CN105434286A - Plant composition and preparation method and application thereof - Google Patents

Abstract

The invention discloses a plant composition and a preparation method and application thereof. The plant composition is obtained by extracting the following raw materials in parts by weight: 35 to 45 parts of fructus kochiae, 35 to 45 parts of gerbera, 35 to 45 parts of radix zanthoxyli, 20 to 30 parts of berberis julianae schneid and 15 to 25 parts of almond. The plant composition has the efficacy of removing old cutin, adjusting skin homergy, diminishing inflammation and suppressing itching, and the process for adding the plant composition into cosmetics is simple. The experimental result shows that the cosmetics containing the plant composition can effectively improve associated symptoms caused by keratosis pilaris, so that skins can be recovered to be smooth and white.

Description

Vegetable composition and its preparation method and application

Technical field

The present invention relates to cosmetic field, be specifically related to a kind of vegetable composition and its preparation method and application.

Background technology

The all keratinization of hair, also known as follicular keratosis, pore keratinization, Corium Gallus domesticus skin etc., this is a kind of genetic dermatosis, opening part due to hair follicle sebum glandular tube has keratinization phenomenon, formed so-called " keratotic plug ", and chosure of pores after sclerosis, can be caused to cause on skin little pimple one by one, so skin surface touches up rough, resemble goose pimples.These outward appearances are just like the little pimple as pin mark, and the distribution of being dispersed in property, color is the colour of skin, bronzing or brown.This is a kind of comparatively common abnormal cutaneous keratinization disease, and many without significant discomfort, time autumn and winter may cause pruritus.People extrude pimple and scratching all can cause inflammation and cutaneous pigmentation.This disease does not have too much influence to life, but very large for women's impact of liking to be beautiful, because it is apt to occur in the women of adolescence to 40 year old.The method that this disease is not also effected a radical cure at present, but suitably some medicines of application can improve skin appearance perception.

Find in the practice of the invention, keratosis pilaris is quite common skin problem, and recovery from illness is difficult, can only improve.Due to the disease that pore keratinization is relevant with cutin, so general treatment is all with exfoliation ointment for first-selection, similarly be A acid, fruit acid, salicylic acid and carbamide etc.The effect of A acid is comparatively deep, directly can have influence on nucleus, removes abnormal keratinization, and life-time service can reach certain therapeutic effect.Salicylic acid, originally as fat-soluble, just along hair follicle opening, can arrive keratinization position along skin oil and fat, and then dissolve cutin, improve symptom.But these methods are all cured the symptoms, not the disease, if often process like this, the barrier function of skin also can be made to become more weak, make skin drier, more responsive.They also have a lot of side effect: 1. may cause that dermatitis causes skin rubefaction, decortication, drying, itches, pain symptom; 2. skin is made to weaken ultraviolet protective capacities; 3. pigementation heighten degree; 4. make outermost layer cutin thinning.Keratosis pilaris cannot effect a radical cure, and can only improve by long-term prescription, and the side effect of common drug is comparatively large, life-time service may cause larger injury to skin.

Summary of the invention

For the problems referred to above, the object of this invention is to provide a kind of vegetable composition and its preparation method and application.Described vegetable composition have remove old cutin, regulation of skin homergy, antiinflammatory move back red, to suppress pruritus effect, and action temperature and, can life-time service, be added into technique in cosmetics simple, adapted to suitability for industrialized production.

The object of the invention is to be achieved through the following technical solutions:

The invention provides a kind of vegetable composition, described vegetable composition extracts gained by following weight parts raw material:

Fructus Kochiae 30-40 part, Herba Leibnitziae 35-45 part, Radix Zanthoxyli 35-45 part, Radix Berberidis 20-30 part, Semen Armeniacae Amarum 15-25 part.

The Fructus Kochiae is the dry mature fruit of chenopod Fructus Kochiae, has the effects such as clearing away heat-damp and promoting diuresis.Modern pharmacological research shows, the Fructus Kochiae have antibacterial, kill the effects such as demodicid mite.The metabolism of Fructus Kochiae extract energy regulation of skin cell, strengthen skin cell tissue inside microcirculation, remove old cell, promote skin nature cleaning function.

