CA2913993A1 - Conotoxin peptides, pharmaceutical compositions and uses thereof - Google Patents
Conotoxin peptides, pharmaceutical compositions and uses thereofInfo
- Publication number
- CA2913993A1 CA2913993A1 CA2913993A CA2913993A CA2913993A1 CA 2913993 A1 CA2913993 A1 CA 2913993A1 CA 2913993 A CA2913993 A CA 2913993A CA 2913993 A CA2913993 A CA 2913993A CA 2913993 A1 CA2913993 A1 CA 2913993A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- pain
- conotoxin peptide
- conotoxin
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical class CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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- 239000004474 valine Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361829633P | 2013-05-31 | 2013-05-31 | |
| US61/829,633 | 2013-05-31 | ||
| US201361843135P | 2013-07-05 | 2013-07-05 | |
| US61/843,135 | 2013-07-05 | ||
| PCT/US2014/040374 WO2014194284A1 (en) | 2013-05-31 | 2014-05-30 | Conotoxin peptides, pharmaceutical compositions and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2913993A1 true CA2913993A1 (en) | 2014-12-04 |
Family
ID=51989449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2913993A Abandoned CA2913993A1 (en) | 2013-05-31 | 2014-05-30 | Conotoxin peptides, pharmaceutical compositions and uses thereof |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10633417B2 (enExample) |
| EP (1) | EP3003344B1 (enExample) |
| JP (1) | JP6681826B2 (enExample) |
| KR (1) | KR20160019469A (enExample) |
| CN (1) | CN105377286B (enExample) |
| AU (1) | AU2014273883B9 (enExample) |
| CA (1) | CA2913993A1 (enExample) |
| HK (1) | HK1221425A1 (enExample) |
| MX (1) | MX367858B (enExample) |
| TW (1) | TWI686205B (enExample) |
| WO (1) | WO2014194284A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI708790B (zh) * | 2014-11-07 | 2020-11-01 | 美商奇尼塔慢性疼痛有限責任公司 | 芋螺毒素（ｃｏｎｏｔｏｘｉｎ）肽之修飾及用途 |
| CN105985410B (zh) * | 2015-02-16 | 2019-11-29 | 海南大学 | 芋螺肽、其药物组合物及用途 |
| US10947274B1 (en) * | 2018-05-01 | 2021-03-16 | University Of Utah Research Foundation | Synthetic analgesic peptides of RgIA analogs |
| US11612661B2 (en) | 2019-01-04 | 2023-03-28 | Kineta Chronic Pain, Llc | Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions |
| CN113493502B (zh) * | 2020-04-01 | 2023-09-12 | 广西大学 | α-芋螺毒素肽TxIE、其药物组合物及用途 |
| KR20230031884A (ko) * | 2020-06-03 | 2023-03-07 | 유타대학연구재단 | 형태적으로 제약된 α-RGIA 유사체 |
| CN114805488B (zh) * | 2021-01-29 | 2023-05-30 | 李威 | 一种靶向神经元烟碱型乙酰胆碱受体的新型多肽分子nAChR_BP及其应用 |
| US20240269228A1 (en) * | 2021-06-03 | 2024-08-15 | University Of Utah Research Foundation | Selective penicillamine substitution enables development of a potent analgesic peptide that acts through a non-opioid based mechanism |
Family Cites Families (43)
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| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| US4569967A (en) | 1983-10-24 | 1986-02-11 | The Salk Institute For Biological Studies | Synthesis of N-substituted peptide amides |
| US4883666A (en) | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
| US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| DE3829752A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration |
| DE3829766A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Verfahren zur herstellung von membranen |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5084350A (en) | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
| US5618531A (en) | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| DK0585368T3 (da) | 1991-04-25 | 1998-03-16 | Univ Brown Res Found | Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter |
| US5854217A (en) | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
| DE69423522T2 (de) | 1993-04-27 | 2000-09-21 | Cytotherapeutics, Inc. | Membran aus einem acrylnitrilpolymer |
| EP0708670A4 (en) | 1993-06-23 | 1998-07-01 | Cytotherapeutics Inc | METHOD AND APPARATUS FOR HERMETICALLY CLOSING IMPLANTABLE MEMBRANE ENCAPSULATING DEVICES |
| US5595972A (en) * | 1993-06-29 | 1997-01-21 | University Of Utah Research Foundation | Conotoxin peptides |
| US5432155A (en) * | 1993-06-29 | 1995-07-11 | The Salk Institute For Biological Studies | Conotoxins I |
| US5514774A (en) * | 1993-06-29 | 1996-05-07 | University Of Utah Research Foundation | Conotoxin peptides |
