CN105311506A - Traditional Chinese medicinal composition for preventing and treating lymphoma and preparation method of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition for preventing and treating lymphoma and preparation method of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for preventing and treating lymphoma, wherein the traditional Chinese medicinal composition is prepared from the following medicinal raw materials in parts by weight: 6-10 parts of lily, 8-14 parts of longseed willowseed herb, 7-12 parts of atalantia buxifolia, 5-10 parts of hypericum patulum, 7-11 parts of wild eucommia bark, 6-9 parts of rhizoma sparganii, 8-13 parts of ricepaperplant root, 7-14 parts of flabellate hemipilia herb, 6-11 parts of gracilaria verrucosa, 3-7 parts of red sage root, 8-15 parts of corn spike, 6-12 parts of eupatorium chinense, 7-13 parts of herb of black medick, 5-9 parts of hairy anemone, 8-12 parts of ficus carica and 9-14 parts of dandelion. The traditional Chinese medicinal composition disclosed by the invention also has the beneficial effects that the medicine prepared by the invention has functions of clearing away heat and toxic materials, relieving cough and asthma, inhibiting cancers and resisting cancers, so as to protect bodies to the greatest extent, inhibit the growth of cancer cells, relieve pain in patients, strengthen physique, enhance body immune function, improve a cure effect and even to achieve clinical curing.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine composition and preparation method of preventing and treating lymphatic cancer.
Background technology
Lymphatic cancer is primary in lymph node or other adenoid malignant tumor, is one of common ten large malignant tumor of China.During this disease is more common in, young, male patient more than women, the age occurred frequently be 45-60 year.This disease can be divided into Hokdkin disease and the large class of non_hodgkin lymphoma two by the difference of its cell component.Its grade malignancy differs, and caused by lymph one histiocyte system neoplasm, mostly occurs in lymph node.
Primary disease cardinal symptom shows as: the lymph node touching enlargement on health, all superficial in early days, therefore often ignore by people.First the lymphatic cancer of about 60% finds the lymphadenectasis at cervical region, the single enlargement of Kai Shi Shi Only, and slowly then number increases, and more enlargement.Lymphatic cancer can betide total lymphoid tissue, on following chin, lower jaw, front cervical region, clavicle, oxter, groin, to indulge by diaphragm chamber or abdominal artery, sometimes then betides internal organs and cause pressure symptom; If betide stomach, small intestinal or large intestine, abdominal distention may be had, have blood in stool, vomit, the symptom of the peptic ulcer such as stomachache or gastrointestinal dysfunction; If lymphoma invades bone marrow, then may produce the general blood cell such as green around the gills, fever, abnormal bleeding and reduce disease, in periphery blood, visible abnormal lymph corpuscle occurs sometimes.Primary disease is equivalent to the category such as Chinese medicine " indurated subcutaneous mass ", " carbuncle of yin nature ", " dislike and drench ", " grandular plague ", " cervical carcinoma with cachexia ", " sucutaneous nodule ".This disease is body healthy energy interior-deficiency mainly, and pathogenic factor fills caused by Sheng.Healthy energy interior-deficiency is main with internal organs virtual loss, and deficient qi and blood etc. are relevant; Evil Sheng is then many by QI stagnated by cold, and the expectorant toxenia stasis of blood etc. causes.
Lymphoma has height heterogeneity, therefore in treatment, also difference is very large, and different pathological types and lymphoma by stages all exist very big difference from treatment intensity and prognosis.Lymphadenomatous Therapeutic Method is primarily of following several: radiotherapy, chemotherapy, bone marrow transplantation and operative treatment.Owing to also not developing the medicine that generally can kill cancerous cell as broad-spectrum antibiotic now, so the treatment to most of cancer patient, be still and first carry out excision, and then kill cancerous cell by X-ray therapy or chemotherapy.But these two kinds of methods also can kill normal healthy cell while killing cancerous cell, cause resistance and the immunity degradation of cancer patient, and expensive, and costly, general family is difficult to bear.
Application publication number CN104922382A(application number 201510323740.3) Chinese invention patent document disclose a kind of Chinese patent medicine orally-taken pill for the treatment of lymphatic cancer, be made up of the raw material of following weight proportioning: Radix Cirsii Japonici 15g, Flos Rosae Rugosae 10g, Pheretima 10g, Rhizoma Curculiginis 10g, Herba Cirsii 10g, Rhizoma Dioscoreae Bulbiferae 8g, Radix Salviae Miltiorrhizae 10g, Ganoderma 12g, Rhizoma Corydalis 15g, Radix Notoginseng 12g, Spica Prunellae 20g, Hedyotidis Diffusae 30g.Application publication number CN104436032A(application number 201410652042.3) Chinese invention patent document disclose a kind of Chinese medicine preparation for the treatment of lymphatic cancer, be made up of the crude drug of following weight parts: Bulbus Fritillariae Thunbergii 10, Herba Verbenae 10, Spica Prunellae 8, Cortex Fraxini 8, Herba Agrimoniae 10, Caulis Lonicerae 8, Herba Euphorbiae Humifusae 8, Folium Aconiti Kusnezoffii 8, Rhizoma Corydalis 6, Radix Cynanchi Paniculati 6, river heart lotus 8, Semen Sinapis 6, Caulis Clematidis Armandii 8, Radix Rubiae 8, Bulbus Allii Macrostemonis 6, Semen Lepidii (Semen Descurainiae) 6, Rhizoma Phragmitis 8, Radix Curcumae 8, Herba Lophatheri 8.Application publication number CN104173920A(application number 201410375839.3) Chinese invention patent document disclose a kind of medicine for the treatment of lymphatic cancer, be made up of the raw material of following weight ratio: Myrrha 9-15, Radix Sophorae Flavescentis 10-30, Radix Astragali 10-50, Radix Glycyrrhizae 9-15, Rhizoma Pinelliae 9-12, Bufo siccus 0.1-0.5, Scolopendra 3-8, Calculus Bovis 0.03-0.8, Herba Sarcandrae 30-60, Rhizoma Curcumae 9-20, Herba Taraxaci 30-80, Sargassum 9-15, Pericarpium Citri Reticulatae Viride 9-12, Radix Bupleuri 2-6, Radix Angelicae Sinensis 9-20, Flos Carthami 4-7.
Radiotherapy chemotherapy treatment is the important means for the treatment of lymphatic cancer at present, be also can curable main path, but its cure rate is low, and side effect is large, brings huge damage to health.In recent years, TCM Therapy plays more and more important effect in the prevention, treatment, nursing etc. of lymphatic cancer, it can significantly improve lymphatic cancer treatment curative effect, extend patient life cycle and improve quality of life of patient.
Summary of the invention
The object of the invention is, provide a kind of Chinese medicine composition preventing and treating lymphatic cancer, forming by adding kinds of traditional Chinese medicines preparation of raw material, preparation method is simple, has good inhibitory action to lymphoma cell.
Technical scheme of the present invention is:
Prevent and treat a Chinese medicine composition for lymphatic cancer, be prepared from by following bulk drugs, be weight portion: Bulbus Lilii 6-10; Herba Epilobii Pyrricholophi 8-14; East wind Fructus Citri tangerinae 7-12; Herba Hyperici Patuli 5-10; Cortex euonymi grandiflori radicis 7-11; Rhizoma Sparganii 6-9; Radix tetrapanacis Koch 8-13; Herba Hemipiliae Flabellatae 7-14; Gracilaria tenuistipitata 6-11; Radix Lantanae Camaraev 3-7; Popcorn 8-15; Herba Serissae 6-12; Herba Medicaginis Lupulinae 7-13; Radix Anemones Tomentosae 5-9; Fructus Fici 8-12; Herba Taraxaci 9-14.
