CN1053653C - 新l－苏糖酸衍生物 - Google Patents

新l－苏糖酸衍生物 Download PDF

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Publication number
CN1053653C
CN1053653C CN97116835A CN97116835A CN1053653C CN 1053653 C CN1053653 C CN 1053653C CN 97116835 A CN97116835 A CN 97116835A CN 97116835 A CN97116835 A CN 97116835A CN 1053653 C CN1053653 C CN 1053653C
Authority
CN
China
Prior art keywords
threonic acid
threonic
ferrous
acid
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97116835A
Other languages
English (en)
Chinese (zh)
Other versions
CN1200366A (zh
Inventor
于凯
王志文
寇福平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Juneng Industry Co ltd
Original Assignee
Juneng Industry Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN97116835A priority Critical patent/CN1053653C/zh
Application filed by Juneng Industry Co ltd filed Critical Juneng Industry Co ltd
Priority to US09/486,569 priority patent/US6313170B1/en
Priority to HK01102229A priority patent/HK1032534A1/en
Priority to EP98940049A priority patent/EP1038524B1/en
Priority to JP2000508359A priority patent/JP2001514219A/ja
Priority to DE69832722T priority patent/DE69832722T2/de
Priority to KR1020007002104A priority patent/KR100615537B1/ko
Priority to PCT/CN1998/000174 priority patent/WO1999011256A1/zh
Priority to AU88512/98A priority patent/AU8851298A/en
Publication of CN1200366A publication Critical patent/CN1200366A/zh
Application granted granted Critical
Publication of CN1053653C publication Critical patent/CN1053653C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/10—Polyhydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A23L33/165—Complexes or chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN97116835A 1997-08-29 1997-08-29 新l－苏糖酸衍生物 Expired - Fee Related CN1053653C (zh)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CN97116835A CN1053653C (zh) 1997-08-29 1997-08-29 新l－苏糖酸衍生物
HK01102229A HK1032534A1 (en) 1997-08-29 1998-08-28 L-threonate ferrous, as well as pharmaceutical composition and use for improving and treating human anemia thereof
EP98940049A EP1038524B1 (en) 1997-08-29 1998-08-28 L-threonate ferrous, as well as pharmaceutical composition and use for improving and treating human anemia thereof
JP2000508359A JP2001514219A (ja) 1997-08-29 1998-08-28 Ｌ−トレオン酸第１鉄、その医療組成物及び人間の貧血疾患を改善及び治療するためのその使用
US09/486,569 US6313170B1 (en) 1997-08-29 1998-08-28 L-threonate ferrous, as well as pharmaceutical composition and use for improving and treating human anemia thereof
DE69832722T DE69832722T2 (de) 1997-08-29 1998-08-28 Eisen-l-threonat-,pharmazeutische zusammensetzungen und deren verwendung zur verbesserung und behandlung von anämie bei menschen
KR1020007002104A KR100615537B1 (ko) 1997-08-29 1998-08-28 제 1철 ｌ-트레오네이트, 그 약학 조성물 및 인간의 빈혈을 개선 및 치료하기 위해 이를 사용하는 방법
PCT/CN1998/000174 WO1999011256A1 (en) 1997-08-29 1998-08-28 L-threonate ferrous, as well as pharmaceutical composition and use for improving and treating human anemia thereof
AU88512/98A AU8851298A (en) 1997-08-29 1998-08-28 L-threonate ferrous, as well as pharmaceutical composition and use for improvingand treating human anemia thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN97116835A CN1053653C (zh) 1997-08-29 1997-08-29 新l－苏糖酸衍生物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN99123845A Division CN1118450C (zh) 1999-11-12 1999-11-12 新l－苏糖酸衍生物

Publications (2)

Publication Number Publication Date
CN1200366A CN1200366A (zh) 1998-12-02
CN1053653C true CN1053653C (zh) 2000-06-21

Family

ID=5174140

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97116835A Expired - Fee Related CN1053653C (zh) 1997-08-29 1997-08-29 新l－苏糖酸衍生物

