CN105287943A - Compound fructus cannabis capsules, preparation method and applications thereof - Google Patents
Compound fructus cannabis capsules, preparation method and applications thereof Download PDFInfo
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Abstract
The present invention discloses compound fructus cannabis capsules and a preparation method thereof, wherein the compound fructus cannabis capsules are mainly prepared from the following raw materials by weight: 500-1000 parts of fructus cannabis, 500-1000 parts of marine microalgae, 500-1000 parts of ganoderma lucidum, 250-500 parts of camellia nitidissima leaf, 100-200 parts of camellia nitidissima flower, 25-50 parts of camellia nitidissima seeds, 500-1000 parts of black grape, 50-100 parts of walnut meat, 50-100 parts of Chinese Wolfberry, and 500-1000 parts of red date. According to the present invention, the compound fructus cannabis capsules have characteristics of fine formula selection and essence concentration, have effects of significant memory improvement and the like, are main used for preventing and treating hypomnesis, dysmnesia and Alzheimer disease, can further be used for preventing and treating Parkinson's disease, cardiovascular and cerebrovascular diseases, and malignant tumors caused by cerebrovascular diseases, anti-aging, and the like, and can further be used for memory enhancing, learning ability enhancing, intelligence enhancing and body constitution enhancing of teenagers or healthy people.
Description
Technical field
The invention belongs to herbal mixture health product application.More particularly, the present invention relates to a kind of compound recipe Fructus Cannabis preparation being applied to Improving memory power and senile dementia prevention and cure.
Background technology
The pathological change of senile dementia (AlzheimerDisease, also known as Alzheimer) is cerebral cortical atrophy, and Cortical neurons reduces, a large amount of neurofibrillary tangle and senile plaque in cerebral cortex and Hippocampus.Think that forming senile plaque main component is beta amyloid peptide (β-amyloidpeptide is abbreviated as A β or β A) at present.Senile dementia is a kind of chronic degenerative brain degenerative disease betiding geratic period or presenium, slowly to develop the neuropsychic symptom such as cognitive dysfunction and abnormality of personality in various degree such as dysmnesia, disorientation, language function obstacle for feature.Senile dementia can be caused by cerebral degeneration's disease, intracranial infection or the factor such as occupying lesion, cerebrovascular, hypoxia and anoxemia, craniocerebral trauma, metabolic disease.Vascular dementia (VD) refers to that what caused by various cerebrovascular disease take cognitive dysfunction as the dementia syndrome of feature, is one of most common type of senile dementia.
Dysmnesia are that multiple encephalopathy such as senile dementia, vascular dementia have symptom, and incidence rate is high.Hypomnesis is the Cerebral pathology phenomenon caused by many factors, and main cause occurs for it is brain fag and cerebral anoxia.Brain works overloadingly for a long time, the minimizing of neurotransmitter synthesis secretion has influence on information transmission speed and quality, cause dysmnesia, cerebral anoxia causes brain micro-circulation speed to slow down, the metabolism rubbish such as nutrient substance can not be fully oxidized, free radical precipitate, and neurocyte hypoxic-ischemic state causes the acute or chronic injury of neurocyte, affect cerebral neuron activity and response speed, cause memory path not smooth, thinking is obstructed, and the knowledge be accumulated in human brain cannot be extracted and apply at short notice.With age, middle-aged and elderly people cerebrum metabolism slows down, and blood supply is for hypoxgia, and hypomnesis is obvious, may develop into senile dementia.Improving memory research contributes to multiple cerebropathy therapeutic.
Fructus Cannabis is the dry mature fruit of moraceae plants Fructus Cannabis CannabissativaL., and distinguish from source, Urtica cannabina L. is divided into two kinds: one to be that Original plant ganja is grown on temperate zone or tropical climate, toxic; Two is China's bar horse Urtica cannabina L. in the township being derived from world's longevity, and be the peculiar economic plants of China, Guangxi Zhuang Autonomous Region is one of Urtica cannabina L. main product ground, and Ba Ma county of Hechi Prefecture, Donglan County, Fengshan County as edible oil, think secret to longevity using it.Hemp seed oil forms primarily of unsaturated fatty acid, main active is bifurcation-linolenic acid, in the hemp seed oil of the bar horse place of production, its content is more than 15%, be essential fatty acid, have fat-reducing effect, the energy and energy can also be provided to brain, be considered to the optimisation substance that nutrient is provided to brain, improve people's intelligence, prevention brain atrophy, reduce senile dementia and occur.