Herba Leibnitziae has the effect such as calmness, hypnosis, antibacterial, antiinflammatory, antioxidation, blood pressure lowering, and in daily use chemicals, can produce by free radical in T suppression cell, can make skin whitening, by fossil pigments Reduction fading in skin, disappear silt dissipating rashes; Also there is the effects such as antiinflammatory, reducing swelling and alleviating pain, antiallergic, antiviral simultaneously.

Radix Zanthoxyli has effect of blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispelling wind and removing obstruction in the collateral and removing toxic substances and promoting subsidence of swelling, is used for the treatment of stomachache, toothache, rheumatic arthralgia, traumatic injury, venom and burn and scald etc.Effective ingredient contained by Radix Zanthoxyli extract has antibacterial, antiinflammatory, analgesic effect, can alleviate inflammation and pain symptom.

The alkaloid such as main active berberine, berbamine, fibrauretin of Radix Berberidis, has the effects such as antibacterial, antiinflammatory, blood pressure lowering, antioxidation, is usually used in the diseases such as treatment diarrhoea, tuberculosis, tumor.

Semen Armeniacae Amarum contains these compositions of great advantage to appearance of abundant fatty oil, protein, VitAVitE and mineral, and they can help skin to resist oxidation, check melanin generates, and make skin more smooth careful.

The present invention, in order to improve hair week keratinization, takes and removes old cutin, regulation of skin homergy, antiinflammatory move back red, to suppress pruritus method, repair skin fast, prevent and treat pigementation.Screen raw material by great many of experiments, make each raw material effect produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.Find in the practice of the invention, Radix Zanthoxyli and Radix Berberidis jointly use synergism can occur with special ratios, have significant itching-relieving action.

In some embodiments, described vegetable composition extracts gained by following weight parts raw material:

The Fructus Kochiae 35 parts, Herba Leibnitziae 40 parts, Radix Zanthoxyli 40 parts, Radix Berberidis 25 parts, 20 parts, Semen Armeniacae Amarum.

The invention provides a kind of preparation method of vegetable composition, the preparation method of described vegetable composition comprises the following steps:

(1) by proportioning raw materials weighing, pulverize, mixing, obtains plant mixture;

(2) in the plant mixture described in step (1), add the ethanol water of 60-80%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:9-1:11, soak after 2 hours, ultrasonic Treatment 20-40 minute, material temperature is 40-60 DEG C, filter, collect filtrate;

(3) being 1.05-1.10 by recording relative density during step (2) gained filtrate reduced in volume to 50 DEG C, obtaining vegetable composition.

In some embodiments, the preparation method of described vegetable composition comprises the following steps:

(1) by proportioning raw materials weighing, pulverize, mixing, obtains plant mixture;

(2) in the plant mixture described in step (1), add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, material temperature is 50 DEG C, filters, and collects filtrate;

(3) being 1.05-1.10 by recording relative density during step (2) gained filtrate reduced in volume to 50 DEG C, obtaining vegetable composition.

Another object of the present invention is to provide the application of a kind of vegetable composition in cosmetics.

Above-mentioned vegetable composition proves through long-term experiment, low to skin irritation, can be used as effective ingredient and directly adds in cosmetics.

Carrier in cosmetics can enumerate excipient, filming agent, bonding agent, extender, disintegrating agent, stabilizing agent, antioxidant, lubricant, diluent, diluent, buffer agent, osmotic pressure regulator, pH adjusting agent, emulsifying agent, antiseptic, surfactant, coloring agent, UV absorbent, wetting agent, thickening agent, active reinforcing agent, anti-inflammatory agent, antibacterial, spice, correctives, flavoring agent etc.

