CN105392880B - 生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法 - Google Patents

生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法 Download PDF

Info

Publication number
CN105392880B
CN105392880B CN201580001286.8A CN201580001286A CN105392880B CN 105392880 B CN105392880 B CN 105392880B CN 201580001286 A CN201580001286 A CN 201580001286A CN 105392880 B CN105392880 B CN 105392880B
Authority
CN
China
Prior art keywords
microorganism
activity
homoserine
acetylhomoserine
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580001286.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN105392880A (zh
Inventor
金贤雅
徐主熙
申容旭
金素影
金相谦
罗光镐
裵智妍
孙晟光
柳慧连
崔珍根
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ CheilJedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CJ CheilJedang Corp filed Critical CJ CheilJedang Corp
Priority to CN201910921151.3A priority Critical patent/CN110592153A/zh
Publication of CN105392880A publication Critical patent/CN105392880A/zh
Application granted granted Critical
Publication of CN105392880B publication Critical patent/CN105392880B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01031—Homoserine O-acetyltransferase (2.3.1.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/03001—Citrate (Si)-synthase (2.3.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01039—Homoserine kinase (2.7.1.39)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01031—Phosphoenolpyruvate carboxylase (4.1.1.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201580001286.8A 2014-06-23 2015-06-22 生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法 Active CN105392880B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910921151.3A CN110592153A (zh) 2014-06-23 2015-06-22 生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020140076779A KR101641770B1 (ko) 2014-06-23 2014-06-23 O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법
KR10-2014-0076779 2014-06-23
PCT/KR2015/006307 WO2015199396A1 (ko) 2014-06-23 2015-06-22 O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910921151.3A Division CN110592153A (zh) 2014-06-23 2015-06-22 生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法

Publications (2)

Publication Number Publication Date
CN105392880A CN105392880A (zh) 2016-03-09
CN105392880B true CN105392880B (zh) 2019-11-08

Family

ID=54938419

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580001286.8A Active CN105392880B (zh) 2014-06-23 2015-06-22 生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法
CN201910921151.3A Pending CN110592153A (zh) 2014-06-23 2015-06-22 生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201910921151.3A Pending CN110592153A (zh) 2014-06-23 2015-06-22 生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法

Country Status (14)

