CN105311202A - Feed additive for preventing perforated disease in head of angelfish and preparation method of feed additive - Google Patents
Feed additive for preventing perforated disease in head of angelfish and preparation method of feed additive Download PDFInfo
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Abstract
The invention relates to a feed additive for preventing perforated disease in head of an angelfish. The invention also relates to a preparation method of the feed additive for preventing the perforated disease in head of the angelfish. The feed additive for preventing the perforated disease in head of the angelfish disclosed by the invention consists of the following components in parts by mass: 26-33 parts of flos chrysanthemi, 17-24 parts of stockpiled folium artemisia argyi, 17-24 parts of radix cynanchi atrati, 15-21 parts of tarragon, 13-19 parts of cornu bubali, 14-18 parts of cortex moutan radicis, 14-18 parts of shepherdspurse herb, 14-18 parts of root, flower or leaf of aconitum gymnandrum maxim., 13-17 parts of bitter apricot kernel, 6-11 parts of cactus juice, 16-25 parts of euphausia superba powder, 14-20 parts of tubificidae powder, 11-17 parts of fish oil, 8-14 parts of honey from S.octophylla(Lour.) and the like. The feed additive for preventing the perforated disease in head of the angelfish disclosed by the invention, since all raw material components are green and pure-natural raw materials, is free from pollution to environment and is capable of effectively preventing the preventing the perforated disease in head of the angelfish.
Description
Technical field
The invention belongs to technical field of aquaculture, particularly relate to a kind of feed additive preventing angle fish head shothole disease; The invention still further relates to a kind of preparation method of feed additive of above-mentioned prevention angle fish head shothole disease.
Background technology
Angle fish, has another name called Spanish mackerel, angel, fairyhood fish, finlet sail fish etc., and beautiful flying fish belongs to, and originates in Guyana of South America, Brazil.Long 12 ~ 15 centimetres of angle fish, Gao Keda 15 ~ 20 centimetres, a little and sharp side is flat, assumes diamond in shape.Dorsal fin and anal fin are grown up very much, tall and straight as jib, therefore have the title of finlet sail fish.Angle fish moves about from the side, and as swallow fly, therefore angle fish is also known as Spanish mackerel.
Suffer from the angle fish of head shothole disease, Early manifestation is loss of appetite, and body surface part scale comes off, and courageous and upright ulcer appears in light red surface then.If continue to worsen, just there will be perforate, as being excavated by soupspoon, the muscular decay of the inside, hyperemia can be seen, time serious, even can see fishbone.Their early stage can't see difference from the feed of fish, swimming, and to the later stage, sick fish will become does not have appetite, often hides the corner at aquarium, and at this time sick fish is also easily subject to the invasion and attack of water mo(u)ld.Head shothole disease is infected by the fine slime mould of column and causes, and belong to bacterial disease, infectiousness is extremely strong, sick fish should be isolated in time.The reason of head shothole disease is the stale bait of long-term feeding, or the bait of feeding height nutrition continuously under low water temperature and causing, its conventional Therapeutic Method is: first use the gentian voiet of 1% concentration (potassium permanganate solution) or ethacridine to smear disease sites, then fix with vaseline the medical aquarium that sick fish is put into 5 mg/litre furacilin solutions by medicinal liquid again, water temperature and former breeding water body are consistent, soak disease fish about 30 minutes, every day 1 time, until sb.'s illness took a favorable turn.But its therapeutic effect is limited, toxicity is larger, environment is easily polluted, and operation is comparatively loaded down with trivial details, angle fish is first pulled out, fixes, adds medicine to by needs, and then dipping, operating process very easily causes the scale of angle fish to come off, while sterilization is prevented or cure a disease, also result in larger damage to angle fish.Therefore, that prevents angle fish head shothole disease has important practice significance, develops a kind of environmental protection, the feedstuff that effectively can prevent angle fish head shothole disease or feed additive, has important economic implications and market prospect.
Summary of the invention
An object of the present invention is to provide a kind of feed additive preventing angle fish head shothole disease, its raw material components is green pure natural material, good bacteriostasis and sterilization effect is had to the pathogen of angle fish head shothole disease, effectively can reduce the sickness rate of angle fish head shothole disease, improve immunity and the survival rate of angle fish.
In order to solve the problems of the technologies described above, the present invention by the following technical solutions, a kind of feed additive preventing angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 26-33 part, Chen Aiye 17-24 part, Radix Cynanchi Atrati 17-24 part, morning glory 17-23 part, Serpentis pimple 17-23 part, Folium Isatidis 17-21 part, Herba Wahlenbergiae 15-21 part, Herba Artemisiae Scopariae grass 15-21 part, Cornu Bubali 13-19 part, Cortex Moutan 14-18 part, Herba Capsellae 14-18 part, Radix aconiti gymnandri 14-18 part, Semen Armeniacae Amarum 13-17 part, Galla Chinensis 12-17 part, Fructus Xanthii 12-17 part, Fructus Cnidii 12-17 part, Herba Sedi Aizoon 11-16 part, Herba Houttuyniae 11-16 part, Folium Eriobotryae 11-16 part, Herba Kalimeridis 10-16 part, Herba Plantaginis 9-14 part, Oleum menthae 7-13 part, Radix et Caulis Opuntiae Dillenii juice 6-11 part, euphausia superba powder 16-25 part, Limnodrilus hoffmeisteri powder 14-20 part, fish oil 11-17 part, winter honey 8-14 part.
Preferably, the feed additive of described prevention angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 29-31 part, Chen Aiye 20-22 part, Radix Cynanchi Atrati 19-21 part, morning glory 19-21 part, Serpentis pimple 19-21 part, Folium Isatidis 18-20 part, Herba Wahlenbergiae 17-19 part, Herba Artemisiae Scopariae grass 17-19 part, Cornu Bubali 15-17 part, Cortex Moutan 15-17 part, Herba Capsellae 15-17 part, Radix aconiti gymnandri 15-16 part, Semen Armeniacae Amarum 14-16 part, Galla Chinensis 14-16 part, Fructus Xanthii 13-15 part, Fructus Cnidii 13-15 part, Herba Sedi Aizoon 13-14 part, Herba Houttuyniae 13-14 part, Folium Eriobotryae 12-14 part, Herba Kalimeridis 12-14 part, Herba Plantaginis 11-12 part, Oleum menthae 9-11 part, Radix et Caulis Opuntiae Dillenii juice 8-10 part, euphausia superba powder 19-22 part, Limnodrilus hoffmeisteri powder 16-18 part, fish oil 13-15 part, winter honey 10-12 part.
