CN105412733A - Traditional Chinese medicine composition used for treating biliary ascariasis - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition used for treating biliary ascariasis. The traditional Chinese medicine composition is prepared from magnolia officinalis, longhairy antenoron herbs, endothelium corneum gigeriae galli, szechwan chinaberry fruit, malt, melon vines, morinda parvifolia, cyrtomium fortunei, radix paeoniae alba, franchet peashrub flowers, lycopodium clavatum, dark plum fruit, radix bupleuri, radix puerariae, virgate wormwood herbs, cinnamon, asarum sieboldii, gynostemma pentaphyllum, rhizoma coptidis, willow branches, rhizoma sparganii, caulis bambusae in taeniis, polygonum cuspidatum, schisandra chinensis, fruit of fiverleaf akebia, aurantii immaturus fructus, pinellia ternate, ovateleaf holly bark and cassia twigs. The traditional Chinese medicine composition is wide in medicine source, easy to prepare, good in curative effect, safe, free of toxic and side effects and suitable for application and popularization, and biliary ascariasis is not prone to relapse.

Description

A kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract.

Background technology

Ascariasis of biliary tract is a kind of complication the most serious in intestinal ascariasis, be more common in 6-8 school age population in year, peasant and late period anemia of pregnant woman.It is that the bellyworm motion caused by a variety of causes is active, and the acute upper abdominal pain piercing biliary tract and occur or biliary tract infection.During outbreak, Principle of Pain is difficult to stand, and wails and cries, very painful.If remedy measures does not catch up with, can there is dehydration in various degree and acidosis, even threat to life in end-stage patients.

Ascarid adult parasitizes hypomere in small intestinal, and when Whole Body and digestive tract function are disorderly, as improper in high heat, diarrhoea, hunger, gastric acidity reduction, eating and drinking without temperance, anthelmintic, stimulation etc. of performing the operation, all can the abnormal movement of excitation polypide, Shang Cuandan road; In addition ascarid alkali in the family way is detested acid, is had boring habit, more easily causes adult to bore gallbladder at cholangitis, calculus and sphincter dilatation etc.The person 80% that scurries into biliary tract, in bile duct, can be bar more than 1-100.After ascarid enters biliary tract, its mechanical stimulus, causes the strong spastic contractions of sphincter, occurs biliary colic, especially the part person of piercing, and irritation more takes place frequently, and enter biliary tract completely at it or exit voluntarily, symptom can be alleviated or disappear.The ascarid great majority entering biliary tract are dead in biliary tract, and its corpse fragment, cuticle, worm's ovum are by the core of calculus after becoming.The ascarid bile duct obstruction pierced caused by biliary tract is incomplete, therefore there is jaundice very less, the antibacterial that mainly ascarid is brought into causes bile duct inflammation, and ASCT, liver abscess, subphrenic abscess, biliary peritonitis, acute pancreatitis, hemobilia, toxic shock etc. can be caused, so that dead.

Clinical manifestation: have improper ascarifuge history more or have whole body and gastrointestinal disorders history, Zeng Youbian, vomiting ascaris worm history.(1) symptom: 1. bore the violent angor of top sample under the normal xiphoid-process for breaking out of stomachache, patient's pale complexion, feel restless, dripping sweat, bend over to split with laughter, cry and shout incessantly, very painful, back can be takeed on to the right during abdominal colic to diffuse, but also can alleviate suddenly.Stomachache mostly is paroxysmal, interval outbreak, and the persistent period is different in size, after pain, as ordinary person's peace and quiet or can tease, or lethargy.This symptom is the feature of biliary ascariasis, helps diagnosis.2. nausea and vomiting: often have generation, how when angor, occurs together, can contain bile or xanthochromia ascarid in spew.What have is " retch ", and patient can not normally take food.3. General Symptoms: early stage without heating of obviously feeling cold, can have feel cold heating and jaundice when complicated with acute pyogenic cholangitis, cholecystitis.As concurrent liver abscess, subphrenic infection, septicemia etc., then there is the high heat of shiver with cold, even toxic shock etc.(2) sign: although early stage upper angina abdominis, abdomen is soft or only upper abdomen is deeply in slight tenderness, without muscle tonus, significantly different from other acute abdomen., as there is liver, gallbladder pyogenic infection, peritonitis, can there be peritoneal irritation sign in late period: abdominal tenderness, rebound tenderness and muscle tonus.Maybe can touch enlargement and have the liver, gallbladder etc. of tenderness.Due to biliary tract ascarid blocking or cholelithiasis depositing, or liver toxicity infringement, jaundice in various degree can be had.

At present, treating biliary ascariasis mainly adopts operative treatment, antihelminthic chemotherapy, ERCP to get the method treatments such as worm.Operative treatment easily brings larger misery to patient; Antihelminthic chemotherapy easily makes polypide remains be retained in gallbladder and form cholelithiasis; ERCP gets worm can only take out part ascarid.So western medicine ascariasis of biliary tract poor effect, there is the deficiencies such as therapeutic effect is poor, treatment time is long, side effect is large.The various neuropathic condition that treatment ascariasis of biliary tract and ascariasis of biliary tract cause, generally comprise Western medicine Drug therapy and topical therapeutic, although this type of therapy prognosis bona, but because medicine is mostly Western medicine, Western medicine side effect is large, many patients have untoward reaction to Western medicine, and the therapeutic effect for ascariasis of biliary tract is not remarkable.

Summary of the invention

The present invention is directed to weak point of the prior art, provide a kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract, this Chinese medicine composition has effect of heat clearing and damp drying, liver-smoothing, qi-regulating, removing mass blood stasis removing, the stagnant parasite killing of row, and treatment ascariasis of biliary tract is evident in efficacy.

