CN105358143B - Acc抑制剂和其用途 - Google Patents

Acc抑制剂和其用途 Download PDF

Info

Publication number
CN105358143B
CN105358143B CN201480036138.5A CN201480036138A CN105358143B CN 105358143 B CN105358143 B CN 105358143B CN 201480036138 A CN201480036138 A CN 201480036138A CN 105358143 B CN105358143 B CN 105358143B
Authority
CN
China
Prior art keywords
compound
acid
composition
inhibitor
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480036138.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN105358143A (zh
Inventor
杰里米·罗伯特·格林伍德
杰拉尔丁·C·哈里曼
乔治·博格
克雷格·E·马斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geely De Appollo
Original Assignee
Geely De Appollo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geely De Appollo filed Critical Geely De Appollo
Publication of CN105358143A publication Critical patent/CN105358143A/zh
Application granted granted Critical
Publication of CN105358143B publication Critical patent/CN105358143B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201480036138.5A 2013-05-10 2014-05-08 Acc抑制剂和其用途 Expired - Fee Related CN105358143B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361821829P 2013-05-10 2013-05-10
US61/821,829 2013-05-10
PCT/US2014/037368 WO2014182950A1 (en) 2013-05-10 2014-05-08 Acc inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
CN105358143A CN105358143A (zh) 2016-02-24
CN105358143B true CN105358143B (zh) 2019-01-22

Family

ID=51867754

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480036138.5A Expired - Fee Related CN105358143B (zh) 2013-05-10 2014-05-08 Acc抑制剂和其用途

Country Status (14)

Country Link
US (1) US9765089B2 (cg-RX-API-DMAC7.html)
EP (1) EP2994128B1 (cg-RX-API-DMAC7.html)
JP (1) JP6417402B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160005364A (cg-RX-API-DMAC7.html)
CN (1) CN105358143B (cg-RX-API-DMAC7.html)
AR (1) AR096243A1 (cg-RX-API-DMAC7.html)
AU (1) AU2014262546B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015028173A2 (cg-RX-API-DMAC7.html)
CA (1) CA2911818A1 (cg-RX-API-DMAC7.html)
CL (1) CL2015003316A1 (cg-RX-API-DMAC7.html)
EA (1) EA030958B1 (cg-RX-API-DMAC7.html)
HK (2) HK1221660A1 (cg-RX-API-DMAC7.html)
MX (1) MX2015015421A (cg-RX-API-DMAC7.html)
WO (1) WO2014182950A1 (cg-RX-API-DMAC7.html)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2911822A1 (en) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
US9988399B2 (en) * 2013-05-10 2018-06-05 Gilead Apollo, Llc Bicyclic compounds as ACC inhibitors and uses thereof
WO2014182945A1 (en) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
JPWO2015056782A1 (ja) 2013-10-17 2017-03-09 塩野義製薬株式会社 新規アルキレン誘導体
US10202361B2 (en) 2014-08-29 2019-02-12 Fmc Corporation Pyridazinones as herbicides
CN107106873A (zh) 2015-01-09 2017-08-29 吉利德阿波罗公司 用于治疗非酒精性脂肪肝病的acc抑制剂组合治疗
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
GB201512286D0 (en) * 2015-07-14 2015-08-19 F2G Ltd Chemical compounds
AR106472A1 (es) * 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
HUE053175T2 (hu) 2015-11-25 2021-06-28 Gilead Apollo Llc ACC-gátló észterek és azok alkalmazása
WO2017091617A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
MX2018006285A (es) 2015-11-25 2018-09-07 Gilead Apollo Llc Composiciones fungicidas que contienen derivados de 2,4-dioxido-1,4-dihidrotieno[2,3-d] pirimidina.
KR20180082556A (ko) * 2015-11-25 2018-07-18 길리어드 아폴로, 엘엘씨 피라졸 acc 억제제 및 그의 용도
WO2017100703A1 (en) * 2015-12-10 2017-06-15 Colin Combs Ems analogues of lyn/src-tyrosine kinase inhibitors
ES2972487T3 (es) 2016-03-02 2024-06-13 Gilead Apollo Llc Formas sólidas de un inhibidor de tienopirimidindiona acc y métodos para la producción del mismo
WO2018041771A1 (de) 2016-09-02 2018-03-08 Bayer Pharma Aktiengesellschaft (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung
RU2019111357A (ru) 2016-09-23 2020-10-23 Байер Акциенгезельшафт N3-циклически замещенные тиеноурацилы и их применение
AU2018209006B2 (en) 2017-01-22 2021-04-22 Sunshine Lake Pharma Co., Ltd. Thienopyrimidine derivative and use thereof in medicine
WO2018171699A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途
WO2018171698A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物及其制备方法和用途
PT4122464T (pt) 2017-03-28 2024-06-27 Gilead Sciences Inc Combinações terapêuticas para o tratamento de doenças do fígado
TWI847306B (zh) 2017-08-24 2024-07-01 丹麥商諾佛 儂迪克股份有限公司 Ｇｌｐ-１組成物及其用途
KR20190036705A (ko) 2017-09-28 2019-04-05 한미약품 주식회사 (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체
US11680070B2 (en) 2018-06-05 2023-06-20 Medshine Discovery Inc. Thieno[2,3-c]pyridazin-4(1H)-one derivative and application thereof
JP7374233B2 (ja) 2019-07-02 2023-11-06 ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 立体配置を有するチエノピリミジン誘導体及び薬物におけるその応用
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
US11673899B2 (en) * 2019-12-05 2023-06-13 Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. Crystal form of thieno[2,3-c]pyridazine-4(1H)-one compound, preparation method therefor and use thereof
WO2021112213A1 (ja) * 2019-12-05 2021-06-10 日本曹達株式会社 ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤
PE20230819A1 (es) 2020-02-18 2023-05-19 Novo Nordisk As Composiciones y usos de glp-1
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
WO2023007360A1 (en) * 2021-07-26 2023-02-02 Rao Dr Boggarapu Prakash Molecules as anticancer agents for targeted treatment of breast and prostate cancer
WO2024089216A1 (en) 2022-10-27 2024-05-02 Syngenta Crop Protection Ag Novel sulfur-containing heteroaryl carboxamide compounds
US12303604B1 (en) 2024-10-16 2025-05-20 Currax Pharmaceuticals Llc Pharmaceutical formulations comprising naltrexone and/or bupropion

