CN105395768A - 一种治疗气血两虚型月经量少的药物组合物 - Google Patents
一种治疗气血两虚型月经量少的药物组合物 Download PDFInfo
- Publication number
- CN105395768A CN105395768A CN201511028688.5A CN201511028688A CN105395768A CN 105395768 A CN105395768 A CN 105395768A CN 201511028688 A CN201511028688 A CN 201511028688A CN 105395768 A CN105395768 A CN 105395768A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- pharmaceutical composition
- blood
- hypomenorrhea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008280 blood Substances 0.000 title claims abstract description 61
- 206010021033 Hypomenorrhoea Diseases 0.000 title claims abstract description 31
- 208000037093 Menstruation Disturbances Diseases 0.000 title claims abstract description 31
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 22
- 230000007812 deficiency Effects 0.000 title abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 38
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 26
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 26
- 238000011282 treatment Methods 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 210000004369 blood Anatomy 0.000 claims description 59
- 241000522226 Campylotropis Species 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 238000002791 soaking Methods 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 239000007919 dispersible tablet Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 230000005906 menstruation Effects 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 13
- 208000024891 symptom Diseases 0.000 abstract description 9
- 230000007774 longterm Effects 0.000 abstract description 2
- 238000011160 research Methods 0.000 abstract description 2
- 206010067484 Adverse reaction Diseases 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 241001166575 Carex platyphylla Species 0.000 abstract 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 235000016854 Cyperus rotundus Nutrition 0.000 abstract 1
- 240000007890 Leonurus cardiaca Species 0.000 abstract 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 241000606278 Triplostegia Species 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000006838 adverse reaction Effects 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 description 21
- 230000001737 promoting effect Effects 0.000 description 17
- 208000019255 Menstrual disease Diseases 0.000 description 13
- 229940079593 drug Drugs 0.000 description 13
