CN104398785A - Traditional Chinese medicine for treating shot-hole disease of soft-shelled turtle, and spray thereof - Google Patents

Traditional Chinese medicine for treating shot-hole disease of soft-shelled turtle, and spray thereof Download PDF

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CN104398785A
CN104398785A CN201410617080.5A CN201410617080A CN104398785A CN 104398785 A CN104398785 A CN 104398785A CN 201410617080 A CN201410617080 A CN 201410617080A CN 104398785 A CN104398785 A CN 104398785A
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parts
radix
herba
rhizoma
chinese medicine
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占水秀
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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Abstract

The invention discloses a traditional Chinese medicine for treating the shot-hole disease of soft-shelled turtle. The traditional Chinese medicine comprises licorice root, Chinese gall, rheum officinale, garlic, honeysuckle flower, wild chrysanthemum flower, Cortex Fraxini, Herba Houttuyniae, Japan Buttercup, Rhizoma Coptidis, Radix Scutellariae, Amur Corktree Bark, isatis root, Rhizoma Alismatis, Chinese angelica, dried orange peel, Radix Asparagi, Weeping Forsythia, Medicine Terminalia Fruit, Artemisia carvifolia, dark plum, pangolin, fortune paulownia flower, Cayratia japonica, Solanum lyratum Thunb, Blackberrylily Rhizome and Trichosanthis Radix. The traditional Chinese medicine can be used for treating the shot-hole disease, and has a substantial curative effect and no side effects. Garlic and other heavy taste materials are used, and are reasonably combined with other medicines in order to realize taste removal and curative effect remaining purposes.

Description

A kind of Chinese medicine and spray agent for the treatment of Trionyx sinensis Wiegmann shothole disease
Technical field
The present invention relates to a kind of veterinary drug, particularly relate to a kind of Chinese medicine and spray agent for the treatment of Trionyx sinensis Wiegmann shothole disease, the invention still further relates to the preparation method of this medicine in addition.
Background technology
Shothole disease is sick also known as scabies, cause primarily of Aeromonas hydrophila, similar with skin fester disease, specifically can see described in " research of the sick malignant bacteria of Trionyx sinensis Wiegmann skin fester disease, furunculosis, blister ", " pathogen separation of Trionyx sinensis (Wiegmann) beancurd sheet, furuncle complication pathogenic bacterium and Susceptibility Test Analysis " etc.So generally itself and skin fester disease are ruled together with medicine, as " controlling experiment of greenhouse Trionyx sinensis Wiegmann beancurd sheet, shothole disease complication ", " pathogen separation of Trionyx sinensis (Wiegmann) beancurd sheet, furuncle, complication pathogenic bacterium and Susceptibility Test Analysis ", the relevant programme for the treatment of skin fester disease can be as a reference.
200910227132.7 relate to a kind of medicine for the treatment of Trionyx sinensis Wiegmann white point and beancurd sheet, comprise oxytetracycline, ciprofloxacin etc.Long-time use antibiotic easily makes Trionyx sinensis Wiegmann produce resistance.201010182385.X relates to a kind of method for the treatment of rotten-skin diseases of trionyx sinensis, and it carries out successively according to the following steps: taken out by the Trionyx sinensis Wiegmann suffering from skin fester disease, carry out lumbar injection with penicillin to it, and the dosage of injection is by per kilogram of body weight 15-20 ten thousand unit.Injectable drug uses inconvenience, and reasonable scheme is sprinkled in pond by medicine, and medicine does not affect the Trionyx sinensis Wiegmann existence in pond simultaneously.201110262972.4 formula relating to a kind of prevention and therapy Trionyx sinensis Wiegmann skin fester disease, each to Rhizoma Coptidis, Radix Glycyrrhizae, Flos Lonicerae and Rhubarb 2g mixing is added in 1kg Trionyx sinensis Wiegmann feedstuff by it.The offer limited effectiveness of single medicine, as " trionyx disease diagnosis and comprehensive diseases prevention " (Zhang Jian) illustrates that the DeGrain of single medicine preferably concentrates the advantage of multi-medicament, rapid and lasting treatment rotten-skin diseases of trionyx sinensis.
