CN105288183A - Preparation for treating depression and preparation method thereof - Google Patents
Preparation for treating depression and preparation method thereof Download PDFInfo
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- CN105288183A CN105288183A CN201510738097.0A CN201510738097A CN105288183A CN 105288183 A CN105288183 A CN 105288183A CN 201510738097 A CN201510738097 A CN 201510738097A CN 105288183 A CN105288183 A CN 105288183A
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Abstract
The invention discloses a preparation for treating depression. The preparation is prepared from the following main raw materials in parts by mass: 8-13 parts of large-leaved gentian, 5-8 parts of exocarpium, 7-11 parts of manyinflorescenced sweetvetch root, 9-13 parts of broadleaf sedge root, 4-8 parts of citron, 8-14 parts of beechey fig leaf, 7-15 parts of root and leaf of Affined Conehead, 9-14 parts of cortex lycii radicis, 6-12 parts of semen boitae, 4-10 parts of thorny elaeagnus fruit, 6-11 parts of dogwood, 8-15 parts of variegate ladyslipper herb, 6-13 parts of chokeberry and 7-12 parts of flower of Japanese glorybower. The preparation disclosed by the invention is reasonable in compatibility of medicines and excellent in medicine selection, performs treatment by ascertaining the causes, searches for the primary cause of disease in treatment, can rapidly relieve the symptoms such as wandering mind and uneasiness, is obvious in treatment effect, fundamentally relieves pain of patients, is fast in effectiveness and good in curative effect and does not have any toxic or side effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly a kind of preparation of Cure of depression and preparation method.
Background technology
Depression is also known as depressive disorder, low for main clinical characteristics with remarkable and lasting mental state, is the main Types of mood disorders.Clinical visible mental state is low unbecoming with its situation, and the downhearted of emotion can from depressed to extremely grieved, and depression of feeling oneself inferior is even pessimistic and worldweary, can have suicidal attempt or behavior; Even occur numb; Some cases have obvious anxiety and mobility intense; The psychotic symptoms such as hallucination, vain hope can be there is in severe patient.Even each outbreak continues at least 2 weeks more than, elder's several years, majority of cases has the tendency of recurrent exerbation, and each outbreak is many can be alleviated, and part can have residual symptoms or transfer to chronic.By 2011, worldwide, ahead of time, sickness rate increases the age of onset of Depressive.Lifetime prevalence is not quite similar in country variant, and have investigation display, the prevalence of China is about 6%, and the prevalence of Japan is then up to 20%.
So far, the cause of disease of depression is also unclear, but certainly, and biological, psychology and all many factors of social environment take part in the pathogenic process of depression.Biological factor relates generally to the aspect such as heredity, neural biochemistry, neuroendocrine, neuranagenesis; It is premorbid personality feature that the psychology in close relations with depression easily suffers from quality, as depressed makings.Manhood meets with irritable life events, is the important trigger condition of the paralepsy causing occurring having clinical meaning.But these factors above are not work separately, emphasize reciprocal action between nature-nurture or stressors at present and thisly interactively occur that time point has important impact in depression generating process.
In western countries, depression is a kind of prevailing mental sickness, and wherein the sickness rate of lifelong depression is between 6%-8%, and along with the progressively aging of population, the sickness rate of depression more than 60 years old in crowd is up to 20%-50%.Have 65%-80% to there will be serious suicide idea in patient, 45%-55% there will be suicide or autolesionism, and lifelong Mortality of suicide is up to 15%-25%.According to " World Health Report in 2002 " that World Health Organization (WHO) delivers, depression has become the fourth-largest illness in the world, may become be only second to cardiopathic second largest disease to the year two thousand twenty depression.Investigation display in 2012, in China, the Psychological Health Problem of the public allows of no optimist, and suffer from depression in various degree, but 90% patient does not recognize more than 2,600 ten thousand people ill.