- 239000000796 flavoring agent Substances 0.000 description 12
- 230000001105 regulatory effect Effects 0.000 description 12
- 230000017531 blood circulation Effects 0.000 description 11
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 230000006870 function Effects 0.000 description 11
- 235000019634 flavors Nutrition 0.000 description 10
- 210000003734 kidney Anatomy 0.000 description 10
- 210000004185 liver Anatomy 0.000 description 9
- 230000027758 ovulation cycle Effects 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- 208000002193 Pain Diseases 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- 201000000736 Amenorrhea Diseases 0.000 description 5
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 230000002175 menstrual effect Effects 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 4
- 206010033557 Palpitations Diseases 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 239000000686 essence Substances 0.000 description 4
- 210000004914 menses Anatomy 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 208000005171 Dysmenorrhea Diseases 0.000 description 3
- 206010013935 Dysmenorrhoea Diseases 0.000 description 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 206010000210 abortion Diseases 0.000 description 3
- 231100000176 abortion Toxicity 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000000481 breast Anatomy 0.000 description 3
- 239000002934 diuretic Substances 0.000 description 3
- 230000001882 diuretic effect Effects 0.000 description 3
- 230000002357 endometrial effect Effects 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000003821 menstrual periods Effects 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 230000001502 supplementing effect Effects 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010020850 Hyperthyroidism Diseases 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 230000005714 functional activity Effects 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 208000007106 menorrhagia Diseases 0.000 description 2
- 201000008383 nephritis Diseases 0.000 description 2
- 230000002611 ovarian Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000028685 Asherman syndrome Diseases 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 208000004145 Endometritis Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 208000002500 Primary Ovarian Insufficiency Diseases 0.000 description 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010063146 Uterine hypoplasia Diseases 0.000 description 1