Preferred scheme is, Bulbus Lilii 7-9; Herba Epilobii Pyrricholophi 10-12; East wind Fructus Citri tangerinae 8.5-10.5; Herba Hyperici Patuli 6-9; Cortex euonymi grandiflori radicis 8.5-9.5; Rhizoma Sparganii 7-8; Radix tetrapanacis Koch 9.5-11.5; Herba Hemipiliae Flabellatae 9-12; Gracilaria tenuistipitata 7-10; Radix Lantanae Camaraev 4-6; Popcorn 10-13; Herba Serissae 8-10; Herba Medicaginis Lupulinae 9-11; Radix Anemones Tomentosae 6-8; Fructus Fici 9-11; Herba Taraxaci 10-13.
Be more preferably, Bulbus Lilii 8; Herba Epilobii Pyrricholophi 11; East wind Fructus Citri tangerinae 9.5; Herba Hyperici Patuli 7.5; Cortex euonymi grandiflori radicis 9; Rhizoma Sparganii 7.5; Radix tetrapanacis Koch 10.5; Herba Hemipiliae Flabellatae 10.5; Gracilaria tenuistipitata 8.5; Radix Lantanae Camaraev 5; Popcorn 11.5; Herba Serissae 9; Herba Medicaginis Lupulinae 10; Radix Anemones Tomentosae 7; Fructus Fici 10; Herba Taraxaci 11.5.
Prevent and treat a preparation method for the pill of the Chinese medicine composition of lymphatic cancer, step is as follows:
(1) Radix tetrapanacis Koch, Herba Serissae and Radix Anemones Tomentosae are together placed in medicine pot, add the rice vinegar (preferably adding the rice vinegar of 2 times amount) of 1.5-2.5 times amount, slow fire heating is boiled to vinegar most, takes out, dries, be ground into fine powder, for subsequent use;
(2) Gracilaria tenuistipitata, Bulbus Lilii, popcorn, Fructus Fici and Herba Taraxaci mixing, add the clear water (preferably adding the clear water of 5 times amount) of 4-6 times amount, slow fire boiling 24-38 minute (preferred slow fire boiling 30 minutes), filter, filtrate is for subsequent use;
(3) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis and Rhizoma Sparganii together grind to form coarse powder, be placed in cotton bag, add the Chinese liquor (preferably adding the Chinese liquor of 2.5 times amount) of 2-3 times amount, lixiviate 2-4 days (preferred lixiviate 3 days), collect lixiviating solution, filter, filtrate recycling ethanol, adds step (2) gained filtrate, and decompression concentration becomes paste, spraying dry gets dry extract powder, for subsequent use;
(4) Herba Epilobii Pyrricholophi, Herba Hyperici Patuli, Herba Hemipiliae Flabellatae, Radix Lantanae Camaraev and Herba Medicaginis Lupulinae is fully dry, be together ground into fine powder, mix with step (1) and (3) gained fine powder, sieve, making pellets by mixing medical powder with honey, make the pill of Semen Phaseoli size, to obtain final product.
Above-mentioned a kind of preparation method of preventing and treating the pill of the Chinese medicine composition of lymphatic cancer, preferred scheme is, in step (3), the number of degrees of Chinese liquor used are 42 °-62 ° (number of degrees of preferred Chinese liquor used are 48 °-54 °, and the number of degrees of the Chinese liquor used be more preferably are 52 °).
Above-mentioned a kind of preparation method of preventing and treating the pill of the Chinese medicine composition of lymphatic cancer, preferred scheme is, the middle 70-100 mesh sieve excessively of step (4) (preferred 80-90 mesh sieve excessively, mistake 85 mesh sieve be more preferably).
The preparation method of described capsule is:
(1) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis, Radix tetrapanacis Koch and Herba Taraxaci are together placed in non iron container, add the yellow wine (preferably adding the yellow wine of 0.6 times amount) of 0.45-0.75 times amount, mix thoroughly, vexed 20-40 minute (preferably vexed 30 minutes), treat that yellow wine is sucked, take out, for subsequent use;
(2) Bulbus Lilii, popcorn, Gracilaria tenuistipitata and Fructus Fici mixing, the cooked Mel adding 0.1-0.2 times amount is mixed thoroughly (the cooked Mel preferably adding 0.15 times amount is mixed thoroughly), puts slow fire stir-fry to yellow in parch container and does not touch with one's hand as degree, take out, for subsequent use;
(3) Rhizoma Sparganii sheet is placed in the Testa Tritici made popular, slow fire adds to be propagandized hotly to medical material surface in yellow, and sieve removes Testa Tritici, is together ground into fine powder with Herba Serissae, Radix Lantanae Camaraev and Radix Anemones Tomentosae, crosses 90-130 mesh sieve (preferred mistake 110 mesh sieve), obtains mixing fine powders, for subsequent use;
(4) by the crude drug after step (1) and (2) process and Herba Epilobii Pyrricholophi, Herba Hyperici Patuli, Herba Hemipiliae Flabellatae and Herba Medicaginis Lupulinae are together placed in frying pan, add the pure water (preferably adding the pure water of 6.5 times amount) of 5-8 times amount, soak under room temperature 2-3 hour (soaking 2.5 hours under preferred room temperature), then big fire is heated to boil, turn little fire and decoct twice slowly, first time decocts 20-36 minute (preferably first time decocts 28 minutes), second time decocts 15-23 minute (preferably second time decocts 20 minutes), filter, filtrate reduced in volume to 75 DEG C relative density is the clear paste of 1.16-1.18, for subsequent use,
(5) join in above-mentioned clear paste by step (3) gained mixing fine powders, add other adjuvant while stirring, mixing, is processed into capsule formulation, obtains final product.
Above-mentioned a kind of preparation method of preventing and treating the capsule of the Chinese medicine composition of lymphatic cancer, preferred scheme is, adjuvant described in step (5) to be content be 1.1% glyceryl monostearate and content be the sucrose fine of 4.5%.
The preparation method of described decoction is:
(1) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis, Radix tetrapanacis Koch and Herba Taraxaci are together placed in non iron container, add the yellow wine (preferably adding the yellow wine of 0.6 times amount) of 0.45-0.75 times amount, mix thoroughly, vexed 20-40 minute (preferably vexed 30 minutes), treat that yellow wine is sucked, take out, for subsequent use;
(2) Bulbus Lilii, popcorn, Gracilaria tenuistipitata and Fructus Fici mixing, add the cooked Mel (preferably adding the cooked Mel of 0.15 times amount) of 0.1-0.2 times amount, mix thoroughly, puts slow fire stir-fry to yellow in parch container and do not touch with one's hand as degree, take out, for subsequent use;
(3) crude drug after step (1) and (2) process and surplus stock medicine are together placed in medicine pot, add the cold water soak 2.5 hours cold water soak of 5 times amount (preferably add 2.5 hours) of 4-6 times amount, then slow fire heating decocts 20-40 minute (preferred slow fire heating decoction 30 minutes), filter, medicinal residues add the cold water (preferred medicinal residues add the cold water of 4 times amount again) of 3.5-4.5 times amount again, slow fire boiling 16-24 minute (preferred slow fire boiling 20 minutes), filter, merge twice filtrate, be evaporated to 1/3 of original volume, 110 DEG C of sterilizing 22-34 minute (preferably 110 DEG C sterilizing 28 minutes), cooling, encapsulation, obtain.
