CN105311623B - 一种代血浆明胶灭菌制剂及其制备方法 - Google Patents
一种代血浆明胶灭菌制剂及其制备方法 Download PDFInfo
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- CN105311623B CN105311623B CN201410431488.3A CN201410431488A CN105311623B CN 105311623 B CN105311623 B CN 105311623B CN 201410431488 A CN201410431488 A CN 201410431488A CN 105311623 B CN105311623 B CN 105311623B
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
交联反应因素 | 对交联反应的影响 | 最优范围 |
交联剂用量 | 在一定范围内用量增加酰化度增加 | 3%~7% |
交联温度 | 温度升高反应速度加快,但过高不利于生产操作 | 38~45℃ |
交联时间 | 2h内时间延长交联程度增加,之后变化不明显 | 1h~2h |
交联pH值 | 最重要的因素,高pH值有利于酰化反应进行 | 9.5~10.5 |
明胶浓度 | 浓度增加有利于交联反应,但不利于生产操作 | 5.5%~10% |
试管编号 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
血细胞混悬液(ml) | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
生理盐水(ml) | 2.5 | 2 | 2.1 | 2.2 | 2.3 | 2.4 | 0 |
蒸馏水(ml) | 0 | 0 | 0 | 0 | 0 | 0 | 2.5 |
本发明产品(ml) | 0 | 0.5 | 0.4 | 0.3 | 0.2 | 0.1 | 0 |
溶血判定 | - | - | - | - | - | - | + |
Claims (9)
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CN103230585B (zh) * | 2013-05-15 | 2014-06-25 | 湖北美林药业有限公司 | 一种聚明胶肽代血浆组合物 |
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Address after: 430000 No.1 Xiaoxiang West Road, Dongxihu District, Wuhan City, Hubei Province Patentee after: Yuanda Medical Nutrition Science (Wuhan) Co.,Ltd. Country or region after: China Address before: 430000 Jinyin Lake Ecological Park, Dongxihu District, Wuhan City, Hubei Province Patentee before: Yuanda Life Science (Wuhan) Co.,Ltd. Country or region before: China |
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CP03 | Change of name, title or address |