- 206010046910 Vaginal haemorrhage Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 201000001389 adhesions of uterus Diseases 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000007368 endocrine function Effects 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 231100000558 gonadal hypoplasia Toxicity 0.000 description 1
- 230000001456 gonadotroph Effects 0.000 description 1
- 230000002984 haematinic effect Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 210000003016 hypothalamus Anatomy 0.000 description 1
- 229960003943 hypromellose Drugs 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
- 231100000545 luteal phase defect Toxicity 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 206010036601 premature menopause Diseases 0.000 description 1
- 208000017942 premature ovarian failure 1 Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 239000003488 releasing hormone Substances 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 208000037921 secondary disease Diseases 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明属于中药领域,涉及治疗月经不调的药物,尤其公开了一种治疗气血两虚型月经量少的药物组合物。该药物组合物由以下药用原料制成:崖棕根、龙眼肉、益母草、双参、熟地黄、血满草、陈皮、白术、香附、锈钉子,各原料的重量份如下:崖棕根15-25份、熟地黄10-20份、龙眼肉10-15份、益母草8-13份、双参10-15份、血满草20-30份、陈皮5-9份、白术9-15份、香附8-18份、锈钉子15-25份。临床研究结果显示:本发明药物组合物观察组较对照组可以明显提高月经过少的临床治愈率及显效率;可明显的改善患者的临床症状,具有更好的远期疗效,并且患者的临床症状不易复发,不良反应少,是一种安全有效的中药制剂,为中医药治疗月经过少提供新的方法。
Description
技术领域
本发明属于中药领域,涉及治疗月经不调的药物,尤其涉及一种治疗气血两虚型月经量少的药物组合物。
背景技术
月经是女性生殖生理活动的外在表现,也是女性最重要的生理基础。月经不调是妇科临床常见病,包括月经先期、月经后期、月经先后不定期、月经过多、月经过少、经期延长。月经周期基本正常,经量明显减少,甚至点滴即净;或经期缩短不足两天,经量亦少者,均称为“月经过少”,属月经病。如果不及时治疗,可发展为闭经,甚至不孕,同时也给患者带来严重的心理压力。
月经过少古代医家多有论述。朱震亨《丹溪心法﹒经水证治》称本证“经水微少”、“经水涩少”亦以四物汤加味治之。王肯堂《证治准绳﹒妇科》沿袭朱丹溪观点提出“经水涩少,为虚为涩,需则补之,涩之濡之”。现代中医学者多认为月经过少病因有虚有实,虚者可因素体血虚,或大病久病病伤血;营血亏虚,或饮食、劳倦、思虑伤脾,脾虚化源不足,可使血海不充;或因禀赋素弱,或少年肾气未充,或多产(包括自然流产及人工流产)房劳伤肾,以致肾气不足,精血不充,血海不盈;实者如感受寒邪,寒客胞宫,血为寒凝,或气滞血瘀,阻滞胞脉,或素多痰湿,或脾失健运,聚湿生痰,痰阻经遂,均可致血不畅行。
西医认为月经是指随卵巢周期性排卵及其分泌的雌、孕激素的周期性变化而引起的子宫内膜的脱落及出血。女性正常月经依赖于下丘脑-垂体-卵巢轴的正常神经内分泌功能及其相互协调和反应正常的子宫内膜。西医没有月经过少的病名,月经过少的发病原因主要有子宫发育不良、子宫内膜结核、子宫内膜炎等子宫因素,卵巢功能早衰或单纯性性腺发育不全等卵巢因素,下丘脑促进性腺释放激素或垂体促性腺激素分泌下调或失调,人工流产术刮宫过深或宫腔电灼术等损伤子宫内膜的基底层导致宫腔粘连等,长期服用某些药物(如口服避孕药),甲亢等其他系列疾病。
西医没有具体的治疗方案,中医临床治疗月经过少处于百家争鸣的时代,众多医家根据各自的临床经验有不同的治疗思路,临床证实都有较好的临床疗效。中医在治疗内分泌疾病和代谢性疾病中具有疗效稳定、毒副作用小的优势。