Preferably, the feed additive of described prevention angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 30 parts, Chen Aiye 21 parts, Radix Cynanchi Atrati 20 parts, 20 parts, morning glory, Serpentis pimple 20 parts, Folium Isatidis 19 parts, Herba Wahlenbergiae 18 parts, Herba Artemisiae Scopariae grass 18 parts, Cornu Bubali 16 parts, Cortex Moutan 16 parts, 16 parts, Herba Capsellae, Radix aconiti gymnandri 16 parts, Semen Armeniacae Amarum 15 parts, Galla Chinensis 15 parts, Fructus Xanthii 14 parts, Fructus Cnidii 14 parts, Herba Sedi Aizoon 13 parts, Herba Houttuyniae 13 parts, Folium Eriobotryae 13 parts, Herba Kalimeridis 13 parts, Herba Plantaginis 12 parts, Oleum menthae 10 parts, Radix et Caulis Opuntiae Dillenii juice 9 parts, euphausia superba powder 20 parts, 17 parts, Limnodrilus hoffmeisteri powder, 14 parts, fish oil, winter honey 11 parts.
Each component effect of the present invention is resolved as follows:
Flos Chrysanthemi energy bactericidal antiphlogistic, inhibited to S. sonnei, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, escherichia coli, vibrio cholera, staphylococcus aureus, group B streptococcus etc., clothes or drink chrysanthemum scented tea can make us long-lived for a long time.Chen Aiye can exorcise evil spirits heal, expelling insect and relieving itching.Radix Cynanchi Atrati another name common vetch grass, know that micro-old, old melon gourd dipper root, mountain cigarette root, hundred swing grass, Baima common vetch, Rhizoma Cynanchi Stauntonii, Radix Tylophorae arenicolae, the upright perennial herb of asclepiadaceae, Cynanchum, root hair shape, has fragrance, has except fidgets due to deficiency, heat clearing away are loose swollen, the effect of granulation promoting pain relieving, fidgets due to deficiency vomiting after can managing property; dribbling urination, nephritis, urinary tract infection; edema, bronchitis and rheumatic lumbago and scelalgia etc.Morning glory has removing water retention by purgation diuresis, effect by expectorant, detumescence, parasite killing anthelmintic, cures mainly the diseases such as limds edema, oedema due to nephritis, cirrhotic ascites, constipation, abdominal pain due to worm stagnation.Serpentis pimple energy anti-inflammtory anti-dysentery, menstruction regulating and pain relieving, hemostasis, can be used for enteritis, bacillary dysentery, menoxenia, dysmenorrhea, rheumatalgia, fracture, traumatic injury swelling and pain due to blood stasis.Folium Isatidis cures mainly pyretic toxicity and sends out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.Herba Wahlenbergiae tonifying the spleen and stomach, lung benefiting kidney, eliminates the phlegm, parasite killing, hemostasis, and heat clearing away of inducing sweat is controlled wind heat and breathed heavily and cough, hemoptysis, epistaxis, infantile convulsion, traumatic injury.Herba Artemisiae Scopariae grass has another name called: Tarragon is careless, Artemisia dracunculus is careless, Herba Artemisiae Sieversianae is careless, his power is dry, for Compositae herbaceos perennial, Herba Artemisiae Scopariae is more with fruit ear essential oil content, main component has B mono-trip alkene, capillin, Herba Artemisiae Scopariae primary colors ketone, capillon etc., cold nature, bitter in the mouth are pungent, have the effect of clearing away damp-heat, jaundice eliminating cellulitis, detoxification sore treatment, long-term drink, hepatic cholagogic, has the effect directly hindering liver and gall tumor cell proliferation.Cornu Bubali has heat clearing away, removing heat from blood, arresting convulsion, the effect of removing toxic substances, can be used for the treatment typhoid fever pestilence pathogenic heat attacking blood system in febrile diseases, mania and irritation, irritated, and delirium, macule, jaundice, spits blood, epistaxis, hematochezia, swollen ulcer drug.Cortex Moutan is the dry root bark of ranunculaceae peony, bitter in the mouth, pungent, and cold nature, has the effects such as clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever, can be used for the treatment of to fall and flutter the pain of injury, carbuncle sore tumefacting virus.Herba Capsellae has the effect with spleen, diuretic, hemostasis, improving eyesight, is usually used in the diseases such as treatment postpartum hemorrhage, dysentery, edema, enteritis, gastric ulcer, cold, fever, the swollen pain of conjunctival congestion.Radix aconiti gymnandri is warm in nature, bitter in the mouth, pungent, has effect of promoting blood circulation to restore menstrual flow, inducing diuresis to remove edema, can treat menoxenia, amenorrhea, stimulate the menstrual flow, the disease such as edema, postnatal blood stasis stomachache, and herb can hyoscine, has stronger toxic action.Semen Armeniacae Amarum is rosaceous plant Prunus armeniaca L.var.ansu Maxim., mature fruit of gathering summer, removing sarcocarp and nucleocapsid, take out seed, dry, can anti-inflammatory and antalgic, the amygdalate water extract of defat is formed with inhibitory action to the mouse writhing reaction caused by acetic acid and the rat granulomatous inflammation caused by cotton balls.Galla Chinensis is cold in nature, sour in the mouth, puckery, has the effects such as pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating hemostasis, removing dampness sore, cures mainly the diseases such as chronic cough of deficiency lung, chronic diarrhea chronic dysentery, hemorrhoidal bleeding of having blood in stool, carbuncle sore tumefacting virus, Skin wet and rotten.Fructus Xanthii dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving.Fructus Cnidii is the dry mature fruit of samphire cnidium monnieri, has resisting pathogenic microbes effect, and Fructus Cnidii all has inhibitory action to acrothesium floccosum, Gypsum Fibrosum sample microspore bacterium, ulotrichy microspore bacterium; Also there is antifungic action, Antifungal activities, insecticidal action.Herba Sedi Aizoon has another name called Herba sedi kamtschatici, has good curative effect to heart disease, hypertension, hyperlipidemia, hepatitis etc.Herba Houttuyniae has heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, the effect of inducing diuresis for treating stranguria syndrome.Folium Isatidis cures mainly pyretic toxicity and sends out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.Folium Eriobotryae is the leaf of rosaceous plant Folium Eriobotryae, has heat clearing away, separates the effect such as summer-heat, stomach function regulating.Herba Kalimeridis is dry herb or the root of feverfew Herba Kalimeridis, and summer, autumn gather, using fresh herb or dry; Its acrid in the mouth, cool in nature, there is cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling, can be used for spitting blood, epistaxis, dysentery, metrorrhagia, wound