The preparation method of described powder is:
(1) Gracilaria tenuistipitata and Cortex euonymi grandiflori radicis mixing, slow fire heats, and fries when to have pitchy focal spot to medical material surface, drench the saline solution (preferably drenching the saline solution into 0.1 times amount) into 0.05-0.15 times amount, fried dry is degree, takes out, together fine powder is smashed into pieces with Rhizoma Sparganii with east wind Fructus Citri tangerinae, for subsequent use;
(2) by Bulbus Lilii, Herba Hemipiliae Flabellatae, Fructus Fici and Herba Taraxaci mixing, the Sucus Zingberis of the Mel and 0.16-0.28 times amount that add 0.1-0.2 times amount is mixed thoroughly (Sucus Zingberis of the Mel and 0.22 times amount that preferably add 0.15 times amount is mixed thoroughly), the supreme gas of Steam by water bath, take out, smash into pureed to pieces, in 56-62 DEG C of dry 2-3 hour (being preferable over 59 DEG C of dryings 2.5 hours), take out, grind into fine powder, for subsequent use;
(3) fully dry, pulverize into fine powder by except step (1) crude drug except (2), mix with step (1) and (2) gained fine powder, cross 45-75 mesh sieve (preferred mistake 60 mesh sieve), sterilizing encapsulates, and to obtain final product.
A kind of Chinese medicine composition preventing and treating lymphatic cancer provided by the invention, scientific formula, preparation method is simple, and gained drug administration is convenient, evident in efficacy.In addition, excellent results of the present invention also shows:
1,the present invention selects plurality of Chinese raw material, scientific compatibility, gained medicine directly acts on cancerous issue, make effective ingredient can arrive focus rapidly, improve the availability of medicine, effectively can kill the growth of cancerous cell and anticancer, and prevent cancerous cell from spreading, thus play the effect of inhibition tumor cell growth and transfer;
2,gained medicine of the present invention has heat-clearing and toxic substances removing, relieving cough and asthma, presses down the anticancer effect of cancer, and to protect body to greatest extent, anticancer grows, and alleviates patient suffering, health invigorating, improves body's immunity, improves cure rate, even reaches clinical cure;
3,medication effect of the present invention is good, taking convenience, and action effect is remarkable.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Bulbus Lilii: base is former: be liliaceous plant Bulbus Lilii, Lilium tenuifolium, Lilium longiflorum and the scale leaf belonging to various plants bulb together thereof.Chemical analysis: lily bulb is containing multiple alkaloid and starch, protein, fat etc. such as colchicine.Pharmacological action: Bulbus Lilii decoct has antitussive action to the mouse cough that ammonia causes, white mice lung perfusion makes flow increase, and the Bufo siccus asthma that can cause antihistaminic.Nature and flavor: sweet micro-hardship are flat.Gui Jing: enter the heart, lung meridian.Function cures mainly: nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.Control lung expense chronic cough, cough and spit expectorant blood; After calentura, waste heat comes clear, and fidgets due to deficiency is palpitated with fear, staring spells; Beriberi edema.(1) nourishing the lung to arrest cough: for cough, the spitting of blood of the dryness of the lung or the deficiency of YIN, often join Bulbus Fritillariae Cirrhosae.(2) clearing away heart-fire for tranquillization:, restlessness of asrhenia type and insomnia, staring spells unclear for waste heat after febrile disease, often joins Radix Rehmanniae.
Herba Epilobii Pyrricholophi: base is former: be the Herb of the long seed LIUYECAI of onagraceae plant.Nature and flavor: bitter in the mouth; Pungent; Cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Arresting bleeding and miscarriage prevention; Removing toxic substances and promoting subsidence of swelling.Cure mainly dysentery; Spit blood; Hemoptysis; Just hematocele; Menorrhagia; Frequent fetal movement; Carbuncle furuncle swells; Scald; Traumatic injury wound is swollen; Traumatic hemorrhage.
East wind Fructus Citri tangerinae: base is former: be Rutaceae Jiu Bing le platymiscium Jiu Bing le, be used as medicine with root and leaf.Nature and flavor: pungent, bitter, tepor.Function cures mainly: expelling pathogenic wind from the body surface, preventing phlegm from forming and stopping coughing, regulating QI to relieve pain.For flu, headache, cough, bronchitis, malaria, stomachache, rheumatic arthritis, lumbago and skelalgia.
Herba Hyperici Patuli: base is former: be the Herb of Garcinia maingayii Herba Hyperici Patuli.Nature and flavor: bitter; Cold.Gui Jing: liver; Kidney; Urinary bladder channel.Function cures mainly: clearing away heat-damp and promoting diuresis detoxifies; Dispersing the stagnated liver-QI and dredging collateral; Stasis-dispelling and pain-killing.Main damp and hot gonorrhea; Hepatitis; Flu; Tonsillitis; The hernia swelling and hanging down of either of the testes; Bones and muscles pain; Traumatic injury.
Cortex euonymi grandiflori radicis: base is former: be the root of Celastraceae plant Flos Caryophylli winged euonymus, root bark or bark.Chemical analysis: root bark, bark are containing hard rubber, and in bark, content is 3.38-17.25%.Nature and flavor: bitter; Pungent; Flat.Gui Jing: spleen; Liver Channel.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation to restore menstrual flow; Blood stasis-eliminating and stagnation-dissipating.Main rheumatalgia; Traumatic injury wound is swollen; Lumbago; Amenorrhea; Dysmenorrhea; Scrofula sucutaneous nodule.
Rhizoma Sparganii: base is former: be the tuber of Sparganiaceae plant rhizoma scirpi or little rhizoma scirpi, spire rhizoma scirpi.Chemical analysis: little rhizoma scirpi is containing volatile oil 0.05%.Nature and flavor: toil are flat.Gui Jing: enter liver.Spleen channel.Function cures mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, and traumatic injury, skin ulcer swells hard.
Radix tetrapanacis Koch: base is former: be the root of Araliaceae rice-paper plant.Chemical analysis: root is containing oleanolic acid-28-β-D-glucopyranosyl ester-3-[α-furyl arabinose-β-D-glucopyranosyloleanate-3-[α-arabinofuranosyl-(1 → 4)]-[β-D-galactopyranosyl (1 → 2)]-methyl-(β-D-glucopyra-nosid) uronate}, oleanolic acid-28-α-rhamnopyranose-(1 → 4)-β-D-Glucopyranose .-(1 → 4)-β-D-glucopyranosyl ester]-3-α-L-arabinofuranose-(1 → 4)-beta d glucopyranosiduronic acid methyl ester, oleanolic acid, oleanolic acid-28-methyl ester-3-[α-furyl arabinose (1 → 4)]-[β-D-galactopyranose-(1 → 2)]-beta d glucopyranosiduronic acid formic acid.Nature and flavor: taste is scorching; Micro-hardship; Cold nature.Function cures mainly: clearing away heat and promoting diuresis; Promote qi circulation digestion promoting; To invigorate blood circulation stimulating milk secretion.Main edema; Stranguria; Food stagnation drink is swollen; Mass in the abdomen; Rheumatic arthralgia; Menoxenia; Agalactia.
Herba Hemipiliae Flabellatae: base is former: be the herb of orchid fan words beak orchid.Nature and flavor: sweet; Micro-hardship; Flat.Gui Jing: lung meridian.Function cures mainly: nourishing YIN and moistening the lung; Tonify deficiency; Hemostasis.Main lung-heat type cough; Consumptive disease is coughed; Deficient impairment caused by overstrain; Deficiency-heat; Night sweat; Lumbago due to renal deficiency; Traumatic hemorrhage.
Gracilaria tenuistipitata: base is former: be the frond of the true Gracilaria tenuistipitata of Gracilaria tenuistipitata section plant, crisp Gracilaria tenuistipitata, eddo Gracilaria tenuistipitata, phoenix tail dish, Thallus Gracilariae, Gracilaria tenuistipitata, flat Gracilaria tenuistipitata etc.Pharmacological action: isolate a kind of new agglutinin of blood from Thallus Gracilariae, relative molecular mass is 49000, and isoelectric point, IP is 3.8, the erythrocytic effect of coagulation, rabbit > horse > Cavia porcellus > goose.This kind of cohesive force to thermo-responsive, but to protease or periodate insensitive.Not suppress by general saccharide.Nature and flavor: sweet; Salty; Cold; Nontoxic.Function cures mainly: heat clearing away; Resolving phlegm and softening hard masses; Diuretic.Main interior-heat; Expectorant knot goiter; Dysuria.