发明内容
发明人结合古今先贤的理论与自己的临床经验,将现代生理病理与中医病因病机、辨证与辨病有机结合起来,认为素体血虚或久病伤血,或堕胎多产数伤于血,或忧思伤脾,劳倦伤食,以致脾虚生化不足,冲任血海亏虚,以致月经量少。据此,提供了一种治疗气血两虚型月经量少的中药制剂,其有补肾生津,补脾健胃兼有调肝之效,先天后天同调,以调畅气机,疏通气血,气血调和,则月经通调,是一种治疗气血两虚型月经量少的理想药物。
本发明是通过以下技术方案实现的:
一种治疗气血虚弱型月经量少的药物组合物,其由以下药用原料制成:崖棕根、龙眼肉、益母草、双参、熟地黄、血满草、陈皮、白术、香附、锈钉子,各原料的重量份如下:崖棕根15-25份、熟地黄10-20份、龙眼肉10-15份、益母草8-13份、双参10-15份、血满草20-30份、陈皮5-9份、白术9-15份、香附8-18份、锈钉子15-25份。
发明人总结认为:女子以血为本,经出肾水,精血互化,气是血脉运行的动力,气血互相依存,调血亦当调气,而气血由脾胃所生,脾的功能是化生血液,补脾胃可以充足身体的血源,肝主一身气之流行和疏泄,疏肝理气则可调畅气机,疏通气血,如果气血调和,则月经通调。方中:崖棕根甘辛温,善益气养血,活血调经;熟地黄甘温,滋阴补血,益精填髓,为君药。双参健脾益肾,补血补气,活血调经,龙眼肉补益心脾,养血安神;血满草祛风活血散瘀,利水通络,兼有强筋骨之效,为臣药。益母草苦辛,微寒,善活血调经,行血养血,行血而不伤新血,养血而不滞瘀血;陈皮、白术理气健脾,使气血生化有源;香附疏肝行气解郁,调经止痛,调和气血;锈钉子活血调经,理气止痛,与香附共调气血,具为佐使。
进一步优选地,一种治疗气血虚弱型月经量少的药物组合物,其由如下优选重量份配比的药用原料制成:崖棕根18-23份、熟地黄13-17份、龙眼肉10-15份、益母草8-13份、双参10-15份、血满草22-26份、陈皮5-9份、白术11-15份、香附10-14份、锈钉子15-20份。
进一步优选地,一种治疗气血虚弱型月经量少的药物组合物,其由如下优选重量份配比的药用原料制成:崖棕根20份、熟地黄15份、龙眼肉12份、益母草10份、双参10份、血满草25份、陈皮8份、白术12份、香附10份、锈钉子17份。
本方所用各药材的药理活性研究现状如下:
崖棕根:【性味】味甘;辛;性温。【归经】肺;肝;肾经。【功能主治】益气养血;活血调经。主气血虚弱;倦怠无力;心悸失眠;月经不调;经闭。
龙眼肉:【性味】甘,温。【归经】归心、脾经。【功能主治】补益心脾,养血安神。用于气血不足,心悸怔忡,健忘失眠,血虚萎黄。
双参:【性味】甘、微苦,平。【功能主治】健脾益肾,活血调经,止崩漏,解毒。用于肾虚腰痛,贫血,咳嗽,遗精,阳萎,风湿关节痛,月经不调,倒经,崩漏,带下,不孕症。外用止血。
熟地黄:【性味】甘,微温。【归经】归肝、肾经。【功能主治】滋阴补血,益精填髓。用于肝肾阴虚,腰膝酸软,骨蒸潮热,盗汗遗精,内热消渴,血虚萎黄,心悸怔忡,月经不调,崩漏下血,眩晕,耳鸣,须发早白。
益母草:【性味】苦、辛,微寒。【归经】归肝、心包经。【功能主治】活血调经,利尿消肿。用于月经不调,痛经,经闭,恶露不尽,水肿尿少;急性肾炎水肿。
血满草:【性味】味辛;甘;性温。【归经】归脾;肾经。【功能主治】祛风;利水;活血;通络。主急慢性肾炎;风湿疼痛;风疹瘙痒;小儿单板机痹后遗症;慢性腰腿痛;扭伤瘀痛;骨折。
陈皮:【性味】苦、辛,温。【归经】归肺、脾经。【功能主治】理气健脾,燥湿化痰。用于胸脘胀满,食少吐泻,咳嗽痰多。
白术:【性味】苦、甘,温。【归经】归脾、胃经。【功能主治】健脾益气,燥湿利水,止汗,安胎。用于脾虚食少,腹胀泄泻,痰饮眩悸,水肿,自汗,胎动不安。土白术健脾,和胃,安胎。用于脾虚食少,泄泻便溏,胎动不安。
香附:【性味】辛、微苦、微甘,平。【归经】归肝、脾、三焦经。【功能主治】行气解郁,调经止痛。用于肝郁气滞,胸、胁、脘腹胀痛,消化不良,胸脘痞闷,寒疝腹痛,乳房胀痛,月经不调,经闭痛经。
锈钉子:【性味】涩,微苦,微温。【功能主治】活血调经;理气止痛;清热利湿。主月经不调;闭经;痛经;白带;痢疾;胃脘痛;外伤出血;黄水疮;水火烫伤。
为了更好地表达本发明的药物组合物,本发明的药物组合物可以制备成临床上常用的剂型,其制备方法主要包含下述步骤:
(1)取配方量的熟地黄,烘干,研磨至200~300目的细粉;
(2)将崖棕根、龙眼肉、益母草、双参、血满草、陈皮、白术、香附、锈钉子加入4-10倍量的水浸泡3-4小时,然后煎煮提取2~3小时,过滤,取药液;在剩余的残渣中再加入4-8倍量的水,煎煮提取1~2小时,过滤,取药液;合并两次药液,浓缩成60℃下相对密度1.15~1.25的稠膏,
(3)将步骤(1)得到的细粉和步骤(2)的稠膏混合,加入适量药学上可接受的载体或/和辅料,按照常规工艺制成口服剂型。
上述所述的口服剂型为片剂、胶囊剂、丸剂、颗粒剂、口服液,软胶囊、分散片、散剂等。
优选地,上述所述的口服剂型为胶囊剂、片剂或颗粒剂,最优选胶囊剂。
上述所述的药学上可接受的载体或/和辅料可以是填充剂、粘合剂、崩解剂、润滑剂、稀释剂、调味剂当中的一种或几种,如:填充剂、稀释剂可选淀粉、糖粉、糊精、微晶纤维素、乳糖、预胶化淀粉、甘露醇等;可选择的粘合剂有羧甲基纤维素钠、羟丙基纤维素、淀粉浆、乙基纤维素、羟丙甲纤维素、胶化淀粉等;可选择的崩解剂有干淀粉、交联聚维酮、交联羧甲基纤维素钠、羧甲基淀粉钠,低取代羟丙基纤维素等;可选择的润滑剂有;硬脂酸镁、滑石粉、十二烷基硫酸钠、微粉硅胶等;调味剂如甜味素、阿斯巴甜等。