Country Link
US (2) US10465217B2 (https=)
EP (2) EP2998388B1 (https=)
JP (2) JP6336074B2 (https=)
KR (1) KR101641770B1 (https=)
CN (2) CN105392880B (https=)
AU (1) AU2015264911B2 (https=)
BR (2) BR122020005905B1 (https=)
DK (1) DK2998388T3 (https=)
ES (1) ES2833432T3 (https=)
MY (1) MY185764A (https=)
PL (1) PL2998388T3 (https=)
RU (1) RU2614253C1 (https=)
SG (1) SG11201509451WA (https=)
WO (1) WO2015199396A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111315877B (zh) * 2017-06-30 2023-08-08 Cj第一制糖株式会社 新型o-琥珀酰高丝氨酸转移酶变体及使用其生产o-琥珀酰高丝氨酸的方法
CN110129294B (zh) * 2018-02-02 2021-12-24 中国科学院天津工业生物技术研究所 高丝氨酸乙酰基转移酶突变体及其宿主细胞和应用
KR101915433B1 (ko) 2018-02-13 2018-11-05 씨제이제일제당 (주) 시트레이트 신타아제 (Citrate synthase)의 활성이 약화된 변이형 폴리펩타이드 및 이를 이용한 L-아미노산 생산방법
CN113122486B (zh) * 2019-12-31 2023-06-13 江南大学 一种丙二酸的全生物合成的方法
KR102285951B1 (ko) 2020-01-30 2021-08-04 씨제이제일제당 주식회사 시트레이트 신타아제의 활성이 약화된 신규한 변이형 폴리펩티드 및 이를 이용한 l-아미노산 생산 방법
CN115427580A (zh) * 2020-02-07 2022-12-02 代谢探索者公司 用于改善依克多因产生的经修饰的微生物和方法
KR102344689B1 (ko) * 2020-09-01 2021-12-29 씨제이제일제당 주식회사 L-발린 생산 미생물 및 이를 이용한 l-발린 생산 방법
CN112501144B (zh) * 2021-02-02 2021-04-20 中国科学院天津工业生物技术研究所 高丝氨酸乙酰转移酶突变体及其在生产o-乙酰高丝氨酸中的应用
KR102525073B1 (ko) * 2021-03-10 2023-04-24 씨제이제일제당 주식회사 신규한 시트레이트 신타아제 변이체 및 이를 이용한 l-발린 생산 방법
KR102525074B1 (ko) * 2021-03-10 2023-04-24 씨제이제일제당 주식회사 신규한 시트레이트 신타아제 변이체 및 이를 이용한 o-아세틸-l-호모세린 또는 l-메티오닌 생산 방법
KR102525072B1 (ko) * 2021-03-10 2023-04-24 씨제이제일제당 주식회사 신규한 시트레이트 신타아제 변이체 및 이를 이용한 l-아미노산 생산 방법
CN113388564B (zh) * 2021-06-04 2022-03-01 浙江工业大学 一种o-乙酰-l-高丝氨酸生产菌、构建方法及应用
KR102952497B1 (ko) * 2022-03-28 2026-04-15 씨제이제일제당 주식회사 O-아세틸 호모세린 생산 미생물 및 이를 이용한 o-아세틸 호모세린 또는 l-메치오닌 생산 방법
KR20230139598A (ko) * 2022-03-28 2023-10-05 씨제이제일제당 (주) O-아세틸 호모세린 생산 미생물 및 이를 이용한 o-아세틸 호모세린 또는 l-메치오닌 생산 방법
KR20240147322A (ko) 2023-03-31 2024-10-08 씨제이제일제당 (주) 미생물 발효를 활용한 o-아세틸 호모세린 제조 공정

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080293101A1 (en) * 2006-07-27 2008-11-27 Peters Matthew W Engineered microorganisms for increasing product yield in biotransformations, related methods and systems
CN102002473A (zh) * 2009-08-28 2011-04-06 Cj第一制糖株式会社 产生o-乙酰高丝氨酸的微生物和利用所述微生物产生o-乙酰高丝氨酸的方法
CN103797027A (zh) * 2010-12-21 2014-05-14 Cj第一制糖株式会社 具有高丝氨酸乙酰转移酶活性的修饰多肽和表达其的微生物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58170488A (ja) 1982-03-31 1983-10-07 Ajinomoto Co Inc 発酵法によるｌ−アスパラギン酸の製造法
WO2005054490A1 (en) * 2003-12-05 2005-06-16 Ajinomoto Co., Inc. L-threonine producing bacterium belonging to the genus escherichia and method for producing l-threonine
JP4913818B2 (ja) * 2005-10-31 2012-04-11 エボニック デグサ ゲーエムベーハー Ｌ−メチオニン調製のための微生物および方法
KR100905381B1 (ko) 2006-07-28 2009-06-30 씨제이제일제당 (주) Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법
JP5656183B2 (ja) * 2006-08-22 2015-01-21 国立大学法人 東京医科歯科大学 滑膜由来間葉幹細胞（ＭＳＣｓ）の軟骨・半月板再生への応用
US7851180B2 (en) * 2008-04-04 2010-12-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
US9005952B2 (en) 2008-04-04 2015-04-14 Cj Cheiljedang Corporation Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism
RU2411289C2 (ru) * 2008-09-30 2011-02-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Бактерия, принадлежащая к роду pantoea, - продуцент l-аспартата или метаболита, являющегося производным l-аспартата, и способ получения l-аспартата или метаболита, являющегося производным l-аспартата
US8609396B2 (en) * 2009-08-28 2013-12-17 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
WO2011073738A1 (en) 2009-12-14 2011-06-23 Metabolic Explorer Use of inducible promoters in the production of methionine
RU2010101135A (ru) * 2010-01-15 2011-07-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) Бактерия семейства enterobacteriaceae - продуцент l-аспартата или метаболитов, производных l-аспартата, и способ получения l-аспартата или метаболитов, производных l-аспартата