Radix Lantanae Camaraev: base is former: be the root of Verbenaceae lantana.Chemical analysis: root is containing stachyose, verbascose, ajugose, verbascotetraose, lantanoseA, B, theveside, theviridoside, all square rafter glycosides, 8-shows Semen Strychni glycoside, shanzhiside methyl ester, lantanolic acid, 22 β-O-Radix Angelicae Sinensis acyl oleanolic acid, 22 beta-hydroxy oleanolic acid, 19a-Hydroxyursolic Acid, its ursolic acid Radix Achyranthis Bidentatae leaf lantana diketone of Lantaiursolic acid i.e. 3 β-isovaleryl-19 α-hydroxyl, different Radix Achyranthis Bidentatae leaf lantana diketone, 6-methoxyl group Radix Achyranthis Bidentatae leaf lantana diketone, 7-methoxyl group Radix Achyranthis Bidentatae leaf lantana diketone, 6-methoxyl group different Radix Achyranthis Bidentatae leaf horse tassel stolen goods diketone, 7-methoxyl group different Radix Achyranthis Bidentatae leaf lantana diketone etc.Pharmacological action: 1. antiinflammatory action gavage gives Radix Lantanae Camaraev water drug-decocting concentrating liquid 20g/(kgd), 40g/(kgd), continuous 3-6d, can show the rat paw edema percentage rate suppressed caused by Ovum Gallus domesticus album; Show and reduce the mouse peritoneal capillary permeability that acetic acid causes and to increase, in obvious antiinflammatory action.2. analgesic activity gavage gives the water drug-decocting concentrating liquid of above-mentioned dosage, shows minimizing acetic acid induced mice writhing response number of times; Extend the thermostimulation induced mice pain sensation response latency, in certain analgesic activity.3. immunization gavage gives the water drug-decocting concentrating liquid of above-mentioned dosage, continuous 5d, can dramatically the Thymus and spleen weight increasing young mice, and prompting Radix Lantanae Camaraev may have enhancing immunity function.Toxicity: have mild toxicity to mice.Nature and flavor: bitter in the mouth; Cold in nature.Gui Jing: bladder; Liver; Kidney channel.Function cures mainly: clearing away heat-fire; Detoxicating and resolving stagnation of pathogens.Main cold, fever, summer-heat headache; Toothache due to stomach-fire; Pharyngolaryngitis; Mumps; Rheumatic arthralgia; Scrofula sucutaneous nodule.
Popcorn: base is former: be the zeistic male flower fringe of grass.Pharmacological action: 1. on hyperlipidemia and atherosclerotic impact, the rising of Pollen Maydis (add normal saline, homogenate is broken, centrifugal fears supernatant liquid filtering) the mice serum T-CHOL (TC) that 5g/kg gavage can suppress intravenous injection TirtonWR-1339 or hypercholesterolemia of feeding to cause effectively, triacylglycerol (TG).8g/kg feeds and can show z and and reduce hypercholesterolemia family chicken (the carrying out Hangzhoupro kind) serum TC, the TG that cause, the rising of low density lipoprotein, LDL, increases the content of serum high-density LP, and makes a chicken area of aorta atherosclerotic plaque reduce 74.1%.Pollen Maydis also has obvious reducing effect to rabbit hyperlipidemia, and the blood coagulation of hyperlipemia rabbit and fibrinolytic function recovery political party aorta atheromatous plaque can be made obviously to alleviate and reduce.2. resist myocardial ischemia, anoxia functions, Pollen Maydis supernatant 0.25g/kg lumbar injection, can show the myocardial ischemia in rats resisting pituitrin and cause, myocardial ischemia reacting positive rate obviously reduced; Extend the electrocardio extinction time after mouse breathing stopping.But in vitro tests, Pollen Maydis has no significant effect myocardial oxygen consumption.In addition, Pollen Maydis supernatant can make Cavia porcellus auricle shrinkage amplitude obviously increase, increased heart rate.3. improving micro_circulation effect, Pollen Maydis supernatant 0.25g/kg lumbar injection obviously can alleviate the formation of the cloudy stagnant and microthrombus of suslik blood flow that high molecular dextran causes, improve erythrocyte aggregation, alleviate the effect that high molecular dextran raises rat whole blood specific viscosity.4. on the impact of Free Radical Level in Musca Domestica Life-span and brain, add 5% Pollen Maydis in the medium, housefly survival curve parallel move to right (having the trend of lengthening the life), in brain, superoxide dismutase activity and protein content obviously increase, and free radical luminous intensity and lipofuscin content reduce.5. on the impact of erythrocyte membrane 26S Proteasome Structure and Function.6. strengthen the syngignoscism 7. of sub-threshold dose pentobarbital sodium to gastral effect, Pollen Maydis 3g/kg is oral makes obviously shorten the I period (inertia phase) of the complex wave of dividing a word with a hyphen at the end of a line of clear-headed guinea pig ileum, colon myoelectricity, and II period, irregular spike activity obviously extended mutually.8. antifatigue effect, Pollen homogenate 1.5g/kg gavage obviously can extend the swimming time of mice.Nature and flavor: sweet in the mouth; Cool in nature. function cures mainly: depressed liver-energy dispersing and function of gallbladder promoting.Main hepatitis; Cholecystitis.
Herba Serissae: base is former: be Compositae feverwort Herba Serissae, be used as medicine with root.Pharmacological action: every day, with Herba Serissae feed rabbit, Cavia porcellus, without acute poisoning phenomenon, but can cause chronic poisoning, infringement liver and kidney, produce glycosuria (without albuminuria and blood glucose too high).The toxicity of cured leaf is less, and chronic poisoning causes primarily of wherein contained volatile oil, and this material is thermo-labile, volatile.Nature and flavor: bitter in the mouth; Pungent; Property is put down; Poisonous.Function cures mainly: heat-clearing and toxic substances removing; Dispersing liver and promoting blood circulation.Main anemopyretic cold; Chest and hypochondrium; Gastralgia abdominal distention; Traumatic injury; Carbuncle sore tumefacting virus; Venom.
Herba Medicaginis Lupulinae: base is former: be the herb of leguminous plant shamrock.Chemical analysis: herb is containing estrogen-like composition.Seed contains Saponin, galactose.Root and in spending containing multiple Saponin, as the hydrolysis of medicagenic acid glycoside obtains medicagenic acid, hederagenin and people's bean soap alcohol B, C, D, E, F etc.4 kinds of triterpenoid saponin, i.e. soyasaponinss are got again subsequently, hederagenin-3-O-β-D-glucopyanoside, medicagenic acid-3-O-β-D-glucopyanoside and the two glucopyanoside of medicagenic acid-3,28-from root.Hua Zhongshang contains flavone compound: larix sibirica flavone and its 5 '-O-β-D-Glucose glycoside, 3,5 '-O-β-D-diglucoside, 3,7,5 '-O-β-D-tri-glucose glycoside, the glycoside of nimbecetin, Quercetin and myricetin-3-O-glucoside.Aerial parts is containing carotene, vitamin C, vitamin B1, vitamin B2, pyridoxol, pantothenic acid and nicotinic acid.Nature and flavor: sweet; Bitter; Micro-puckery; Cool in nature; Mild toxicity.Gui Jing: lung; Liver; Gallbladder; Kidney channel.Function cures mainly: clearing away heat-damp and promoting diuresis; Relaxing muscles and tendons and activating QI and blood in the collateral; Relieving cough and asthma; Removing pathogenic heat from blood and toxic substance from the body.Main jaundice due to damp-heat; Pyretic stranguria; Stone jaundice due to damp-heat; Pyretic stranguria; Stranguria caused by urinary stone; Rheumatic arthralgia; Cough with asthma; Hemorrhoidal bleeding; Finger furuncle; Venom.