本发明是发明人经过反复研究,逐步改进,最后成功的一种疗效较好的气血虚弱型月经量少的的药物,并得到临床验证,详见如下:
1资料与方法
1.1一般资料:观察2013年10月至2014年8月就诊于我院妇科门诊确诊为月经量少证属气血两虚证的患者96例,随机分为观察组与对照组进行观察,每组48例。观察组年龄18-34岁,平均年龄23.2±3.1岁,对照组年龄18-35岁,平均23.9±3.5岁;观察组病程最长3.8年,最短5个月,平均1.85±0.86年,对照组病程最长3.5年,最短6个月,平均1.76±0.78年,两组一般资料比较无统计学差异(P>0.05),具有可比性。
1.2诊断标准:按照张玉珍等编著《中医妇科学》和中华人民共和国卫生部2002年颁布的《中药新药治疗月经不调的临床研究指导原则》的月经过少的诊断标准。
月经过少:月经过少是指月经周期正常,月经血量较常量明显减少,甚至点滴即净,或经行时间不足2天,经量亦少的月经病。
中医辨证标准:参考中华人民共和国卫生部2002年颁布的《中药新药治疗月经不调的临床研究指导原则》的有关内容,制定气血两虚证:
主症:月经量少,经血淡红,经质稀薄,神疲乏力;
次症:面色淡白或姜黄,少气懒言,头晕眼花,心浮气短,失眠,自汗;
舌脉:舌质淡或胖,苔薄,脉细弱;
具有3项主症,2项或2项以上次症、结合舌脉即可诊断。
1.3排除标准:有内分泌异常、黄体功能不全、宫腔器质性病变者;有甲状腺功能亢进、结核、严重贫血等慢性消耗性疾病者;3个月内有口服激素、使用避孕药者;服药过程中出现不良反应者;未按规定用药,无法判断疗效或资料不全等影响疗效或统计处理者。
1.4治疗方法:
观察组:月经第5天开始使用本发明实施例1制备的胶囊剂,每日2-4粒,服用至月经来潮时停服,以3个月为一个疗程,连续服用3个月。
对照组:驴胶补血颗粒,一次20克,每日两次,早晚各一次,开水冲服,于月经周期第5天开始用药,月经来潮时停服,以3个月为一个疗程,连续服用3个月。
1.5治疗前后观察指标:
1.5.1治疗前后患者的相关症状。
1.5.2用药期间药物不良反应的观察:观察用药期间有无出现不良反应并记录,如胃肠道不适、过敏反应、阴道出血时间延长等。
1.5.3随访性观测:治疗结束后第三次月经来潮后随访,记录相关症状观察。
1.6疗效标准:根据《中药新药治疗月经不调的临床研究指导原则》,拟定以下疗效标准:痊愈:治疗后月经周期、经量恢复正常,其他症状消失,停药3个月经周期未复发者。显效:月经量增加1/3,其他症状消失减轻,积分较治疗前减少70%,停药3个月经周期无复发者。有效:治疗后月经周期、经量、经期较治疗前改善,其他症状较治疗前减轻,积分较治前减少30~69%。无效:治疗后月经周期、经量及经期无改善,积分较治疗前减少30%以下。
1.7统计学方法:采用SPSS16.0统计软件进行计算。各数值以表示,计量资料采用t检验,计数资料采用χ2检验,以P<0.05为差异有统计学意义。
2结果
2.1两组患者疗效比较:上述96例患者治疗后,观察组治愈19例,显效21例,有效7例,无效1例,显效率83.3%,总有效率97.9%;对照组治愈8例,显效16例,有效18例,无效6例,显效率50.0%,总有效率87.5%,观察组与对照组显效率、总有效率比较,差异有统计学意义(P<0.05),说明观察组较对照组可以明显的提高月经过少的临床治愈率及显效率。见表1。
表1两组患者疗效比较(n%,例)
注:与对照组比较,*P<0.05。
2.2用药期间药物不良反应的观察:观察组患者用药期间有无患者出现轻度胃肠道反应。对照组患者用药期间有12例患者出现轻度胃肠道反应,如口干、腹泻、口气重,观察组与对照组比较,差异有统计学意义,观察组不良反应更少,患者依从性更好。
治疗结果显示:观察组较对照组可以明显提高月经过少的临床治愈率及显效率;可明显的改善患者的临床症状,具有更好的远期疗效,并且患者的临床症状不易复发,不良反应少,是一种安全有效的中药制剂,为中医药治疗月经过少提供新的方法。
总之,与现有技术相比,本发明具有以下有益效果:
本发明中药制剂所选药材配伍相宜,符合中医药学和现代医药学理论,立法全面,用药周到,重视肝肾脾胃等脏腑的调节,培补后天之本,使气血生化有源;气血双补,气为血之帅,气旺则血自生,血旺则经自调;补血药中配以行气活血药,使补而不滞、滋而不腻。诸药相伍,共奏健脾益气、滋阴补血、养血活血之效。通补相宜、动静结合,从根本上治疗月经量少,疗效显著,患者依从性较好,服用方便,可有效地减轻病者负担和痛苦,能够达到标本兼治的目的,而被广大患者认可。
具体实施方式
以下通过具体实施例进一步描述本发明,本发明不仅仅限于以下实施例。在本发明的范围内或者在不脱离本发明的内容、精神和范围内,对本发明进行的变更、组合或替换,对于本领域的技术人员来说是显而易见的,且包含在本发明的范围之内。
实施例1
处方:崖棕根20份、熟地黄15份、龙眼肉12份、益母草10份、双参10份、血满草25份、陈皮8份、白术12份、香附10份、锈钉子17份。
制备方法:(1)取配方量的熟地黄,烘干,研磨至200~300目的细粉;
(2)将配方量的崖棕根、龙眼肉、益母草、双参、血满草、陈皮、白术、香附、锈钉子加入4-10倍量的水浸泡3-4小时,然后煎煮提取2~3小时,过滤,取药液;在剩余的残渣中再加入4-8倍量的水,煎煮提取1~2小时,过滤,取药液;合并两次药液,浓缩成60℃下相对密度1.15~1.25的稠膏,
(3)将步骤(1)得到的细粉和步骤(2)的稠膏混合,按照常规工艺制成胶囊剂。
本发明药物组合物胶囊,每粒相当于含有生药1.40g.