| CA2169292C (en) | 1993-08-12 | 2010-11-23 | E. Edward Baetge | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| US5550050A (en) | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
| US5776747A (en) | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
| US5834029A (en) | 1994-07-20 | 1998-11-10 | Cytotherapeutics, Inc. | Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment |
| IN181898B (enExample) | 1995-06-07 | 1998-10-24 | Cytotherapeutics Inc | |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| AU7204996A (en) | 1995-10-02 | 1997-04-28 | Cytotherapeutics, Inc. | Method for treating amyotrophic lateral sclerosis |
| US5844077A (en) | 1997-04-28 | 1998-12-01 | Cytotherapeutics, Inc. | Use of conantokins for producing analgesia or for neuroprotection |
| US5866682A (en) * | 1997-05-15 | 1999-02-02 | University Of Utah Research Foundation | Conopeptides AuIA, AuIB and AuIC |
| US6265541B1 (en) * | 1997-12-31 | 2001-07-24 | University Of Utah Research Foundation | Uses of α-conotoxin peptides |
| AUPP589598A0 (en) | 1998-09-14 | 1998-10-08 | University Of Queensland, The | Novel peptides |
| CA2361138A1 (en) * | 1999-01-22 | 2000-07-27 | University Of Utah Research Foundation | Alpha-conotoxin peptides |
| US6797808B1 (en) * | 1999-01-29 | 2004-09-28 | University Of Utah Research Foundation | α-conotoxin peptides |
| US6767896B1 (en) * | 1999-01-29 | 2004-07-27 | Cognetix, Inc. | Conotoxin peptides |
| EP1151100A4 (en) * | 1999-02-04 | 2002-07-17 | Univ Utah Res Found | TAU-CONOTOXIN PEPTIDE |
| AU2740401A (en) * | 1999-12-30 | 2001-07-16 | Cognetix, Inc. | O-superfamily conotoxin peptides |
| US6767895B2 (en) * | 2000-06-30 | 2004-07-27 | Cognetix, Inc. | I-superfamily conotoxins |
| JP2004537253A (ja) * | 2000-07-21 | 2004-12-16 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | ミュー−コノペプチド |
| US20030109670A1 (en) | 2001-02-09 | 2003-06-12 | University Of Utah Research Foundation | Cone snail peptides |
| US7387997B2 (en) * | 2004-11-09 | 2008-06-17 | University Of Utah | α-conotoxin MII analogues |
| CA2566832A1 (en) | 2006-04-13 | 2007-10-13 | The University Of Queensland | Cyclised alpha-conotoxin peptides |
| US9284358B2 (en) * | 2006-07-18 | 2016-03-15 | University Of Utah Research Foundation | Conotoxin peptides |
| WO2008011006A2 (en) | 2006-07-18 | 2008-01-24 | University Of Utah Research Foundation | Methods for treating pain and screening analgesic compounds |
| US8765677B2 (en) * | 2009-09-21 | 2014-07-01 | The University Of Queensland | Omega conotoxin peptides |
| JP6336979B2 (ja) * | 2012-08-07 | 2018-06-06 | ハイナン ユニバーシティ | α−コノトキシンペプチド、その医薬組成物及びそれらの使用 |
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- 2014-05-30 WO PCT/US2014/040374 patent/WO2014194284A1/en not_active Ceased
- 2014-05-30 EP EP14803477.0A patent/EP3003344B1/en not_active Not-in-force
- 2014-05-30 CN CN201480037106.7A patent/CN105377286B/zh not_active Expired - Fee Related
- 2014-05-30 HK HK16109735.3A patent/HK1221425A1/zh unknown
- 2014-05-30 KR KR1020157036731A patent/KR20160019469A/ko not_active Ceased
- 2014-05-30 CA CA2913993A patent/CA2913993A1/en not_active Abandoned
- 2014-05-30 MX MX2015016492A patent/MX367858B/es active IP Right Grant
- 2014-05-30 JP JP2016517065A patent/JP6681826B2/ja not_active Expired - Fee Related
- 2014-05-30 AU AU2014273883A patent/AU2014273883B9/en not_active Ceased
- 2014-05-30 US US14/894,967 patent/US10633417B2/en active Active
- 2014-05-30 TW TW103119136A patent/TWI686205B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN105377286B (zh) | 2021-07-02 |
| AU2014273883A1 (en) | 2015-12-17 |
| US10633417B2 (en) | 2020-04-28 |
| TW201503897A (zh) | 2015-02-01 |
| US20160122388A1 (en) | 2016-05-05 |
| WO2014194284A1 (en) | 2014-12-04 |
| EP3003344B1 (en) | 2020-11-25 |
| JP6681826B2 (ja) | 2020-04-15 |
| AU2014273883B2 (en) | 2019-11-07 |
| JP2016520620A (ja) | 2016-07-14 |
| EP3003344A4 (en) | 2016-12-28 |
| MX2015016492A (es) | 2016-07-14 |
| HK1221425A1 (zh) | 2017-06-02 |
| AU2014273883B9 (en) | 2020-06-18 |
| TWI686205B (zh) | 2020-03-01 |
| CN105377286A (zh) | 2016-03-02 |
| EP3003344A1 (en) | 2016-04-13 |
| MX367858B (es) | 2019-09-09 |
| KR20160019469A (ko) | 2016-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190521 |
|
| FZDE | Discontinued |
Effective date: 20220803 |
|
| FZDE | Discontinued |
Effective date: 20220803 |