Above-mentioned purpose of the present invention is realized by following technical proposals:

Be used for the treatment of a Chinese medicine composition for ascariasis of biliary tract, the crude drug of described Chinese medicine composition is made up of Cortex Magnoliae Officinalis, Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Fructus Toosendan, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae, Herba Morindae Parvifoliae, Rhizoma Osmundae, the Radix Paeoniae Alba, Flos Caraganae Franchetianae, Herba Lycopodii, Fructus Mume, Radix Bupleuri, Radix Puerariae, Herba Artemisiae Scopariae, Cortex Cinnamomi, Herba Asari, Herb Gynostemmae Pentaphylli, Rhizoma Coptidis, Ramulus Salicis Babylonicae, Rhizoma Sparganii, Caulis Bambusae In Taenia, Rhizoma Polygoni Cuspidati, Fructus Schisandrae Chinensis, Fructus Akebiae, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, Cortex Ilicis Rotundae, Ramulus Cinnamomi.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 3-6 part, Herba Lysimachiae 8-13 part, Endothelium Corneum Gigeriae Galli 3-5 part, Fructus Toosendan 11-15 part, Fructus Hordei Germinatus 5-10 part, Caulis et Folium fici Tikouae 2-5 part, Herba Morindae Parvifoliae 4-9 part, Rhizoma Osmundae 12-20 part, Radix Paeoniae Alba 10-16 part, Flos Caraganae Franchetianae 3-8 part, Herba Lycopodii 5-12 part, Fructus Mume 12-17 part, Radix Bupleuri 7-12 part, Radix Puerariae 4-9 part, Herba Artemisiae Scopariae 15-20 part, Cortex Cinnamomi 10-15 part, Herba Asari 8-12 part, Herb Gynostemmae Pentaphylli 2-5 part, Rhizoma Coptidis 3-7 part, Ramulus Salicis Babylonicae 11-14 part, Rhizoma Sparganii 9-15 part, Caulis Bambusae In Taenia 3-6 part, Rhizoma Polygoni Cuspidati 8-13 part, Fructus Schisandrae Chinensis 3-5 part, Fructus Akebiae 1-3 part, Fructus Aurantii Immaturus 5-10 part, Rhizoma Pinelliae 5-10 part, Cortex Ilicis Rotundae 13-16 part, Ramulus Cinnamomi 3-10 part.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 6 parts, Herba Lysimachiae 8 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Toosendan 15 parts, 5 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 3 parts, Herba Morindae Parvifoliae 5 parts, Rhizoma Osmundae 12 parts, the Radix Paeoniae Alba 16 parts, Flos Caraganae Franchetianae 3 parts, Herba Lycopodii 12 parts, Fructus Mume 12 parts, Radix Bupleuri 10 parts, Radix Puerariae 9 parts, Herba Artemisiae Scopariae 15 parts, Cortex Cinnamomi 15 parts, Herba Asari 8 parts, Herb Gynostemmae Pentaphylli 5 parts, Rhizoma Coptidis 3 parts, Ramulus Salicis Babylonicae 14 parts, Rhizoma Sparganii 9 parts, Caulis Bambusae In Taenia 6 parts, Rhizoma Polygoni Cuspidati 8 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 1 part, Fructus Aurantii Immaturus 10 parts, the Rhizoma Pinelliae 5 parts, Cortex Ilicis Rotundae 16 parts, Ramulus Cinnamomi 10 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 4 parts, Herba Lysimachiae 10 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Toosendan 13 parts, 6 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 4 parts, Herba Morindae Parvifoliae 8 parts, Rhizoma Osmundae 20 parts, the Radix Paeoniae Alba 10 parts, Flos Caraganae Franchetianae 8 parts, Herba Lycopodii 5 parts, Fructus Mume 17 parts, Radix Bupleuri 12 parts, Radix Puerariae 4 parts, Herba Artemisiae Scopariae 20 parts, Cortex Cinnamomi 10 parts, Herba Asari 12 parts, Herb Gynostemmae Pentaphylli 2 parts, Rhizoma Coptidis 7 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 15 parts, Caulis Bambusae In Taenia 3 parts, Rhizoma Polygoni Cuspidati 13 parts, Fructus Schisandrae Chinensis 3 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 5 parts, the Rhizoma Pinelliae 10 parts, Cortex Ilicis Rotundae 13 parts, Ramulus Cinnamomi 3 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 5 parts, Herba Lysimachiae 12 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Toosendan 12 parts, 9 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 4 parts, Herba Morindae Parvifoliae 7 parts, Rhizoma Osmundae 13 parts, the Radix Paeoniae Alba 11 parts, Flos Caraganae Franchetianae 4 parts, Herba Lycopodii 6 parts, Fructus Mume 13 parts, Radix Bupleuri 7 parts, Radix Puerariae 5 parts, Herba Artemisiae Scopariae 18 parts, Cortex Cinnamomi 11 parts, Herba Asari 9 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 6 parts, Ramulus Salicis Babylonicae 12 parts, Rhizoma Sparganii 13 parts, Caulis Bambusae In Taenia 4 parts, Rhizoma Polygoni Cuspidati 9 parts, Fructus Schisandrae Chinensis 4 parts, Fructus Akebiae 2 parts, Fructus Aurantii Immaturus 6 parts, the Rhizoma Pinelliae 6 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 5 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 4 parts, Herba Lysimachiae 11 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Toosendan 14 parts, 8 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 3 parts, Herba Morindae Parvifoliae 6 parts, Rhizoma Osmundae 17 parts, the Radix Paeoniae Alba 15 parts, Flos Caraganae Franchetianae 7 parts, Herba Lycopodii 11 parts, Fructus Mume 16 parts, Radix Bupleuri 8 parts, Radix Puerariae 8 parts, Herba Artemisiae Scopariae 16 parts, Cortex Cinnamomi 14 parts, Herba Asari 11 parts, Herb Gynostemmae Pentaphylli 3 parts, Rhizoma Coptidis 5 parts, Ramulus Salicis Babylonicae 13 parts, Rhizoma Sparganii 14 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 12 parts, Fructus Schisandrae Chinensis 3 parts, Fructus Akebiae 1 part, Fructus Aurantii Immaturus 10 parts, the Rhizoma Pinelliae 9 parts, Cortex Ilicis Rotundae 13 parts, Ramulus Cinnamomi 7 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 6 parts, Herba Lysimachiae 9 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Toosendan 12 parts, 7 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 5 parts, Herba Morindae Parvifoliae 9 parts, Rhizoma Osmundae 15 parts, the Radix Paeoniae Alba 12 parts, Flos Caraganae Franchetianae 5 parts, Herba Lycopodii 9 parts, Fructus Mume 15 parts, Radix Bupleuri 9 parts, Radix Puerariae 7 parts, Herba Artemisiae Scopariae 19 parts, Cortex Cinnamomi 13 parts, Herba Asari 10 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 4 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 11 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 10 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 8 parts, the Rhizoma Pinelliae 8 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 9 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 3 parts, Herba Lysimachiae 8 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Toosendan 15 parts, 7 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 2 parts, Herba Morindae Parvifoliae 4 parts, Rhizoma Osmundae 19 parts, the Radix Paeoniae Alba 14 parts, Flos Caraganae Franchetianae 6 parts, Herba Lycopodii 7 parts, Fructus Mume 14 parts, Radix Bupleuri 9 parts, Radix Puerariae 6 parts, Herba Artemisiae Scopariae 17 parts, Cortex Cinnamomi 13 parts, Herba Asari 10 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 4 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 11 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 10 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 8 parts, the Rhizoma Pinelliae 8 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 4 parts.