The invention provides a kind of emulsion, described emulsion comprises the component of following percentage by weight:

Sorbitan stearate: 1.3-1.7wt%

PEG-60 Span60: 1.6-2.0wt%,

Glyceryl stearate/PEG-100 stearate: 1-3wt%,

Cetearyl alcohol: 0.3-0.7wt%,

Isopropyl myristate: 4-5wt%,

White mineral oil: 8-10wt%,

Polydimethylsiloxane: 1-3wt%,

Butylated hydroxytoluene: 0.03-0.07wt%,

Methyl hydroxybenzoate: 0.1-0.14wt%,

Propyl hydroxybenzoate: 0.06-0.1wt%,

Glycerol: 3-5wt%,

Sorbitol: 6-10wt%,

Xanthan gum: 0.1-0.14wt%,

Acrylate/C10-30 alkyl acrylate cross-linked polymer: 0.1-0.3wt%,

Silicon stone: 0.3-0.7wt%,

Citric acid: 0.03-0.05wt%,

Polyacrylamide/C13-14 isoparaffin/laureth-7:0.3-0.5wt%,

Bisabolol: 0.2-0.4wt%,

Potassium hydroxide: 0.06-0.08wt%,

Vitamin A palmitate: 0.3-0.5wt%,

Carbamide: 3-5wt%,

Methylisothiazolinone: 0.06-0.1wt%,

Vegetable composition provided by the invention: 2-8wt%,

Deionized water: surplus.

A kind of vegetable composition provided by the invention and the application in cosmetics thereof have the following advantages and beneficial effect:

1, there is the metabolism of regulation of skin cell, promote effect that old cutin upgrades, effectively can prevent, improve or eliminate Keratoderma symptom.

2, there is effect of anti-inflammation, make skin relieving the swelling and redness.

3, there is effect of reduction skin pigment, effectively can prevent, improve or eliminate skin pigmentation.

4, there is significant itching-relieving efficacies.

5, to skin action temperature and, can skin care, prevent xerosis cutis, prevent the further keratinization of skin.

6, to join in cosmetics technique simple for vegetable composition provided by the invention, adapts to suitability for industrialized production.

Detailed description of the invention

Embodiment 1

Fructus Kochiae 300g, Herba Leibnitziae 450g, Radix Zanthoxyli 350g, Radix Berberidis 300g, Semen Armeniacae Amarum 150g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, and material temperature is 50 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition A1.

Embodiment 2

Fructus Kochiae 350g, Herba Leibnitziae 400g, Radix Zanthoxyli 400g, Radix Berberidis 250g, Semen Armeniacae Amarum 200g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 60%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:9, soaks after 2 hours, ultrasonic Treatment 20 minutes, and material temperature is 40 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition A2.

Embodiment 3

Fructus Kochiae 350g, Herba Leibnitziae 400g, Radix Zanthoxyli 400g, Radix Berberidis 250g, Semen Armeniacae Amarum 200g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, and material temperature is 50 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition A3.

Embodiment 4

Fructus Kochiae 350g, Herba Leibnitziae 400g, Radix Zanthoxyli 400g, Radix Berberidis 250g, Semen Armeniacae Amarum 200g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 80%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:11, soaks after 2 hours, ultrasonic Treatment 40 minutes, and material temperature is 60 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition A4.

Embodiment 5

Fructus Kochiae 400g, Herba Leibnitziae 350g, Radix Zanthoxyli 450g, Radix Berberidis 200g, Semen Armeniacae Amarum 250g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, and material temperature is 50 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition A5.

Comparative example 1

Fructus Kochiae 250g, Herba Leibnitziae 500g, Radix Zanthoxyli 300g, Radix Berberidis 350g, Semen Armeniacae Amarum 100g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, and material temperature is 50 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition B1.

Comparative example 2

Fructus Kochiae 450g, Herba Leibnitziae 300g, Radix Zanthoxyli 500g, Radix Berberidis 150g, Semen Armeniacae Amarum 300g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, and material temperature is 50 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition B2.

Comparative example 3

Fructus Kochiae 350g, Herba Leibnitziae 400g, Radix Zanthoxyli 400g, Radix Berberidis 250g, Semen Armeniacae Amarum 200g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 50%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:8, soaks after 2 hours, ultrasonic Treatment 20 minutes, and material temperature is 30 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition B3.

Comparative example 4

Fructus Kochiae 350g, Herba Leibnitziae 400g, Radix Zanthoxyli 400g, Radix Berberidis 250g, Semen Armeniacae Amarum 200g are weighed by proportioning, pulverize, mixing, obtains plant mixture.In plant mixture, add the ethanol water of 90%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:12, soaks after 2 hours, ultrasonic Treatment 50 minutes, and material temperature is 70 DEG C, filters, and collects filtrate.Recording relative density when concentrating filtrate to 50 DEG C is 1.05-1.10, obtains vegetable composition B4.