China's marine microalgae aboundresources, marine microalgae represents wide application prospect in health food, medicine, feedstuff, cosmetics, biological pesticide, waste water control etc.The higher kind of industrialization level is mainly: chlorella (Chlorella), spirulina (Spirulina) and salt alga (Dunaliella).Algae oil is a kind of natural ω of being rich in-3 extracted from marine microalgae is polyunsaturated fatty acid (PUFA), to nervus centralis and retinal development and maintain normal physiological function and play an important role, mainly comprise docosahexenoic acid (DHA) and clupanodonic acid (DPA) etc.In human body, DHA is mainly present in phospholipid form in the film phosphatidyl ethanolamine of central nervous system cell (as large brain synaptosome cell) and retina cell (as retinal light injury photoreceptor), accounts for about 10% of human brain fat.DHA lack cause offspring born after grow that delayed, neurotransmission extends, cognitive and memory ability declines.Squalene has another name called zamene, squalene, a kind of unsaturated hydrocarbons compounds useful to health, there are the functions such as blood circulation promoting, activation equipment somatic cell, antioxidation, anti-inflammation and sterilization, cytothesis, for various ischemic disease, heart disease, hepatitis and prevention and control of cancer.In algae oil, Squalene content is no less than the average content of the olive oil of Squalene content in plant source oils and fats.Squalene is mainly derived from deepwater shark liver oil, but containing the eicosapentaenoic acid (EPA) that infant can be suppressed to grow in a large number in fish oil, and in the algae oil of ocean, EPA content is very low, is applicable to different crowd long-term taking.Algae oil promotes that Infant and adolescent intelligent development and prevention middle-aged and elderly people cardiovascular and cerebrovascular disease are better than fish oil.
Ganoderma spore oil contains 18 kinds of fatty acid compositions, comprises unsaturated fatty acid, satisfied fatty acid, loop chain fatty acid etc.Ganoderma spore oil can be protected the neuron of damaged thus slow down parkinson disease pathological changes process.This prompting Ganoderma and Ganoderma spore oil may contribute to cerebral neuron growth, grow.
Camellia nitidissima Chi (Camelliachrysantha) is Theaceae (Theaceae) Camellia (Camellia) Sectio Chrysantha (sect.Chrysantha) plant, is mainly distributed in Guangxi.Camellia nitidissima Chi contains flavonoid, tea polyphenols, tea polysaccharide, saponins and various trace elements and vitamin etc.Camellia nitidissima Chi water extract has antibacterial, antianaphylaxis, Tumor suppression growth, defying age, antioxidant activity, enhancing human body immunity function, reduces the functions such as cholesterol, blood pressure lowering, reduction metabolism syndrome.Contained Quercetin reduces blood pressure, strengthen capillary resistance, reduce capillary fragility, blood fat reducing, coronary artery dilator, increases the effects such as coronary flow.Quercetin effectively can suppress Cu
2+the amyloid beta Segment A β 1 ~ 40 of induction assembles, to established Cu
2+-A β 1 ~ 40 aggregation has obvious depolymerisation, effectively prevents Cu
2+decline with the SH-SY5Y cell viability that A β 1 ~ 40 induces jointly, Quercetin has potential preventive and therapeutic effect to senile dementia.
Black Grape rich in mineral substances calcium, potassium, phosphorus, ferrum and vitamin B1, B2, B6, C etc., multiple amino acid needed by human body, colors, as: procyanidin, chlorophyll etc., resveratrol etc.Colors has very strong anti-oxidation, and vitamin C increases resistance of human body.The content of mineral substances such as potassium, magnesium, calcium are also higher than common fruit, most important to the ionic equilibrium maintaining human body.In Pericarpium Vitis viniferae, Resveratrol content is higher, can reach 50 ~ 100mg/kg.Resveratrol chemistry (E)-3 by name, 5,4-trihydroxy stilbene, being that vine produces a kind of phytoalexin to resist mycete invasion, retaining in Pericarpium Vitis viniferae after generation, having obvious preventive effect to hormone-dependent tumor, also can there is preventive effect to osteoporosis, acne and senile dementia, there are antiviral and immunoregulation effect, monomer defying age enzyme a kind of in human body is worked, play the various age-related disease of prevention, extend the latent effect of life expectancy.
The Semen Juglandis traditional Chinese medical science is widely used, warm in nature, sweet in the mouth, nontoxic, stomach invigorating, enriches blood, lung moistening, to repose.Semen Juglandis benefiting qi and nourishing blood, moistening the lung and resolving the phlegm, the beneficial gate of vitality, place three is burnt, and warming the lung intestine moistening, controls deficiency and coldness and breath with cough, and waist foot heavily aches, trusted subordinate's colic, dysentery hemorrhoidal hamorrhage.Walnut oil configuration is similar to breast milk, absorption easy to digest, is beneficial to the childhood development phase, women's trimester of pregnancy and postpartum recovery.
Fructus Lycii is the mature fruit of matrimony vine of solanaceae plant, have tonify deficiency to calm the nerves, improving eyesight dispeled the wind, nourishing kidney lung moistening, promoting immunity, defying age, antitumor, scavenging free radicals, resisting fatigue, radioprotective, protect the liver, reproductive function protection and the effect such as improvement.