At present, the medicine of Cure of depression is a lot, publication number CN103127467A(application number 201310078150.X) the Chinese medicine that patent document discloses a kind of Cure of depression, it is made up of following raw material medicaments: Acanthopanax brachypus 30-50 part, Caulis Polygoni Multiflori 30-50 part, Herba menyanthis 20-40 part, Herba Hyperici perforati 20-40 part, Rhodobryum roseum Limpr. 20-40 part, Fructus Akebiae 20-40 part, Coagulum Opuntiae sucus 20-40 part, Radix Platycodonis 10-20 part, Rhizoma Curcumae Longae 10-20 part, Herba Apocyni veneti 10-20 part, Periostracum Cicadae 10-20 part, Testa sojae atricolor 10-20 part, Fructus Jujubae 10-20 part.Publication number CN104095938A(application number 201410379705.9) the Mongolian medicinal preparation that patent document discloses a kind of Cure of depression, said preparation is any clinical acceptable dosage form be made up according to a conventional method of the crude drug of following weight parts: Syringa pinnatifolia Hemsl. 10-14 part, Fructus Choerospondiatis 8-12 part, Semen Myristicae 8-12 part, Radix Angelicae Sinensis 6-10 part, Flos Carthami 6-10 part, Flos Caryophylli 2-6 part, Fructus Piperis Longi 2-4 part.Publication number CN104606609A(application number 201510064445.0) the Chinese medicine preparation that patent document discloses a kind of Cure of depression, be made up of the raw material of Chinese medicine of following weight portion: cyperus iria L. rhizoma scirpi 20-45 part, Rhodiola dumulosa 10-15 part, Herba Pugionii Cornuti 25-40 part, Passiflora edulis sims 5-15 part, Adeps Bovis seu Bubali 10-25 part, SANYE Rhizoma et radix valerianae 20-30 part, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) 5-15 part, Fructus Hedychii Spicati 8-20 part, Poria 40-65 part, Massa Medicata Fermentata 40-60 part, Radix Scrophulariae 10-30 part, Fructus Alpiniae Oxyphyllae 30-45 part, Fructus Musae 40-60 part, Radix Glycyrrhizae 45-60 part.
The Therapeutic Method of current depression is a lot, and as psychotherapy, sleep deprivation treatment, phototherapy and electric convulsive treatment etc., but the present age is still based on Drug therapy, and psychotherapy is auxiliary.The medicines such as doctor trained in Western medicine many employings resist melancholy agent, tranquilizer, sleeping pill, psychosis, therapeutic effect is obvious, instant effect, but side effect is large, there is certain dependency, expensive, and ignore the treatment of depression cause of disease old complaint, treatment often only rests on surface, can not tackle the problem at its root.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of preparation of Cure of depression, invention formulation compatibility rationally, select YAOJING good, examine thus control, treatment must aim at the pathogenesis of disease, can alleviate absentminded rapidly, the symptoms such as malaise, therapeutic effect is remarkable, fundamentally relieve the misery of patient, instant effect, curative effect be high, have no side effect.Another object of the present invention is just to provide the preparation method of the preparation of above-mentioned a kind of Cure of depression.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A preparation for Cure of depression, takes off the primary raw material stating quality proportioning and is prepared from: Radix Gentianae Macrophyllae 8-13 part; Exocarpium Citri Grandis 5-8 part; Radix Hedysari 7-11 part; Radix caricis siderostictae 9-13 part; Fructus Citri 4-8 part; Caulis et Folium Fici beecheyanae 8-14 part; Strobilanthes aehobarbus W. W. Smith 7-15 part; Cortex Lycii 9-14 part; Semen Platycladi 6-12 part; Fructus Elaeagni 4-10 part; Fructus Corni 6-11 part; Herba Cyperipedii Margaritacei 8-15 part; Sorbus domestica 6-13 part; Flos clerodendri japonici 7-12 part.
A preparation for Cure of depression, preferred scheme is, takes off the primary raw material stating quality proportioning and is prepared from: Radix Gentianae Macrophyllae 10-12 part; Exocarpium Citri Grandis 6-7 part; Radix Hedysari 8-10 part; Radix caricis siderostictae 10-12 part; Fructus Citri 5-7 part; Caulis et Folium Fici beecheyanae 10-12 part; Strobilanthes aehobarbus W. W. Smith 10-12 part; Cortex Lycii 11-13 part; Semen Platycladi 8-10 part; Fructus Elaeagni 6-8 part; Fructus Corni 8-10 part; Herba Cyperipedii Margaritacei 11-13 part; Sorbus domestica 9-11 part; Flos clerodendri japonici 9-11 part.
A preparation for Cure of depression, the scheme be more preferably is, takes off the primary raw material stating quality proportioning and is prepared from
:radix Gentianae Macrophyllae 11 parts; Exocarpium Citri Grandis 6.5 parts; Radix Hedysari 9 parts; Radix caricis siderostictae 11 parts; Fructus Citri 6 parts; Caulis et Folium Fici beecheyanae 11 parts; Strobilanthes aehobarbus W. W. Smith 11 parts; Cortex Lycii 12 parts; Semen Platycladi 9 parts; Fructus Elaeagni 7 parts; Fructus Corni 9 parts; Herba Cyperipedii Margaritacei 12 parts; Sorbus domestica 10 parts; Flos clerodendri japonici 10 parts.