Radix Anemones Tomentosae: base is former: be the root of the large fire weed of ranunculaceae plant.Nature and flavor: bitter; Temperature; Slightly poisonous.Gui Jing: lung; Large intestine channel.Function cures mainly: reduce phlegm; Dissipating blood stasis; Promoting digestion and removing stagnation; Preventing the attack (or recurrence) of malaria; Removing toxic substances; Parasite killing.Main impairment caused by overstrain cough with asthma; Traumatic injury; Infantile malnutrition; Malaria; Furuncle carbuncle furuncle; Stubborn dermatitis.
Fructus Fici: base is former: be the dry holder of moraceae plants Fructus Fici.Pharmacological action: 1, Fructus Fici is containing abundant nutritional labeling, edible.When constipation, can be used as food aperient.2, the material of water extract gained after active carbon, acetone treatment of dry fruit has the effect of anti-Emhorn sarcoma.3, in immature fruit, the milk of gained can suppress rat implantation sarcoma, mice spontaneous mammary carcinoma, causes neoplasm necrosis; The development of transplantability adenocarcinoma, myelomatosis, lymphosarcoma can be delayed again, make it degenerate.Nature and flavor: sweet; Cool in nature.Gui Jing: lung; Stomach; Large intestine channel.Function cures mainly: clearing away heat and promoting production of body fluid; Spleen benefiting and stimulating the appetite; Removing toxic substances and promoting subsidence of swelling.Main laryngopharynx swelling and pain; Cough caused by dryness hoarseness; Milk is rare; The hot constipation of intestinal; Inappetence; Dyspepsia, dysentery; Carbuncle; Tinea disease.
Herba Taraxaci: base is former: be the whole herb with root of feverfew Herba Taraxaci.Chemical analysis: Herba Taraxaci herb is containing taraxasterol, choline, inulin and pectin etc.Nature and flavor: bitter sweet, cold.Gui Jing: enter liver, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.
embodiment 1prevent and treat a Chinese medicine composition for lymphatic cancer, be prepared from by following bulk drugs, be weight portion (30g/ part): Bulbus Lilii 6 parts; Herba Epilobii Pyrricholophi 8 parts; East wind Fructus Citri tangerinae 7 parts; Herba Hyperici Patuli 5 parts; Cortex euonymi grandiflori radicis 7 parts; Rhizoma Sparganii 6 parts; Radix tetrapanacis Koch 8 parts; Herba Hemipiliae Flabellatae 7 parts; Gracilaria tenuistipitata 6 parts; Radix Lantanae Camaraev 3 parts; Popcorn 8 parts; Herba Serissae 6 parts; Herba Medicaginis Lupulinae 7 parts; Radix Anemones Tomentosae 5 parts; Fructus Fici 8 parts; Herba Taraxaci 9 parts.
A kind of preparation method of preventing and treating the pill of the Chinese medicine composition of lymphatic cancer is:
(1) Radix tetrapanacis Koch, Herba Serissae and Radix Anemones Tomentosae are together placed in medicine pot, add the rice vinegar of 1.5 times amount, slow fire heating is boiled to vinegar most, takes out, dries, be ground into fine powder, for subsequent use;
(2) Gracilaria tenuistipitata, Bulbus Lilii, popcorn, Fructus Fici and Herba Taraxaci mixing, add the clear water of 4 times amount, slow fire boiling 24 minutes, filter, filtrate is for subsequent use;
(3) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis and Rhizoma Sparganii together grind to form coarse powder, are placed in cotton bag, add 42 ° of Chinese liquor of 2 times amount, lixiviate 2 days, collect lixiviating solution, filter, filtrate recycling ethanol, adds step (2) gained filtrate, decompression concentration becomes paste, and spraying dry gets dry extract powder, for subsequent use;
(4) Herba Epilobii Pyrricholophi, Herba Hyperici Patuli, Herba Hemipiliae Flabellatae, Radix Lantanae Camaraev and Herba Medicaginis Lupulinae is fully dry, be together ground into fine powder, mix with step (1) and (3) gained fine powder, cross 70 mesh sieves, making pellets by mixing medical powder with honey, makes the pill of Semen Phaseoli size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 8-10 ball, and warm water takes, 30 days courses for the treatment of.
embodiment 2prevent and treat a Chinese medicine composition for lymphatic cancer, be prepared from by following bulk drugs, be weight portion (10g/ part): Bulbus Lilii 10 parts; Herba Epilobii Pyrricholophi 14 parts; East wind Fructus Citri tangerinae 12 parts; Herba Hyperici Patuli 10 parts; Cortex euonymi grandiflori radicis 11 parts; Rhizoma Sparganii 9 parts; Radix tetrapanacis Koch 13 parts; Herba Hemipiliae Flabellatae 14 parts; Gracilaria tenuistipitata 11 parts; Radix Lantanae Camaraev 7 parts; Popcorn 15 parts; Herba Serissae 12 parts; Herba Medicaginis Lupulinae 13 parts; Radix Anemones Tomentosae 9 parts; Fructus Fici 12 parts; Herba Taraxaci 14 parts.
A kind of preparation method of preventing and treating the capsule of the Chinese medicine composition of lymphatic cancer is:
(1) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis, Radix tetrapanacis Koch and Herba Taraxaci are together placed in non iron container, add the yellow wine of 0.6 times amount, mix thoroughly, vexed 30 minutes, treat that yellow wine is sucked, and take out, for subsequent use;
(2) Bulbus Lilii, popcorn, Gracilaria tenuistipitata and Fructus Fici mixing, the cooked Mel adding 0.15 times amount is mixed thoroughly, puts slow fire stir-fry to yellow in parch container and does not touch with one's hand as degree, take out, for subsequent use;
(3) Rhizoma Sparganii sheet is placed in the Testa Tritici made popular, slow fire adds to be propagandized hotly to medical material surface in yellow, and sieve removes Testa Tritici, is together ground into fine powder with Herba Serissae, Radix Lantanae Camaraev and Radix Anemones Tomentosae, crosses 110 mesh sieves, obtains mixing fine powders, for subsequent use;
(4) crude drug after step (1) and (2) process and Herba Epilobii Pyrricholophi, Herba Hyperici Patuli, Herba Hemipiliae Flabellatae and Herba Medicaginis Lupulinae are together placed in frying pan, add the pure water of 6.5 times amount, soak 2.5 hours under room temperature, then big fire is heated to boil, and turn little fire and decoct twice slowly, first time decocts 28 minutes, second time decocts 20 minutes, filter, filtrate reduced in volume to 75 DEG C relative density is the clear paste of 1.16-1.18, for subsequent use;
(5) step (3) gained mixing fine powders is joined in above-mentioned clear paste, add while stirring other adjuvant (adjuvant to be content be 1.1% glyceryl monostearate and content be the sucrose fine of 4.5%), mixing, is processed into capsule formulation, obtains final product.
The instructions of taking of gained capsule of the present invention is: every day three times, each 4-6 grain, and warm water takes, 30 days courses for the treatment of.