Fructus Jujubae sweet in the mouth, warm in nature, invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, be used for the treatment of insufficiency of the spleen weak, anorexia and loose stool, deficiency of qi and blood etc.Normal food Fructus Jujubae can treat physical weakness, neurasthenia, incoordination between the spleen and stomach, dyspepsia, epersalgia cough, anemia are become thin, and nourishing the liver preventing cancer function is especially outstanding, has saying of " solar eclipse three Fructus Jujubaes, at the age of one hundred years old bear one's age well ".
Modern society's dog-eat-dog, excessively requires mental skill and has jeopardized teenager memory and intelligence and health, and simultaneously with China's aged tendency of population, hypomnesis, senile dementia sickness rate is in rising trend.Increase with cardiovascular and cerebrovascular disease, VD sickness rate is in rising trend, accounts for dull-witted 60%-70%, occupy senile dementia sickness rate the first.Exploitation effectively control medicine for senile dementia is one of current medical research field vital task.But effectively the Chinese medicine preparation of control hypomnesis and senile dementia still comparatively lacks, especially compound preparation investigation and application is lacked, existing preparation effect is not very desirable, and mostly be single component preparation, action pathway is single, what have may produce certain toxic and side effects, is difficult to meet clinical demand and the market demand.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above, and the advantage will illustrated at least is below provided.
A further object of the invention is to provide a kind of compound recipe fructus cannabis capsules and its preparation method and application, compound recipe fructus cannabis capsules of the present invention can be used for preventing and treating hypomnesis, dysmnesia, senile dementia, also can be used for parkinson disease, cardiovascular and cerebrovascular disease, tumor and defying age that control cerebrovascular causes, compound recipe fructus cannabis capsules of the present invention can also be used for teenager or healthy personage's memory reinforcing, study idea and intelligence and body constitution, and without any side effects.
In order to realize according to these objects of the present invention and other advantage, provide a kind of compound recipe fructus cannabis capsules, make primarily of the following raw material with parts by weight: Fructus Cannabis 500-1000 part, marine microalgae 500-1000 part, Ganoderma 500-1000 part, leaf of Camellia nitidissima Chi 250-500 part, JINHUA Flos Camelliae Japonicae 100-200 part, Camellia nitidissima Chi seed 25-50 part, Black Grape 500-1000 part, Semen Juglandis 50-100 part, Fructus Lycii 50-100 part and Fructus Jujubae 500-1000 part.
Preferably, described compound recipe fructus cannabis capsules, makes primarily of the following raw material with parts by weight: Fructus Cannabis 700-800 part, marine microalgae 700-800 part, Ganoderma 700-800 part, leaf of Camellia nitidissima Chi 350-400 part, JINHUA Flos Camelliae Japonicae 140-160 part, Camellia nitidissima Chi seed 35-40 part, Black Grape 700-800 part, Semen Juglandis 70-80 part, Fructus Lycii 70-80 part and Fructus Jujubae 700-800 part.
A preparation method for compound recipe fructus cannabis capsules, comprises the following steps:
Step one, by after the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii and Fructus Jujubae drying, pulverize respectively, mixed powder is obtained after mixing, adding volume fraction is that the ethanol of 50%-95% carries out alcohol extraction, filters to obtain the first medicinal liquid and the first medicinal residues;
Step 2, described first medicinal residues are added water and carry out water extraction, after filtration the second medicinal liquid;
Step 3, by described first medicinal liquid and described second medicinal liquid mixing, after concentrating under reduced pressure, spraying dry obtains extract powder;
Step 4, described extract powder and pharmaceutically acceptable mixed with excipients is even, granulate, fill, obtain described compound recipe fructus cannabis capsules.
Preferably, the preparation method of described compound recipe fructus cannabis capsules, in step, after above-mentioned raw materials is pulverized, first the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma and Semen Juglandis are obtained miscella and press residue through squeezing, again the leaf of Camellia nitidissima Chi of described press residue and above-mentioned weight portion, JINHUA Flos Camelliae Japonicae, Camellia nitidissima Chi seed, Black Grape, Fructus Lycii and Fructus Jujubae are mixed to get described mixed powder, carry out alcohol extraction;
In described step 4, described extract powder, described miscella and pharmaceutically acceptable mixed with excipients is even, obtained described compound recipe fructus cannabis capsules.
Preferably, the preparation method of described compound recipe fructus cannabis capsules, in step one, described drying refers to low-temperature reduced-pressure drying or vacuum drying, and baking temperature is lower than 70 DEG C.
Preferably, the preparation method of described compound recipe fructus cannabis capsules, in step 2, described water extraction is specially and adds water reflux, extract, 2 times, each 1h, and amount of water is 10-20 times of described first medicinal residues weight.
Preferably, the preparation method of described compound recipe fructus cannabis capsules, in step, described alcohol extraction is specially: add volume fraction be 70% ethanol 70-80 DEG C decompression or heating in vacuum reflux 2 times, each 1h, wherein, the 10-20 of described volume fraction to be the addition of the ethanol of 70% be described mixed powder weight doubly.