Present invention also offers the preparation method preparation of above-mentioned a kind of Cure of depression being made pharmaceutically acceptable powder, decoction, pill, tablet and granule.
The preparation method of the preparation powder of described a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass doubly, the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in step (2) gained concentrated solution, stir, dry, add step (1) gains, mixing, pulverize, cross 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) by step (3)-(4) gained medicated powder mix homogeneously, sterile packaged.
Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 15 days courses for the treatment of by the warm waters of about 50 DEG C.
The preparation method of the preparation decoction of described a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add the rice wine of 30o-40o, moistening 3-5 days, take out, dry, smash, cross 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 40-50 minute, filter, add step (1) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, add step (4) gained medicated powder, mixing, filters, adds step (2) gained concentrated solution, mixing, sterile packaged.
The preparation method of the preparation decoction of above-mentioned a kind of Cure of depression, the consumption of the preferred rice wine of step (3) is 3-5 times of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass, and the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times.
Instructions of taking: each 50-80ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 15 days courses for the treatment of.
The preparation method of the preparation pill of described a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass doubly, the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 40-50 minute, filter, add step (1) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 10-15 ball, every day 3 times, 15 days courses for the treatment of.
The preparation method of the formulation tablet of described a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass doubly, the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 40-50 minute, filter, add step (1) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, add step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2, every day 3 times, 15 days courses for the treatment of.
The preparation method of the preparation granules agent of described a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass doubly, the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 40-50 minute, filter, add step (1) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, add step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, being concentrated into relative density is 1.10.-1.20(40 DEG C) thick paste, add simple syrup, mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
The preparation method of the preparation granules agent of above-mentioned a kind of Cure of depression, the consumption of the preferred simple syrup of step (4) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
Instructions of taking: each 1 bag, every day 3 times, 15 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, invention formulation compatibility rationally, select YAOJING good, examine thus control, treatment must aim at the pathogenesis of disease, can alleviate absentminded rapidly, the symptoms such as malaise, therapeutic effect is remarkable, fundamentally relieves the misery of patient, and instant effect, curative effect be high, have no side effect.
2, invention formulation selected materials great majority are Chinese medicine material, not containing hormone, are rich in the elite of Chinese medicine, giving consideration to both the incidental and fundamental, special effect, and healing anti-mental disorder effect is good.
3, invention formulation have calm the nerves relieving convulsion, resolving depression is had one's ideas straightened out, effect of liver-smoothing, qi-regulating, adjustment QI and blood, Yin Yang balancing, good effect, cure rate is high, without recurrence, treating both the principal and secondary aspects of a disease, curative effect highly significant, generally takes medicine and just can take effect for 5-7 days.
4, invention formulation not only can effectively activate brain autoimmune function and produce large number of biological active substance, cerebral cortex is made to enter rapidly loose mental sickness relaxation state, and can brain blood circulation be improved, improve oxygen content of blood, rapid alleviation brain is tired, correct disorderly brain function, recover the normal propagation of cerebral neuron.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1a preparation for Cure of depression, takes off the primary raw material stating weight proportion and is prepared from (getting 80g for every part): Radix Gentianae Macrophyllae 8 parts; Exocarpium Citri Grandis 5 parts; Radix Hedysari 7 parts; Radix caricis siderostictae 9 parts; Fructus Citri 4 parts; Caulis et Folium Fici beecheyanae 8 parts; Strobilanthes aehobarbus W. W. Smith 7 parts; Cortex Lycii 9 parts; Semen Platycladi 6 parts; Fructus Elaeagni 4 parts; Fructus Corni 6 parts; Herba Cyperipedii Margaritacei 8 parts; Sorbus domestica 6 parts; Flos clerodendri japonici 7 parts.
The preparation method of the preparation powder of above-mentioned a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 55 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 6 times amount quality of medicinal materials, extract 2 times, each extraction 50 minutes, by extracting solution sucking filtration, discards filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add the rice wine (consumption is 4 times of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass) of 35o, moistening 4 days, take out, dry, smash, cross 140 mesh sieves;
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in step (2) gained concentrated solution, stir, dry, add step (1) gains, mixing, pulverize, cross 140 mesh sieves;
(5) by step (3)-(4) gained medicated powder mix homogeneously, sterile packaged.
Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 15 days courses for the treatment of by the warm waters of about 50 DEG C.
embodiment 2a preparation for Cure of depression, takes off the primary raw material stating weight proportion and is prepared from (every part of 20g): Radix Gentianae Macrophyllae 13 parts; Exocarpium Citri Grandis 8 parts; Radix Hedysari 11 parts; Radix caricis siderostictae 13 parts; Fructus Citri 8 parts; Caulis et Folium Fici beecheyanae 14 parts; Strobilanthes aehobarbus W. W. Smith 15 parts; Cortex Lycii 14 parts; Semen Platycladi 12 parts; Fructus Elaeagni 10 parts; Fructus Corni 11 parts; Herba Cyperipedii Margaritacei 15 parts; Sorbus domestica 13 parts; Flos clerodendri japonici 12 parts.
The preparation method of the preparation decoction of above-mentioned a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 55 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 6 times amount quality of medicinal materials, extract 2 times, each extraction 50 minutes, by extracting solution sucking filtration, discards filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add the rice wine (consumption is 4 times of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass) of 35o, moistening 4 days, take out, dry, smash, cross 140 mesh sieves;
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 45 minutes, filter, add step (1) gains, add water and continue decoction 35 minutes, filter, merging filtrate, add step (4) gained medicated powder, mixing, filters, adds step (2) gained concentrated solution, mixing, sterile packaged.
Instructions of taking: each 70ml, every day 3 times, 15 days courses for the treatment of.
model case onewhat XX, female, 37 years old, people from Linyi.Mrs's He dedication is strong, and afterwards because of work contradiction, cause psychical conflict, just occur insomnia afterwards, metal fatigue, self-induction hypomnesis, brain is unintelligible, and emotion is passionnate, and himself is also very worried.The state of an illness increases the weight of gradually, frequent all night, often there is palpitation and short breath, uncomfortable in chest, myasthenia of limbs in sleeplessness, even sore waist and aching in the waist and the back, informal dress sleeping pill, controls cardiopathic medicine etc., and effect is bad, so remove examination in hospital, last diagnostic is depression, and Mrs He feels very painful, is not improved after treating a wheat harvesting period.
After taking 2 courses for the treatment of of preparation decoction (embodiment 2) of a kind of Cure of depression of the present invention, nervously uncomfortable in chestly to take a turn for the better to some extent, anxiety makes moderate progress.Continue to take transference cure after 1 course for the treatment of, emotion is steady.Later stage follows up a case by regular visits to and learns and be emotionally stable, and again do not occur obvious anxious state of mind, the state of an illness is not more repeatedly.Recover good, can normally go to work.
embodiment 3a preparation for Cure of depression, takes off the primary raw material stating weight proportion and is prepared from (getting 50g for every part): Radix Gentianae Macrophyllae 10 parts; Exocarpium Citri Grandis 6 parts; Radix Hedysari 8 parts; Radix caricis siderostictae 10 parts; Fructus Citri 5 parts; Caulis et Folium Fici beecheyanae 10 parts; Strobilanthes aehobarbus W. W. Smith 10 parts; Cortex Lycii 11 parts; Semen Platycladi 8 parts; Fructus Elaeagni 6 parts; Fructus Corni 8 parts; Herba Cyperipedii Margaritacei 11 parts; Sorbus domestica 9 parts; Flos clerodendri japonici 9 parts.
The preparation method of the preparation pill of above-mentioned a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 55 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 6 times amount quality of medicinal materials, extract 2 times, each extraction 50 minutes, by extracting solution sucking filtration, discards filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add the rice wine (consumption is 4 times of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass) of 35o, moistening 4 days, take out, dry, smash, cross 140 mesh sieves;
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 45 minutes, filter, add step (1) gains, add water and continue decoction 35 minutes, filter, merging filtrate, add step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, being condensed into relative density is 1.20(40 DEG C) thick paste, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 15 days courses for the treatment of.
embodiment 4a preparation for Cure of depression, takes off the primary raw material stating weight proportion and is prepared from (getting 35g for every part): Radix Gentianae Macrophyllae 12 parts; Exocarpium Citri Grandis 7 parts; Radix Hedysari 10 parts; Radix caricis siderostictae 12 parts; Fructus Citri 7 parts; Caulis et Folium Fici beecheyanae 12 parts; Strobilanthes aehobarbus W. W. Smith 12 parts; Cortex Lycii 13 parts; Semen Platycladi 10 parts; Fructus Elaeagni 8 parts; Fructus Corni 10 parts; Herba Cyperipedii Margaritacei 13 parts; Sorbus domestica 11 parts; Flos clerodendri japonici 11 parts.