Further, described Chinese medicine composition is prepared in accordance with the following steps:

(1) get each medical material of components by weight percent described in described Chinese medicine preparation, after mix homogeneously, be ground into smalls with pulverizer, be screened into 100 order ~ 200 object powder;

(2) by powder obtained in step (1), add the 10-12 water doubly of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the 12-13 water doubly of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the 14-15 water doubly of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, 120 orders filter, at filtrate heating is concentrated into 60 DEG C, relative density is 1.10 ~ 1.13, obtain concentrated solution, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make 80 order fine powders,

(3) the 80 order fine powders that step (2) is obtained are added suitable adjuvant and make granule, capsule, tablet.

The invention still further relates to the application of a kind of described Chinese medicine composition being used for the treatment of ascariasis of biliary tract in treatment biliary tract ascarid disease drug.

The Chinese medicine composition being used for the treatment of ascariasis of biliary tract provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Cortex Magnoliae Officinalis: bitter, pungent, temperature.Return spleen, stomach, lung, large intestine channel.Effect with cure mainly: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.

Herba Lysimachiae: sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Function cures mainly: relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.

Endothelium Corneum Gigeriae Galli is sweet, flat, returns spleen, stomach, small intestinal, urinary bladder channel, has effect of strengthening the spleen to promote digestion, only incontinence of urine, the inducing decomposition of calculi, is mainly used in food stagnation and does not disappear, vomiting dysentery, infantile malnutrition etc.

Fructus Toosendan: Chinese crude drug is the mature fruit of Meliaceae deciduous tree toosendanin, cold in nature, and bitter in the mouth is the one of qi-activating drug.There are soothing liver-QI promoting the circulation of QI to relieve pain, the drug effect of anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.But also be make efficiently without the important source material of the free of contamination novel plant pesticide of residual hazard.The sedimentation of Fructus Toosendan bitter cold, mainly enters Liver Channel, catharsis liver-heat, and promoting the circulation of QI to relieve pain, control the stagnation of QI and have the card of heat especially suitable.

Fructus Hordei Germinatus: nature and flavor: sweet is flat.Gui Jing: return spleen, stomach warp.Effect: spleen benefiting and stimulating the appetite, moves back newborn relieving distension.Cure mainly: do not disappear for food stagnation, women's ablactation, Fructus Hordei Germinatus (parched to brown) relieving dyspepsia.Do not disappear for food stagnation, abdominal distention.

Caulis et Folium fici Tikouae is stem, the leaf of moraceae plants Radix Pachyrhizi Erosi.Nature and flavor: bitter, cold.Function cures mainly: heat clearing away, and dampness removing is invigorated blood circulation, removing toxic substances.Control cough due to pathogenic wind-heat, dysentery, edema, jaundice, rheumatalgia, bleeding hemorrhoids, amenorrhea, leukorrhagia, infantile dyspepsia, traumatic injury, innominate toxic swelling.

Herba Morindae Parvifoliae is the Herb of dicotyledon medicine Maguireothamnus speciosus spire Radix Morindae Officinalis.Nature and flavor are sweet, cool.Function cures mainly: heat-clearing and toxic substances removing; Eliminating stasis to stop pain; Stomach function regulating removing dampness.Main cold cough; Pertussis; Dyspepsia; Eczema; Traumatic injury, lumbar muscle strain.

Rhizoma Osmundae, bitter, cool.Enter liver, stomach warp.Function cures mainly: kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control anemopyretic cold.Warm macule, spits blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia, skin infection, hematuria, menorrhagia, and knife injury is hemorrhage, ascarid, rich worm, taeniasis, artificial abortion, postpartum hemorrhage.

The Radix Paeoniae Alba is the famous traditional parts of generic medicinal plants of China, and applicating history is long, and Radix Paeoniae begins to be loaded in Eastern Han Dynasty's Shennong's Herbal, is classified as middle product, and note has " main pathogen, the Radix Paeoniae Alba is suffered from abdominal pain, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating ".Nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior disease.

Flos Caraganae Franchetianae is the flower of leguminous plant Yunnan caragana.Nature and flavor: property is put down, sweet and slightly bitter taste.Function cures mainly: QI invigorating kidney tonifying.Control dizziness headache, tinnitus dim eyesight, pulmonary tuberculosis cough, infantile malnutrition.

Herba Lycopodii, comes from " classifying herbal ".Nature and flavor: micro-hardship, pungent, temperature.Gui Jing: return liver,spleen,kidney warp.Function cures mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.For anemofrigid-damp arthralgia; Joint aches; Skin numbness; Tetraparesis; Edema; Traumatic injury; Jaundice; Cough; Skin infection; Herpes; Scald.

Fructus Mume: sour, puckery is flat.Return liver, spleen, lung, large intestine channel.Effect with cure mainly: astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung. chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache; Ascariasis of biliary tract.

Radix Bupleuri toil, cold nature, enters liver and gall warp.Induce sweat and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.For curing mainly cold, fever, alternate attack of chill and fever, malaria, few positive disease, stagnation of QI due to depression of the liver, collapse of QI, sternal rib pain, proctoptosis, uterus comes off, menoxenia.

Radix Puerariae, sweet in the mouth, pungent, cool in nature.Enter spleen, stomach warp.There is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, effect that relieving restlessness is only warm.For typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.Be used for Hypertension neck pain, angina pectoris clinically, but also there is hypoglycemic activity.

Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis." herbal classic ": the raw pathogenic heat gas of main air, accumulation of heat jaundice." not Lu ": control the whole body jaundice, dysuria, except feverish sensation in the head, removes mass in the large intestine.Supplement to the Herbal: get round by bribery, go stagnant heat, typhoid fever uses it." medical center bun is wanted ": hard kidney, dry spleen wets, and goes strongly fragrant, antipyretic." book on Chinese herbal medicine is new again ": pathogenic fire purging, suppressing the hyperactive liver, reduces phlegm, cough-relieving diaphoresis, dampness removing, detumescence, treats all poison of skin ulcer fire.