Preferably, the preparation method of described compound recipe fructus cannabis capsules, in step one, described alcohol extraction is specially:
A, in described mixed powder, add the ethanol that volume fraction is 95%, its addition is 10 times of described mixed powder weight, and 60-100 DEG C of heating and refluxing extraction 1-2 time, each 1-2h, by extracting liquid filtering, obtains filtrate and filtering residue;
B, in described filtering residue, add the ethanol that volume fraction is 50%, its addition is 10 times of described filtering residue weight, 60-100 DEG C of heating and refluxing extraction 1-2 time, each 1-2h, by extracting liquid filtering, obtain described first medicinal residues, the filtrate of alcohol extraction is merged to obtain described first medicinal liquid.
Preferably, the preparation method of described compound recipe fructus cannabis capsules, in step one, described alcohol extraction is specially: in described mixed powder, add ethanol ultrasonic extraction 1-3 time that volume fraction is 50%, its addition be the 10-20 of described mixed powder weight doubly.
An application for compound recipe fructus cannabis capsules, described compound recipe fructus cannabis capsules is in the application of Improving memory power and senile dementia prevention and cure.
Effect: be improved memory; There is provided the nutrition energy and energy to brain, delay brain atrophy; The neuron of protection damaged delays pathological changes; Protection cardiovascular and cerebrovascular vessel; Blood circulation promoting and blood stasis dispelling, QI invigorating tonify deficiency; Blood fat reducing; Scavenging free radicals, antioxidation; Strengthen the effects such as immunity.
Purposes: control hypomnesis, dysmnesia, senile dementia, also can be used for defying age, parkinson disease, cardiovascular and cerebrovascular disease, tumor etc. that control cerebrovascular causes.Also can be used for teenager or healthy personage's memory reinforcing, study idea and intelligence and body constitution.
Using method: oral, 1 ~ 3 time on the one, each 2 ~ 4.
Effect duration: 1 year.
The present invention at least comprises following beneficial effect:
1) the invention provides a kind of compound recipe bar horse fructus cannabis capsules, by Fructus Cannabis, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii, Fructus Jujubae 10 kinds of primary raw material compositions, succession traditional Chinese medicine theory marrow, played a role by multicomponent multipath synergistic mechanism, overcome single component preparation limitation, fully with comprehensive utilization China bar horse Urtica cannabina L., Camellia nitidissima Chi, Ganoderma, the Special Traditional Chinese Medicine resources such as marine microalgae, the Nature essential ingredient of concentrated brain-strengthening longevity, remarkable Improving memory power, there is provided the nutrition energy and energy to brain simultaneously, delay brain atrophy, the neuron of protection damaged delays pathological changes, protection cardiovascular and cerebrovascular vessel, blood circulation promoting and blood stasis dispelling, QI invigorating tonify deficiency, blood fat reducing, scavenging free radicals, antioxidation, strengthen immunity etc., be mainly used in preventing and treating hypomnesis, dysmnesia and senile dementia, also can be used for preventing and treating parkinson disease, cardiovascular and cerebrovascular disease, tumor that cerebrovascular causes and anti-ageingly to wait for a long time.It is without any side effects,
2) compound recipe bar horse fructus cannabis capsules of the present invention, its pharmacological mechanism had is as follows:
Say from western medicine, senile dementia pathological change is cerebral cortical atrophy, Cortical neurons reduces, a large amount of neurofibrillary tangle and senile plaque in cerebral cortex and Hippocampus, think that forming senile plaque main component is beta amyloid peptide (β-amyloidpeptide is abbreviated as A β or β A) at present.The amyloid beta Segment A β 1 ~ 40 that in primary raw material of the present invention, Quercetin contained by Camellia nitidissima Chi can suppress Cu2+ to induce assembles, obvious depolymerisation is had to established Cu2+-A β 1 ~ 40 aggregation, the SH-SY5Y cell viability preventing Cu2+ and A β 1 ~ 40 from jointly inducing declines, and has potential preventive and therapeutic effect to senile dementia.And Quercetin also reduces blood pressure, strengthen capillary resistance, reduce capillary fragility, blood fat reducing, coronary artery dilator, increases coronary flow, thus improves brain blood circulation and brain tissue metabolism.In primary raw material of the present invention, contained by Black Grape skin, resveratrol has scavenging free radicals and antioxidation, reduces radical pair brain tissue damage, also has certain anti-aging effects.Primary raw material mini-bus horse Fructus Cannabis of the present invention and microalgae supplement cerebral tissue institute required linolenic fatty acid, DHA and Squalene etc., contribute to repairing injured neurons and function thereof, delay brain atrophy.