The preparation method of the formulation tablet of above-mentioned a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 55 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 6 times amount quality of medicinal materials, extract 2 times, each extraction 50 minutes, by extracting solution sucking filtration, discards filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add the rice wine (consumption is 4 times of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass) of 35o, moistening 4 days, take out, dry, smash, cross 140 mesh sieves;
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 45 minutes, filter, add step (1) gains, add water and continue decoction 35 minutes, filter, merging filtrate, add step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, being condensed into relative density is 1.20(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 15 days courses for the treatment of.
model case twoyu XX, man, 29 years old, people from Yantai City.Mr. Yu is not so good from little health, short-tempered, is easy to get angry because of some minor matters, graduates from university after working, and oneself sensation and people get along difficult, and have a hunch that oneself is so good to others, others is but hypocritical and malignant.In the course of time, even dare not speak in public occasion, uneasy from head to foot, speak not agile.And gradually his sleep quality is also very bad, often insomnia whole night, and after getting up morning nervous unable, the mental status is very poor.Go examination in hospital to be diagnosed as depression, Multiple Hospitalization is treated, and be all remission at that time, but symptom can recur in time running into unhappy thing.
After taking 2 courses for the treatment of of preparation (embodiment 4) of a kind of Cure of depression of the present invention, symptom obviously alleviates, and suspicious symptom is obviously alleviated, and the symptoms such as insomnia, spirit difference are also obviously alleviated.So after continuing to take 2 courses for the treatment of, all malaise symptoms disappear.Follow up a case by regular visits to 1 year state always better, also do not recur, and temper is obviously got well a lot.
embodiment 5a preparation for Cure of depression, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Radix Gentianae Macrophyllae 11 parts; Exocarpium Citri Grandis 6.5 parts; Radix Hedysari 9 parts; Radix caricis siderostictae 11 parts; Fructus Citri 6 parts; Caulis et Folium Fici beecheyanae 11 parts; Strobilanthes aehobarbus W. W. Smith 11 parts; Cortex Lycii 12 parts; Semen Platycladi 9 parts; Fructus Elaeagni 7 parts; Fructus Corni 9 parts; Herba Cyperipedii Margaritacei 12 parts; Sorbus domestica 10 parts; Flos clerodendri japonici 10 parts.
The preparation method of the preparation granules agent of above-mentioned a kind of Cure of depression, step is as follows:
(1) refined honey is added the boiled water dilution of 55 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 6 times amount quality of medicinal materials, extract 2 times, each extraction 50 minutes, by extracting solution sucking filtration, discards filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add the rice wine (consumption is 4 times of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass) of 35o, moistening 4 days, take out, dry, smash, cross 140 mesh sieves;
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 45 minutes, filter, add step (1) gains, add water and continue decoction 35 minutes, filter, merging filtrate, add step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, being concentrated into relative density is 1.15(40 DEG C) thick paste, add simple syrup (consumption is 6% of thick paste quality), mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 15 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Gentianae Macrophyllae: acrid in the mouth, hardship, property is put down.Return stomach, liver, gallbladder meridian.For the dry root of gentianaceae plant Radix Gentianae Macrophyllae, gentiana straminea maxim, gentiana crassicaulis Duthie or Gentiana dahurica.There is wind-damp dispelling, clearing away damp-heat, effect of stopping numbness pain.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, and day feeds hectic fever, and infantile malnutrition generates heat.
Exocarpium Citri Grandis: bitter in the mouth, pungent, warm in nature.Return spleen, lung meridian.For immaturity or the maturescent outside rind of rutaceae Citrus grandis or Fructus Citri grandis.There is drying dampness to eliminate phlegm, regulate the flow of vital energy, the effect helped digestion.For wind and cold cough with asthma abundant expectoration, vomiting singultus, accumulation of food in the stomach and intes tine due to indigestion, abdominal distention.
Radix Hedysari: sweet in the mouth, warm in nature.Return lung, spleen channel.For the dry root of leguminous plant Hedysarum polybotrys Hand.-Mazz..There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, lack of appetite is just clear, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, and carbuncle difficulty is burst, blood deficiency and yellow complexion, and interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix caricis siderostictae: sweet in the mouth, pungent, warm in nature.Return lung, liver, kidney channel.For the root of sedge sesame leaf sedge.There is benefiting QI and nourishing blood, effect of promoting blood flow to regulate menstruation.For deficient qi and blood, lassitude, palpitation and insomnia, menoxenia, amenorrhea.