实施例2
处方:崖棕根18份、熟地黄15份、龙眼肉10份、益母草10份、双参12份、血满草22份、陈皮8份、白术12份、香附12份、锈钉子15份。
制备方法:参照实施例1的操作进行。
实施例3
处方:崖棕根20份、熟地黄17份、龙眼肉15份、益母草13份、双参10份、血满草20份、陈皮5份、白术15份、香附12份、锈钉子15份。
制备方法:参照实施例1的操作进行。
实施例4
处方:崖棕根15份、熟地黄12份、龙眼肉10份、益母草10份、双参15份、血满草25份、陈皮6份、白术10份、香附8份、锈钉子20份。
制备方法:参照实施例1的操作进行。
实施例5
处方:崖棕根25份、熟地黄18份、龙眼肉10份、益母草8份、双参12份、血满草30份、陈皮8份、白术15份、香附15份、锈钉子15份。
制备方法:参照实施例1的操作进行。
实施例6
处方:崖棕根20份、熟地黄10份、龙眼肉15份、益母草8份、双参10份、血满草26份、陈皮9份、白术15份、香附14份、锈钉子20份。
制备方法:参照实施例1的操作进行。
实施例7
处方:崖棕根23份、熟地黄16份、龙眼肉12份、益母草10份、双参12份、血满草22份、陈皮6份、白术13份、香附10份、锈钉子18份。
制备方法:参照实施例1的操作进行。
实施例8
处方:崖棕根22份、熟地黄17份、龙眼肉15份、益母草8份、双参15份、血满草22份、陈皮8份、白术15份、香附12份、锈钉子20份。
制备方法:参照实施例1的操作进行。
实施例9
处方:崖棕根20份、熟地黄15份、龙眼肉12份、益母草10份、双参10份、血满草25份、陈皮8份、白术12份、香附10份、锈钉子17份。
制备方法:(1)取配方量的熟地黄,烘干,研磨至200~300目的细粉;
(2)将配方量的崖棕根、龙眼肉、益母草、双参、血满草、陈皮、白术、香附、锈钉子加入4-10倍量的水浸泡3-4小时,然后煎煮提取2~3小时,过滤,取药液;在剩余的残渣中再加入4-8倍量的水,煎煮提取1~2小时,过滤,取药液;合并两次药液,浓缩成60℃下相对密度1.15~1.25的稠膏;
(3)将步骤(1)得到的细粉和步骤(2)的稠膏混合,按照常规工艺制成颗粒剂。
实施例10
处方:崖棕根20份、熟地黄15份、龙眼肉12份、益母草10份、双参10份、血满草25份、陈皮8份、白术12份、香附10份、锈钉子17份。
制备方法:(1)取配方量的熟地黄,烘干,研磨至200~300目的细粉;
(2)将配方量的崖棕根、龙眼肉、益母草、双参、血满草、陈皮、白术、香附、锈钉子加入4-10倍量的水浸泡3-4小时,然后煎煮提取2~3小时,过滤,取药液;在剩余的残渣中再加入4-8倍量的水,煎煮提取1~2小时,过滤,取药液;合并两次药液,浓缩成60℃下相对密度1.15~1.25的稠膏;
(3)将步骤(1)得到的细粉和步骤(2)的稠膏混合,按照常规工艺制成片剂。
Claims (9)
1.一种治疗气血虚弱型月经量少的药物组合物,其特征在于由以下药用原料制成:崖棕根、龙眼肉、益母草、双参、熟地黄、血满草、陈皮、白术、香附、锈钉子。
2.如权利要求1所述的药物组合物,其特征在于由以下重量份配比的药用原料制成:崖棕根15-25份、熟地黄10-20份、龙眼肉10-15份、益母草8-13份、双参10-15份、血满草20-30份、陈皮5-9份、白术9-15份、香附8-18份、锈钉子15-25份。
3.如权利要求2所述的药物组合物,其特征在于由以下重量份配比的药用原料制成:崖棕根18-23份、熟地黄13-17份、龙眼肉10-15份、益母草8-13份、双参10-15份、血满草22-26份、陈皮5-9份、白术11-15份、香附10-14份、锈钉子15-20份。
4.如权利要求3所述的药物组合物,其特征在于由以下重量份配比的药用原料制成:崖棕根20份、熟地黄15份、龙眼肉12份、益母草10份、双参10份、血满草25份、陈皮8份、白术12份、香附10份、锈钉子17份。
5.如权利要求1-4所述的药物组合物,其特征在于制备方法主要包含下述步骤:
(1)取配方量的熟地黄,烘干,研磨至200~300目的细粉;
(2)将配方量的崖棕根、龙眼肉、益母草、双参、血满草、陈皮、白术、香附、锈钉子加入4-10倍量的水浸泡3-4小时,然后煎煮提取2~3小时,过滤,取药液;在剩余的残渣中再加入4-8倍量的水,煎煮提取1~2小时,过滤,取药液;合并两次药液,浓缩成60℃下相对密度1.15~1.25的稠膏;
(3)将步骤(1)得到的细粉和步骤(2)的稠膏混合,加入适量药学上可接受的载体或/和辅料,按照常规工艺制成口服剂型。
6.如权利要求1-5所述的药物组合物,其特征在于所述的口服剂型为片剂、胶囊剂、丸剂、颗粒剂、口服液、软胶囊、分散片、散剂等。
7.如权利要求6所述的药物组合物,其特征在于所述的口服剂型优选为片剂、胶囊剂或颗粒剂。
8.如权利要求7所述的药物组合物,其特征在于所述的口服剂型最优选为胶囊剂。