Typical case: grandson XX, female, 51 years old, people from Zaozhuang.Patient is because of family's contradiction before 2 years, and spirit is upset sequela, and whole body many places edema, lymphadenectasis, is diagnosed as lymphoma after local hospital inspection.Through hospital's suggestion row Radiotherapy chemotherapy, after treating a stage, patient stops because physical reason cannot stand radiotherapy.After leaving hospital, household looks about traditional Chinese medicine secret recipe, wishes by treatment by Chinese herbs disease.By making some inquiries about, coming my institute on August 17th, 2012 and checking treatment.Check: there is many places node at the places such as patient's cervical region, groin, gastral cavity abdomen mass in the abdomen, shallow complexion, have a dizzy spell, severe palpitation, shortness of breath and fatigue, inappetence, pale tongue, white and thin fur, thready and weak pulse.Lymphoma is diagnosed as through microscope biopsy.
Take a kind of capsule preventing and treating the Chinese medicine composition of lymphatic cancer of the present embodiment gained, instructions of taking: every day three times, each 4-6 grain, warm water takes, 30 days courses for the treatment of.After treating two courses for the treatment of, entire patient's edema obviously disappears, and lymphadenectasis phenomenon obviously alleviates, and other malaise symptoms are also significantly improved; Again after two courses for the treatment of of continual cure, entire patient's edema disappears completely, and enlarged lymph node dissipates, and lab testing indices recovers normal substantially, and after this patient adheres to medication treatment always, pays a return visit after 1 year, without recurrence, and clinical cure.
embodiment 3prevent and treat a Chinese medicine composition for lymphatic cancer, be prepared from by following bulk drugs, be weight portion (25g/ part): Bulbus Lilii 7 parts; Herba Epilobii Pyrricholophi 10 parts; East wind Fructus Citri tangerinae 8.5 parts; Herba Hyperici Patuli 6 parts; Cortex euonymi grandiflori radicis 8.5 parts; Rhizoma Sparganii 7 parts; Radix tetrapanacis Koch 9.5 parts; Herba Hemipiliae Flabellatae 9 parts; Gracilaria tenuistipitata 7 parts; Radix Lantanae Camaraev 4 parts; Popcorn 10 parts; Herba Serissae 8 parts; Herba Medicaginis Lupulinae 9 parts; Radix Anemones Tomentosae 6 parts; Fructus Fici 9 parts; Herba Taraxaci 10 parts.
A kind of preparation method of preventing and treating the decoction of the Chinese medicine composition of lymphatic cancer is:
(1) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis, Radix tetrapanacis Koch and Herba Taraxaci are together placed in non iron container, add the yellow wine of 0.6 times amount, mix thoroughly, vexed 30 minutes, treat that yellow wine is sucked, and take out, for subsequent use;
(2) Bulbus Lilii, popcorn, Gracilaria tenuistipitata and Fructus Fici mixing, add the cooked Mel of 0.15 times amount, mix thoroughly, puts slow fire stir-fry to yellow in parch container and do not touch with one's hand as degree, take out, for subsequent use;
(3) crude drug and surplus stock medicine after step (1) and (2) process are together placed in medicine pot, add the cold water soak 2.5 hours of 5 times amount, then slow fire heats decoction 30 minutes, filter, medicinal residues add the cold water of 4 times amount again, slow fire boiling 20 minutes, filter, merge twice filtrate, be evaporated to 1/3 of original volume, 110 DEG C of sterilizings 28 minutes, cooling, encapsulation, to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, each 150-180mL, warmly takes, 30 days courses for the treatment of.
embodiment 4prevent and treat a Chinese medicine composition for lymphatic cancer, be prepared from by following bulk drugs, be weight portion (15g/ part): Bulbus Lilii 9 parts; Herba Epilobii Pyrricholophi 12 parts; East wind Fructus Citri tangerinae 10.5 parts; Herba Hyperici Patuli 9 parts; Cortex euonymi grandiflori radicis 9.5 parts; Rhizoma Sparganii 8 parts; Radix tetrapanacis Koch 11.5 parts; Herba Hemipiliae Flabellatae 12 parts; Gracilaria tenuistipitata 10 parts; Radix Lantanae Camaraev 6 parts; Popcorn 13 parts; Herba Serissae 10 parts; Herba Medicaginis Lupulinae 11 parts; Radix Anemones Tomentosae 8 parts; Fructus Fici 11 parts; Herba Taraxaci 13 parts.
A kind of preparation method of preventing and treating the powder of the Chinese medicine composition of lymphatic cancer is:
(1) Gracilaria tenuistipitata and Cortex euonymi grandiflori radicis mixing, slow fire heats, and fry when to have pitchy focal spot to medical material surface, drench the saline solution into 0.1 times amount, fried dry is degree, takes out, together smashs into fine powder to pieces with east wind Fructus Citri tangerinae and Rhizoma Sparganii, for subsequent use;
(2) by Bulbus Lilii, Herba Hemipiliae Flabellatae, Fructus Fici and Herba Taraxaci mixing, the Sucus Zingberis of the Mel and 0.22 times amount that add 0.15 times amount is mixed thoroughly, the supreme gas of Steam by water bath, takes out, smashs into pureed to pieces, in 59 DEG C of dryings 2.5 hours, takes out, grinds into fine powder, for subsequent use;
(3) fully dry, pulverize into fine powder by except step (1) crude drug except (2), mix with step (1) and (2) gained fine powder, cross 60 mesh sieves, sterilizing encapsulates, and to obtain final product.
The instructions of taking of gained powder of the present invention is: every day three times, each 20-25g, hot water decoction, 30 days courses for the treatment of.
Typical case: old XX, man, 57 years old, people from Dezhou.Patient 7 months cause coughs, pharyngalgia and dysphagias go to examination in hospital, and be diagnosed as left side antiadoncus, after Drug therapy two weeks, patients symptomatic has no and alleviates, and increases the weight of on the contrary.Come my institute on November 16th, 2013 to check.Check: entire patient is weak, Mian Se Koushi is white, and color of the lip is in vain light, cervical lymph enlargement, poor appetite, thin white fur of tongue, thready and weak pulse.Neck breast abdomen CT points out: oropharynx left side wall soft tissue shadow, and local pharyngeal cavity is narrow, multiple lymph node after peritoneum.Left side tonsil pathology prompting: mucous membrane tissue volume cell infiltration, is dispersed in heterocyst; Lymphoma is diagnosed as through pathological tissue cell biopsy.
Take a kind of powder preventing and treating the Chinese medicine composition of lymphatic cancer of the present embodiment gained, instructions of taking: every day three times, each 20-25g, hot water decoction, 30 days courses for the treatment of.After treating two courses for the treatment of, conditions of patients obviously alleviates, and diet is normal, and without cough and dysphagia, enlarged lymph node obviously dissipates, again two courses for the treatment of of continual cure, and patient condition position disappears, and the state of an illness is almost recovered, and physical recovery is normal.Advise and adhere to taking medicine, pay a return visit after half a year, patient is without recurrence.
embodiment 5prevent and treat a Chinese medicine composition for lymphatic cancer, be prepared from by following bulk drugs, be weight portion (20g/ part): Bulbus Lilii 8 parts; Herba Epilobii Pyrricholophi 11 parts; East wind Fructus Citri tangerinae 9.5 parts; Herba Hyperici Patuli 7.5 parts; Cortex euonymi grandiflori radicis 9 parts; Rhizoma Sparganii 7.5 parts; Radix tetrapanacis Koch 10.5 parts; Herba Hemipiliae Flabellatae 10.5 parts; Gracilaria tenuistipitata 8.5 parts; Radix Lantanae Camaraev 5 parts; Popcorn 11.5 parts; Herba Serissae 9 parts; Herba Medicaginis Lupulinae 10 parts; Radix Anemones Tomentosae 7 parts; Fructus Fici 10 parts; Herba Taraxaci 11.5 parts.