Shothole disease symptom is similar from skin fester disease but have different, and main manifestations is that scabies appears in body surface, and then develops into perforation, so medication should distinguish with skin fester disease.Such as, norfloxacin to skin fester disease and shothole disease all effective in cure, but chloromycetin and kanamycin have good efficacy to shothole disease, but are unsuitable for treating skin fester disease." application of Chinese herbal medicine in trionyx disease control ", " Prevention Technique of common diseases of soft-shelled turtle " etc. describe and are exclusively used in the sick relevant programme for the treatment of perforation (scabies), and 201310387105.2 disclose a kind of patent formula for the treatment of the pharmaceutical composition of Trionyx sinensis Wiegmann scabies disease.
Summary of the invention
The present invention proposes a kind of Chinese medicine and spray agent for the treatment of Trionyx sinensis Wiegmann shothole disease, and it may be used for treatment Trionyx sinensis Wiegmann shothole disease, and Be very effective, can improve Trionyx sinensis Wiegmann antibacterium ability, the ability of especially anti-Aeromonas simultaneously.
For solving the problems of the technologies described above, the present invention constructs following technical proposals:
A kind of Chinese medicine for the treatment of Trionyx sinensis Wiegmann shothole disease, it is characterized in that, according to the mass fraction, consist of the following composition: 30 parts, Radix Glycyrrhizae, Galla Chinensis 30 parts, Radix Et Rhizoma Rhei 30 parts, 20 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.
A kind of Chinese medicine for the treatment of Trionyx sinensis Wiegmann shothole disease, it is characterized in that, according to the mass fraction, consist of the following composition: 30 parts, Radix Glycyrrhizae, Galla Chinensis 30 parts, Radix Et Rhizoma Rhei 30 parts, 30 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Pericarpium Citri Reticulatae 18 parts, Radix Angelicae Sinensis 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.
A kind of Chinese medicine for the treatment of Trionyx sinensis Wiegmann shothole disease, it is characterized in that, according to the mass fraction, consist of the following composition: Galla Chinensis 40 parts, 30 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 30 parts, 20 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.
Treat a preparation method for the Chinese medicine of Trionyx sinensis Wiegmann shothole disease, it is characterized in that, comprise the following steps:
Extracting liquorice, Galla Chinensis, Cortex Fraxini, Herba Houttuyniae, Herba Ranunculi Japonici, Radix Isatidis, Rhizoma Alismatis, Radix Angelicae Sinensis, Radix Asparagi, Fructus Forsythiae, Fructus Chebulae, Herba Artemisiae Annuae, Fructus Mume, Squama Manis, Flos Paulowniae, Herba Cayatiae Japonicae, Herba Solani Lyrati, Rhizoma Belamcandae, Radix Trichosanthis, pulverize, add the water of twice quality, be warming up to 50 DEG C, multistage microwave amplifier under power 400W, frequency 2450MHZ, extraction time 20min, filters, obtains filtrate;
Pulverized by Pericarpium Citri Reticulatae, add the water of 2 times of quality, 2h at a simmer, extracting juice, Bulbus Allii is pulverized, and adds in medicine juice, obtains Bulbus Allii mixed liquor;
By Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri mixing, in 80 DEG C of water-baths, be the alcoholic solution reflux, extract, filtrate 2 times of 70% by the volume fraction of 10 times amount, each 2h, merging extracted twice liquid;
Mixing filtrate, Bulbus Allii mixed liquor and extracting solution, slow fire boiling, until yield rate is 1g/ml, namely makes described prescription.