Fructus Citri: acrid in the mouth, hardship, acid, warm in nature.Return liver, spleen, lung meridian.For rutaceae structure rafter or fragrant round dry mature fruit.There is liver-smoothing, qi-regulating, alleviating distention in middle-JIAO, the effect of reducing phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavity abdomen feeling of fullness, vomits addicted to gas, and abundant expectoration is coughed.
Caulis et Folium Fici beecheyanae: sweet in the mouth, light, warm in nature.Return lung, spleen, kidney three warp.For stem, the leaf of moraceae plants Fructus Fici Beecheyanae.There is invigorating the spleen and replenishing QI, invigorating the spleen for eliminating dampness, bone and muscle strengthening, detumescence, effect of promoting blood circulation and detoxication.For rheumatic arthritis, the middle deficiency of vital energy is weak, and QI and blood is on the decline, and extremity are aching and limp, stiffness of the muscle and joint, traumatic injury, amenorrhea, galactostasis.
Strobilanthes aehobarbus W. W. Smith: lightly seasoned, micro-hardship, property is put down.GUIXIN, lung, Liver Channel.For root and the leaf of the purple cloud dish of acanthaceous plant capillary copper.There is liver heat removing dampness removing, effect of promoting blood circulation to remove blood stasis.For jaundice due to damp-heat, conjunctival congestion and swelling pain, menoxenia, puerperal abdonimal pain.
Cortex Lycii: sweet in the mouth, cold in nature.Return lung, liver, kidney channel.For the dry root bark of matrimony vine of solanaceae plant or lycium barbarum.There is removing heat from blood except steaming, effect of lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat is quenched one's thirst.
Semen Platycladi: sweet in the mouth, property is put down.GUIXIN, kidney, large intestine channel.For the dry mature kernal of Cupressaceae plant Cacumen Platycladi.There is tranquilizing by nourishing the heart, hidroschesis, effect of intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
Fructus Elaeagni: sour in the mouth, puckery, property is put down.Return lung, stomach, large intestine channel.For the fruit of Elaeangnaceae plant Fructus Elaeagni.There is astringing to arrest diarrhea, strengthening the spleen to promote digestion, relieving cough and asthma, effect of hemostasis.For having loose bowels, dysentery, inappetence, dyspepsia, cough and asthma, metrorrhagia, hemorrhoid hematochezia.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.For the drying and ripening sarcocarp of Fructus Corni English section plant Fructus Corni.There is liver and kidney tonifying, effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, sun is passed out semen repeatly, enuresis frequent micturition, bleeding not during menses, and profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Herba Cyperipedii Margaritacei: sweet in the mouth, slightly warm in nature.Return lung, kidney, urinary bladder channel.For the herb of orchid variegated leaf lady's slipper.There is tonifying liver improving eyesight, effect of promoting blood flow to regulate menstruation.Eyeball is hidden, blurred vision, nyctalopia, rheumatic numbness, menoxenia for nebula.
Sorbus domestica: sweet in the mouth, hardship, property is put down.Return lung, spleen channel.For the fruit of Rosaceae Sorbus plant flowers Chinese catalpa.There is relieving cough and resolving phlegm, effect of invigorating spleen for diuresis.For cough, asthma, insufficiency of the spleen edema, gastritis.
Flos clerodendri japonici: sweet in the mouth, property is put down.Return spleen channel.For the flower of Verenaceae Zhi Wu Cheng paulownia.Have and calm the nerves, effect of hemostasis.For palpitation and insomnia, bleeding hemorrhoids.
test examplein order to verify the curative effect of the preparation of a kind of Cure of depression of the present invention, We conducted contrast test.Experiment sieving patients with depression 200 people, is divided into matched group and experimental group randomly, and wherein experimental group has 150 people, and matched group has 50 people.
Diagnostic criteria: 1. depressed: lose interest to daily routines, loses happy sense, has a worried look all day, anxiously, even pessimistic desperate; Severe patient is filled with despair helpless, and thinking lives does not look like.2. retardation of thinking: conscious brain is bad to be made, and does not remember thing, and ponder a problem difficulty.Patient feel brain absolutely empty, become stupid.3. to move suppression: do not like activity, feel lazy from head to foot.Walk slowly, speech is few.Serious may not eating is motionless, can't take care of oneself.4. somatization: have no appetite, also there is various problem in sleep, gradually can become weak, tired.