The traditional Chinese medical science thinks that senile dementia belongs to " dementia " " forgetful " " forgetful " category, motherland's Chinese medicine thinks that kidney qi deficiency of kidney-essence is its basic pathogenesis.Its sick position is at brain, in close relations with conscience spleen renal dysfunction.Senile dementia is blunt from natural disposition, natural gift is not enough, and person is different.Old man-year height asthenia, kidney qi deficiency of kidney-essence, insufficiency of vital energy and blood, brain is hollow, and brain is become homeless foster, phlegm stagnating in meridian in brain, stagnation and deficiency of QI blood stasis in brain, visceral dysfunction, clear key is covered, because of void can so that the stasis of blood, the stasis of blood then makes void more for a long time, finally causes dysfunction of the mind.Its Therapeutic Principle should catch blood stasis due to qi deficiency, treating both the principal and secondary aspects of a disease, kidney tonifying, essence replenishing, invigorating the spleen and benefiting QI, nourshing blood and promoting blood circulation.In primary raw material of the present invention, Ganoderma, Fructus Jujubae, Fructus Lycii, Semen Juglandis play benefiting QI for activating blood circulation, blood stasis dispersing and phlegm expelling, strengthening brain and inducing resuscitation effect.
Compound recipe bar horse fructus cannabis capsules plays comprehensive effect by multicomponent Mutiple Targets multipath synergistic mechanism, improves patients of senile dementia MMSE, ADL and HDS integrated value etc., improves patient's memory, obtain remarkable result.
3) compound recipe fructus cannabis capsules compact of the present invention, dosage is accurate, successful, natural green safety and environmental protection, applicable crowd is wider, except the memory of middle-aged and elderly people being improved and has effect, also can be used for teenager or healthy personage's memory reinforcing, study idea, improve intelligence and body constitution, and facilitate modern carry preservation and take in time, can reduce and take precautions against risk and harm, safeguarding healthy, economic benefit and social benefit prospect considerable.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, can implement according to this with reference to description word to make those skilled in the art.
It should be noted that experimental technique described in following embodiment if no special instructions, is conventional method, described reagent and material, if no special instructions, all can obtain from commercial channels.
The invention discloses a kind of compound recipe fructus cannabis capsules extremely preparation method and application, those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.Method of the present invention and application be described by preferred embodiment, related personnel obviously can not depart from content of the present invention, spirit and scope methods and applications as herein described are changed or suitably change with combination realize and apply the technology of the present invention.
The invention provides a kind of compound recipe fructus cannabis capsules, make primarily of the following raw material with parts by weight: Fructus Cannabis 500-1000 part, marine microalgae 500-1000 part, Ganoderma 500-1000 part, leaf of Camellia nitidissima Chi 250-500 part, JINHUA Flos Camelliae Japonicae 100-200 part, Camellia nitidissima Chi seed 25-50 part, Black Grape 500-1000 part, Semen Juglandis 50-100 part, Fructus Lycii 50-100 part and Fructus Jujubae 500-1000 part.
Wherein, the source of the present invention to the raw material except Fructus Cannabis is not particularly limited, and for commercially available, the wherein poisonous India Urtica cannabina L. source carried in non-background technology in the present invention of Fructus Cannabis, but China's plantation, wherein Israel and Palestine horse Urtica cannabina L. is good.
Compound recipe fructus cannabis capsules of the present invention is made primarily of above-mentioned raw materials, prepared by pharmaceutically acceptable adjuvant of can arranging in pairs or groups, these adjuvants comprise starch, polyvidone, octadecanol, hexadecanol, stearic acid, citric acid, microcrystalline Cellulose, dextrin, lactose, mannitol, sodium bicarbonate, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose (L-HPC), crospolyvinylpyrrolidone, magnesium stearate, Pulvis Talci or micropowder silica gel etc., but are not limited to above-mentioned disclosed adjuvant.
Described compound recipe fructus cannabis capsules, makes primarily of the following raw material with parts by weight: Fructus Cannabis 700-800 part, marine microalgae 700-800 part, Ganoderma 700-800 part, leaf of Camellia nitidissima Chi 350-400 part, JINHUA Flos Camelliae Japonicae 140-160 part, Camellia nitidissima Chi seed 35-40 part, Black Grape 700-800 part, Semen Juglandis 70-80 part, Fructus Lycii 70-80 part and Fructus Jujubae 700-800 part.
A preparation method for compound recipe fructus cannabis capsules, comprises the following steps:
Step one, by after the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii and Fructus Jujubae drying, pulverize respectively, mixed powder is obtained after mixing, adding volume fraction is that the ethanol of 50%-95% carries out alcohol extraction, filters to obtain the first medicinal liquid and the first medicinal residues;
Step 2, described first medicinal residues are added water and carry out water extraction, after filtration the second medicinal liquid;
Step 3, by described first medicinal liquid and described second medicinal liquid mixing, after concentrating under reduced pressure, spraying dry obtains extract powder;
Step 4, described extract powder and pharmaceutically acceptable mixed with excipients is even, granulate, fill, obtain described compound recipe fructus cannabis capsules.