9.权利要求1-8任一所述的药物组合物在制备治疗气血虚弱型月经量少的药物中的应用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201511028688.5A CN105395768A (zh) | 2015-12-30 | 2015-12-30 | 一种治疗气血两虚型月经量少的药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201511028688.5A CN105395768A (zh) | 2015-12-30 | 2015-12-30 | 一种治疗气血两虚型月经量少的药物组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105395768A true CN105395768A (zh) | 2016-03-16 |
Family
ID=55461763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201511028688.5A Pending CN105395768A (zh) | 2015-12-30 | 2015-12-30 | 一种治疗气血两虚型月经量少的药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105395768A (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108686081A (zh) * | 2017-04-10 | 2018-10-23 | 洛阳士雄聚元医疗集团股份有限公司 | 一种治疗妇女因气血两虚导致月经量少的中药 |
-
2015
- 2015-12-30 CN CN201511028688.5A patent/CN105395768A/zh active Pending
Non-Patent Citations (1)
Title |
---|
崔应珉等: "《气血理论临证指南》", 30 November 2002, 郑州大学出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108686081A (zh) * | 2017-04-10 | 2018-10-23 | 洛阳士雄聚元医疗集团股份有限公司 | 一种治疗妇女因气血两虚导致月经量少的中药 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102836409B (zh) | 用于治疗产后恶露不绝的中药及制备方法 | |
CN105412787A (zh) | 治疗产后月经不调的药物 | |
CN103263647B (zh) | 一种治疗产后恶露不绝的中药及制备方法 | |
CN104523889B (zh) | 一种治疗滑胎的中药制剂及其制备方法 | |
CN105395768A (zh) | 一种治疗气血两虚型月经量少的药物组合物 | |
CN105641445A (zh) | 一种治疗青春期多囊卵巢综合征的药物组合物及制备方法 | |
CN104056173A (zh) | 一种治疗孕妇妊娠期气血两亏的中药组合物 | |
CN104644996A (zh) | 一种治疗乳腺增生的药物组合物及其用途 | |
CN104547396A (zh) | 一种治疗月经后期的中药组合物 | |
CN104547700B (zh) | 一种治疗月经先期的中药组合物 | |
CN105311396A (zh) | 一种治疗子宫内膜薄致月经过少的中药制剂 | |
CN105327067A (zh) | 一种治疗流产术后内分泌正常型月经过少的中药制剂 | |
CN105597020A (zh) | 一种治疗多囊卵巢综合征合并乳腺增生的药物组合物 | |
CN105535199A (zh) | 一种治疗多囊卵巢综合征合并乳腺增生的药物制剂 | |
CN104523971A (zh) | 一种治疗气血虚弱型痛经的中药组合物及其制备方法 | |
CN104587128A (zh) | 一种治疗甲减的药物组合物及其用途 | |
CN105031017B (zh) | 一种治疗药物流产后出血的护理用药物及其制备方法 | |
CN105596631A (zh) | 一种治疗避孕药致月经过少的药物制剂 | |
CN105362963A (zh) | 一种治疗寒凝血瘀型月经量少的药物制剂 | |
CN105535348A (zh) | 一种用于避孕药致月经过少的药物组合物及其制备方法 | |
CN105456620A (zh) | 一种用于治疗多囊卵巢综合征合并乳腺增生的药物组合物 | |
CN105497423A (zh) | 一种用于避孕药致月经过少的药物组合物 | |
CN105362695A (zh) | 一种治疗月经过少伴痤疮的药物制剂及其制备方法 | |
CN105535800A (zh) | 一种治疗多囊卵巢综合征并复发性流产的药物组合物 | |
CN105521158A (zh) | 一种治疗慢性子宫内膜炎致月经量少的药物制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160316 |