-03-23 2020-12-04 伊莱利利公司 用于与抗pd-1抗体组合的抗cd137抗体
CN115337406A (zh) * 2021-05-13 2022-11-15 清华大学 一种抗体药物偶联物及其制备方法和应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI729512B (zh) 2008-12-09 2021-06-01 美商建南德克公司 抗pd-l1抗體及其於增進t細胞功能之用途
CN112587658A (zh) * 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
US10548985B2 (en) 2014-01-10 2020-02-04 Birdie Biopharmaceuticals, Inc. Compounds and compositions for treating EGFR expressing tumors
MX2016012779A (es) 2014-03-31 2017-04-27 Genentech Inc Terapia de combinacion con agentes antiangiogénesis y agonistas de unión a ox40.
CA2954446A1 (en) 2014-07-09 2016-01-14 Shanghai Birdie Biotech, Inc. Anti-pd-l1 combinations for treating tumors
CN112546238A (zh) 2014-09-01 2021-03-26 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
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