hemorrhage, jaundice, edema, stranguria with turbid discharge, flu, cough, pharyngalgia sore throat, hemorrhoid, carbuncle, erysipelas, infantile malnutrition.Herba Plantaginis has another name called wheel dish, is Plantaginaceae perennial herb, not only can be medicinal, and edible, its energy clearing away heat and promoting diuresis, removing heat from blood, removing toxic substances, cures mainly accumulation of heat in the urinary bladder, dysuria, stranguria with turbid discharge leukorrhagia, heat-damp in summer dysentery, epistaxis, hematuria, liver-heat conjunctival congestion, laryngopharynx swelling and pain, carbuncle sore tumefacting virus.Oleum menthae light weight a surname is loose, has dispelling wind and heat pathogens, declares the merit of malicious rash: can be used for controlling wind heat bundle table, measles without adequate eruption; Also can treat rubella pruritus, get the effect that its rash of dispeling the wind is antipruritic.Radix et Caulis Opuntiae Dillenii sweet in the mouth is put down, spleen reinforcing stomach invigorating, beneficial strength of one's legs, except chronic diarrhea, and all right heat-clearing and toxic substances removing, scattered silt is subsided a swelling, benefiting stomach and stopping pain, and antitussive is interior with controlling taste-blindness rate, acute dysentery, cough; Mumps is controlled in external, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald.Euphausia superba powder is the nutrient source of high quality protein; average protein content accounts for about 60%; and the astaxanthin contained in euphausia superba powder serves fundamental role at the active oxygen species apoplexy due to endogenous wind of protection Fish, the beta-carotene contained in euphausia superba powder and astaxanthin play an important role in the immune system regulating Fish.Containing the multiple medicinal ingredient such as Pheretima element, Pheretima toxolysin, xanthine, antihistaminic and vitamin B in Limnodrilus hoffmeisteri body, and to angle fish, there is food calling effect.Fish oil can provide energy for angle fish, and has food calling effect.Winter honey refers to the Mel gathered in the crops in the winter time, has the effect of removing toxic substances, doctor's skin ulcer, pain relieving; Mel is directly embrocated on skin or wound, has the effect of antiinflammatory, pain relieving, stop blooding, alleviate edema, promotion wound healing; Eat and can alleviate alimentary toxicosis, treatment gastroenteritic ulcer and tripe abdomen pain; In addition, winter honey can coordinating the actions of various ingredients in a prescription, improves feedstuff mouthfeel, improves the property of medicine.
Another object of the present invention is to provide a kind of preparation method of feed additive of above-mentioned prevention angle fish head shothole disease, and the preparation method of the feed additive of this prevention angle fish head shothole disease comprises the following steps:
(1) take Flos Chrysanthemi by proportioning, add the water that parts by weight are 3 times of Flos Chrysanthemi parts by weight, at 70-80 DEG C, soak 48-72h, filter to obtain the infusion of Flos Chrysanthemi;
(2) take Chen Aiye, Radix Cynanchi Atrati, morning glory and Serpentis pimple by proportioning, the gross weight of Chen Aiye, Radix Cynanchi Atrati, morning glory and Serpentis pimple is denoted as 1 part, takes the purified water of 10 parts, at 70-80 DEG C, 2-3h is soaked in water-bath, obtains soak;
(3) boil 2h after the soak that step (2) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 5 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(4) Folium Isatidis, Herba Wahlenbergiae, Herba Artemisiae Scopariae grass, Cornu Bubali, Cortex Moutan, Herba Capsellae, Radix aconiti gymnandri, Semen Armeniacae Amarum, Galla Chinensis, Fructus Xanthii, Fructus Cnidii, Herba Sedi Aizoon, Herba Houttuyniae, Folium Eriobotryae, Herba Kalimeridis and Herba Plantaginis is taken respectively by said ratio, load ball mill grinding 2h, cross 80 mesh sieves, obtain grounds travel;
(5) grounds travel that extracting solution step (3) obtained and step (4) obtain is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(6) Antarctic krill is dry, grind or pulverize with pulverizer, cross 80 mesh sieves, obtain euphausia superba powder;
(7) Limnodrilus hoffmeisteri is dry, grind or pulverize with pulverizer, cross 80 mesh sieves, obtain Limnodrilus hoffmeisteri powder;
(8) Oleum menthae, Radix et Caulis Opuntiae Dillenii juice, euphausia superba powder, Limnodrilus hoffmeisteri powder, fish oil and winter honey is taken according to proportioning, mix homogeneously with the infusion of the Flos Chrysanthemi of step (1) gained, the extract of step (5) gained, obtain object.
The preparation method of described Radix et Caulis Opuntiae Dillenii juice is: smashed to pieces by Radix et Caulis Opuntiae Dillenii or grind or squeeze the juice with juice extractor, and gained juice is Radix et Caulis Opuntiae Dillenii juice.
In step (7), by the method for Limnodrilus hoffmeisteri drying be: cleaned by Limnodrilus hoffmeisteri fresh water, then use distilled water flushing three times, vacuum lyophilization is to finish-drying.The advantage of vacuum lyophilization is thoroughly dry, can not make the active substance inactivation in Limnodrilus hoffmeisteri body in dry process.
The using method of the feed additive of prevention angle fish head shothole disease of the present invention is: throw something and feed after being mixed homogeneously with the weight ratio of 1:30-1:10 with commercially available normal feedstuff by the feed additive of prevention angle fish head shothole disease of the present invention, preferably, the feed additive of prevention angle fish head shothole disease of the present invention and the weight ratio of commercially available normal feedstuff are 1:20.
In preparation method, crude drug purified water soaking a period of time, medical material deliquescing, cell expansion, effective ingredient is easily fried, and medical material contains starch, protein, after soaking, prevent when decocting, the starch gelatinization on medical material surface, protein coagulating, the capillary channel on blocking medical material surface, make the moisture when decocting enter not go, effective ingredient is not easily fried, affects curative effect of medication; Decoction can change the irritation effect of medicine, relatively mildly acts on angle fish, promotes that angle fish is to the absorption of medicine; Grinding makes the starch in medical material, protein is separated out more fully at subsequent step; Supercritical extraction, immersion, concentration step retain the effective ingredient in Chinese medicine of the present invention to greatest extent.