In another kind of technical scheme, the preparation method of described compound recipe fructus cannabis capsules, in step, after above-mentioned raw materials is pulverized, first the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma and Semen Juglandis are obtained miscella and press residue through squeezing, again the leaf of Camellia nitidissima Chi of described press residue and above-mentioned weight portion, JINHUA Flos Camelliae Japonicae, Camellia nitidissima Chi seed, Black Grape, Fructus Lycii and Fructus Jujubae are mixed to get described mixed powder, carry out alcohol extraction;
In described step 4, described extract powder, described miscella and pharmaceutically acceptable mixed with excipients is even, obtained described compound recipe fructus cannabis capsules.
In another kind of technical scheme, the preparation method of described compound recipe fructus cannabis capsules, in step one, described drying refers to low-temperature reduced-pressure drying or vacuum drying, and baking temperature is lower than 70 DEG C.
In another kind of technical scheme, the preparation method of described compound recipe fructus cannabis capsules, in step 2, described water extraction is specially and adds water reflux, extract, 2 times, each 1h, and amount of water is 10-20 times of described first medicinal residues weight.
In another kind of technical scheme, the preparation method of described compound recipe fructus cannabis capsules, in step, described alcohol extraction is specially: add volume fraction be 70% ethanol 70-80 DEG C decompression or heating in vacuum reflux 2 times, each 1h, wherein, the 10-20 of described volume fraction to be the addition of the ethanol of 70% be described mixed powder weight doubly.
In another kind of technical scheme, the preparation method of described compound recipe fructus cannabis capsules, in step one, described alcohol extraction is specially:
A, in described mixed powder, add the ethanol that volume fraction is 95%, its addition is 10 times of described mixed powder weight, and 60-100 DEG C of heating and refluxing extraction 1-2 time, each 1-2h, by extracting liquid filtering, obtains filtrate and filtering residue;
B, in described filtering residue, add the ethanol that volume fraction is 50%, its addition is 10 times of described filtering residue weight, 60-100 DEG C of heating and refluxing extraction 1-2 time, each 1-2h, by extracting liquid filtering, obtain described first medicinal residues, the filtrate of alcohol extraction is merged to obtain described first medicinal liquid.The filtrate of alcohol extraction comprises the filtrate of alcohol extraction in steps A and step B.
In another kind of technical scheme, the preparation method of described compound recipe fructus cannabis capsules, in step one, described alcohol extraction is specially: in described mixed powder, add ethanol ultrasonic extraction 1-3 time that volume fraction is 50%, its addition be the 10-20 of described mixed powder weight doubly.
An application for compound recipe fructus cannabis capsules, described compound recipe fructus cannabis capsules is in the application of Improving memory power and senile dementia prevention and cure.
Below in conjunction with embodiment, set forth the present invention further:
Embodiment 1:
A kind of compound recipe fructus cannabis capsules, makes primarily of the following raw material with parts by weight: Fructus Cannabis 500 parts, marine microalgae 500 parts, Ganoderma 500 parts, leaf of Camellia nitidissima Chi 250 parts, JINHUA Flos Camelliae Japonicae 100 parts, 25 parts, Camellia nitidissima Chi seed, Black Grape 500 parts, Semen Juglandis 50 parts, Fructus Lycii 50 parts and Fructus Jujubae 500 parts.
Embodiment 2:
A kind of compound recipe fructus cannabis capsules, makes primarily of the following raw material with parts by weight: Fructus Cannabis 750 parts, marine microalgae 750 parts, Ganoderma 750 parts, leaf of Camellia nitidissima Chi 375 parts, JINHUA Flos Camelliae Japonicae 150 parts, 37.5 parts, Camellia nitidissima Chi seed, Black Grape 750 parts, Semen Juglandis 75 parts, Fructus Lycii 75 parts and Fructus Jujubae 750 parts.
Embodiment 3:
A kind of compound recipe fructus cannabis capsules, makes primarily of the following raw material with parts by weight: Fructus Cannabis 1000 parts, marine microalgae 1000 parts, Ganoderma 1000 parts, leaf of Camellia nitidissima Chi 500 parts, JINHUA Flos Camelliae Japonicae 200 parts, 50 parts, Camellia nitidissima Chi seed, Black Grape 1000 parts, Semen Juglandis 100 parts, Fructus Lycii 100 parts and Fructus Jujubae 1000 parts.
Embodiment 4:
A kind of compound recipe fructus cannabis capsules, makes primarily of the following raw material with parts by weight: Fructus Cannabis 700 parts, marine microalgae 700 parts, Ganoderma 700 parts, leaf of Camellia nitidissima Chi 350 parts, JINHUA Flos Camelliae Japonicae 140 parts, 35 parts, Camellia nitidissima Chi seed, Black Grape 700 parts, Semen Juglandis 70 parts, Fructus Lycii 70 parts and Fructus Jujubae 700 parts.