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070208040A1 (en) * 2006-03-02 2007-09-06 Elfatih Elzein A2a adenosine receptor antagonists
US20080287465A1 (en) * 2004-07-21 2008-11-20 Athersys, Inc. Cyclic N-Hydroxy Imides as Inhibitors of Flap Endonuclease and Uses Thereof
EP2351743A1 (en) * 2008-10-27 2011-08-03 Takeda Pharmaceutical Company Limited Bicyclic compound
US20130116233A1 (en) * 2011-11-09 2013-05-09 Abbvie Inc. Novel inhibitor compounds of phosphodiesterase type 10a
CN104105485A (zh) * 2011-11-11 2014-10-15 尼普斯阿波罗有限公司 Acc抑制剂和其用途

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US3325503A (en) 1965-02-18 1967-06-13 Diamond Alkali Co Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation
US3296272A (en) 1965-04-01 1967-01-03 Dow Chemical Co Sulfinyl- and sulfonylpyridines
FR1453897A (fr) * 1965-06-16 1966-07-22 Dérivés du thiophène et de thiéno pyridazines
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
DE3338292A1 (de) 1983-10-21 1985-05-02 Basf Ag, 6700 Ludwigshafen 7-amino-azolo(1,5-a)-pyrimidine und diese enthaltende fungizide
CA1249832A (en) 1984-02-03 1989-02-07 Shionogi & Co., Ltd. Azolyl cycloalkanol derivatives and agricultural fungicides
US5304732A (en) 1984-03-06 1994-04-19 Mgi Pharma, Inc. Herbicide resistance in plants
BR8600161A (pt) 1985-01-18 1986-09-23 Plant Genetic Systems Nv Gene quimerico,vetores de plasmidio hibrido,intermediario,processo para controlar insetos em agricultura ou horticultura,composicao inseticida,processo para transformar celulas de plantas para expressar uma toxina de polipeptideo produzida por bacillus thuringiensis,planta,semente de planta,cultura de celulas e plasmidio
DE3545319A1 (de) 1985-12-20 1987-06-25 Basf Ag Acrylsaeureester und fungizide, die diese verbindungen enthalten
EP0242236B2 (en) 1986-03-11 1996-08-21 Plant Genetic Systems N.V. Plant cells resistant to glutamine synthetase inhibitors, made by genetic engineering
MY100846A (en) 1986-05-02 1991-03-15 Stauffer Chemical Co Fungicidal pyridyl imidates
ATE82966T1 (de) 1986-08-12 1992-12-15 Mitsubishi Chem Ind Pyridincarboxamid-derivate und ihre verwendung als fungizides mittel.
FR2629098B1 (fr) 1988-03-23 1990-08-10 Rhone Poulenc Agrochimie Gene chimerique de resistance herbicide
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
NZ231804A (en) 1988-12-19 1993-03-26 Ciba Geigy Ag Insecticidal toxin from leiurus quinquestriatus hebraeus
ES2199931T3 (es) 1989-03-24 2004-03-01 Syngenta Participations Ag Plantas transgenicas resistentes a enfermedades.
ZW13690A1 (en) 1989-08-30 1990-11-21 Aeci Ltd Active ingredient dosage device
ES2074547T3 (es) 1989-11-07 1995-09-16 Pioneer Hi Bred Int Lectinas larvicidas, y resistencia inducida de las plantas a los insectos.
AU628229B2 (en) 1989-11-10 1992-09-10 Agro-Kanesho Co. Ltd. Hexahydrotriazine compounds and insecticides
JPH0747582B2 (ja) 1989-12-11 1995-05-24 杏林製薬株式会社 キナゾリン―３―アルカン酸誘導体とその塩およびその製造法
ATE116099T1 (de) 1990-03-12 1995-01-15 Du Pont Wasserdispergierbare oder wasserlösliche pestizide granulate aus hitzeaktivierten bindemitteln.
ES2173077T3 (es) 1990-06-25 2002-10-16 Monsanto Technology Llc Plantas que toleran glifosato.
ES2091878T3 (es) 1990-10-11 1996-11-16 Sumitomo Chemical Co Composicion plaguicida.
JP2828186B2 (ja) 1991-09-13 1998-11-25 宇部興産株式会社 アクリレート系化合物、その製法及び殺菌剤
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