Treat a spray agent for Trionyx sinensis Wiegmann shothole disease, it is characterized in that, according to the mass fraction, consist of the following composition: Chinese herbal medicine 100 parts, Gypsum Fibrosum preparata 8 ~ 10 parts, acetic acid 8 ~ 10 parts, phosphoric acid 8 ~ 10 parts, norfloxacin 1 ~ 5 part, vitamin C 4 parts, 1 ~ 5 part, erythromycin.
Be used for the treatment of a preparation method for the spray agent of rotten-skin diseases of trionyx sinensis, it is characterized in that, comprise the following steps:
Prepare prescription, after adding Gypsum Fibrosum preparata, norfloxacin, be warming up to 60 DEG C, keep 2min, near room temperature, add acetic acid, phosphoric acid, vitamin C and erythromycin, after mix homogeneously, namely make described spray agent.
Prescription of the present invention may be used for treating shothole disease, evident in efficacy, has no side effect.Although employ the highly seasoned materials such as Bulbus Allii, reasonable compatibility other drug, reaches the object de-tasting and do not go curative effect.Especially itself and western medicine antibiotics are share, add the compositions such as Gypsum Fibrosum preparata simultaneously, curative effect can be improved further.
Detailed description of the invention
Describe in detail the present invention below, unaccomplished matter is see the routine techniques knowledge of pharmacopeia 2010 or aquaculture field.
Embodiment one
The Chinese medicine for the treatment of Trionyx sinensis Wiegmann shothole disease, according to the mass fraction, consist of the following composition: 30 parts, Radix Glycyrrhizae, Galla Chinensis 30 parts, Radix Et Rhizoma Rhei 30 parts, 20 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.
Preparation method comprises the following steps: extracting liquorice, Galla Chinensis, Cortex Fraxini, Herba Houttuyniae, Herba Ranunculi Japonici, Radix Isatidis, Rhizoma Alismatis, Radix Angelicae Sinensis, Radix Asparagi, Fructus Forsythiae, Fructus Chebulae, Herba Artemisiae Annuae, Fructus Mume, Squama Manis, Flos Paulowniae, Herba Cayatiae Japonicae, Herba Solani Lyrati, Rhizoma Belamcandae, Radix Trichosanthis, pulverize, add the water of twice quality, be warming up to 50 DEG C, multistage microwave amplifier under power 400W, frequency 2450MHZ, extraction time 20min, filters, obtains filtrate; Pulverized by Pericarpium Citri Reticulatae, add the water of 2 times of quality, 2h at a simmer, extracting juice, Bulbus Allii is pulverized, and adds in medicine juice, obtains Bulbus Allii mixed liquor; By Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri mixing, in 80 DEG C of water-baths, be the alcoholic solution reflux, extract, filtrate 2 times of 70% by the volume fraction of 10 times amount, each 2h, merging extracted twice liquid; Mixing filtrate, Bulbus Allii mixed liquor and extracting solution, slow fire boiling, until yield rate is 1g/ml, namely makes described prescription.
Yield rate 1g/ml refers to the fried 1ml prescription (water preparation) of 1g raw material.Slow fire adopts medical science routine to understand, and refers to and refers to that fire when decocting medicinal herbs is little and slow, generally must not in 1min boiled 1L water.
Embodiment two
The Chinese medicine for the treatment of Trionyx sinensis Wiegmann shothole disease, according to the mass fraction, consist of the following composition: 30 parts, Radix Glycyrrhizae, Galla Chinensis 30 parts, Radix Et Rhizoma Rhei 30 parts, 30 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Pericarpium Citri Reticulatae 18 parts, Radix Angelicae Sinensis 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.Preparation method is as embodiment one.
Embodiment three
The Chinese medicine for the treatment of Trionyx sinensis Wiegmann shothole disease, according to the mass fraction, consist of the following composition: Galla Chinensis 40 parts, 30 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 30 parts, 20 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.Preparation method is as embodiment one.