The feed additive of prevention angle fish head shothole disease of the present invention, the mechanism of action according to head shothole disease, the suitable component selected, and organically combined, there is significant cooperative synergism effect, play the function of each component to greatest extent, and the component of the feed additive of prevention angle fish head shothole disease of the present invention is environmental protection raw material, environmental sound, has significant bactericidal and bacteriostatic effect to the pathogen of angle fish head shothole disease.Because the fish oil in Chinese herbal feed additive of the present invention has food calling effect, euphausia superba powder, Limnodrilus hoffmeisteri powder delicious flavour, winter honey can be in harmonious proportion and improve feedstuff mouthfeel, therefore feed additive of the present invention can stimulate the taste bud of angle fish, induction angle fish ingests and with the addition of the normal feedstuff of feed additive of the present invention, therefore the composition that can strengthen angle fish immunity and resistance, the pathogen of angle fish head shothole disease be had to remarkable bactericidal and bacteriostatic effect in additive of the present invention can enter in angle fish body, and plays it and act on accordingly.
Compared with prior art, the invention has the beneficial effects as follows:
(1) Flos Chrysanthemi energy bactericidal antiphlogistic, inhibited to S. sonnei, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, escherichia coli, vibrio cholera, staphylococcus aureus, group B streptococcus etc., clothes or drink chrysanthemum scented tea can make us long-lived for a long time.Chen Aiye can exorcise evil spirits heal, expelling insect and relieving itching.Radix Cynanchi Atrati another name common vetch grass, know that micro-old, old melon gourd dipper root, mountain cigarette root, hundred swing grass, Baima common vetch, Rhizoma Cynanchi Stauntonii, Radix Tylophorae arenicolae, the upright perennial herb of asclepiadaceae, Cynanchum, root hair shape, has fragrance, has except fidgets due to deficiency, heat clearing away are loose swollen, the effect of granulation promoting pain relieving, fidgets due to deficiency vomiting after can managing property; dribbling urination, nephritis, urinary tract infection; edema, bronchitis and rheumatic lumbago and scelalgia etc.Morning glory has removing water retention by purgation diuresis, effect by expectorant, detumescence, parasite killing anthelmintic, cures mainly the diseases such as limds edema, oedema due to nephritis, cirrhotic ascites, constipation, abdominal pain due to worm stagnation.Serpentis pimple energy anti-inflammtory anti-dysentery, menstruction regulating and pain relieving, hemostasis, can be used for enteritis, bacillary dysentery, menoxenia, dysmenorrhea, rheumatalgia, fracture, traumatic injury swelling and pain due to blood stasis.Folium Isatidis cures mainly pyretic toxicity and sends out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.Herba Wahlenbergiae tonifying the spleen and stomach, lung benefiting kidney, eliminates the phlegm, parasite killing, hemostasis, and heat clearing away of inducing sweat is controlled wind heat and breathed heavily and cough, hemoptysis, epistaxis, infantile convulsion, traumatic injury.Herba Artemisiae Scopariae grass has another name called: Tarragon is careless, Artemisia dracunculus is careless, Herba Artemisiae Sieversianae is careless, his power is dry, for Compositae herbaceos perennial, Herba Artemisiae Scopariae is more with fruit ear essential oil content, main component has B mono-trip alkene, capillin, Herba Artemisiae Scopariae primary colors ketone, capillon etc., cold nature, bitter in the mouth are pungent, have the effect of clearing away damp-heat, jaundice eliminating cellulitis, detoxification sore treatment, long-term drink, hepatic cholagogic, has the effect directly hindering liver and gall tumor cell proliferation.Cornu Bubali has heat clearing away, removing heat from blood, arresting convulsion, the effect of removing toxic substances, can be used for the treatment typhoid fever pestilence pathogenic heat attacking blood system in febrile diseases, mania and irritation, irritated, and delirium, macule, jaundice, spits blood, epistaxis, hematochezia, swollen ulcer drug.Cortex Moutan is the dry root bark of ranunculaceae peony, bitter in the mouth, pungent, and cold nature, has the effects such as clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever, can be used for the treatment of to fall and flutter the pain of injury, carbuncle sore tumefacting virus.Herba Capsellae has the effect with spleen, diuretic, hemostasis, improving eyesight, is usually used in the diseases such as treatment postpartum hemorrhage, dysentery, edema, enteritis, gastric ulcer, cold, fever, the swollen pain of conjunctival congestion.Radix aconiti gymnandri is warm in nature, bitter in the mouth, pungent, has effect of promoting blood circulation to restore menstrual flow, inducing diuresis to remove edema, can treat menoxenia, amenorrhea, stimulate the menstrual flow, the disease such as edema, postnatal blood stasis stomachache, and herb can hyoscine, has stronger toxic action.Semen Armeniacae Amarum is rosaceous plant Prunus armeniaca L.var.ansu Maxim., mature fruit of gathering summer, removing sarcocarp and nucleocapsid, take out seed, dry, can anti-inflammatory and antalgic, the amygdalate water extract of defat is formed with inhibitory action to the mouse writhing reaction caused by acetic acid and the rat granulomatous inflammation caused by cotton balls.Galla Chinensis is cold in nature, sour in the mouth, puckery, has the effects such as pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating hemostasis, removing dampness sore, cures mainly the diseases such as chronic cough of deficiency lung, chronic diarrhea chronic dysentery, hemorrhoidal bleeding of having blood in stool, carbuncle sore tumefacting virus, Skin wet and rotten.Fructus Xanthii dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, pain relieving.Fructus Cnidii is the dry mature fruit of samphire cnidium monnieri, has resisting pathogenic microbes effect, and Fructus Cnidii all has inhibitory action to acrothesium floccosum, Gypsum Fibrosum sample microspore bacterium, ulotrichy microspore bacterium; Also there is antifungic action, Antifungal activities, insecticidal action.Herba Sedi Aizoon has another name called Herba sedi kamtschatici, has good curative effect to heart disease, hypertension, hyperlipidemia, hepatitis etc.Herba Houttuyniae has heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, the effect of inducing diuresis for treating stranguria syndrome.Folium Isatidis cures mainly pyretic toxicity and sends out the