CN105377306B - Glp-1衍生物和其用途 - Google Patents

Glp-1衍生物和其用途 Download PDF

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CN105377306B
CN105377306B CN201480035036.1A CN201480035036A CN105377306B CN 105377306 B CN105377306 B CN 105377306B CN 201480035036 A CN201480035036 A CN 201480035036A CN 105377306 B CN105377306 B CN 105377306B
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derivative
xaa
glp
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chem
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CN105377306A (zh
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S.里德茨-朗格
P.索尔伯格
J．科福伊德
I.佩特斯森
C.W.托诺伊
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Novo Nordisk AS
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CN201480035036.1A 2013-06-20 2014-06-19 Glp-1衍生物和其用途 Active CN105377306B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP13173068.1 2013-06-20
EP13173068 2013-06-20
US201361841995P 2013-07-02 2013-07-02
US61/841995 2013-07-02
EP13175092.9 2013-07-04
EP13175092 2013-07-04
US201361845647P 2013-07-12 2013-07-12
US61/845647 2013-07-12
PCT/EP2014/062952 WO2014202727A1 (en) 2013-06-20 2014-06-19 Glp-1 derivatives and uses thereof

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CN105377306A CN105377306A (zh) 2016-03-02
CN105377306B true CN105377306B (zh) 2020-03-17

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US (1) US10195255B2 (https=)
EP (1) EP3010546B1 (https=)
JP (1) JP6475233B2 (https=)
KR (1) KR20160021183A (https=)
CN (1) CN105377306B (https=)
AU (1) AU2014283221A1 (https=)
BR (1) BR112015030948A2 (https=)
CA (1) CA2915922A1 (https=)
ES (1) ES2646538T3 (https=)
MX (1) MX2015016564A (https=)
WO (1) WO2014202727A1 (https=)

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JP6475233B2 (ja) 2013-06-20 2019-02-27 ノヴォ ノルディスク アー／エス Ｇｌｐ−１誘導体及びその使用
JP6730278B2 (ja) * 2014-11-27 2020-07-29 ノヴォ ノルディスク アー／エス Ｇｌｐ−１誘導体及びその使用
WO2016097108A1 (en) 2014-12-17 2016-06-23 Novo Nordisk A/S Glp-1 derivatives and uses thereof
AU2016270373A1 (en) 2015-06-05 2018-01-04 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
CN108697768B (zh) 2015-12-23 2022-07-22 约翰霍普金斯大学 长效glp-1r激动剂作为神经系统病状和神经退行性病状的治疗方法
CN106928343A (zh) * 2015-12-30 2017-07-07 深圳翰宇药业股份有限公司 索玛鲁肽的制备方法
US10946074B2 (en) 2016-03-03 2021-03-16 Novo Nordisk A/S GLP-1 derivatives and uses thereof
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018113340A1 (zh) * 2016-12-20 2018-06-28 中国药科大学 多肽p11及其用途
MX2020010505A (es) 2018-04-05 2021-01-15 Sun Pharmaceutical Ind Ltd Analogos novedosos de glp-1.
WO2019243502A1 (en) * 2018-06-21 2019-12-26 Novo Nordisk A/S Novel compounds for treatment of obesity
EA202191105A1 (ru) 2018-10-22 2021-08-03 Янссен Фармацевтика Нв Слитые белки, полученные из глюкагоноподобного пептида 1 (glp1) и ростового фактора дифференцировки 15 (gdf15), и их применение
SG11202103137WA (en) * 2018-10-26 2021-04-29 Novo Nordisk As Stable semaglutide compositions and uses thereof
WO2020118843A1 (zh) * 2018-12-12 2020-06-18 四川利通科创生物医药科技有限公司 一种glp-1突变体及其制备方法和用途
CN110590934B (zh) * 2019-09-25 2020-12-08 北京乐普医药科技有限公司 一种glp-1化合物
CN111253475B (zh) * 2020-02-18 2021-03-09 江苏诺泰澳赛诺生物制药股份有限公司 Glp-1激动多肽化合物及其盐与合成方法及用途
AR122579A1 (es) * 2020-06-12 2022-09-21 Lilly Co Eli Proceso para preparar un agonista dual glp-1 / glucagón
CN114729060B (zh) 2020-09-30 2022-11-25 北京质肽生物医药科技有限公司 多肽缀合物和使用方法
TWI850611B (zh) 2020-12-18 2024-08-01 丹麥商諾佛 儂迪克股份有限公司 Glp-1及澱粉素受體之共促效劑
EP4323413A4 (en) 2022-03-30 2025-10-15 Beijing Ql Biopharmaceutical Co Ltd LIQUID PHARMACEUTICAL COMPOSITIONS OF POLYPEPTIDE CONJUGATES AND METHODS OF USE THEREOF
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