CN105377286B - 芋螺毒素(conotoxin)肽，其医药组合物和用途 - Google Patents

芋螺毒素(conotoxin)肽，其医药组合物和用途 Download PDF

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Publication number
CN105377286B
CN105377286B CN201480037106.7A CN201480037106A CN105377286B CN 105377286 B CN105377286 B CN 105377286B CN 201480037106 A CN201480037106 A CN 201480037106A CN 105377286 B CN105377286 B CN 105377286B
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pain
conotoxin peptide
conotoxin
peptide
seq
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CN105377286A (zh
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J·迈克尔·麦金托什
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University of Utah Research Foundation Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480037106.7A 2013-05-31 2014-05-30 芋螺毒素(conotoxin)肽，其医药组合物和用途 Expired - Fee Related CN105377286B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361829633P 2013-05-31 2013-05-31
US61/829,633 2013-05-31
US201361843135P 2013-07-05 2013-07-05
US61/843,135 2013-07-05
PCT/US2014/040374 WO2014194284A1 (en) 2013-05-31 2014-05-30 Conotoxin peptides, pharmaceutical compositions and uses thereof

Publications (2)

Publication Number Publication Date
CN105377286A CN105377286A (zh) 2016-03-02
CN105377286B true CN105377286B (zh) 2021-07-02

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CN201480037106.7A Expired - Fee Related CN105377286B (zh) 2013-05-31 2014-05-30 芋螺毒素(conotoxin)肽，其医药组合物和用途

Country Status (11)

Country Link
US (1) US10633417B2 (enExample)
EP (1) EP3003344B1 (enExample)
JP (1) JP6681826B2 (enExample)
KR (1) KR20160019469A (enExample)
CN (1) CN105377286B (enExample)
AU (1) AU2014273883B9 (enExample)
CA (1) CA2913993A1 (enExample)
HK (1) HK1221425A1 (enExample)
MX (1) MX367858B (enExample)
TW (1) TWI686205B (enExample)
WO (1) WO2014194284A1 (enExample)

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Publication number Priority date Publication date Assignee Title
TWI708790B (zh) * 2014-11-07 2020-11-01 美商奇尼塔慢性疼痛有限責任公司 芋螺毒素（ｃｏｎｏｔｏｘｉｎ）肽之修飾及用途
CN105985410B (zh) * 2015-02-16 2019-11-29 海南大学 芋螺肽、其药物组合物及用途
US10947274B1 (en) * 2018-05-01 2021-03-16 University Of Utah Research Foundation Synthetic analgesic peptides of RgIA analogs
US11612661B2 (en) 2019-01-04 2023-03-28 Kineta Chronic Pain, Llc Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions
CN113493502B (zh) * 2020-04-01 2023-09-12 广西大学 α-芋螺毒素肽TxIE、其药物组合物及用途
KR20230031884A (ko) * 2020-06-03 2023-03-07 유타대학연구재단 형태적으로 제약된 α-RGIA 유사체
CN114805488B (zh) * 2021-01-29 2023-05-30 李威 一种靶向神经元烟碱型乙酰胆碱受体的新型多肽分子nAChR_BP及其应用
US20240269228A1 (en) * 2021-06-03 2024-08-15 University Of Utah Research Foundation Selective penicillamine substitution enables development of a potent analgesic peptide that acts through a non-opioid based mechanism

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CN101448516A (zh) * 2006-04-13 2009-06-03 昆士兰大学 环化α-芋螺毒素肽
US20120220539A1 (en) * 2006-07-18 2012-08-30 University Of Utah Research Foundation Conotoxin peptides
US20120329717A1 (en) * 2009-09-21 2012-12-27 Richard Lewis Novel omega conotoxin peptides

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US20120220539A1 (en) * 2006-07-18 2012-08-30 University Of Utah Research Foundation Conotoxin peptides
US20120329717A1 (en) * 2009-09-21 2012-12-27 Richard Lewis Novel omega conotoxin peptides

Also Published As

Publication number Publication date
AU2014273883A1 (en) 2015-12-17
US10633417B2 (en) 2020-04-28
CA2913993A1 (en) 2014-12-04
TW201503897A (zh) 2015-02-01
US20160122388A1 (en) 2016-05-05
WO2014194284A1 (en) 2014-12-04
EP3003344B1 (en) 2020-11-25
JP6681826B2 (ja) 2020-04-15
AU2014273883B2 (en) 2019-11-07
JP2016520620A (ja) 2016-07-14
EP3003344A4 (en) 2016-12-28
MX2015016492A (es) 2016-07-14
HK1221425A1 (zh) 2017-06-02
AU2014273883B9 (en) 2020-06-18
TWI686205B (zh) 2020-03-01
CN105377286A (zh) 2016-03-02
EP3003344A1 (en) 2016-04-13
MX367858B (es) 2019-09-09
KR20160019469A (ko) 2016-02-19

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