Cortex Cinnamomi: base is former: be dried bark and the branch skin of canella Cortex Cinnamomi.Chemical analysis: skin is containing volatile oil (title Oleum Cinnamomi) 1 ~ 2%, and main component is cinnamic aldehyde 75 ~ 90%, and containing a small amount of acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, phenylpropyl acetate etc.This product is not containing eugenol.Still mucous, tannin etc.Nature and flavor: Xin Gan, heat.Gui Jing: enter kidney, spleen, urinary bladder channel.Function cures mainly: complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower.

Herba Asari: nature and flavor are pungent, warm; Effect: dispel the wind, cold expelling, row water, has one's ideas straightened out.Herba Asari can outer dispersing wind and cold, again can in dispel YIN-cold, pain relieving simultaneously.

Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature; Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.After small number of patients is taken medicine, there is the symptom such as nausea and vomiting, abdominal distention diarrhoea (or constipation), dizziness, dim eyesight, tinnitus.After taking Herb Gynostemmae Pentaphylli, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time of hungering and thirst, and not only treats constipation but also control loose stool.Reaction that is excited to cerebral cortex and that suppress can keep suitable balance, has dual regulation to nervus centralis.There is excellent analgesia, sleeping, antitonic effect.

Rhizoma Coptidis, bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.

Ramulus Salicis Babylonicae, bitter, cold, return bright, the JUE YIN meridian of foot sun, dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain.

Rhizoma Sparganii: acrid in the mouth; Puckery; Cool.Enter liver.Spleen channel.Control lump in the abdomen, gather, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, postnatal blood stasis is suffered from abdominal pain, traumatic injury.Cough due to lung-heat controlled by mongolian medicine, asthma abundant expectoration, liver-heat, arteries and veins heat, the hot hectic fever due to YIN-deficiency of consumptive disease, and " precious day " is sick, fracture.

Caulis Bambusae In Taenia is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro BambusatuldoidesMunro, major part allusion quotation bamboo Sinocalamusbeecheyanus (Munro) Mc-Clurevar.pubescensP.F.Li or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle Phyllostachysnigra (Lodd.) Munrovar.henonis (Mitf.) StapfexRendle.Nature and flavor: sweet, are slightly cold.Attach to the lung and stomach meridians.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.

The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus." medical center bun will " carries it: hard kidney, strong Yang yi Jing, strengthening bone and muscle, increases strength.Apply to get injured by a fall and lose place, can reunion of fractured tendons and bones.

Fructus Schisandrae Chinensis is warm in nature; Sour in the mouth, sweet, return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Thirsty for Tianjin wound, deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.Modern study, containing abundant organic acid, vitamin, flavonoid, phytosterol and the lignan having potent reactivation, it is also one of the minority medical material having essence, gas, god's three large tonifications concurrently.

Fructus Akebiae: source: " decoction pieces is newly joined ".Nature and flavor: sweet, cold.Cure mainly: liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, cave warp, and uterus drops.

Fructus Aurantii Immaturus: temperature; Bitter, pungent, sour; Return spleen, stomach warp.Dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.

Cortex Ilicis Rotundae: medical material Ji Yuan: be bark or the root bark of holly plant Ilex rotunda Thunb..Nature and flavor are bitter; Cold.Return lung, liver, large intestine channel.Function cures mainly: heat-clearing and toxic substances removing; Dampness removing; Pain relieving.Main cold, fever; Laryngopharynx swelling and pain; Stomachache; Administration's diarrhea due to damp pathogen rushes down; Jaundice; Dysentery; Traumatic injury; Rheumatic arthralgia; Eczema; Furuncle.

Ramulus Cinnamomi acrid-sweet flavor, warm in nature, it is the interior temperature medicine that interior cold is commonly used, there is effect of complement sun, ventilation quality, promoting blood circulation, warming the spleen and stomach, normal and invigorating the liver and kidney medicine, fill blood medicine compatibility, treatment insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, has the effect of significantly analgesia and anti-cancer and cancer-preventing.

Motherland's medical science is early recognized ascariasis, " Medical Treasures of the Golden Chamber falls the swollen fingers and arms convulsion inguinal hernia ascarid abnormal pulse card that falls and controls " is recorded: " ascariasis of biliary tract person; when vomiting ascaris, make patient's quietness with occasional restlessness; this is the coldness of ZANG-organ, ascaris invading up to the diaphragm, thus tired; and the moment stops again; restlessness and vomiting after eating person, ascarid ascarides smelling food and then crawling upward, and its people works as from vomiting ascaris." traditional Chinese medical science thinks, the category that ascariasis of biliary tract belongs to substantially " ascariasis of biliary tract ", etiology and pathogenesis is internal organs deficiency and coldness, ascarid disturbs chest and diaphragm to pain; Cardinal symptom is: paroxysmal severe pain appears in right upper quadrant of the abdomen, often with feeling sick and vomiting etc., and cold extremities due to sweating, white and thin fur, deep and stringy pulse or heavy volt.Control and work as using medicines of both cold and hot natures simultaneously, relieving colic caused by ascaris parasite killing.