US6069298A (en) 1993-02-05 2000-05-30 Regents Of The University Of Minnesota Methods and an acetyl CoA carboxylase gene for conferring herbicide tolerance and an alteration in oil content of plants
US6303181B1 (en) 1993-05-17 2001-10-16 Electrochemicals Inc. Direct metallization process employing a cationic conditioner and a binder
DE4322211A1 (de) 1993-07-03 1995-01-12 Basf Ag Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
US5773704A (en) 1996-04-29 1998-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herbicide resistant rice
SK286030B6 (sk) 1996-07-17 2008-01-07 Michigan State University Rastlinný materiál cukrovej repy rezistentnej voči herbicídom, spôsob produkcie herbicídne rezistentnej rastliny cukrovej repy a spôsob kontroly burín v prítomnosti týchto rastlín
US5773702A (en) 1996-07-17 1998-06-30 Board Of Trustees Operating Michigan State University Imidazolinone herbicide resistant sugar beet plants
DE19650197A1 (de) 1996-12-04 1998-06-10 Bayer Ag 3-Thiocarbamoylpyrazol-Derivate
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
WO1999014187A1 (de) 1997-09-18 1999-03-25 Basf Aktiengesellschaft Benzamidoxim-derivat, zwischenprodukte und verfahren zu deren herstellung und deren verwendung als fungizide
DE19750012A1 (de) 1997-11-12 1999-05-20 Bayer Ag Isothiazolcarbonsäureamide
WO1999027783A1 (en) 1997-12-04 1999-06-10 Dow Agrosciences Llc Fungicidal compositions and methods, and compounds and methods for the preparation thereof
GB9817623D0 (en) * 1998-08-13 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
TR200101381T2 (tr) 1998-11-17 2002-05-21 Kumiai Chemical Industry Co., Ltd. Pirimidinilbenzimidazol ve triazinilbenzimidazol türevleri ve tarım/bahçe ekinleri mantar mücadele ilacı.
IT1303800B1 (it) 1998-11-30 2001-02-23 Isagro Ricerca Srl Composti dipeptidici aventi elevata attivita' fungicida e loroutilizzo agronomico.
JP3417862B2 (ja) 1999-02-02 2003-06-16 新東工業株式会社 酸化チタン光触媒高担持シリカゲルおよびその製造方法
AU770077B2 (en) 1999-03-11 2004-02-12 Dow Agrosciences Llc Heterocyclic substituted isoxazolidines and their use as fungicides
US6586617B1 (en) 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
UA73307C2 (uk) 1999-08-05 2005-07-15 Куміаі Кемікал Індастрі Ко., Лтд. Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення
DE10021412A1 (de) 1999-12-13 2001-06-21 Bayer Ag Fungizide Wirkstoffkombinationen
AU773363B2 (en) 2000-01-25 2004-05-20 Syngenta Participations Ag Herbicidal composition
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
IL167955A (en) 2000-02-04 2007-10-31 Sumitomo Chemical Co Inilines are converted by troiril
CA2407396C (en) 2000-04-28 2013-12-31 Basf Aktiengesellschaft Use of the maize x112 mutant ahas 2 gene and imidazolinone herbicides for selection of transgenic monocots
AU2001285900B2 (en) 2000-08-25 2005-02-17 Syngenta Participations Ag Novel insecticidal toxins derived from bacillus thuringiensis insecticidal crystal proteins
EP1322614A2 (en) 2000-09-18 2003-07-02 E. I. du Pont de Nemours and Company Pyridinyl amides and imides for use as fungicides
AU2864002A (en) 2000-11-17 2002-05-27 Dow Agrosciences Llc Compounds having fungicidal activity and processes to make and use same
US6548738B2 (en) 2000-12-26 2003-04-15 Research Development Foundation ACC2-knockout mice and uses thereof
JP5034142B2 (ja) 2001-04-20 2012-09-26 住友化学株式会社 植物病害防除剤組成物