diseases such as speckle, erysipelas, laryngopharynx swelling and pain, aphtha of the mouth and tongue, sore and toxic.Folium Eriobotryae is the leaf of rosaceous plant Folium Eriobotryae, has heat clearing away, separates the effect such as summer-heat, stomach function regulating.Herba Kalimeridis is dry herb or the root of feverfew Herba Kalimeridis, and summer, autumn gather, using fresh herb or dry; Its acrid in the mouth, cool in nature, there is cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling, can be used for spitting blood, epistaxis, dysentery, metrorrhagia, wound hemorrhage, jaundice, edema, stranguria with turbid discharge, flu, cough, pharyngalgia sore throat, hemorrhoid, carbuncle, erysipelas, infantile malnutrition.Herba Plantaginis has another name called wheel dish, is Plantaginaceae perennial herb, not only can be medicinal, and edible, its energy clearing away heat and promoting diuresis, removing heat from blood, removing toxic substances, cures mainly accumulation of heat in the urinary bladder, dysuria, stranguria with turbid discharge leukorrhagia, heat-damp in summer dysentery, epistaxis, hematuria, liver-heat conjunctival congestion, laryngopharynx swelling and pain, carbuncle sore tumefacting virus.Oleum menthae light weight a surname is loose, has dispelling wind and heat pathogens, declares the merit of malicious rash: can be used for controlling wind heat bundle table, measles without adequate eruption; Also can treat rubella pruritus, get the effect that its rash of dispeling the wind is antipruritic.Radix et Caulis Opuntiae Dillenii sweet in the mouth is put down, spleen reinforcing stomach invigorating, beneficial strength of one's legs, except chronic diarrhea, and all right heat-clearing and toxic substances removing, scattered silt is subsided a swelling, benefiting stomach and stopping pain, and antitussive is interior with controlling taste-blindness rate, acute dysentery, cough; Mumps is controlled in external, mastitis, carbuncle furuncle and phyma poison, venom, burn and scald.Euphausia superba powder is the nutrient source of high quality protein; average protein content accounts for about 60%; and the astaxanthin contained in euphausia superba powder serves fundamental role at the active oxygen species apoplexy due to endogenous wind of protection Fish, the beta-carotene contained in euphausia superba powder and astaxanthin play an important role in the immune system regulating Fish.Containing the multiple medicinal ingredient such as Pheretima element, Pheretima toxolysin, xanthine, antihistaminic and vitamin B in Limnodrilus hoffmeisteri body, and to angle fish, there is food calling effect.Fish oil can provide energy for angle fish, and has food calling effect.Winter honey refers to the Mel gathered in the crops in the winter time, has the effect of removing toxic substances, doctor's skin ulcer, pain relieving; Mel is directly embrocated on skin or wound, has the effect of antiinflammatory, pain relieving, stop blooding, alleviate edema, promotion wound healing; Eat and can alleviate alimentary toxicosis, treatment gastroenteritic ulcer and tripe abdomen pain; In addition, winter honey can coordinating the actions of various ingredients in a prescription, improves feedstuff mouthfeel, improves the property of medicine.
(2) component of the feed additive of prevention angle fish head shothole disease of the present invention is environmental protection raw material, environmental sound, uses safer.The feed additive of prevention angle fish head shothole disease of the present invention, the mechanism of action according to head shothole disease, the suitable component selected, and organically combined, there is significant cooperative synergism effect, play the function of each component to greatest extent, to the pathogen of angle fish head shothole disease, there is significant bactericidal and bacteriostatic effect.Because the fish oil in Chinese herbal feed additive of the present invention has food calling effect, euphausia superba powder, Limnodrilus hoffmeisteri powder delicious flavour, winter honey can be in harmonious proportion and improve feedstuff mouthfeel, therefore feed additive of the present invention can stimulate the taste bud of angle fish, induction angle fish ingests and with the addition of the normal feedstuff of feed additive of the present invention, therefore the composition that can strengthen angle fish immunity and resistance, the pathogen of angle fish head shothole disease be had to remarkable bactericidal and bacteriostatic effect in additive of the present invention can enter in angle fish body, and plays it and act on accordingly.
(3) in preparation method, crude drug purified water soaking a period of time, medical material deliquescing, cell expansion, effective ingredient is easily fried, and medical material contains starch, protein, after soaking, prevent when decocting, the starch gelatinization on medical material surface, protein coagulating, the capillary channel on blocking medical material surface, make the moisture when decocting enter not go, effective ingredient is not easily fried, affects curative effect of medication; Decoction can change the irritation effect of medicine, relatively mildly acts on angle fish, promotes that angle fish is to the absorption of medicine; Grinding makes the starch in medical material, protein is separated out more fully at subsequent step; Supercritical extraction, immersion, concentration step retain the effective ingredient in Chinese medicine of the present invention to greatest extent.
Detailed description of the invention
Following embodiment is convenient to understand the present invention better, but does not limit the present invention.Experimental technique in following embodiment, if no special instructions, is conventional method.
Embodiment 1
In the present invention's first detailed description of the invention, feed ingredient and preparation method thereof is as follows:
A kind of feed additive preventing angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 31 parts, Chen Aiye 22 parts, Radix Cynanchi Atrati 21 parts, 21 parts, morning glory, Serpentis pimple 21 parts, Folium Isatidis 20 parts, Herba Wahlenbergiae 19 parts, Herba Artemisiae Scopariae grass 19 parts, Cornu Bubali 17 parts, Cortex Moutan 17 parts, 17 parts, Herba Capsellae, Radix aconiti gymnandri 18 parts, Semen Armeniacae Amarum 17 parts, Galla Chinensis 17 parts, Fructus Xanthii 17 parts, Fructus Cnidii 15 parts, Herba Sedi Aizoon 15 parts, Herba Houttuyniae 15 parts, Folium Eriobotryae 15 parts, Herba Kalimeridis 14 parts, Herba Plantaginis 14 parts, Oleum menthae 13 parts, Radix et Caulis Opuntiae Dillenii juice 11 parts, euphausia superba powder 19 parts, 16 parts, Limnodrilus hoffmeisteri powder, 13 parts, fish oil, winter honey 10 parts.