Exclusion standard: the age is at under-18s or over-65s; To drug allergy person; Merge gouty nephropathy, renal insufficiency person; Merge severe primary disease and the insanes such as the heart, liver, kidney, brain and hemopoietic system; Curative effect or data not congruent affect the treatment evaluation or safety judgement person cannot be judged.
Experimental group: the preparation granules agent (embodiment 5) of taking a kind of Cure of depression of the present invention, each 1 bag, every day 3 times, 15 days courses for the treatment of.Matched group: adopt other treatment scheme, such as fluoxetine hydrochloride capsules, proxetine hydrochloride tablets, wherein fluoxetine hydrochloride capsules, generally only need once oral 20mg every morning, can add to 40mg every day if desired, dosage and the course for the treatment of follow the doctor's advice.Proxetine hydrochloride tablets, oral, a 20mg, 1 time on the one.
Criterion of therapeutical effect: cure: mental state and emotion are normally, resourceful, normally, somatization disappears, and can adapt to daily life work completely for diet, sleep.Effective: mental state and emotion are clearly better, anxiety reduces, and self evaluation increases, and diet, sleeps normal, substantially can adapt to daily life.Invalid: symptom is not improved.
The Comparison of therapeutic of matched group and experimental group, concrete condition is as shown in table 1:
Table 1
As can be seen from Table 1, take the cure rate of the preparation of a kind of Cure of depression of the present invention up to 72.67%, effective percentage is up to 96.67%; And the cure rate taking other drug only 38%, effective percentage also only has 78%, and inefficiency is up to 22%.So the successful of the preparation of a kind of Cure of depression of the present invention is better than the effect of other drug.
Use HAMD (HAMD scale) and Self-rating depression scale (SDS scale) to evaluate depressive state, according to HAMD Measuring scale assessing, the state of an illness is lighter, and total score is lower; The state of an illness is heavier, and total score is higher, and wherein total score is more than 35 points, may be major depression; More than 20 points, it may be the depression of light or medium degree; If be less than 8 points, patient does not just have depressive symptom.According to SDS Measuring scale assessing, index range is 0.25-1.0, and index is higher, and Degree of Depression is heavier.SDS Scoring Index person below 0.5 is without depressed; 0.50-0.59 is slight to minor depressive; 0.60-0.69 be in severe depression; More than 0.70 is severe depression.
HAMD scoring before and after statistical experiment group and treatment of control group, SDS scoring is compared in table 2, HAMD scoring before and after treatment, SDS scoring is compared, and difference all has significant (p < 0.05).
Table 2: two groups of rear HAMD scorings before the treatment, SDS scoring is compared
Can find out, originally the HAMD of experimental group and matched group marks (average mark) and SDS scoring (average mark) no significant difference, and the HAMD after treatment marks (average mark) and SDS marks, and (average mark) diversity is comparatively large, can find out that the curative effect of experimental group is obviously better than the curative effect of matched group.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. a preparation for Cure of depression, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Radix Gentianae Macrophyllae 8-13 part; Exocarpium Citri Grandis 5-8 part; Radix Hedysari 7-11 part; Radix caricis siderostictae 9-13 part; Fructus Citri 4-8 part; Caulis et Folium Fici beecheyanae 8-14 part; Strobilanthes aehobarbus W. W. Smith 7-15 part; Cortex Lycii 9-14 part; Semen Platycladi 6-12 part; Fructus Elaeagni 4-10 part; Fructus Corni 6-11 part; Herba Cyperipedii Margaritacei 8-15 part; Sorbus domestica 6-13 part; Flos clerodendri japonici 7-12 part.
2. preparation according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Radix Gentianae Macrophyllae 10-12 part; Exocarpium Citri Grandis 6-7 part; Radix Hedysari 8-10 part; Radix caricis siderostictae 10-12 part; Fructus Citri 5-7 part; Caulis et Folium Fici beecheyanae 10-12 part; Strobilanthes aehobarbus W. W. Smith 10-12 part; Cortex Lycii 11-13 part; Semen Platycladi 8-10 part; Fructus Elaeagni 6-8 part; Fructus Corni 8-10 part; Herba Cyperipedii Margaritacei 11-13 part; Sorbus domestica 9-11 part; Flos clerodendri japonici 9-11 part.