DE10136065A1 (de) 2001-07-25 2003-02-13 Bayer Cropscience Ag Pyrazolylcarboxanilide
AR037228A1 (es) 2001-07-30 2004-11-03 Dow Agrosciences Llc Compuestos del acido 6-(aril o heteroaril)-4-aminopicolinico, composicion herbicida que los comprende y metodo para controlar vegetacion no deseada
FR2828196A1 (fr) 2001-08-03 2003-02-07 Aventis Cropscience Sa Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture
BR0211610A (pt) 2001-08-09 2006-04-04 Northwest Plant Breeding Compa mudas de trigo com maior resistência a herbicidas de imidazolinona
BR0211808A (pt) 2001-08-09 2004-09-08 Univ Saskatchewan Plantas de trigo possuindo resistência aumentada a herbicidas de imidazolinas
US7897845B2 (en) 2001-08-09 2011-03-01 University Of Saskatchewan Wheat plants having increased resistance to imidazolinone herbicides
ES2330089T3 (es) 2001-08-17 2009-12-04 Mitsui Chemicals Agro, Inc. Derivado de 3-fenoxi-4-piridazinol y composicion herbicida que lo contiene.
US7230167B2 (en) 2001-08-31 2007-06-12 Syngenta Participations Ag Modified Cry3A toxins and nucleic acid sequences coding therefor
US6977300B2 (en) 2001-11-09 2005-12-20 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US7304070B2 (en) 2001-11-09 2007-12-04 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
AU2002361696A1 (en) 2001-12-17 2003-06-30 Syngenta Participations Ag Novel corn event
WO2003053145A1 (en) 2001-12-21 2003-07-03 Nissan Chemical Industries, Ltd. Bactericidal composition
TWI327462B (en) 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
DE10204390A1 (de) 2002-02-04 2003-08-14 Bayer Cropscience Ag Disubstituierte Thiazolylcarboxanilide
HK1079785B (zh) 2002-03-05 2007-08-10 辛根塔参与股份公司 邻环丙基-n-甲酰苯胺及其作为杀菌剂的用途
CN100348599C (zh) * 2002-06-06 2007-11-14 卫材R&D管理有限公司 新的稠合咪唑衍生物
AU2003282264B2 (en) 2002-07-10 2008-10-09 The Department Of Agriculture, Western Australia Wheat plants having increased resistance to imidazolinone herbicides
GB0227966D0 (en) 2002-11-29 2003-01-08 Syngenta Participations Ag Organic Compounds
ES2324472T3 (es) * 2003-01-06 2009-08-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Herbicidas que inhiben la accion de acetil-coa carboxilasa en vegetales para su uso como pesticidas.
WO2004083193A1 (ja) 2003-03-17 2004-09-30 Sumitomo Chemical Company, Limited アミド化合物およびこれを含有する殺菌剤組成物
US7423031B2 (en) 2003-05-01 2008-09-09 Irm Llc Compounds and compositions as protein kinase inhibitors
AU2004243416B2 (en) 2003-05-28 2009-06-11 Basf Se Wheat plants having increased tolerance to imidazolinone herbicides
HUE035897T2 (en) 2003-06-23 2018-05-28 Pioneer Hi Bred Int Incorporating the green-capability of a single gene-controlled option into the plant
MXPA06002155A (es) 2003-08-29 2007-01-25 Inst Nac De Technologia Agrope Plantas de arroz que tienen una tolerancia incrementada a los herbicidas de imidazolinona.
TWI355894B (en) 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
NZ549218A (en) 2004-03-10 2009-04-30 Basf Ag 5,6-Dialkyl-7-amino-triazolopyrimidines, method for their production, their use for controlling pathogenic fungi and agents containing said compounds
DE502005009861D1 (de) 2004-03-10 2010-08-19 Basf Se 5,6-dialkyl-7-amino-triazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
BRPI0510887A (pt) 2004-06-03 2007-12-26 Du Pont mistura fungicida, composição fungicida e método para o controle de doenças de plantas