Country Status (9)

Country Link
US (1) US6313170B1 (enExample)
EP (1) EP1038524B1 (enExample)
JP (1) JP2001514219A (enExample)
KR (1) KR100615537B1 (enExample)
CN (1) CN1053653C (enExample)
AU (1) AU8851298A (enExample)
DE (1) DE69832722T2 (enExample)
HK (1) HK1032534A1 (enExample)
WO (1) WO1999011256A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1074762C (zh) * 1998-08-18 2001-11-14 北京巨能亚太生命科学研究中心 L－苏糖酸铬盐、其制备方法及其应用
CN1196480C (zh) * 2001-07-03 2005-04-13 北京巨能亚太生命科学研究中心 L－苏糖酸钙在制备预防或治疗骨折的药物中的用途
JP4300753B2 (ja) * 2001-05-31 2009-07-22 味の素株式会社 貧血抑制剤及び食欲抑制剤
CN1197561C (zh) * 2001-07-03 2005-04-20 北京巨能亚太生命科学研究中心 L－苏糖酸钙在制备预防或治疗损及软骨的疾病的药物中的用途
AU2008227465B2 (en) * 2007-03-22 2014-02-06 Magceutics, Inc. Magnesium compositions and uses thereof
US8142803B2 (en) 2007-03-22 2012-03-27 Magceutics, Inc. Magnesium compositions and uses thereof for neurological disorders
WO2011003045A1 (en) * 2009-07-01 2011-01-06 Magceutics, Inc. Slow release magnesium composition and uses thereof
CN104961636B (zh) * 2015-07-14 2016-08-31 启东东岳药业有限公司 L-苏糖酸镁合成方法
CN108289875A (zh) 2015-09-11 2018-07-17 纽罗森特里亚股份有限公司 苏糖酸盐化合物及其使用方法
CN105326855A (zh) * 2015-10-27 2016-02-17 南京大学 易吸收复合夹层式螯合镁钙片
WO2026017897A1 (en) 2024-07-18 2026-01-22 Malian Biologicals Gmbh Iron supplementation in affective disorders and/or post-traumatic stress disorder (ptsd) and/or serotonin-dependent diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582914A (en) * 1985-01-31 1986-04-15 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors
US4611067A (en) * 1985-01-31 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070085A (en) * 1987-04-10 1991-12-03 Oxycal Laboratories, Inc. Compositions and methods for administering therapeutically active compounds
WO1990012571A1 (en) * 1989-04-07 1990-11-01 Oxycal Laboratories, Inc. Compositions and methods for administering vitamin c
JPH0678247B2 (ja) * 1988-10-04 1994-10-05 大塚製薬株式会社 Ｎｍｒ造影用鉄含有製剤
JPH03291231A (ja) 1990-04-06 1991-12-20 Asahi Breweries Ltd 貧血改善剤
CN1060216A (zh) * 1990-09-25 1992-04-15 奥克斯可尔公司 含有治疗活性化合物的组合物及其施用方法
CN1228409A (zh) * 1998-03-05 1999-09-15 江西赣江制药有限责任公司 L－苏糖酸和苏糖酸盐(或酯)的制剂

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582914A (en) * 1985-01-31 1986-04-15 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors
US4611067A (en) * 1985-01-31 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein

Also Published As

Publication number Publication date
KR20010023461A (ko) 2001-03-26
WO1999011256A1 (en) 1999-03-11
US6313170B1 (en) 2001-11-06
EP1038524B1 (en) 2005-12-07
AU8851298A (en) 1999-03-22
EP1038524A1 (en) 2000-09-27
KR100615537B1 (ko) 2006-08-25
WO1999011256A8 (en) 1999-08-05
HK1032534A1 (en) 2001-07-27
DE69832722D1 (de) 2006-01-12
DE69832722T2 (de) 2006-09-07
EP1038524A4 (en) 2002-08-07
JP2001514219A (ja) 2001-09-11
CN1200366A (zh) 1998-12-02

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