In Chinese medicine composition of the present invention, the expectorant of Cortex Magnoliae Officinalis dampness, the therapeutic method to keep the adverse QI flowing downwards is removed full, Herba Lysimachiae relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, Endothelium Corneum Gigeriae Galli strengthening the spleen to promote digestion, only incontinence of urine, the inducing decomposition of calculi, Fructus Toosendan has soothing liver-QI promoting the circulation of QI to relieve pain, the drug effect of anthelmintic, Fructus Hordei Germinatus spleen benefiting and stimulating the appetite, move back newborn relieving distension, Caulis et Folium fici Tikouae clearing away heat-damp and promoting diuresis, promoting blood circulation and detoxication, Herba Morindae Parvifoliae heat-clearing and toxic substances removing, eliminating stasis to stop pain, stomach function regulating removing dampness, Rhizoma Osmundae has parasite killing, heat-clearing and toxic substances removing, the effect of cooling blood for hemostasis, Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant, Flos Caraganae Franchetianae QI invigorating kidney tonifying, Herba Lycopodii expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, Fructus Mume is astringed the lung, astringing intestine to stop diarrhea, promote the production of body fluid, relieving colic caused by ascaris, Radix Bupleuri induces sweat and brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, Radix Puerariae yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only, Herba Artemisiae Scopariae clearing away damp-heat, Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation, Herba Asari expelling wind and cold, row water is had one's ideas straightened out, Herb Gynostemmae Pentaphylli benefiting vital QI for tranquillizing, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication, Ramulus Salicis Babylonicae dispels the wind diuresis, alleviating pain and detumescence, Rhizoma Sparganii regulating qi to disperse stagnation, promoting blood circulation and stopping pain, Caulis Bambusae In Taenia removing heat-phlegm, relieve restlessness and prevent vomiting, Rhizoma Polygoni Cuspidati heat-clearing and toxic substances removing, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, Fructus Schisandrae Chinensis convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming, Fructus Akebiae liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis, Fructus Aurantii Immaturus dispelling the stagnated QI removing food stagnancy, to reduce phlegm loose painful abdominal mass, Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, Cortex Ilicis Rotundae heat-clearing and toxic substances removing, dampness removing pain relieving, Ramulus Cinnamomi complement sun, ventilation quality, promoting blood circulation, warming the spleen and stomach.Each component organic assembling, dialectical compatibility and mutually assist a ruler in governing a country, enhance effect of this pharmaceutical composition heat clearing and damp drying, liver-smoothing, qi-regulating, removing mass blood stasis removing, the stagnant parasite killing of row, thus reach the object of curing ascariasis of biliary tract.

Chinese medicine composition medicine source of the present invention is extensive, prepares easy, good effect, not easily recurs, safe without toxic side effect, be applicable to applying.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.

Embodiment 1:

A kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract of the present invention, get following traditional Chinese medicine raw medicine: Cortex Magnoliae Officinalis 6 parts, Herba Lysimachiae 8 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Toosendan 15 parts, 5 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 3 parts, Herba Morindae Parvifoliae 5 parts, Rhizoma Osmundae 12 parts, the Radix Paeoniae Alba 16 parts, Flos Caraganae Franchetianae 3 parts, Herba Lycopodii 12 parts, Fructus Mume 12 parts, Radix Bupleuri 10 parts, Radix Puerariae 9 parts, Herba Artemisiae Scopariae 15 parts, Cortex Cinnamomi 15 parts, Herba Asari 8 parts, Herb Gynostemmae Pentaphylli 5 parts, Rhizoma Coptidis 3 parts, Ramulus Salicis Babylonicae 14 parts, Rhizoma Sparganii 9 parts, Caulis Bambusae In Taenia 6 parts, Rhizoma Polygoni Cuspidati 8 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 1 part, Fructus Aurantii Immaturus 10 parts, the Rhizoma Pinelliae 5 parts, Cortex Ilicis Rotundae 16 parts, Ramulus Cinnamomi 10 parts.

Wherein, described Chinese medicine composition is prepared according to following method:

(1) get each medical material of components by weight percent described in described Chinese medicine preparation, after mix homogeneously, be ground into smalls with pulverizer, be screened into 100 order ~ 200 object powder;

(2) by powder obtained in step (1), add the 10-12 water doubly of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the 12-13 water doubly of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the 14-15 water doubly of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, 120 orders filter, at filtrate heating is concentrated into 60 DEG C, relative density is 1.10 ~ 1.13, obtain concentrated solution, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make 80 order fine powders,

(3) the 80 order fine powders that step (2) is obtained are added suitable adjuvant and make granule, capsule, tablet.

Embodiment 2:

A kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract of the present invention, get following traditional Chinese medicine raw medicine: Cortex Magnoliae Officinalis 4 parts, Herba Lysimachiae 10 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Toosendan 13 parts, 6 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 4 parts, Herba Morindae Parvifoliae 8 parts, Rhizoma Osmundae 20 parts, the Radix Paeoniae Alba 10 parts, Flos Caraganae Franchetianae 8 parts, Herba Lycopodii 5 parts, Fructus Mume 17 parts, Radix Bupleuri 12 parts, Radix Puerariae 4 parts, Herba Artemisiae Scopariae 20 parts, Cortex Cinnamomi 10 parts, Herba Asari 12 parts, Herb Gynostemmae Pentaphylli 2 parts, Rhizoma Coptidis 7 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 15 parts, Caulis Bambusae In Taenia 3 parts, Rhizoma Polygoni Cuspidati 13 parts, Fructus Schisandrae Chinensis 3 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 5 parts, the Rhizoma Pinelliae 10 parts, Cortex Ilicis Rotundae 13 parts, Ramulus Cinnamomi 3 parts.

Preparation method is with embodiment 1.

Embodiment 3:

A kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract of the present invention, get following traditional Chinese medicine raw medicine: Cortex Magnoliae Officinalis 5 parts, Herba Lysimachiae 12 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Toosendan 12 parts, 9 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 4 parts, Herba Morindae Parvifoliae 7 parts, Rhizoma Osmundae 13 parts, the Radix Paeoniae Alba 11 parts, Flos Caraganae Franchetianae 4 parts, Herba Lycopodii 6 parts, Fructus Mume 13 parts, Radix Bupleuri 7 parts, Radix Puerariae 5 parts, Herba Artemisiae Scopariae 18 parts, Cortex Cinnamomi 11 parts, Herba Asari 9 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 6 parts, Ramulus Salicis Babylonicae 12 parts, Rhizoma Sparganii 13 parts, Caulis Bambusae In Taenia 4 parts, Rhizoma Polygoni Cuspidati 9 parts, Fructus Schisandrae Chinensis 4 parts, Fructus Akebiae 2 parts, Fructus Aurantii Immaturus 6 parts, the Rhizoma Pinelliae 6 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 5 parts.

Preparation method is with embodiment 1.