BRPI0512118A (pt) 2004-06-18 2008-02-06 Basf Ag composto, processo para combater fungos nocivos, e, agente fungicida
JP2008502625A (ja) 2004-06-18 2008-01-31 ビーエーエスエフ　アクチェンゲゼルシャフト Ｎ−（オルト−フェニル）−１−メチル−３−トリフルオロメチルピラゾール−４−カルボキシアニリドおよびそれらの殺菌剤としての使用
GB0418048D0 (en) 2004-08-12 2004-09-15 Syngenta Participations Ag Method for protecting useful plants or plant propagation material
WO2006087325A1 (de) 2005-02-16 2006-08-24 Basf Aktiengesellschaft 5-alkoxyalkyl-6-alkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
DE102005007160A1 (de) 2005-02-16 2006-08-24 Basf Ag Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen
DE102005009458A1 (de) 2005-03-02 2006-09-07 Bayer Cropscience Ag Pyrazolylcarboxanilide
SI1912991T1 (sl) 2005-08-10 2011-03-31 Glaxosmithkline Llc One Franklin Plaza Derivati ksantina kot selektivni hm74a agonisti
AR059010A1 (es) 2006-01-13 2008-03-05 Dow Agrosciences Llc 6-( aril polisustituido )-4- aminopicolinatos y su uso como herbicidas
BRPI0708036A2 (pt) 2006-02-09 2011-05-17 Syngenta Participations Ag método de proteção de material de propagação de planta, planta e/ou órgãos de planta
BRPI0713836A2 (pt) * 2006-07-25 2013-05-28 Cephalon Inc composto, composiÇço farmacÊutica e mÉtodo para tratar distérbio
TW200823225A (en) 2006-11-01 2008-06-01 Astrazeneca Ab New compounds
JP5686596B2 (ja) 2007-05-25 2015-03-18 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜貫通コンダクタンス制御因子の調節因子
CN101481380B (zh) * 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
CA2729656A1 (en) 2008-07-02 2010-01-07 Avexa Limited Imidazopyrimidinones and uses thereof
US20110244059A1 (en) 2008-08-20 2011-10-06 The University Of Medicine And Dentistry Of New Jersey Inhibiting obesity progression by inhibiting adipocyte differentiation with a pre-adipocyte autophagy inhibitor
US20100113473A1 (en) 2008-10-30 2010-05-06 Player Mark R Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor
US20100280067A1 (en) 2009-04-30 2010-11-04 Pakala Kumara Savithru Sarma Inhibitors of acetyl-coa carboxylase
CA2819400A1 (en) 2010-11-30 2012-06-07 Takeda Pharmaceutical Company Limited Bicyclic compound
WO2014182945A1 (en) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
CA2911822A1 (en) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
US9988399B2 (en) 2013-05-10 2018-06-05 Gilead Apollo, Llc Bicyclic compounds as ACC inhibitors and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080287465A1 (en) * 2004-07-21 2008-11-20 Athersys, Inc. Cyclic N-Hydroxy Imides as Inhibitors of Flap Endonuclease and Uses Thereof
US20070208040A1 (en) * 2006-03-02 2007-09-06 Elfatih Elzein A2a adenosine receptor antagonists
EP2351743A1 (en) * 2008-10-27 2011-08-03 Takeda Pharmaceutical Company Limited Bicyclic compound
US20130116233A1 (en) * 2011-11-09 2013-05-09 Abbvie Inc. Novel inhibitor compounds of phosphodiesterase type 10a
CN104105485A (zh) * 2011-11-11 2014-10-15 尼普斯阿波罗有限公司 Acc抑制剂和其用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Novel 1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine Derivatives as;Esther Arranz等;《J. Med. Chem.》;19980915;第41卷(第21期);第4109-4117页 *
Synthesis of New Hetero[1,2,4]thiadiazin-3-one S,S-Dioxides and Oxazolo[3,2-b]hetero[1,2,4]thiadiazine S,S-Dioxides as Potential Psychotropic Drugs;Salvador Vega等;《J. Heterocyclic Chem.》;20050731;第42卷(第5期);第763-773页 *