The preparation method of the feed additive of above-mentioned prevention angle fish head shothole disease comprises the following steps:
(1) take Flos Chrysanthemi by proportioning, add the water that parts by weight are 3 times of Flos Chrysanthemi parts by weight, at 70-80 DEG C, soak 48-72h, filter to obtain the infusion of Flos Chrysanthemi;
(2) take Chen Aiye, Radix Cynanchi Atrati, morning glory and Serpentis pimple by proportioning, the gross weight of Chen Aiye, Radix Cynanchi Atrati, morning glory and Serpentis pimple is denoted as 1 part, takes the purified water of 10 parts, at 70-80 DEG C, 2-3h is soaked in water-bath, obtains soak;
(3) boil 2h after the soak that step (2) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 5 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(4) Folium Isatidis, Herba Wahlenbergiae, Herba Artemisiae Scopariae grass, Cornu Bubali, Cortex Moutan, Herba Capsellae, Radix aconiti gymnandri, Semen Armeniacae Amarum, Galla Chinensis, Fructus Xanthii, Fructus Cnidii, Herba Sedi Aizoon, Herba Houttuyniae, Folium Eriobotryae, Herba Kalimeridis and Herba Plantaginis is taken respectively by said ratio, load ball mill grinding 2h, cross 80 mesh sieves, obtain grounds travel;
(5) grounds travel that extracting solution step (3) obtained and step (4) obtain is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(6) Antarctic krill is dry, grind or pulverize with pulverizer, cross 80 mesh sieves, obtain euphausia superba powder;
(7) Limnodrilus hoffmeisteri is dry, grind or pulverize with pulverizer, cross 80 mesh sieves, obtain Limnodrilus hoffmeisteri powder;
(8) Oleum menthae, Radix et Caulis Opuntiae Dillenii juice, euphausia superba powder, Limnodrilus hoffmeisteri powder, fish oil and winter honey is taken according to proportioning, mix homogeneously with the infusion of the Flos Chrysanthemi of step (1) gained, the extract of step (5) gained, obtain object.
The preparation method of described Radix et Caulis Opuntiae Dillenii juice is: smashed to pieces by Radix et Caulis Opuntiae Dillenii or grind or squeeze the juice with juice extractor, and gained juice is Radix et Caulis Opuntiae Dillenii juice.
In step (7), by the method for Limnodrilus hoffmeisteri drying be: cleaned by Limnodrilus hoffmeisteri fresh water, then use distilled water flushing three times, vacuum lyophilization is to finish-drying.
Embodiment 2
In the present invention's second detailed description of the invention, feed ingredient and preparation method thereof is as follows:
A kind of feed additive preventing angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 33 parts, Chen Aiye 20 parts, Radix Cynanchi Atrati 23 parts, 23 parts, morning glory, Serpentis pimple 23 parts, Folium Isatidis 17 parts, Herba Wahlenbergiae 15 parts, Herba Artemisiae Scopariae grass 15 parts, Cornu Bubali 15 parts, Cortex Moutan 18 parts, 18 parts, Herba Capsellae, Radix aconiti gymnandri 16 parts, Semen Armeniacae Amarum 13 parts, Galla Chinensis 12 parts, Fructus Xanthii 12 parts, Fructus Cnidii 13 parts, Herba Sedi Aizoon 14 parts, Herba Houttuyniae 14 parts, Folium Eriobotryae 16 parts, Herba Kalimeridis 16 parts, Herba Plantaginis 11 parts, Oleum menthae 11 parts, Radix et Caulis Opuntiae Dillenii juice 9 parts, euphausia superba powder 16 parts, 20 parts, Limnodrilus hoffmeisteri powder, 17 parts, fish oil, winter honey 12 parts.
The preparation method of the feed additive of the prevention angle fish head shothole disease of the present embodiment is with embodiment 1.
Embodiment 3
In the present invention's the 3rd detailed description of the invention, feed ingredient and preparation method thereof is as follows:
A kind of feed additive preventing angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 29 parts, Chen Aiye 24 parts, Radix Cynanchi Atrati 24 parts, 19 parts, morning glory, Serpentis pimple 19 parts, Folium Isatidis 18 parts, Herba Wahlenbergiae 17 parts, Herba Artemisiae Scopariae grass 17 parts, Cornu Bubali 16 parts, Cortex Moutan 15 parts, 15 parts, Herba Capsellae, Radix aconiti gymnandri 15 parts, Semen Armeniacae Amarum 16 parts, Galla Chinensis 16 parts, Fructus Xanthii 13 parts, Fructus Cnidii 12 parts, Herba Sedi Aizoon 13 parts, Herba Houttuyniae 13 parts, Folium Eriobotryae 14 parts, Herba Kalimeridis 12 parts, Herba Plantaginis 12 parts, Oleum menthae 11 parts, Radix et Caulis Opuntiae Dillenii juice 10 parts, euphausia superba powder 25 parts, 14 parts, Limnodrilus hoffmeisteri powder, 15 parts, fish oil, winter honey 8 parts.
The preparation method of the feed additive of the prevention angle fish head shothole disease of the present embodiment is with embodiment 1.
Embodiment 4
In the present invention's the 4th detailed description of the invention, feed ingredient and preparation method thereof is as follows:
A kind of feed additive preventing angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 26 parts, Chen Aiye 17 parts, Radix Cynanchi Atrati 19 parts, 17 parts, morning glory, Serpentis pimple 19 parts, Folium Isatidis 18 parts, Herba Wahlenbergiae 17 parts, Herba Artemisiae Scopariae grass 15 parts, Cornu Bubali 13 parts, Cortex Moutan 17 parts, 14 parts, Herba Capsellae, Radix aconiti gymnandri 14 parts, Semen Armeniacae Amarum 14 parts, Galla Chinensis 14 parts, Fructus Xanthii 15 parts, Fructus Cnidii 15 parts, Herba Sedi Aizoon 11 parts, Herba Houttuyniae 11 parts, Folium Eriobotryae 12 parts, Herba Kalimeridis 14 parts, Herba Plantaginis 12 parts, Oleum menthae 9 parts, Radix et Caulis Opuntiae Dillenii juice 8 parts, euphausia superba powder 22 parts, 18 parts, Limnodrilus hoffmeisteri powder, 11 parts, fish oil, winter honey 14 parts.
The preparation method of the feed additive of the prevention angle fish head shothole disease of the present embodiment is with embodiment 1.