Embodiment 4:

A kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract of the present invention, get following traditional Chinese medicine raw medicine: Cortex Magnoliae Officinalis 4 parts, Herba Lysimachiae 11 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Toosendan 14 parts, 8 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 3 parts, Herba Morindae Parvifoliae 6 parts, Rhizoma Osmundae 17 parts, the Radix Paeoniae Alba 15 parts, Flos Caraganae Franchetianae 7 parts, Herba Lycopodii 11 parts, Fructus Mume 16 parts, Radix Bupleuri 8 parts, Radix Puerariae 8 parts, Herba Artemisiae Scopariae 16 parts, Cortex Cinnamomi 14 parts, Herba Asari 11 parts, Herb Gynostemmae Pentaphylli 3 parts, Rhizoma Coptidis 5 parts, Ramulus Salicis Babylonicae 13 parts, Rhizoma Sparganii 14 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 12 parts, Fructus Schisandrae Chinensis 3 parts, Fructus Akebiae 1 part, Fructus Aurantii Immaturus 10 parts, the Rhizoma Pinelliae 9 parts, Cortex Ilicis Rotundae 13 parts, Ramulus Cinnamomi 7 parts.

Preparation method is with embodiment 1.

Embodiment 5:

A kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract of the present invention, get following traditional Chinese medicine raw medicine: Cortex Magnoliae Officinalis 6 parts, Herba Lysimachiae 9 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Toosendan 12 parts, 7 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 5 parts, Herba Morindae Parvifoliae 9 parts, Rhizoma Osmundae 15 parts, the Radix Paeoniae Alba 12 parts, Flos Caraganae Franchetianae 5 parts, Herba Lycopodii 9 parts, Fructus Mume 15 parts, Radix Bupleuri 9 parts, Radix Puerariae 7 parts, Herba Artemisiae Scopariae 19 parts, Cortex Cinnamomi 13 parts, Herba Asari 10 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 4 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 11 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 10 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 8 parts, the Rhizoma Pinelliae 8 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 9 parts.

Preparation method is with embodiment 1.

Embodiment 6:

A kind of Chinese medicine composition being used for the treatment of ascariasis of biliary tract of the present invention, get following traditional Chinese medicine raw medicine: Cortex Magnoliae Officinalis 3 parts, Herba Lysimachiae 8 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Toosendan 15 parts, 7 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 2 parts, Herba Morindae Parvifoliae 4 parts, Rhizoma Osmundae 19 parts, the Radix Paeoniae Alba 14 parts, Flos Caraganae Franchetianae 6 parts, Herba Lycopodii 7 parts, Fructus Mume 14 parts, Radix Bupleuri 9 parts, Radix Puerariae 6 parts, Herba Artemisiae Scopariae 17 parts, Cortex Cinnamomi 13 parts, Herba Asari 10 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 4 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 11 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 10 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 8 parts, the Rhizoma Pinelliae 8 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 4 parts.

Preparation method is with embodiment 1.

Acute toxicity test:

Application mice 40, male and female half and half, body weight 23-26g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 6, (concentration is 8.51g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.55 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>42.55 crude drug/kg, every day, maximum dosage-feeding was 85.1 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 35g) oral administration gavage Chinese medicine of the present invention is 608 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Six months long term toxicity tests:

Chinese medicine embodiment 1 tablet of the present invention presses 13.85,22.53 and 43.74g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical reasoning:

In order to verify the effect of Chinese medicine composition of the present invention, in November ,-2014 in July, 2013, the routine ascariasis of biliary tract patient of outpatient service place Stochastic choice 180, is divided into treatment group and matched group two groups at random, treatment group 90 example, 3 ~ 61 years old age, 31.5 years old mean age; Matched group 90 example, 3 ~ 62 years old age, 30.8 years old mean age.Treatment group and matched group patient are in sex, and at the age, the course of disease, skin lesion, the aspect there was no significant differences such as symptom have comparability.

Diagnostic criteria:

(1) symptom

1. stomachache often bores the violent angor of top sample under the xiphoid-process that breaks out, patient's pale complexion, feel restless, dripping sweat, bend over to split with laughter, cry and shout incessantly, very painful, back can be takeed on to the right during abdominal colic and diffuse, but also can alleviate suddenly.Stomachache mostly is paroxysmal, interval outbreak, and the persistent period is different in size, after pain, as ordinary person's peace and quiet or can tease, or lethargy.This symptom is the feature of biliary ascariasis, helps diagnosis.Angor often in an endless stream enters caused by biliary tract in sphincter place or most adult because of polypide incarceration, and even angor is again and again shown effect, is difficult to alleviate.When sphincter is tired, lax, ascarid all enters biliary tract or exits biliary tract, temporary transient static time, symptom can respite.When there is biliary tract infection, then stomachache continues.When merging liver abscess, hepatic region, lower back distending pain can be had.When merging acute pancreatitis, stomachache extends in the middle part of upper abdomen, upper left abdomen and lower back.If ascarid causes biliary tract perforation, full abdomen continuing vigorous stomachache and peritoneal irritation sign can be there is.When ascarid causes hemobilia, the explosive pain of upper abdomen, slight jaundice and massive bleeding from upper digestive tract three can be had to levy.When biliary tract infection is serious, septicemia etc. can be there is.

2. nausea and vomiting often has generation, how when angor, occurs together, can contain bile or xanthochromia ascarid in spew.What have is " retch ", and patient can not normally take food.

3. General Symptoms is early stage without heating of obviously feeling cold, and can have feel cold heating and jaundice when complicated with acute pyogenic cholangitis, cholecystitis.As concurrent liver abscess, subphrenic infection, septicemia etc., then there is the high heat of shiver with cold, even toxic shock etc.

(2) sign

Although early stage upper angina abdominis, abdomen is soft or only upper abdomen is deeply in slight tenderness, without muscle tonus, significantly different from other acute abdomen., as there is liver, gallbladder pyogenic infection, peritonitis, can there be peritoneal irritation sign in late period: abdominal tenderness, rebound tenderness and muscle tonus.Maybe can touch enlargement and have the liver, gallbladder etc. of tenderness.Due to biliary tract ascarid blocking or cholelithiasis depositing, or liver toxicity infringement, jaundice in various degree can be had.

Therapeutic scheme:

Treatment group takes the embodiment of the present invention 3 gained tablet, oral, every day 2 times, each 2, within 3 days, is 1 course for the treatment of.

Matched group uses other medicine (example hydrochloric acid Ergamisole, mebendazole sheet etc.), and wherein, levamisole hydrochloride tablets: oral, adult 3/5-1 sheet/10kg, empty stomach or decoction being taken at a draught before sleeping, child dose is 1/10kg.Mebendazole sheet: every day 2 times, serve on 3 by each 1, and adult and child all take by above-mentioned dosage.