Embodiment 6 anti-inflammatory effect is verified

(1) test specimen: according to the vegetable composition that embodiment 1-5 and comparative example 1-4 is obtained, be divided into tested material a1, a2, a3, a4, a5, b1, b2, b2, b3 with after normal saline dilution 10 times respectively, embodiment 1 gained vegetable composition A1 dilutes to obtain tested material a1, embodiment 2 gained vegetable composition A2 dilutes to obtain tested material a2, embodiment 3 gained vegetable composition A3 dilutes to obtain tested material a3, embodiment 4 gained vegetable composition A4 dilutes to obtain tested material a4, embodiment 5 gained vegetable composition A5 dilutes to obtain tested material a5, comparative example 1 gained vegetable composition B1 dilutes to obtain tested material b1, comparative example 2 gained vegetable composition B2 dilutes to obtain tested material b2, comparative example 3 gained vegetable composition B3 dilutes to obtain tested material b3, comparative example 4 gained vegetable composition B4 dilutes to obtain tested material b4, take normal saline as blank reagent, with 0.01g/kg acetyl salicylic acid solution for positive control,

(2) experimental animal: the adult mice of health, skin zero damage, regular grade, totally 110, body weight is 20 ± 2g, is provided (animal productiong credit number: SCXK (river) 2001-0011) by Sichuan Province's medical experiment Institute of Botany, the experimental animal quality certification is numbered: 2001A032, the temperature of Animal House is 23 DEG C, and humidity is 52%RH, and drinking water is tap water, carry out random packet before experiment, often organize 10; Test prospective adaptation raises 7 days, feed of freely drinking water.

(3) test reagent:

Dimethylbenzene, purchased from Sichuan Ke Long chemical reagent factory.

Normal saline, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.

Aspirin, purchased from Cologne, Sichuan pharmaceutcal corporation, Ltd.

(4) experimental procedure:

1. mice is weighed respectively, labelling.

2. 9 groups of mices use different tested material 0.5mL gavage respectively, 1 group of mice is as blank group 0.5mL normal saline gavage, 1 group of mice as positive controls with the acetyl salicylic acid solution gavage of 0.5mL, every day gavage twice, at least 8 hours are separated during twice gavage, continuous gastric infusion 8 days, feed of freely drinking water.

3. after last administration 30 minutes, namely 50 μ L caused by dimethylbenzene xylene are coated with at the left ear positive and negative of mice scorching.

4. put to death mice after 1 hour after last administration, cut ears.

5. lay auricle with the card punch of diameter 7mm at the symmetrical position of left and right ear, weigh in the balance heavily, record its quality, calculate its swelling rate.

(5) experimental result

Table 1 mice ear method measures the antiinflammation result of vegetable composition

Table 2 mice ear method measures the antiinflammation result of vegetable composition

* swelling rate=[(left ear quality-auris dextra quality)/auris dextra quality] × 100%

(6) interpretation of result

From table 1 and 2, compare with blank group, each tested material has obvious inhibitory action to mice auricle swelling, points out vegetable composition provided by the present invention to have the effect of antiinflammatory.Each tested material is compared with positive control, and wherein the anti-inflammatory effects of tested material a1-5 is all better than positive control, and the anti-inflammatory effects of tested material b1-4 is slightly worse than positive control.Tested material a1, a3, a5 are only that proportioning raw materials is different with the difference of b1-2, it can thus be appreciated that the raw material of vegetable composition Yin Teding proportioning provided by the invention produces synergism, has stronger anti-inflammatory effects.Tested material a2-4 compares with b3-4 and learns, their proportioning raw materials is identical and preparation method is different, and the anti-inflammatory effects of tested material a2-4 is comparatively obvious, and wherein the effect of tested material a3 is the most remarkable.