Embodiment 5
In the present invention's the 5th detailed description of the invention, feed ingredient and preparation method thereof is as follows:
A kind of feed additive preventing angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 28 parts, Chen Aiye 22 parts, Radix Cynanchi Atrati 17 parts, 23 parts, morning glory, Serpentis pimple 17 parts, Folium Isatidis 21 parts, Herba Wahlenbergiae 21 parts, Herba Artemisiae Scopariae grass 21 parts, Cornu Bubali 19 parts, Cortex Moutan 14 parts, 14 parts, Herba Capsellae, Radix aconiti gymnandri 15 parts, Semen Armeniacae Amarum 14 parts, Galla Chinensis 13 parts, Fructus Xanthii 13 parts, Fructus Cnidii 17 parts, Herba Sedi Aizoon 16 parts, Herba Houttuyniae 16 parts, Folium Eriobotryae 11 parts, Herba Kalimeridis 10 parts, Herba Plantaginis 9 parts, Oleum menthae 7 parts, Radix et Caulis Opuntiae Dillenii juice 6 parts, euphausia superba powder 18 parts, 16 parts, Limnodrilus hoffmeisteri powder, 15 parts, fish oil, winter honey 10 parts.
The preparation method of the feed additive of the prevention angle fish head shothole disease of the present embodiment is with embodiment 1.
Embodiment 6
In the present invention's the 6th detailed description of the invention, feed ingredient and preparation method thereof is as follows:
A kind of feed additive preventing angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 30 parts, Chen Aiye 21 parts, Radix Cynanchi Atrati 20 parts, 20 parts, morning glory, Serpentis pimple 20 parts, Folium Isatidis 19 parts, Herba Wahlenbergiae 18 parts, Herba Artemisiae Scopariae grass 18 parts, Cornu Bubali 16 parts, Cortex Moutan 16 parts, 16 parts, Herba Capsellae, Radix aconiti gymnandri 16 parts, Semen Armeniacae Amarum 15 parts, Galla Chinensis 15 parts, Fructus Xanthii 14 parts, Fructus Cnidii 14 parts, Herba Sedi Aizoon 13 parts, Herba Houttuyniae 13 parts, Folium Eriobotryae 13 parts, Herba Kalimeridis 13 parts, Herba Plantaginis 12 parts, Oleum menthae 10 parts, Radix et Caulis Opuntiae Dillenii juice 9 parts, euphausia superba powder 20 parts, 17 parts, Limnodrilus hoffmeisteri powder, 14 parts, fish oil, winter honey 11 parts.
The preparation method of the feed additive of the prevention angle fish head shothole disease of the present embodiment is with embodiment 1.
Experimental result
Preventive effect is tested
With normal feedstuff group of throwing something and feeding (for normal commercial diet) for matched group, to add the feedstuff group of the embodiment of the present invention 6 in normal feedstuff for experimental group, often group establish 3 parallel, in experimental group, the additive of embodiment 6 and the weight ratio of normal feedstuff are 1:20.Choose 6 aquariums, healthy angle fish 60, healthy angle fish is all assigned to 6 aquariums at random, each aquarium 10 angle fish, add the angle fish that 1 is suffered from head shothole disease in each aquarium.The results are shown in Table 1:
The effect situation of table 1 feed additive prevention of the present invention head shothole disease
From table 1, the Chinese herbal feed additive of prevention angle fish fish head portion of the present invention shothole disease effectively can reduce the incidence rate of angle fish fish head portion shothole disease.
Bacteriostatic test checks
Adopt nitrofural to do matched group, the feed additive of the prevention angle fish head shothole disease of the embodiment of the present invention 6 is that experimental group carries out antibacterial inspection.
The preparation of culture medium: take in the water-soluble 800mL of beef extract 5g, adds peptone 10g and dissolves, and adds casein 34g and dissolves, then adds NaCl5g dissolving, is adjusted to pH7.6 ~ 7.8, is diluted to 1000mL.Add agar powder 18g, autoclaving 15min, when being cooled to 40 DEG C ~ 50 DEG C, a kind of rhyme scheme in Chinese operas serving as the prelude to a complete score for voices, solidifies, and the 4 DEG C of refrigerators placing no bacteria pollution are for subsequent use.
Strain is: the fine slime mould of column.
Matched group antibacterial liquid is prepared: be dissolved in respectively in 10ml sterile deionized water by 1 part of nitrofural, diluted respectively by liquor strength, with stock solution than being 1:2,1:4,1:8,1:16,1:32.
Experimental group antibacterial liquid is prepared: be dissolved in 10ml sterile deionized water by the feed additive of the prevention angle fish head shothole disease of the embodiment of the present invention 6, diluted respectively by liquor strength, with stock solution than being 1:2,1:4,1:8,1:16,1:32.To the fungistatic effect of myxobacter in table 2:
The bactericidal and bacteriostatic effect of the feed additive of table 2 prevention of the present invention angle fish head shothole disease
From table 2, the feed additive of the prevention angle fish head shothole disease of embodiments of the invention 1 has good bactericidal and bacteriostatic effect to the fine slime mould of the pathogen column of head shothole disease.
The above is only the preferred embodiment of the present invention, is noted that for those skilled in the art, and under the premise without departing from the principles of the invention, can also make some improvement, these improvement should be considered as protection scope of the present invention.
Claims (8)
1. one kind is prevented the feed additive of angle fish head shothole disease, it is characterized in that: be made up of each component of following masses number: Flos Chrysanthemi 26-33 part, Chen Aiye 17-24 part, Radix Cynanchi Atrati 17-24 part, morning glory 17-23 part, Serpentis pimple 17-23 part, Folium Isatidis 17-21 part, Herba Wahlenbergiae 15-21 part, Herba Artemisiae Scopariae grass 15-21 part, Cornu Bubali 13-19 part, Cortex Moutan 14-18 part, Herba Capsellae 14-18 part, Radix aconiti gymnandri 14-18 part, Semen Armeniacae Amarum 13-17 part, Galla Chinensis 12-17 part, Fructus Xanthii 12-17 part, Fructus Cnidii 12-17 part, Herba Sedi Aizoon 11-16 part, Herba Houttuyniae 11-16 part, Folium Eriobotryae 11-16 part, Herba Kalimeridis 10-16 part, Herba Plantaginis 9-14 part, Oleum menthae 7-13 part, Radix et Caulis Opuntiae Dillenii juice 6-11 part, euphausia superba powder 16-25 part, Limnodrilus hoffmeisteri powder 14-20 part, fish oil 11-17 part, winter honey 8-14 part.