Embodiment 5:
A kind of compound recipe fructus cannabis capsules, makes primarily of the following raw material with parts by weight: Fructus Cannabis 800 parts, marine microalgae 800 parts, Ganoderma 800 parts, leaf of Camellia nitidissima Chi 400 parts, JINHUA Flos Camelliae Japonicae 160 parts, 40 parts, Camellia nitidissima Chi seed, Black Grape 800 parts, Semen Juglandis 80 parts, Fructus Lycii 80 parts and Fructus Jujubae 800 parts.
Embodiment 6:
On the formula basis of embodiment 1-5, a kind of preparation method of compound recipe fructus cannabis capsules, comprises the following steps:
Step one, by after the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii and Fructus Jujubae drying, pulverize respectively, mixed powder is obtained after mixing, add ethanol and carry out alcohol extraction, filter to obtain the first medicinal liquid and the first medicinal residues;
Step 2, described first medicinal residues are added water and carry out water extraction, after filtration the second medicinal liquid;
Step 3, by described first medicinal liquid and described second medicinal liquid mixing, after concentrating under reduced pressure, spraying dry obtains extract powder;
Step 4, described extract powder and pharmaceutically acceptable mixed with excipients is even, granulate, fill, obtain described compound recipe fructus cannabis capsules.
Described drying refers to low-temperature reduced-pressure drying or vacuum drying, and baking temperature is lower than 70 DEG C.
Described water extraction is specially and adds water reflux, extract, 2 times, each 1h, and amount of water is 10 times, 15 times or 20 times of described first medicinal residues weight.
Described alcohol extraction is specially: add volume fraction be 70% ethanol reflux 2 times in 70-80 DEG C of decompression or heating in vacuum, each 1h, wherein, 10 times, 15 times or 20 times of described volume fraction to be the addition of the ethanol of 70% be described mixed powder weight.
Embodiment 7:
On the formula basis of embodiment 1-5, a kind of preparation method of compound recipe fructus cannabis capsules, comprises the following steps:
Step one, by after the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii and Fructus Jujubae drying, pulverize respectively, mixed powder is obtained after mixing, add ethanol and carry out alcohol extraction, filter to obtain the first medicinal liquid and the first medicinal residues;
Step 2, described first medicinal residues are added water and carry out water extraction, after filtration the second medicinal liquid;
Step 3, by described first medicinal liquid and described second medicinal liquid mixing, after concentrating under reduced pressure, spraying dry obtains extract powder;
Step 4, described extract powder and pharmaceutically acceptable mixed with excipients is even, granulate, fill, obtain described compound recipe fructus cannabis capsules.
Described drying refers to low-temperature reduced-pressure drying or vacuum drying, and baking temperature is lower than 70 DEG C.
Described water extraction is specially and adds water reflux, extract, 2 times, each 1h, and amount of water is 10 times, 15 times or 20 times of described first medicinal residues weight.
Described alcohol extraction is specially:
A, in described mixed powder, add the ethanol that volume fraction is 95%, its addition is 10 times of described mixed powder weight, and 60-100 DEG C of heating and refluxing extraction 1-2 time, each 1-2h, by extracting liquid filtering, obtains filtrate and filtering residue;
B, in described filtering residue, add the ethanol that volume fraction is 50%, its addition is 10 times of described filtering residue weight, 60-100 DEG C of heating and refluxing extraction 1-2 time, each 1-2h, by extracting liquid filtering, obtain described first medicinal residues, the filtrate of alcohol extraction is merged to obtain described first medicinal liquid.
Embodiment 8:
On the formula basis of embodiment 1-5, a kind of preparation method of compound recipe fructus cannabis capsules, comprises the following steps:
Step one, by after the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii and Fructus Jujubae drying, pulverize respectively, mixed powder is obtained after mixing, add ethanol and carry out alcohol extraction, filter to obtain the first medicinal liquid and the first medicinal residues;
Step 2, described first medicinal residues are added water and carry out water extraction, after filtration the second medicinal liquid;
Step 3, by described first medicinal liquid and described second medicinal liquid mixing, after concentrating under reduced pressure, spraying dry obtains extract powder;
Step 4, described extract powder and pharmaceutically acceptable mixed with excipients is even, granulate, fill, obtain described compound recipe fructus cannabis capsules.
Described drying refers to low-temperature reduced-pressure drying or vacuum drying, and baking temperature is lower than 70 DEG C.
Described water extraction is specially and adds water reflux, extract, 2 times, each 1h, and amount of water is 10 times, 15 times or 20 times of described first medicinal residues weight.
Described alcohol extraction is specially: in described mixed powder, add ethanol ultrasonic extraction 1-3 time that volume fraction is 50%, its addition is 10 times, 15 times or 20 times of described mixed powder weight.