Efficacy determination:

Effective: ascariasis of biliary tract transference cure, observe half a year without bounce-back person;

Take a turn for the better: ascariasis of biliary tract symptom is obviously improved, and body constitution progressively strengthens;

Invalid: ascariasis of biliary tract symptom, without change, does not reach improvement standard person.

Therapeutic outcome

Two groups of therapeutic effect compare in table 1

Table 1 liang group patient effective percentage relative analysis

Group	Number of cases	Effective	Take a turn for the better	Do not heal	Effectively total
						Treatment group	90	67(74.4％)	21(23.3％)	2(2.2％)	88(97.8％)
Matched group	90	39(43.3％)	25(27.8％)	26(28.9％)	44(71.1％)

Wherein, total effective rate=cure rate+obvious effective rate.

Table 1 result shows, the Chinese medicine composition for the treatment of ascariasis of biliary tract of the present invention is more obvious than western medicine result.In the routine sufferer of treatments period 180 there is untoward reaction in none example.

Model case:

Case 1

Zhao, man, 11 years old, Qingdao City Laoshan District people.Patient main suit: before two weeks, once had ascarid at will to discharge, this morning, and its right upper quadrant of the abdomen pain is severe, with RHC tenderness under xiphoid-process, was biliary ascariasis through hospital's ultrasonic examination, and first beaten analgesic in hospital, pain alleviates to some extent.Take the embodiment of the present invention 1 tablet, one time 2,2 times on the one, started abdominal part not pain mistake again evening on the same day, then taken 2 days, recovery from illness.

Case 2

Money, man, 22 years old, Qingdao Jimo people.Patient main suit: before 3 years, because having ascarid in just and carrying out antihelminthic chemotherapy, afterwards, carried out an antihelminthic chemotherapy every year.Time at dusk its an awful ache in the belly, and accompany Nausea and vomiting, be biliary ascariasis through hospital's ultrasonic examination, take the embodiment of the present invention 3 granule, one time 2,2 times on the one, after 8 hours, abdominal part is pain no longer, has then taken 2 days, recovery from illness.

Case 3:

Grandson, man, 41 years old, people from Laiyang, Yantai.Patient main suit: other day once felt intermittent stomachache, because not affecting orthobiosis, so the head of a family does not take notice of.Because heat, drink one bottle of frozen water, eat again two large ice lollys, afterwards less than half an hour, its abdominal part starts violent pain, and accompanies Nausea and vomiting, be biliary ascariasis through hospital's ultrasonic examination, take the embodiment of the present invention 6 capsule, one time 2,2 times on the one, after 8 hours, abdominal part is pain no longer, has then taken 2 days, recovery from illness.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. be used for the treatment of a Chinese medicine composition for ascariasis of biliary tract, it is characterized in that: the crude drug of described Chinese medicine composition is made up of Cortex Magnoliae Officinalis, Herba Lysimachiae, Endothelium Corneum Gigeriae Galli, Fructus Toosendan, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae, Herba Morindae Parvifoliae, Rhizoma Osmundae, the Radix Paeoniae Alba, Flos Caraganae Franchetianae, Herba Lycopodii, Fructus Mume, Radix Bupleuri, Radix Puerariae, Herba Artemisiae Scopariae, Cortex Cinnamomi, Herba Asari, Herb Gynostemmae Pentaphylli, Rhizoma Coptidis, Ramulus Salicis Babylonicae, Rhizoma Sparganii, Caulis Bambusae In Taenia, Rhizoma Polygoni Cuspidati, Fructus Schisandrae Chinensis, Fructus Akebiae, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, Cortex Ilicis Rotundae, Ramulus Cinnamomi.

2. the Chinese medicine composition being used for the treatment of ascariasis of biliary tract according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 3-6 part, Herba Lysimachiae 8-13 part, Endothelium Corneum Gigeriae Galli 3-5 part, Fructus Toosendan 11-15 part, Fructus Hordei Germinatus 5-10 part, Caulis et Folium fici Tikouae 2-5 part, Herba Morindae Parvifoliae 4-9 part, Rhizoma Osmundae 12-20 part, Radix Paeoniae Alba 10-16 part, Flos Caraganae Franchetianae 3-8 part, Herba Lycopodii 5-12 part, Fructus Mume 12-17 part, Radix Bupleuri 7-12 part, Radix Puerariae 4-9 part, Herba Artemisiae Scopariae 15-20 part, Cortex Cinnamomi 10-15 part, Herba Asari 8-12 part, Herb Gynostemmae Pentaphylli 2-5 part, Rhizoma Coptidis 3-7 part, Ramulus Salicis Babylonicae 11-14 part, Rhizoma Sparganii 9-15 part, Caulis Bambusae In Taenia 3-6 part, Rhizoma Polygoni Cuspidati 8-13 part, Fructus Schisandrae Chinensis 3-5 part, Fructus Akebiae 1-3 part, Fructus Aurantii Immaturus 5-10 part, Rhizoma Pinelliae 5-10 part, Cortex Ilicis Rotundae 13-16 part, Ramulus Cinnamomi 3-10 part.

3. the Chinese medicine composition being used for the treatment of ascariasis of biliary tract according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 6 parts, Herba Lysimachiae 8 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Toosendan 15 parts, 5 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 3 parts, Herba Morindae Parvifoliae 5 parts, Rhizoma Osmundae 12 parts, the Radix Paeoniae Alba 16 parts, Flos Caraganae Franchetianae 3 parts, Herba Lycopodii 12 parts, Fructus Mume 12 parts, Radix Bupleuri 10 parts, Radix Puerariae 9 parts, Herba Artemisiae Scopariae 15 parts, Cortex Cinnamomi 15 parts, Herba Asari 8 parts, Herb Gynostemmae Pentaphylli 5 parts, Rhizoma Coptidis 3 parts, Ramulus Salicis Babylonicae 14 parts, Rhizoma Sparganii 9 parts, Caulis Bambusae In Taenia 6 parts, Rhizoma Polygoni Cuspidati 8 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 1 part, Fructus Aurantii Immaturus 10 parts, the Rhizoma Pinelliae 5 parts, Cortex Ilicis Rotundae 16 parts, Ramulus Cinnamomi 10 parts.

4. the Chinese medicine composition being used for the treatment of ascariasis of biliary tract according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 4 parts, Herba Lysimachiae 10 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Toosendan 13 parts, 6 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 4 parts, Herba Morindae Parvifoliae 8 parts, Rhizoma Osmundae 20 parts, the Radix Paeoniae Alba 10 parts, Flos Caraganae Franchetianae 8 parts, Herba Lycopodii 5 parts, Fructus Mume 17 parts, Radix Bupleuri 12 parts, Radix Puerariae 4 parts, Herba Artemisiae Scopariae 20 parts, Cortex Cinnamomi 10 parts, Herba Asari 12 parts, Herb Gynostemmae Pentaphylli 2 parts, Rhizoma Coptidis 7 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 15 parts, Caulis Bambusae In Taenia 3 parts, Rhizoma Polygoni Cuspidati 13 parts, Fructus Schisandrae Chinensis 3 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 5 parts, the Rhizoma Pinelliae 10 parts, Cortex Ilicis Rotundae 13 parts, Ramulus Cinnamomi 3 parts.

5. the Chinese medicine composition being used for the treatment of ascariasis of biliary tract according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 5 parts, Herba Lysimachiae 12 parts, Endothelium Corneum Gigeriae Galli 3 parts, Fructus Toosendan 12 parts, 9 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 4 parts, Herba Morindae Parvifoliae 7 parts, Rhizoma Osmundae 13 parts, the Radix Paeoniae Alba 11 parts, Flos Caraganae Franchetianae 4 parts, Herba Lycopodii 6 parts, Fructus Mume 13 parts, Radix Bupleuri 7 parts, Radix Puerariae 5 parts, Herba Artemisiae Scopariae 18 parts, Cortex Cinnamomi 11 parts, Herba Asari 9 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 6 parts, Ramulus Salicis Babylonicae 12 parts, Rhizoma Sparganii 13 parts, Caulis Bambusae In Taenia 4 parts, Rhizoma Polygoni Cuspidati 9 parts, Fructus Schisandrae Chinensis 4 parts, Fructus Akebiae 2 parts, Fructus Aurantii Immaturus 6 parts, the Rhizoma Pinelliae 6 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 5 parts.

6. the Chinese medicine composition being used for the treatment of ascariasis of biliary tract according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 4 parts, Herba Lysimachiae 11 parts, Endothelium Corneum Gigeriae Galli 4 parts, Fructus Toosendan 14 parts, 8 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 3 parts, Herba Morindae Parvifoliae 6 parts, Rhizoma Osmundae 17 parts, the Radix Paeoniae Alba 15 parts, Flos Caraganae Franchetianae 7 parts, Herba Lycopodii 11 parts, Fructus Mume 16 parts, Radix Bupleuri 8 parts, Radix Puerariae 8 parts, Herba Artemisiae Scopariae 16 parts, Cortex Cinnamomi 14 parts, Herba Asari 11 parts, Herb Gynostemmae Pentaphylli 3 parts, Rhizoma Coptidis 5 parts, Ramulus Salicis Babylonicae 13 parts, Rhizoma Sparganii 14 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 12 parts, Fructus Schisandrae Chinensis 3 parts, Fructus Akebiae 1 part, Fructus Aurantii Immaturus 10 parts, the Rhizoma Pinelliae 9 parts, Cortex Ilicis Rotundae 13 parts, Ramulus Cinnamomi 7 parts.

7. the Chinese medicine composition being used for the treatment of ascariasis of biliary tract according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 6 parts, Herba Lysimachiae 9 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Toosendan 12 parts, 7 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 5 parts, Herba Morindae Parvifoliae 9 parts, Rhizoma Osmundae 15 parts, the Radix Paeoniae Alba 12 parts, Flos Caraganae Franchetianae 5 parts, Herba Lycopodii 9 parts, Fructus Mume 15 parts, Radix Bupleuri 9 parts, Radix Puerariae 7 parts, Herba Artemisiae Scopariae 19 parts, Cortex Cinnamomi 13 parts, Herba Asari 10 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 4 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 11 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 10 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 8 parts, the Rhizoma Pinelliae 8 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 9 parts.

8. the Chinese medicine composition being used for the treatment of ascariasis of biliary tract according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Cortex Magnoliae Officinalis 3 parts, Herba Lysimachiae 8 parts, Endothelium Corneum Gigeriae Galli 5 parts, Fructus Toosendan 15 parts, 7 parts, Fructus Hordei Germinatus, Caulis et Folium fici Tikouae 2 parts, Herba Morindae Parvifoliae 4 parts, Rhizoma Osmundae 19 parts, the Radix Paeoniae Alba 14 parts, Flos Caraganae Franchetianae 6 parts, Herba Lycopodii 7 parts, Fructus Mume 14 parts, Radix Bupleuri 9 parts, Radix Puerariae 6 parts, Herba Artemisiae Scopariae 17 parts, Cortex Cinnamomi 13 parts, Herba Asari 10 parts, Herb Gynostemmae Pentaphylli 4 parts, Rhizoma Coptidis 4 parts, Ramulus Salicis Babylonicae 11 parts, Rhizoma Sparganii 11 parts, Caulis Bambusae In Taenia 5 parts, Rhizoma Polygoni Cuspidati 10 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Akebiae 3 parts, Fructus Aurantii Immaturus 8 parts, the Rhizoma Pinelliae 8 parts, Cortex Ilicis Rotundae 14 parts, Ramulus Cinnamomi 4 parts.

9. the arbitrary described Chinese medicine composition being used for the treatment of ascariasis of biliary tract of claim 3-8, is characterized in that, be prepared in accordance with the following steps:

(1) get each medical material of components by weight percent described in described Chinese medicine preparation, after mix homogeneously, be ground into smalls with pulverizer, be screened into 100 order ~ 200 object powder;

(2) by powder obtained in step (1), add the 10-12 water doubly of medical material gross weight, soak after 45-60 minute, decoct 1 time, decocting time 2 hours, after filtration, add the 12-13 water doubly of medical material gross weight, decoct the 2nd time, decocting time 3 hours, after filtration, add the 14-15 water doubly of medical material gross weight, decoct the 3rd time, decocting time 4 hours, after filtration, merge 3 filtrates, 120 orders filter, at filtrate heating is concentrated into 60 DEG C, relative density is 1.10 ~ 1.13, obtain concentrated solution, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make 80 order fine powders,

(3) the 80 order fine powders that step (2) is obtained are added suitable adjuvant and make granule, capsule, tablet.

10. the application of the Chinese medicine composition being used for the treatment of ascariasis of biliary tract as described in as arbitrary in claim 1-9 in treatment biliary tract ascarid disease drug.