A kind of preparation method of preventing and treating the pill of the Chinese medicine composition of lymphatic cancer is:
(1) Radix tetrapanacis Koch, Herba Serissae and Radix Anemones Tomentosae are together placed in medicine pot, add the rice vinegar of 2 times amount, slow fire heating is boiled to vinegar most, takes out, dries, be ground into fine powder, for subsequent use;
(2) Gracilaria tenuistipitata, Bulbus Lilii, popcorn, Fructus Fici and Herba Taraxaci mixing, add the clear water of 5 times amount, slow fire boiling 30 minutes, filter, filtrate is for subsequent use;
(3) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis and Rhizoma Sparganii together grind to form coarse powder, are placed in cotton bag, add 52 ° of Chinese liquor of 2.5 times amount, lixiviate 3 days, collect lixiviating solution, filter, filtrate recycling ethanol, adds step (2) gained filtrate, decompression concentration becomes paste, and spraying dry gets dry extract powder, for subsequent use;
(4) Herba Epilobii Pyrricholophi, Herba Hyperici Patuli, Herba Hemipiliae Flabellatae, Radix Lantanae Camaraev and Herba Medicaginis Lupulinae is fully dry, be together ground into fine powder, mix with step (1) and (3) gained fine powder, cross 85 mesh sieves, making pellets by mixing medical powder with honey, makes the pill of Semen Phaseoli size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 8-10 ball, and warm water takes, 30 days courses for the treatment of.
test example 1a kind of applied research preventing and treating the Chinese medicine composition (embodiment 5) of lymphatic cancer of gained of the present invention:
1, data and method
1.1 physical data
Screen 186 routine lymphatic cancer patients in November ,-2013 in May, 2011 four hospital's oncologies, wherein male patient's totally 102 examples, female patient is totally 84 examples, the oldest 71 years old, minimum 53 years old of age.All patients all make a definite diagnosis through the check pathological section (biopsy) of lymph node or other affected tissue or organ.
1.2 Therapeutic Method
All patients take gained medicine of the present invention, instructions of taking: every day three times, each 8-10 ball, and warm water takes, 30 days courses for the treatment of.Observe four courses for the treatment of of treatment altogether.
1.3 curative effect determinate standard
Solid tumor Objective evaluation standard according to WHO is divided into:
Complete incidence graph (CR): all lesions visible disappear completely and at least maintain more than 4 weeks;
Partial rcsponse (PR): the maximum diameter of tumor focus and the product in maximum perpendicular footpath thereof reduce more than 50%, maintain more than 4 weeks;
Take a turn for the better (MR): two footpath products of tumor focus reduce more than 25%, but < 50%, occur without new focus;
Stable (SD): tumor focus two footpath product reduces < 25%, or increase < 25%, occur without new focus;
Progress (PD): tumor focus two footpath product increases > 25%, or occurs new focus.
Effective percentage=complete remission rate+partial rcsponse rate+improvement rate.
1.4 therapeutic outcome
Table 1: the therapeutic outcome taking the lymphatic cancer patient of medicine of the present invention
Therapeutic outcome: after taking gained of the present invention a kind of four courses for the treatment of of traditional Chinese medicine composition for treating of preventing and treating lymphatic cancer,
Complete incidence graph 113 example (60.8%) in all 186 routine lymphatic cancer patients taken one's test, partial rcsponse 49 example (26.3%), 19 examples that take a turn for the better (10.2%), stablize 5 examples (2.7%), and progress 0 example, effective percentage is 97.3%, evident in efficacy.
The present invention select Bulbus Lilii, Herba Epilobii Pyrricholophi, east wind Fructus Citri tangerinae, Herba Hyperici Patuli, Cortex euonymi grandiflori radicis, Rhizoma Sparganii, Radix tetrapanacis Koch, Herba Hemipiliae Flabellatae, Gracilaria tenuistipitata, Radix Lantanae Camaraev and popcorn etc. totally 16 taste primary raw materials be prepared from.Fang Zhong, Bulbus Lilii has nourishing the lung to arrest cough, effect of clearing away heart-fire for tranquillization; Herba Epilobii Pyrricholophi clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling; The preventing phlegm from forming and stopping coughing of east wind Fructus Citri tangerinae, regulating QI to relieve pain; Herba Hyperici Patuli heat-clearing and toxic substances removing, dispersing the stagnated liver-QI and dredging collateral, stasis-dispelling and pain-killing; Cortex euonymi grandiflori radicis expelling wind and removing dampness, promoting blood circulation to restore menstrual flow, blood stasis-eliminating and stagnation-dissipating; Rhizoma Sparganii removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving; Herba Hemipiliae Flabellatae nourishing YIN and moistening the lung; Radix Lantanae Camaraev clearing away heat-fire, detoxicating and resolving stagnation of pathogens; Popcorn has obvious reducing effect to hyperlipidemia, resists myocardial ischemia, anoxia functions and improving micro_circulation effect.Herba Taraxaci has heat-clearing and toxic substances removing, the effect of diuresis eliminating stagnation.All medicines share, and have heat-clearing and toxic substances removing, relieving cough and asthma, press down the effect that cancer is anticancer, strengthen body immunity, extend patient vitals.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. prevent and treat a Chinese medicine composition for lymphatic cancer, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Bulbus Lilii 6-10; Herba Epilobii Pyrricholophi 8-14; East wind Fructus Citri tangerinae 7-12; Herba Hyperici Patuli 5-10; Cortex euonymi grandiflori radicis 7-11; Rhizoma Sparganii 6-9; Radix tetrapanacis Koch 8-13; Herba Hemipiliae Flabellatae 7-14; Gracilaria tenuistipitata 6-11; Radix Lantanae Camaraev 3-7; Popcorn 8-15; Herba Serissae 6-12; Herba Medicaginis Lupulinae 7-13; Radix Anemones Tomentosae 5-9; Fructus Fici 8-12; Herba Taraxaci 9-14.
2. a kind of Chinese medicine composition preventing and treating lymphatic cancer as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Bulbus Lilii 7-9; Herba Epilobii Pyrricholophi 10-12; East wind Fructus Citri tangerinae 8.5-10.5; Herba Hyperici Patuli 6-9; Cortex euonymi grandiflori radicis 8.5-9.5; Rhizoma Sparganii 7-8; Radix tetrapanacis Koch 9.5-11.5; Herba Hemipiliae Flabellatae 9-12; Gracilaria tenuistipitata 7-10; Radix Lantanae Camaraev 4-6; Popcorn 10-13; Herba Serissae 8-10; Herba Medicaginis Lupulinae 9-11; Radix Anemones Tomentosae 6-8; Fructus Fici 9-11; Herba Taraxaci 10-13.
3. a kind of Chinese medicine composition preventing and treating lymphatic cancer as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Bulbus Lilii 8; Herba Epilobii Pyrricholophi 11; East wind Fructus Citri tangerinae 9.5; Herba Hyperici Patuli 7.5; Cortex euonymi grandiflori radicis 9; Rhizoma Sparganii 7.5; Radix tetrapanacis Koch 10.5; Herba Hemipiliae Flabellatae 10.5; Gracilaria tenuistipitata 8.5; Radix Lantanae Camaraev 5; Popcorn 11.5; Herba Serissae 9; Herba Medicaginis Lupulinae 10; Radix Anemones Tomentosae 7; Fructus Fici 10; Herba Taraxaci 11.5.