Embodiment 7 itching-relieving efficacies is verified

(1) test specimen: according to the vegetable composition that embodiment 1-5 and comparative example 1-4 is obtained, take normal saline as blank reagent, clobetasol propionate emulsifiable paste is positive control;

(2) experimental animal: the adult mice of health, skin zero damage, regular grade, totally 110, body weight is 20 ± 2g, is provided (animal productiong credit number: SCXK (river) 2001-0011) by Sichuan Province's medical experiment Institute of Botany, the experimental animal quality certification is numbered: 2001A032, the temperature of Animal House is 23 DEG C, and humidity is 52%RH, and drinking water is tap water, carry out random packet before experiment, often organize 10; Test prospective adaptation raises 7 days, feed of freely drinking water.

(3) test reagent:

Dextran, purchased from Sichuan Ke Long pharmaceutical factory.

(4) experimental procedure:

1., after mouse back shaves hair about 2cm × 3cm, by group is different, 0.5ml each sample is evenly applied on depilation district skin, once a day, continuous three days.

2. 30min after last administration, gives every mouse tail vein injection 0.025% dextran with the dosage of 1.25mg/kg.

3. observe immediately and record the time that the number of times of mice pruritus in 30min and each pruritus continue, and calculating the total time that in its 30min, pruritus continues.

(5) experimental result:

Table 3 vegetable composition is on the impact of dextran induced mice skin pruritus

Group	Number of cases	Pruritus number of times/time	Persistent period/s
				Blank	10	19.1	124.50
Positive control	10	12.70	89.20
				Vegetable composition A1	10	12.50	83.60
Vegetable composition A2	10	11.70	82.30
				Vegetable composition A3	10	11.10	81.40
Vegetable composition A4	10	11.80	82.70
				Vegetable composition A5	10	12.30	84.10
Vegetable composition B1	10	12.90	87.10
				Vegetable composition B2	10	13.10	92.20
Vegetable composition B4	10	13.10	93.70
				Vegetable composition B5	10	13.50	94.50

(6) evaluation of result:

From table 3, compare with blank group, each tested material all has remarkable minimizing to the antipruritic pruritus number of times of mice and pruritus persistent period, points out vegetable composition provided by the present invention to have antipruritic effect.Wherein the antipruritic effect of vegetable composition A1-5 is all better than positive control, and the antipruritic effect of vegetable composition B1-4 is relatively not obvious.Vegetable composition A1, A3, A5 are only that proportioning raw materials is different with the difference of B1-2, it can thus be appreciated that the raw material of vegetable composition Yin Teding proportioning provided by the invention produces synergism, has stronger antipruritic effect.Vegetable composition A2-4 with B3-4 compares and learns, their proportioning raw materials is identical and preparation method is different, and the anti-inflammatory effects of vegetable composition A2-4 is comparatively obvious, and wherein the effect of vegetable composition A3 is the most remarkable.

Embodiment more than 8 irritation test

(1) test specimen: according to the vegetable composition obtained by embodiment 1-5 and comparative example 1-4, is divided into tested material c1, c2, c3, c4, c5, d1, d2, d3, d4 with the water dilution of equivalent respectively, embodiment 1 gained vegetable composition A1 dilutes to obtain tested material c1, embodiment 2 gained vegetable composition A2 dilutes to obtain tested material c2, embodiment 3 gained vegetable composition A3 dilutes to obtain tested material c3, embodiment 4 gained vegetable composition A4 dilutes to obtain tested material c4, embodiment 5 gained vegetable composition A5 dilutes to obtain tested material c5, comparative example 1 gained vegetable composition B1 dilutes to obtain tested material d1, comparative example 2 gained vegetable composition B2 dilutes to obtain tested material d2, comparative example 3 gained vegetable composition B3 dilutes to obtain tested material d3, comparative example 4 gained vegetable composition B4 dilutes to obtain tested material d4,

(2) experimental animal: the adult white new zealand rabbit of health, skin zero damage, regular grade, totally 24, body weight is 2.2-2.5kg, thered is provided (animal productiong credit number: SCXK (Guangdong) 2003-0002) by Guangdong Medical Lab Animal Center, the experimental animal quality certification is numbered: 0003296, laboratory animal occupancy permit number: SYXK (Guangdong) 2003-0011, the temperature of Animal House is 23 DEG C, humidity is 52%RH, drinking water is tap water, carries out random packet before experiment, often organizes 4;

(3) test procedure:

1. cut by hair spinal column both sides, laboratory animal back before test, unhairing scope is respectively 3cmX3cm, application area 2.5cmX2.5cm;

2. O.5g get tested material spreads upon on the skin of side, and opposite side, as blank, smears 1 every day, smears 14 days continuously.From second day, smear front cropping at every turn, remain tested material, observed result after a hour with water or nonirritant solvent cleaning, the standards of grading specified according to " cosmetics health specification " (2007 editions) are marked.

(4) experimental result:

Table 4 tested material c1, c2, c3 many skin irritation reaction results

Table 5 tested material c4, c5, d1 many skin irritation reaction results

Table 6 tested material d2, d3, d4 many skin irritation reaction results

(5) evaluation of result

Every day every, animal average integral=Σ erythema and edema integration/animal subject number/14, judged skin irritation intensity with table 5;

Table 5 skin irritation strength grading

Integral mean value	Intensity
		0～<0.5	Nonirritant
0.5～<2.0	Subexcite
		2.0～<6.0	Moderate stimulation
6.0～8.0	Strong and stimulating

Tested material a1-a5 and the equal nonirritant of b3-4 of experimental group can be found out from table 4-7, prove thus to use raw material of the present invention, solvent and preparation method to extract and the vegetable composition that obtains to the comparatively safe nonirritant of skin.Tested material b1-b2 all has minimal irritation, and its solvent used is all identical with tested material a2-4 with preparation method, and only its proportioning raw materials is different, and it reduces the zest of skin with during specific proportioning use to describe raw material.

Embodiment 9

Vegetable composition A3 described in embodiment 3 is added in cosmetics as effective ingredient, obtained emulsion.

The composition of the emulsion of table 8 containing vegetable composition and preparation process

Embodiment 10 efficacy assessments

(1) experiment purpose

Evaluated by relative analysis, the improvement of pimple, pore that the emulsion obtained by Evaluation operation example 9 causes hair week keratinization general red, pruritus, pigementation and therapeutic efficiency, also have each emulsion to improve effect to xerodermatic.Positive control is made with a certain commercially available emulsion laying claim to treatment hair week keratinization effect.

(2) experimental technique

Collection xerosis cutis and have women's callus patient 120 people of keratosis pilaris shape in various degree, and have xerosis cutis and existing keratosis pilaris shape in various degree male's callus patient 90 people, be divided into 7 groups at random, often organize 30 people, 26.4 years old mean age, experimenter is healthy, without hereditary or passing medical history, without bad life habits etc.Carry out observation of curative effect for embodiment 7 gained emulsion, observe trier before testing and test area skin moisture, pimple, pore general red, pruritus, pigementation in test process and improve situation.

In the region of the selected about 5 × 5cm size in experimenter's hair week left and right sides, keratinization affected part as Experimental Area, by this region dimidiation, half tries out emulsion, and half is kept for reference contrast.Applying amount is about 5g, sooner or later respectively once, uses 8 weeks continuously.

(3) evaluation methodology

Trier's hair week keratinization improvement degree contrasts the Experimental Area of not smearing and makes self evaluation.

Trier's skin moisture content utilize moisture of skin scatter and disappear tester (TM210Tewameter) measure, not yet start the water loss amount first measuring recipient site skin before trying out, start to measure a moisture of skin windage in latter every two weeks on probation, recipient site measures after cleaning up 2 hours, the each repetition of each mensuration 5 times, calculates its TEWL average.

(4) experimental result

The pimple that emulsion tried out by table 9 improves degree

The general red improvement degree of pore of emulsion tried out by table 10

The pruritus that emulsion tried out by table 11 improves degree

The pigementation that emulsion tried out by table 12 improves degree

The moisture of skin windage measured value of emulsion tried out by table 13

(4) interpretation of result:

As can be seen from table 9-12, compared with blank, the obtained emulsion of embodiment 9 all has improvement result in various degree to the pimple of trier, pore general red, pruritus, pigementation symptom.Wherein the effect of latex A is better than blank and is slightly inferior to a certain commercially available emulsion, and the effect of emulsion B, C, D, E is all better than a certain commercially available emulsion, the effective ingredient concentration described in latex A does not reach valid density, its action effect is dose dependent, but when effective ingredient addition is greater than 8wt%, the lifting of its dosage to action effect is not obvious.

