AU2015264911B2 - Microorganism producing O-Acetyl homoserine and the method of producing O-Acetyl homoserine using the same - Google Patents

Microorganism producing O-Acetyl homoserine and the method of producing O-Acetyl homoserine using the same Download PDF

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AU2015264911B2
AU2015264911B2 AU2015264911A AU2015264911A AU2015264911B2 AU 2015264911 B2 AU2015264911 B2 AU 2015264911B2 AU 2015264911 A AU2015264911 A AU 2015264911A AU 2015264911 A AU2015264911 A AU 2015264911A AU 2015264911 B2 AU2015264911 B2 AU 2015264911B2
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homoserine
microorganism
activity
acetyl
acetyl homoserine
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AU2015264911A1 (en
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Jee Yeon BAE
Jin Geun Choi
Hyun Ah Kim
Sang Kyoum Kim
So Young Kim
Kwang Ho Na
Ju Hee Seo
Yong Uk Shin
Sung Kwang Son
Hye Ryun YOO
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CJ CheilJedang Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01031—Homoserine O-acetyltransferase (2.3.1.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/03001—Citrate (Si)-synthase (2.3.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01039—Homoserine kinase (2.7.1.39)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01031—Phosphoenolpyruvate carboxylase (4.1.1.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2015264911A 2014-06-23 2015-06-22 Microorganism producing O-Acetyl homoserine and the method of producing O-Acetyl homoserine using the same Active AU2015264911B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020140076779A KR101641770B1 (ko) 2014-06-23 2014-06-23 O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법
KR10-2014-0076779 2014-06-23
PCT/KR2015/006307 WO2015199396A1 (ko) 2014-06-23 2015-06-22 O-아세틸 호모세린을 생산하는 미생물 및 상기 미생물을 이용하여 o-아세틸 호모세린을 생산하는 방법

Publications (2)

Publication Number Publication Date
AU2015264911A1 AU2015264911A1 (en) 2016-01-21
AU2015264911B2 true AU2015264911B2 (en) 2017-11-23

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US (2) US10465217B2 (https=)
EP (2) EP2998388B1 (https=)
JP (2) JP6336074B2 (https=)
KR (1) KR101641770B1 (https=)
CN (2) CN105392880B (https=)
AU (1) AU2015264911B2 (https=)
BR (2) BR122020005905B1 (https=)
DK (1) DK2998388T3 (https=)
ES (1) ES2833432T3 (https=)
MY (1) MY185764A (https=)
PL (1) PL2998388T3 (https=)
RU (1) RU2614253C1 (https=)
SG (1) SG11201509451WA (https=)
WO (1) WO2015199396A1 (https=)

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RU2804941C1 (ru) * 2019-12-20 2023-10-09 СиДжей ЧеилДжеданг Корпорейшн Вариант белка внутренней мембраны и способ получения целевого продукта с его использованием

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CN111315877B (zh) * 2017-06-30 2023-08-08 Cj第一制糖株式会社 新型o-琥珀酰高丝氨酸转移酶变体及使用其生产o-琥珀酰高丝氨酸的方法
CN110129294B (zh) * 2018-02-02 2021-12-24 中国科学院天津工业生物技术研究所 高丝氨酸乙酰基转移酶突变体及其宿主细胞和应用
KR101915433B1 (ko) 2018-02-13 2018-11-05 씨제이제일제당 (주) 시트레이트 신타아제 (Citrate synthase)의 활성이 약화된 변이형 폴리펩타이드 및 이를 이용한 L-아미노산 생산방법
CN113122486B (zh) * 2019-12-31 2023-06-13 江南大学 一种丙二酸的全生物合成的方法
KR102285951B1 (ko) 2020-01-30 2021-08-04 씨제이제일제당 주식회사 시트레이트 신타아제의 활성이 약화된 신규한 변이형 폴리펩티드 및 이를 이용한 l-아미노산 생산 방법
CN115427580A (zh) * 2020-02-07 2022-12-02 代谢探索者公司 用于改善依克多因产生的经修饰的微生物和方法
KR102344689B1 (ko) * 2020-09-01 2021-12-29 씨제이제일제당 주식회사 L-발린 생산 미생물 및 이를 이용한 l-발린 생산 방법
CN112501144B (zh) * 2021-02-02 2021-04-20 中国科学院天津工业生物技术研究所 高丝氨酸乙酰转移酶突变体及其在生产o-乙酰高丝氨酸中的应用
KR102525073B1 (ko) * 2021-03-10 2023-04-24 씨제이제일제당 주식회사 신규한 시트레이트 신타아제 변이체 및 이를 이용한 l-발린 생산 방법
KR102525074B1 (ko) * 2021-03-10 2023-04-24 씨제이제일제당 주식회사 신규한 시트레이트 신타아제 변이체 및 이를 이용한 o-아세틸-l-호모세린 또는 l-메티오닌 생산 방법
KR102525072B1 (ko) * 2021-03-10 2023-04-24 씨제이제일제당 주식회사 신규한 시트레이트 신타아제 변이체 및 이를 이용한 l-아미노산 생산 방법
CN113388564B (zh) * 2021-06-04 2022-03-01 浙江工业大学 一种o-乙酰-l-高丝氨酸生产菌、构建方法及应用
KR102952497B1 (ko) * 2022-03-28 2026-04-15 씨제이제일제당 주식회사 O-아세틸 호모세린 생산 미생물 및 이를 이용한 o-아세틸 호모세린 또는 l-메치오닌 생산 방법
KR20230139598A (ko) * 2022-03-28 2023-10-05 씨제이제일제당 (주) O-아세틸 호모세린 생산 미생물 및 이를 이용한 o-아세틸 호모세린 또는 l-메치오닌 생산 방법
KR20240147322A (ko) 2023-03-31 2024-10-08 씨제이제일제당 (주) 미생물 발효를 활용한 o-아세틸 호모세린 제조 공정

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Publication number Priority date Publication date Assignee Title
RU2804941C1 (ru) * 2019-12-20 2023-10-09 СиДжей ЧеилДжеданг Корпорейшн Вариант белка внутренней мембраны и способ получения целевого продукта с его использованием

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PL2998388T3 (pl) 2021-05-17
JP6607974B2 (ja) 2019-11-20
KR101641770B1 (ko) 2016-07-22
BR122020005905B1 (pt) 2022-07-26
BR112015029716A2 (pt) 2017-09-26
EP3783096B1 (en) 2024-03-13
KR20160000098A (ko) 2016-01-04
RU2614253C1 (ru) 2017-03-24
EP2998388A4 (en) 2017-03-22
SG11201509451WA (en) 2016-01-28
CN105392880A (zh) 2016-03-09
EP2998388B1 (en) 2020-10-07
JP6336074B2 (ja) 2018-06-06
BR112015029716B1 (pt) 2022-07-19
JP2018046875A (ja) 2018-03-29
EP2998388A1 (en) 2016-03-23
US10815509B2 (en) 2020-10-27
CN105392880B (zh) 2019-11-08
DK2998388T3 (da) 2020-11-23
AU2015264911A1 (en) 2016-01-21
US20170101655A1 (en) 2017-04-13
ES2833432T3 (es) 2021-06-15
CN110592153A (zh) 2019-12-20
WO2015199396A1 (ko) 2015-12-30
US20200024626A1 (en) 2020-01-23
EP3783096A1 (en) 2021-02-24
JP2016526927A (ja) 2016-09-08
MY185764A (en) 2021-06-04
US10465217B2 (en) 2019-11-05

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