Also Published As

Publication number Publication date
CN105358143A (zh) 2016-02-24
WO2014182950A1 (en) 2014-11-13
US9765089B2 (en) 2017-09-19
BR112015028173A2 (pt) 2017-07-25
CA2911818A1 (en) 2014-11-13
EP2994128A1 (en) 2016-03-16
HK1221419A1 (zh) 2017-06-02
KR20160005364A (ko) 2016-01-14
JP2016520064A (ja) 2016-07-11
EP2994128B1 (en) 2019-01-30
EP2994128A4 (en) 2016-11-23
AU2014262546A1 (en) 2015-11-26
MX2015015421A (es) 2016-06-21
HK1221660A1 (zh) 2017-06-09
CL2015003316A1 (es) 2016-07-29
AR096243A1 (es) 2015-12-16
AU2014262546B2 (en) 2018-11-08
EA030958B1 (ru) 2018-10-31
JP6417402B2 (ja) 2018-11-07
US20160185799A1 (en) 2016-06-30
EA201591961A1 (ru) 2016-06-30

Similar Documents

Publication Publication Date Title
CN105358143B (zh) Acc抑制剂和其用途
JP6434498B2 (ja) Ａｃｃ阻害剤及びその使用
CN106905346B (zh) Acc抑制剂和其用途
JP6417401B2 (ja) Ａｃｃ阻害剤及びその使用
JP6417403B2 (ja) Ａｃｃ阻害剤及びその使用
CN108368125A (zh) Acc抑制剂及其用途
CN108290902A (zh) 酯类acc抑制剂及其用途
BR112018010113B1 (pt) Composto de pirazol útil como inibidor da acetil-coa carboxilase (acc)

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: Delaware

Applicant after: GILEAD APOLLO, LLC

Address before: Massachusetts, USA

Applicant before: Appollo Limited by Share Ltd.

Address after: Massachusetts, USA

Applicant after: Appollo Limited by Share Ltd.

Address before: Massachusetts, USA

Applicant before: NIMBUS APOLLO, Inc.

COR Change of bibliographic data
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1221419

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190122

Termination date: 20200508

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1221419

Country of ref document: HK