Emulsion latex A, B, C, D, E to scatter and disappear the improvement all had in various degree to trier's moisture of skin as can be seen from Table 13, effect is all better than blank and a certain commercially available emulsion, the water holding capacity that vegetable composition provided by the present invention contributes to repairing skin barrier, improves skin self is described, prevents to deepen keratosis pilaris shape because of xerosis cutis.

The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.

Claims (6)

1. a vegetable composition, is characterized in that, described vegetable composition extracts gained by following weight parts raw material:

Fructus Kochiae 30-40 part, Herba Leibnitziae 35-45 part, Radix Zanthoxyli 35-45 part, Radix Berberidis 20-30 part, Semen Armeniacae Amarum 15-25 part.

2. a kind of vegetable composition according to claim 1, is characterized in that, described vegetable composition extracts gained by following weight parts raw material:

The Fructus Kochiae 35 parts, Herba Leibnitziae 40 parts, Radix Zanthoxyli 40 parts, Radix Berberidis 25 parts, 20 parts, Semen Armeniacae Amarum.

3. the preparation method of a kind of vegetable composition according to claim 1 and 2, is characterized in that, the preparation method of described vegetable composition comprises the following steps:

(1) by proportioning raw materials weighing, pulverize, mixing, obtains plant mixture;

(2) in the plant mixture described in step (1), add the ethanol water of 60-80%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:9-1:11, soak after 2 hours, ultrasonic Treatment 20-40 minute, material temperature is 40-60 DEG C, filter, collect filtrate;

(3) being 1.05-1.10 by recording relative density during step (2) gained filtrate reduced in volume to 50 DEG C, obtaining vegetable composition.

4. the preparation method of a kind of vegetable composition according to claim 3, is characterized in that, the preparation method of described vegetable composition comprises the following steps:

(1) by proportioning raw materials weighing, pulverize, mixing, obtains plant mixture;

(2) in the plant mixture described in step (1), add the ethanol water of 70%, wherein the solid-liquid ratio g/ml of plant mixture and ethanol water is 1:10, soaks after 2 hours, ultrasonic Treatment 30 minutes, material temperature is 50 DEG C, filters, and collects filtrate;

(3) being 1.05-1.10 by recording relative density during step (2) gained filtrate reduced in volume to 50 DEG C, obtaining vegetable composition.

5. the application of a kind of vegetable composition in cosmetics according to any one of claim 1-4.

6. an emulsion, is characterized in that, described emulsion comprises the component of following percentage by weight:

Sorbitan stearate: 1.3-1.7wt%

PEG-60 Span60: 1.6-2.0wt%,

Glyceryl stearate/PEG-100 stearate: 1-3wt%,

Cetearyl alcohol: 0.3-0.7wt%,

Isopropyl myristate: 4-5wt%,

White mineral oil: 8-10wt%,

Polydimethylsiloxane: 1-3wt%,

Butylated hydroxytoluene: 0.03-0.07wt%,

Methyl hydroxybenzoate: 0.1-0.14wt%,

Propyl hydroxybenzoate: 0.06-0.1wt%,

Glycerol: 3-5wt%,

Sorbitol: 6-10wt%,

Xanthan gum: 0.1-0.14wt%,

Acrylate/C10-30 alkyl acrylate cross-linked polymer: 0.1-0.3wt%,

Silicon stone: 0.3-0.7wt%,

Citric acid: 0.03-0.05wt%,

Polyacrylamide/C13-14 isoparaffin/laureth-7:0.3-0.5wt%,

Bisabolol: 0.2-0.4wt%,

Potassium hydroxide: 0.06-0.08wt%,

Vitamin A palmitate: 0.3-0.5wt%,

Carbamide: 3-5wt%,

Methylisothiazolinone: 0.06-0.1wt%,

Vegetable composition as described in any one of claim 1-4: 2-8wt%,

Deionized water: surplus.