Embodiment four
The spray agent for the treatment of Trionyx sinensis Wiegmann shothole disease, according to the mass fraction, consists of the following composition: Chinese herbal medicine 100 parts, Gypsum Fibrosum preparata 8 ~ 10 parts, acetic acid 8 ~ 10 parts, phosphoric acid 8 ~ 10 parts, norfloxacin 1 ~ 5 part, vitamin C 4 parts, 1 ~ 5 part, erythromycin.
Preparation method: prepare prescription, after adding Gypsum Fibrosum preparata, norfloxacin, is warming up to 60 DEG C, keeps 2min, near room temperature, adds acetic acid, phosphoric acid, vitamin C and erythromycin, namely make described spray agent after mix homogeneously.
Experiment one
Test method:
1, plant is divided into the test tank of equal-volume (50cm × 50cm × 40cm), is labeled as 30 groups according to Chinese medicine ingredients.Often group adopts same water source (tap water after lake water or aeration), without being communicated with between group.Water temperature 20 to 28 DEG C, pH=6-8.
2, get Trionyx sinensis Wiegmann 600 tail at random in ill plant, be placed in test tank by 20 tails/component.Every day throws in bait by the 3-4% of Trionyx sinensis Wiegmann body weight, and 8: 00,13: 00,16: 00 respectively throw something and feed once.Every day puts half water from bottom, injects water source to 60 ± 10cm simultaneously.
3, daily check, takes out dead or is about to dead Trionyx sinensis Wiegmann, in order to avoid cross infection, affecting result of the test.
Experimental Comparison:
Different Chinese herbal medicine decoctions is thrown according to group name.According to reality survival number, delimit the effect of the monomer in treating skin fester disease of each Chinese medicine ingredients as following table: it is better that "+" represents curative effect more.
Through test, the present invention chooses some drugs, simultaneously proportion optimizing.Bulbus Allii plays therapeutic effect, and Flos Chrysanthemi Indici, Flos Lonicerae, Pericarpium Citri Reticulatae etc. de-taste.Herba Ranunculi Japonici toxic and side effects is little.
Test two
Test material and environment: test Trionyx sinensis Wiegmann derives from breeding soft-shell turtle field, Nanchang City, Jiangxi Province, and the gross area is about 980m 2, total Trionyx sinensis Wiegmann number about 30000, there is Aeromonas hydrophila in this plant, Trionyx sinensis Wiegmann is sporadicly dead, deletes and select shothole disease Trionyx sinensis Wiegmann.Trionyx sinensis Wiegmann test site is located at Duchang County, Jiangxi Province, is less than 10km apart from poyang lake water, and environment is suitable for Trionyx sinensis Wiegmann existence.Between test period February to April, cultivation 30d.
Test method:
1, plant is divided into six groups of test tanks of equal-volume (300cm × 300cm × 80cm), be labeled as A experimental group, B experimental group, C experimental group, D test group, A matched group, B matched group (matched group is common reference group, mentions in other experiments simultaneously) respectively.Often group adopts same water source (tap water after lake water or aeration), without being communicated with between group.Water temperature 20 to 28 DEG C, pH=6-8.
2, get Trionyx sinensis Wiegmann 600 tail at random in ill plant, be placed in six groups of test tanks by 100 tails/component.Every day throws in bait by the 3-4% of Trionyx sinensis Wiegmann body weight, and 8: 00,13: 00,16: 00 respectively throw something and feed once.Every day puts half water from bottom, injects water source to 60 ± 10cm simultaneously.
3, daily check, takes out dead or is about to dead Trionyx sinensis Wiegmann, in order to avoid cross infection, affecting result of the test.
Experimental Comparison:
In A experimental group, B experimental group, C experimental group, spray the prescription of embodiment one to three while throwing in bait respectively, dose concentration 50ml/m 3.Experimental group D throws in the spray agent of embodiment four, dose concentration 50ml/m 3.Control group A throws in antibiotic (oxytetracycline) 15g/m 3.Matched group B does not throw in medicine.
Along with the passing of culturing time, in test tank, dead Trionyx sinensis Wiegmann mantissa is as following table:
Causing a disease of shothole disease was Aeromonas hydrophila originally, had infectiousness, identical with skin fester disease in treatment principle.Although timing is changed water and taken out by dead Trionyx sinensis Wiegmann, antibacterial can remain, breed in water, and morbidity is not easily discovered early stage.Along with the prolongation of time, only change water, do not carry out Drug therapy, the dead quantity of Trionyx sinensis Wiegmann is increasing, the whole association culturing area of crisis.Be used alone antibiotic, early stage is good to bacteriostatic ability, but the later stage is weak.Medicine of the present invention can play certain inhibition early stage, and the later stage can play therapeutical effect, eliminates the threat of skin fester disease completely.If a small amount of Western medicine of compatibility simultaneously, curative effect is more remarkable.In addition, when the concentration of Bulbus Allii is inadequate, offer limited effectiveness, if thrown in a large number, can face again the neural danger of injury Trionyx sinensis Wiegmann, the later death quantity of experimental group is few, illustrates that Bulbus Allii side effect is little.Galla Chinensis, Fructus Chebulae etc. have injury to liver, and the liver protection effect of Radix Glycyrrhizae etc. is also this prescription benefit.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (6)

1. treat the Chinese medicine of Trionyx sinensis Wiegmann shothole disease for one kind, it is characterized in that, according to the mass fraction, consist of the following composition: 30 parts, Radix Glycyrrhizae, Galla Chinensis 30 parts, Radix Et Rhizoma Rhei 30 parts, 20 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.
2. treat the Chinese medicine of Trionyx sinensis Wiegmann shothole disease for one kind, it is characterized in that, according to the mass fraction, consist of the following composition: 30 parts, Radix Glycyrrhizae, Galla Chinensis 30 parts, Radix Et Rhizoma Rhei 30 parts, 30 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Pericarpium Citri Reticulatae 18 parts, Radix Angelicae Sinensis 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.
3. treat the Chinese medicine of Trionyx sinensis Wiegmann shothole disease for one kind, it is characterized in that, according to the mass fraction, consist of the following composition: Galla Chinensis 40 parts, 30 parts, Radix Glycyrrhizae, Radix Et Rhizoma Rhei 30 parts, 20 parts, Bulbus Allii, Flos Lonicerae 20 parts, Flos Chrysanthemi Indici 20 parts, Cortex Fraxini 20 parts, Herba Houttuyniae 20 parts, Herba Ranunculi Japonici 18 parts, Rhizoma Coptidis 18 parts, Radix Scutellariae 18 parts, Cortex Phellodendri 18 parts, Radix Isatidis 18 parts, Rhizoma Alismatis 18 parts, Radix Angelicae Sinensis 12 parts, Pericarpium Citri Reticulatae 12 parts, Radix Asparagi 12 parts, Fructus Forsythiae 12 parts, Fructus Chebulae 12 parts, Herba Artemisiae Annuae 12 parts, Fructus Mume 12 parts, Squama Manis 9 parts, Flos Paulowniae 9 parts, Herba Cayatiae Japonicae 9 parts, Herba Solani Lyrati 9 parts, Rhizoma Belamcandae 9 parts, Radix Trichosanthis 9 parts.
4. treat a preparation method for the Chinese medicine of Trionyx sinensis Wiegmann shothole disease, it is characterized in that, comprise the following steps:
Extracting liquorice, Galla Chinensis, Cortex Fraxini, Herba Houttuyniae, Herba Ranunculi Japonici, Radix Isatidis, Rhizoma Alismatis, Radix Angelicae Sinensis, Radix Asparagi, Fructus Forsythiae, Fructus Chebulae, Herba Artemisiae Annuae, Fructus Mume, Squama Manis, Flos Paulowniae, Herba Cayatiae Japonicae, Herba Solani Lyrati, Rhizoma Belamcandae, Radix Trichosanthis, pulverize, add the water of twice quality, be warming up to 50 DEG C, multistage microwave amplifier under power 400W, frequency 2450MHZ, extraction time 20min, filters, obtains filtrate;
Pulverized by Pericarpium Citri Reticulatae, add the water of 2 times of quality, 2h at a simmer, extracting juice, Bulbus Allii is pulverized, and adds in medicine juice, obtains Bulbus Allii mixed liquor;
By Radix Et Rhizoma Rhei, Flos Chrysanthemi Indici, Flos Lonicerae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri mixing, in 80 DEG C of water-baths, be the alcoholic solution reflux, extract, filtrate 2 times of 70% by the volume fraction of 10 times amount, each 2h, merging extracted twice liquid;
Mixing filtrate, Bulbus Allii mixed liquor and extracting solution, slow fire boiling, until yield rate is 1g/ml, namely makes described prescription.
5. treat a spray agent for Trionyx sinensis Wiegmann shothole disease, it is characterized in that, according to the mass fraction, consist of the following composition: Chinese herbal medicine 100 parts, Gypsum Fibrosum preparata 8 ~ 10 parts, acetic acid 8 ~ 10 parts, phosphoric acid 8 ~ 10 parts, norfloxacin 1 ~ 5 part, vitamin C 4 parts, 1 ~ 5 part, erythromycin.
6. be used for the treatment of a preparation method for the spray agent of rotten-skin diseases of trionyx sinensis, it is characterized in that, comprise the following steps:
Prepare prescription, after adding Gypsum Fibrosum preparata, norfloxacin, be warming up to 60 DEG C, keep 2min, near room temperature, add acetic acid, phosphoric acid, vitamin C and erythromycin, after mix homogeneously, namely make described spray agent.
CN201410617080.5A 2014-11-06 2014-11-06 Traditional Chinese medicine for treating shot-hole disease of soft-shelled turtle, and spray thereof Pending CN104398785A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213599A (en) * 2015-10-29 2016-01-06 青岛海之源智能技术有限公司 Environmental protection preparation for the treatment of angle fish head shothole disease and preparation method thereof
CN105311202A (en) * 2015-10-29 2016-02-10 青岛海之源智能技术有限公司 Feed additive for preventing perforated disease in head of angelfish and preparation method of feed additive
CN106551176A (en) * 2016-10-31 2017-04-05 通化师范学院 A kind of Chinese herbal feed additive compositionss and application thereof
CN106728440A (en) * 2017-03-06 2017-05-31 长沙瑞多康生物科技有限公司 A kind of composition for preventing and treating soft-shelled turtle shothole disease
CN106728441A (en) * 2017-03-06 2017-05-31 长沙瑞多康生物科技有限公司 A kind of composition for preventing and treating soft-shelled turtle shothole disease

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105213599A (en) * 2015-10-29 2016-01-06 青岛海之源智能技术有限公司 Environmental protection preparation for the treatment of angle fish head shothole disease and preparation method thereof
CN105311202A (en) * 2015-10-29 2016-02-10 青岛海之源智能技术有限公司 Feed additive for preventing perforated disease in head of angelfish and preparation method of feed additive
CN106551176A (en) * 2016-10-31 2017-04-05 通化师范学院 A kind of Chinese herbal feed additive compositionss and application thereof
CN106728440A (en) * 2017-03-06 2017-05-31 长沙瑞多康生物科技有限公司 A kind of composition for preventing and treating soft-shelled turtle shothole disease
CN106728441A (en) * 2017-03-06 2017-05-31 长沙瑞多康生物科技有限公司 A kind of composition for preventing and treating soft-shelled turtle shothole disease

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Application publication date: 20150311