3. preparation according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Radix Gentianae Macrophyllae 11 parts; Exocarpium Citri Grandis 6.5 parts; Radix Hedysari 9 parts; Radix caricis siderostictae 11 parts; Fructus Citri 6 parts; Caulis et Folium Fici beecheyanae 11 parts; Strobilanthes aehobarbus W. W. Smith 11 parts; Cortex Lycii 12 parts; Semen Platycladi 9 parts; Fructus Elaeagni 7 parts; Fructus Corni 9 parts; Herba Cyperipedii Margaritacei 12 parts; Sorbus domestica 10 parts; Flos clerodendri japonici 10 parts.
4., according to the arbitrary described preparation of claim 1-3, it is characterized in that, the preparation method of described powder, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass doubly, the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in step (2) gained concentrated solution, stir, dry, add step (1) gains, mixing, pulverize, cross 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) by step (3)-(4) gained medicated powder mix homogeneously, sterile packaged.
5., according to the arbitrary described preparation of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add the rice wine of 30o-40o, moistening 3-5 days, take out, dry, smash, cross 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 40-50 minute, filter, add step (1) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, add step (4) gained medicated powder, mixing, filters, adds step (2) gained concentrated solution, mixing, sterile packaged.
6. the preparation method of preparation according to claim 5, it is characterized in that: the consumption of the preferred rice wine of step (3) is 3-5 times of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass, and the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times.
7., according to the arbitrary described preparation of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass doubly, the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 40-50 minute, filter, add step (1) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, is condensed into the thick paste that relative density is 1.10-1.30, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
8., according to the arbitrary described preparation of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass doubly, the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 40-50 minute, filter, add step (1) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, add step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, is condensed into the thick paste that relative density is 1.10-1.30, makes tablet.
9., according to the arbitrary described preparation of claim 1-3, it is characterized in that, the preparation method of described granule, step is as follows:
(1) refined honey is added the boiled water dilution of 50-60 DEG C, put in pot, moderate heat heats, after sweet liquid boils, drop into Radix Hedysari, stirs evenly, fries to liquid dry loose tack-free in buff, takes out, airing;
(2) Radix Gentianae Macrophyllae, Fructus Citri, Semen Platycladi, Fructus Elaeagni and Fructus Corni are smashed, be placed in extraction pot, add the water of 4-8 times amount quality of medicinal material, extract 2 times, each extraction 40-60 minute, by extracting solution sucking filtration, discard filtering residue, merge extractive liquid, at 60 DEG C of reduced under vacuum to original volume 1/2, obtains concentrated solution;
(3) Radix caricis siderostictae is cut into slices, be placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass doubly, the consumption being more preferably rice wine is Exocarpium Citri Grandis, Cortex Lycii and Sorbus domestica gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 130-150 mesh sieve (preferred 136-144 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Caulis et Folium Fici beecheyanae, Strobilanthes aehobarbus W. W. Smith, Herba Cyperipedii Margaritacei and Flos clerodendri japonici are placed in marmite, decoct with water 40-50 minute, filter, add step (1) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, add step (4) gained medicated powder, mixing, filter, add step (2) gained concentrated solution, mixing, is concentrated into the thick paste that relative density is 1.10.-1.20, adds simple syrup, mixing, make uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
10. the preparation method of preparation according to claim 9, is characterized in that: the consumption of the preferred simple syrup of step (4) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
Priority Applications (1)
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| CN101327296A (en) * | 2008-07-23 | 2008-12-24 | 武汉理工大学 | Compound Chinese medicine preparation for treating and improving insomnia and preparation method thereof |
| CN101549054A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Pharmaceutical composition for safely and effectively treating insomnia and preparation method thereof |
| CN104173933A (en) * | 2014-08-25 | 2014-12-03 | 王浩 | Traditional Chinese medicine composition for treating depressive disorder |
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| CN104800282A (en) * | 2015-05-05 | 2015-07-29 | 张远强 | Medicine combination for treating depression and preparation method thereof |
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| CN101549054A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Pharmaceutical composition for safely and effectively treating insomnia and preparation method thereof |
| CN101327296A (en) * | 2008-07-23 | 2008-12-24 | 武汉理工大学 | Compound Chinese medicine preparation for treating and improving insomnia and preparation method thereof |
| CN104689096A (en) * | 2013-12-09 | 2015-06-10 | 青岛百草汇中草药研究所 | Depressive neurosis treating traditional Chinese medicine composition |
| CN104173933A (en) * | 2014-08-25 | 2014-12-03 | 王浩 | Traditional Chinese medicine composition for treating depressive disorder |
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