2. the feed additive of prevention angle fish head shothole disease according to claim 1, it is characterized in that: the feed additive of described prevention angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 29-31 part, Chen Aiye 20-22 part, Radix Cynanchi Atrati 19-21 part, morning glory 19-21 part, Serpentis pimple 19-21 part, Folium Isatidis 18-20 part, Herba Wahlenbergiae 17-19 part, Herba Artemisiae Scopariae grass 17-19 part, Cornu Bubali 15-17 part, Cortex Moutan 15-17 part, Herba Capsellae 15-17 part, Radix aconiti gymnandri 15-16 part, Semen Armeniacae Amarum 14-16 part, Galla Chinensis 14-16 part, Fructus Xanthii 13-15 part, Fructus Cnidii 13-15 part, Herba Sedi Aizoon 13-14 part, Herba Houttuyniae 13-14 part, Folium Eriobotryae 12-14 part, Herba Kalimeridis 12-14 part, Herba Plantaginis 11-12 part, Oleum menthae 9-11 part, Radix et Caulis Opuntiae Dillenii juice 8-10 part, euphausia superba powder 19-22 part, Limnodrilus hoffmeisteri powder 16-18 part, fish oil 13-15 part, winter honey 10-12 part.
3. the feed additive of prevention angle fish head shothole disease according to claim 1, it is characterized in that: the feed additive of described prevention angle fish head shothole disease, be made up of each component of following masses number: Flos Chrysanthemi 30 parts, Chen Aiye 21 parts, Radix Cynanchi Atrati 20 parts, 20 parts, morning glory, Serpentis pimple 20 parts, Folium Isatidis 19 parts, Herba Wahlenbergiae 18 parts, Herba Artemisiae Scopariae grass 18 parts, Cornu Bubali 16 parts, Cortex Moutan 16 parts, 16 parts, Herba Capsellae, Radix aconiti gymnandri 16 parts, Semen Armeniacae Amarum 15 parts, Galla Chinensis 15 parts, Fructus Xanthii 14 parts, Fructus Cnidii 14 parts, Herba Sedi Aizoon 13 parts, Herba Houttuyniae 13 parts, Folium Eriobotryae 13 parts, Herba Kalimeridis 13 parts, Herba Plantaginis 12 parts, Oleum menthae 10 parts, Radix et Caulis Opuntiae Dillenii juice 9 parts, euphausia superba powder 20 parts, 17 parts, Limnodrilus hoffmeisteri powder, 14 parts, fish oil, winter honey 11 parts.
4. a preparation method for the feed additive of the prevention angle fish head shothole disease according to any one of claim 1-3, is characterized in that: comprise the following steps:
(1) take Flos Chrysanthemi by proportioning, add the water that parts by weight are 3 times of Flos Chrysanthemi parts by weight, at 70-80 DEG C, soak 48-72h, filter to obtain the infusion of Flos Chrysanthemi;
(2) take Chen Aiye, Radix Cynanchi Atrati, morning glory and Serpentis pimple by proportioning, the gross weight of Chen Aiye, Radix Cynanchi Atrati, morning glory and Serpentis pimple is denoted as 1 part, takes the purified water of 10 parts, at 70-80 DEG C, 2-3h is soaked in water-bath, obtains soak;
(3) boil 2h after the soak that step (2) obtains being heated to boiling, be separated and take out fried liquid, continue the purified water adding 5 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(4) Folium Isatidis, Herba Wahlenbergiae, Herba Artemisiae Scopariae grass, Cornu Bubali, Cortex Moutan, Herba Capsellae, Radix aconiti gymnandri, Semen Armeniacae Amarum, Galla Chinensis, Fructus Xanthii, Fructus Cnidii, Herba Sedi Aizoon, Herba Houttuyniae, Folium Eriobotryae, Herba Kalimeridis and Herba Plantaginis is taken respectively by said ratio, load ball mill grinding 2h, cross 80 mesh sieves, obtain grounds travel;
(5) grounds travel that extracting solution step (3) obtained and step (4) obtain is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(6) Antarctic krill is dry, grind or pulverize with pulverizer, cross 80 mesh sieves, obtain euphausia superba powder;
(7) Limnodrilus hoffmeisteri is dry, grind or pulverize with pulverizer, cross 80 mesh sieves, obtain Limnodrilus hoffmeisteri powder;
(8) Oleum menthae, Radix et Caulis Opuntiae Dillenii juice, euphausia superba powder, Limnodrilus hoffmeisteri powder, fish oil and winter honey is taken according to proportioning, mix homogeneously with the infusion of the Flos Chrysanthemi of step (1) gained, the extract of step (5) gained, obtain object.
5. the preparation method of the feed additive of prevention angle fish head shothole disease according to claim 4, it is characterized in that: the preparation method of described Radix et Caulis Opuntiae Dillenii juice is: smashed to pieces by Radix et Caulis Opuntiae Dillenii or grind or squeeze the juice with juice extractor, and gained juice is Radix et Caulis Opuntiae Dillenii juice.
6. the preparation method of the feed additive of prevention angle fish head shothole disease according to claim 4, it is characterized in that: in step (7), by the method for Limnodrilus hoffmeisteri drying be: cleaned by Limnodrilus hoffmeisteri fresh water, then use distilled water flushing three times, vacuum lyophilization is to finish-drying.
7. a using method for the feed additive of the prevention angle fish head shothole disease according to any one of claim 1-3, is characterized in that: throw something and feed after being mixed homogeneously with the weight ratio of 1:30-1:10 with commercially available normal feedstuff by the feed additive of prevention angle fish head shothole disease of the present invention.
8. the using method of the feed additive of prevention angle fish head shothole disease according to claim 7, is characterized in that: the feed additive of prevention angle fish head shothole disease of the present invention and the weight ratio of commercially available normal feedstuff are 1:20.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288550A (en) * | 2014-09-28 | 2015-01-21 | 六安市裕安区平桥运宝特种水产养殖场 | Traditional Chinese medicine for treating perforated disease of turtle |
| CN104398785A (en) * | 2014-11-06 | 2015-03-11 | 占水秀 | Traditional Chinese medicine for treating shot-hole disease of soft-shelled turtle, and spray thereof |
-
2015
- 2015-10-29 CN CN201510718191.XA patent/CN105311202A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288550A (en) * | 2014-09-28 | 2015-01-21 | 六安市裕安区平桥运宝特种水产养殖场 | Traditional Chinese medicine for treating perforated disease of turtle |
| CN104398785A (en) * | 2014-11-06 | 2015-03-11 | 占水秀 | Traditional Chinese medicine for treating shot-hole disease of soft-shelled turtle, and spray thereof |
Non-Patent Citations (1)
| Title |
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| 马光: "中华鳖穿孔病的防治", 《河北渔业》 * |
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Application publication date: 20160210 |