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080293101A1 (en) * 2006-07-27 2008-11-27 Peters Matthew W Engineered microorganisms for increasing product yield in biotransformations, related methods and systems
CN102002473A (zh) * 2009-08-28 2011-04-06 Cj第一制糖株式会社 产生o-乙酰高丝氨酸的微生物和利用所述微生物产生o-乙酰高丝氨酸的方法
CN103797027A (zh) * 2010-12-21 2014-05-14 Cj第一制糖株式会社 具有高丝氨酸乙酰转移酶活性的修饰多肽和表达其的微生物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Evidence for Isosteric and Allosteric Nucleotide Inhibition of Citrate Synthase from Multiple-Inhibition Studies;S. HARFORD et al.;《Biochem.J.》;19751231;第151卷;第455-458页 *
高效表达N-乙酰高丝氨酸内酯酶-木聚糖酶融合蛋白及其酶学性质;张美超等;《微生物学报》;20111231;第51卷(第8期);第1052-1061页 *

Also Published As

Publication number Publication date
AU2015264911B2 (en) 2017-11-23
PL2998388T3 (pl) 2021-05-17
JP6607974B2 (ja) 2019-11-20
KR101641770B1 (ko) 2016-07-22
BR122020005905B1 (pt) 2022-07-26
BR112015029716A2 (pt) 2017-09-26
EP3783096B1 (en) 2024-03-13
KR20160000098A (ko) 2016-01-04
RU2614253C1 (ru) 2017-03-24
EP2998388A4 (en) 2017-03-22
SG11201509451WA (en) 2016-01-28
CN105392880A (zh) 2016-03-09
EP2998388B1 (en) 2020-10-07
JP6336074B2 (ja) 2018-06-06
BR112015029716B1 (pt) 2022-07-19
JP2018046875A (ja) 2018-03-29
EP2998388A1 (en) 2016-03-23
US10815509B2 (en) 2020-10-27
DK2998388T3 (da) 2020-11-23
AU2015264911A1 (en) 2016-01-21
US20170101655A1 (en) 2017-04-13
ES2833432T3 (es) 2021-06-15
CN110592153A (zh) 2019-12-20
WO2015199396A1 (ko) 2015-12-30
US20200024626A1 (en) 2020-01-23
EP3783096A1 (en) 2021-02-24
JP2016526927A (ja) 2016-09-08
MY185764A (en) 2021-06-04
US10465217B2 (en) 2019-11-05

Similar Documents

Publication Publication Date Title
CN105392880B (zh) 生产o-乙酰基高丝氨酸的微生物和用其生产o-乙酰基高丝氨酸的方法
JP5945336B2 (ja) キシロース利用能が付与されたコリネバクテリウム属微生物、及びそれを用いたｌ−リジンの生産方法
CN106715687B (zh) 丙酮酸脱氢酶突变体、包含突变体的微生物和通过使用微生物生产l-氨基酸的方法
US10501763B2 (en) Microorganism producing O-acetyl-homoserine and method for producing O-acetylhomoserine using the same
CN114729338A (zh) 变异二氢吡啶二羧酸还原酶多肽和使用其生产l-苏氨酸的方法
US10597686B2 (en) Polypeptide having the activity of exporting O-acetyl-homoserine
CN107849094A (zh) 葡糖酸阻抑物变体、包含其的产l‑赖氨酸的微生物和使用该微生物产生l‑赖氨酸的方法
EP3061814B1 (en) Microorganism producing o-succinyl homoserine and method for producing o-succinyl homoserine by using same
CN106574232A (zh) 具有l‑赖氨酸生产能力的微生物和使用其的l‑赖氨酸生产方法
JP6502515B2 (ja) キノリン酸生産能を有する微生物及びそれを用いてキノリン酸を生産する方法
BR112019009942B1 (pt) Micro-organismo do gênero corynebacterium que produz l-lisina e método para produzir l-lisina

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant