CN105431415A - 通过烯烃的弗瑞德-克来福特烷基化进行的8-氯-3-苯并[d]氮杂*的新合成方法 - Google Patents

通过烯烃的弗瑞德-克来福特烷基化进行的8-氯-3-苯并[d]氮杂*的新合成方法 Download PDF

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Publication number
CN105431415A
CN105431415A CN201480041113.4A CN201480041113A CN105431415A CN 105431415 A CN105431415 A CN 105431415A CN 201480041113 A CN201480041113 A CN 201480041113A CN 105431415 A CN105431415 A CN 105431415A
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formula
salt
compound
solvent
reaction
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CN201480041113.4A
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English (en)
Chinese (zh)
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G·斯塔夫伯
J·克吕佐
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Lek Pharmaceuticals dd
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Lek Pharmaceuticals dd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201480041113.4A 2013-05-20 2014-05-19 通过烯烃的弗瑞德-克来福特烷基化进行的8-氯-3-苯并[d]氮杂*的新合成方法 Pending CN105431415A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13168419 2013-05-20
EP13168419.3 2013-05-20
PCT/EP2014/060221 WO2014187768A1 (fr) 2013-05-20 2014-05-19 Nouveaux procédés de synthèse d'une 8-chloro-3-benzo[d]azépine par alkylation de friedel-crafts d'oléfine

Publications (1)

Publication Number Publication Date
CN105431415A true CN105431415A (zh) 2016-03-23

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ID=48430602

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480041113.4A Pending CN105431415A (zh) 2013-05-20 2014-05-19 通过烯烃的弗瑞德-克来福特烷基化进行的8-氯-3-苯并[d]氮杂*的新合成方法

Country Status (3)

Country Link
EP (1) EP2999692A1 (fr)
CN (1) CN105431415A (fr)
WO (1) WO2014187768A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105348197B (zh) * 2015-11-23 2018-07-03 中国药科大学 一种盐酸绿卡色林的制备方法
CN109265418B (zh) * 2018-09-19 2023-02-14 华南理工大学 一种含羰基的基于二苯并呋喃的室温磷光材料及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009051747A1 (fr) * 2007-10-15 2009-04-23 Concert Pharmaceuticals, Inc. Lorcasérine deutérée
CN101466684A (zh) * 2006-04-03 2009-06-24 艾尼纳制药公司 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体
CN101547892A (zh) * 2006-12-05 2009-09-30 艾尼纳制药公司 制备(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓的方法和其中间体
CN101573346A (zh) * 2006-12-31 2009-11-04 贝林格尔.英格海姆国际有限公司 3-氨基四氢呋喃-3-羧酸衍生物的合成方法及其作为药物的用途
CN102648170A (zh) * 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
PL2332921T3 (pl) 2003-06-17 2016-08-31 Arena Pharm Inc Chlorowodorek 8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny
US8822727B2 (en) 2008-03-04 2014-09-02 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-HT2C agonist (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CA2808900A1 (fr) * 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Formes posologiques a dissolution rapide d'agonistes de 5-ht2c
WO2012030938A1 (fr) * 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Sels de lorcasérine dotés d'acides optiquement actifs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101466684A (zh) * 2006-04-03 2009-06-24 艾尼纳制药公司 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体
CN101547892A (zh) * 2006-12-05 2009-09-30 艾尼纳制药公司 制备(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓的方法和其中间体
CN101573346A (zh) * 2006-12-31 2009-11-04 贝林格尔.英格海姆国际有限公司 3-氨基四氢呋喃-3-羧酸衍生物的合成方法及其作为药物的用途
WO2009051747A1 (fr) * 2007-10-15 2009-04-23 Concert Pharmaceuticals, Inc. Lorcasérine deutérée
CN102648170A (zh) * 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARCO BANDINI, MICHELE TRAGNI, AND ACHILLE UMANI-RONCHI: "IronACHTUNGTRENUNG(III)-Catalyzed Intramolecular Friedel–Crafts Alkylation of Electron-Deficient Arenes with π-Activated Alcohols", 《ADV. SYNTH. CATAL.》 *

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Publication number Publication date
EP2999692A1 (fr) 2016-03-30
WO2014187768A1 (fr) 2014-11-27

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Application publication date: 20160323