4. a kind of preparation method of preventing and treating the pill of the Chinese medicine composition of lymphatic cancer as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Radix tetrapanacis Koch, Herba Serissae and Radix Anemones Tomentosae are together placed in medicine pot, add the rice vinegar (preferably adding the rice vinegar of 2 times amount) of 1.5-2.5 times amount, slow fire heating is boiled to vinegar most, takes out, dries, be ground into fine powder, for subsequent use;
(2) Gracilaria tenuistipitata, Bulbus Lilii, popcorn, Fructus Fici and Herba Taraxaci mixing, add the clear water (preferably adding the clear water of 5 times amount) of 4-6 times amount, slow fire boiling 24-38 minute (preferred slow fire boiling 30 minutes), filter, filtrate is for subsequent use;
(3) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis and Rhizoma Sparganii together grind to form coarse powder, be placed in cotton bag, add the Chinese liquor (preferably adding the Chinese liquor of 2.5 times amount) of 2-3 times amount, lixiviate 2-4 days (preferred lixiviate 3 days), collect lixiviating solution, filter, filtrate recycling ethanol, adds step (2) gained filtrate, and decompression concentration becomes paste, spraying dry gets dry extract powder, for subsequent use;
(4) Herba Epilobii Pyrricholophi, Herba Hyperici Patuli, Herba Hemipiliae Flabellatae, Radix Lantanae Camaraev and Herba Medicaginis Lupulinae is fully dry, be together ground into fine powder, mix with step (1) and (3) gained fine powder, sieve, making pellets by mixing medical powder with honey, make the pill of Semen Phaseoli size, to obtain final product.
5. a kind of preparation method of preventing and treating the pill of the Chinese medicine composition of lymphatic cancer according to claim 4, it is characterized in that, in step (3), the number of degrees of Chinese liquor used are 42 °-62 ° (number of degrees of preferred Chinese liquor used are 48 °-54 °, and the number of degrees of the Chinese liquor used be more preferably are 52 °).
6. a kind of preparation method of preventing and treating the pill of the Chinese medicine composition of lymphatic cancer according to claim 4, is characterized in that, the middle 70-100 mesh sieve excessively of step (4) (preferred 80-90 mesh sieve excessively, mistake 85 mesh sieve be more preferably).
7. a kind of preparation method of preventing and treating the capsule of the Chinese medicine composition of lymphatic cancer as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis, Radix tetrapanacis Koch and Herba Taraxaci are together placed in non iron container, add the yellow wine (preferably adding the yellow wine of 0.6 times amount) of 0.45-0.75 times amount, mix thoroughly, vexed 20-40 minute (preferably vexed 30 minutes), treat that yellow wine is sucked, take out, for subsequent use;
(2) Bulbus Lilii, popcorn, Gracilaria tenuistipitata and Fructus Fici mixing, the cooked Mel adding 0.1-0.2 times amount is mixed thoroughly (the cooked Mel preferably adding 0.15 times amount is mixed thoroughly), puts slow fire stir-fry to yellow in parch container and does not touch with one's hand as degree, take out, for subsequent use;
(3) Rhizoma Sparganii sheet is placed in the Testa Tritici made popular, slow fire adds to be propagandized hotly to medical material surface in yellow, and sieve removes Testa Tritici, is together ground into fine powder with Herba Serissae, Radix Lantanae Camaraev and Radix Anemones Tomentosae, crosses 90-130 mesh sieve (preferred mistake 110 mesh sieve), obtains mixing fine powders, for subsequent use;
(4) by the crude drug after step (1) and (2) process and Herba Epilobii Pyrricholophi, Herba Hyperici Patuli, Herba Hemipiliae Flabellatae and Herba Medicaginis Lupulinae are together placed in frying pan, add the pure water (preferably adding the pure water of 6.5 times amount) of 5-8 times amount, soak under room temperature 2-3 hour (soaking 2.5 hours under preferred room temperature), then big fire is heated to boil, turn little fire and decoct twice slowly, first time decocts 20-36 minute (preferably first time decocts 28 minutes), second time decocts 15-23 minute (preferably second time decocts 20 minutes), filter, filtrate reduced in volume to 75 DEG C relative density is the clear paste of 1.16-1.18, for subsequent use,
(5) join in above-mentioned clear paste by step (3) gained mixing fine powders, add other adjuvant while stirring, mixing, is processed into capsule formulation, obtains final product.
8. a kind of preparation method of preventing and treating the capsule of the Chinese medicine composition of lymphatic cancer according to claim 7, is characterized in that, adjuvant described in step (5) to be content be 1.1% glyceryl monostearate and content be the sucrose fine of 4.5%.
9. a kind of preparation method of preventing and treating the decoction of the Chinese medicine composition of lymphatic cancer as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) east wind Fructus Citri tangerinae, Cortex euonymi grandiflori radicis, Radix tetrapanacis Koch and Herba Taraxaci are together placed in non iron container, add the yellow wine (preferably adding the yellow wine of 0.6 times amount) of 0.45-0.75 times amount, mix thoroughly, vexed 20-40 minute (preferably vexed 30 minutes), treat that yellow wine is sucked, take out, for subsequent use;
(2) Bulbus Lilii, popcorn, Gracilaria tenuistipitata and Fructus Fici mixing, add the cooked Mel (preferably adding the cooked Mel of 0.15 times amount) of 0.1-0.2 times amount, mix thoroughly, puts slow fire stir-fry to yellow in parch container and do not touch with one's hand as degree, take out, for subsequent use;
(3) crude drug after step (1) and (2) process and surplus stock medicine are together placed in medicine pot, add the cold water soak 2.5 hours cold water soak of 5 times amount (preferably add 2.5 hours) of 4-6 times amount, then slow fire heating decocts 20-40 minute (preferred slow fire heating decoction 30 minutes), filter, medicinal residues add the cold water (preferred medicinal residues add the cold water of 4 times amount again) of 3.5-4.5 times amount again, slow fire boiling 16-24 minute (preferred slow fire boiling 20 minutes), filter, merge twice filtrate, be evaporated to 1/3 of original volume, 110 DEG C of sterilizing 22-34 minute (preferably 110 DEG C sterilizing 28 minutes), cooling, encapsulation, obtain.
10. a kind of preparation method of preventing and treating the powder of the Chinese medicine composition of lymphatic cancer as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Gracilaria tenuistipitata and Cortex euonymi grandiflori radicis mixing, slow fire heats, and fries when to have pitchy focal spot to medical material surface, drench the saline solution (preferably drenching the saline solution into 0.1 times amount) into 0.05-0.15 times amount, fried dry is degree, takes out, together fine powder is smashed into pieces with Rhizoma Sparganii with east wind Fructus Citri tangerinae, for subsequent use;
(2) by Bulbus Lilii, Herba Hemipiliae Flabellatae, Fructus Fici and Herba Taraxaci mixing, the Sucus Zingberis of the Mel and 0.16-0.28 times amount that add 0.1-0.2 times amount is mixed thoroughly (Sucus Zingberis of the Mel and 0.22 times amount that preferably add 0.15 times amount is mixed thoroughly), the supreme gas of Steam by water bath, take out, smash into pureed to pieces, in 56-62 DEG C of dry 2-3 hour (being preferable over 59 DEG C of dryings 2.5 hours), take out, grind into fine powder, for subsequent use;
(3) fully dry, pulverize into fine powder by except step (1) crude drug except (2), mix with step (1) and (2) gained fine powder, cross 45-75 mesh sieve (preferred mistake 60 mesh sieve), sterilizing encapsulates, and to obtain final product.
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| CN1187353A (en) * | 1996-03-26 | 1998-07-15 | 李敏 | Powder for curing tuberculosis and producing process thereof |
| CN1148502A (en) * | 1996-09-20 | 1997-04-30 | 缪兴财 | Zhiyuwan pill for curing cancer |
| CN101972454A (en) * | 2010-11-03 | 2011-02-16 | 何玉伟 | Medicament for treating lymphoma |
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Address after: 563000 Hongkong Road, Zunyi, Guizhou, No. 521, No. Applicant after: Zhang Xiuzhen Address before: 250000 Ji'nan Province, Lixia District,, East Shili River, No. 10 Applicant before: Zhang Xiuzhen |
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Application publication date: 20160210 |