Embodiment 9:
On the formula basis of embodiment 1-5, a kind of preparation method of compound recipe fructus cannabis capsules, comprises the following steps:
Step one, by after the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii and Fructus Jujubae drying, pulverize respectively, first the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma and Semen Juglandis are obtained miscella and press residue through squeezing, again the leaf of Camellia nitidissima Chi of described press residue and above-mentioned weight portion, JINHUA Flos Camelliae Japonicae, Camellia nitidissima Chi seed, Black Grape, Fructus Lycii and Fructus Jujubae are mixed to get described mixed powder, add ethanol and carry out alcohol extraction, filter to obtain the first medicinal liquid and the first medicinal residues;
Step 2, described first medicinal residues are added water and carry out water extraction, after filtration the second medicinal liquid;
Step 3, by described first medicinal liquid and described second medicinal liquid mixing, after concentrating under reduced pressure, spraying dry obtains extract powder;
Step 4, described extract powder, described miscella and pharmaceutically acceptable mixed with excipients is even, granulate, fill, obtain described compound recipe fructus cannabis capsules.
Wherein, described drying refers to low-temperature reduced-pressure drying or vacuum drying, and baking temperature is lower than 70 DEG C.
Described water extraction is specially and adds water reflux, extract, 2 times, each 1h, and amount of water is 10 times, 15 times or 20 times of described first medicinal residues weight.
Described alcohol extraction is specially: add volume fraction be 70% ethanol reflux 2 times in 70-80 DEG C of decompression or heating in vacuum, each 1h, wherein, 10 times, 15 times or 20 times of described volume fraction to be the addition of the ethanol of 70% be described mixed powder weight.
Embodiment 10:
Get required Fructus Cannabis, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii, Fructus Jujubae respectively selected, clean, less than 70 DEG C low-temperature reduced-pressures or vacuum drying, be ground into fine powder for subsequent use.Wherein get fire Fructus Cannabis powder 1000g, marine microalgae powder 1000g, Ganoderma powder 1000g, leaf of Camellia nitidissima Chi powder 500g, pollen of Camellia nitidissima Chi 200g, Camellia nitidissima Chi seed meal 50g, Black Grape powder 1000g, Semen Juglandis powder 100g, medlar powder 100g, red date powder 1000g, obtain mixed powder, add 70% ethanol of mixed powder weight 10 ~ 20 times, 70 ~ 80 DEG C of decompressions or heating in vacuum reflux 2 times, each 1h, gained extracting solution filters, medicinal residues are added 10 ~ 20 times of water reflux, extract, 2 times, each 1h, gained extracting solution filters, merge extracted twice liquid, filtrate is also concentrated through 60 ~ 70 DEG C of decompression recycling ethanols, spraying dry, obtain extract powder.
Get said extracted thing powder, add the mixing of appropriate excipient starch, with 95% ethanol or starch slurry for binding agent makes soft material, 14 orders are granulated, and 12 order granulate, make granule, 50 ~ 60 DEG C of dryings of decompression low temperature, control granule moisture content only 2%.Add appropriate magnesium stearate (general consumption is 0.1 ~ 1% of particle weight) again, mixing.Calculate correct loading (general No. 1 capsule 0.1 ~ 0.4g), adjustment filling machine enters powder amount and speed to control weight differential scope, makes 1000, qualified through quality inspection, obtains compound recipe and clings to horse fructus cannabis capsules.
Wherein, usual excipients, except starch, also has one or more in polyvidone, octadecanol, hexadecanol, stearic acid, citric acid, microcrystalline Cellulose, dextrin, lactose, mannitol, sodium bicarbonate, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, carboxymethyl starch sodium, low substituted hydroxy-propyl methylcellulose (L-HPC), crospolyvinylpyrrolidone, magnesium stearate, Pulvis Talci or micropowder silica gel etc.
Embodiment 11:
The extract obtained powder of above-described embodiment 10 is also by such as under type acquisition.The preparation method of mixed powder, with embodiment 6, adds 95% ethanol of mixed powder gross weight 10 times, in 60-100 DEG C of reflux 1 ~ 2 time, each 1 ~ 2h, extracting liquid filtering, filtering residue adds 50% ethanol of filtering residue weight 10 times, 60-100 DEG C of reflux 1 ~ 2 time, each 1 ~ 2h, extracting liquid filtering, filtering residue uses 10 times of water again, 60-100 DEG C of heating and refluxing extraction 2 times, each 1 ~ 2h, extracting liquid filtering.Merge three extracting solution filtrates, concentrating under reduced pressure, carries out drying with spray dryer, obtains extract powder.
Embodiment 12:
Above-described embodiment 10 is extract obtained also by such as under type acquisition.The preparation method of mixed powder, with embodiment 6, adds 10 ~ 20 times of 50% ethanol, supersound extraction 1 ~ 3 time, filter, filtrate through salting out method or acid-base method or ultrafiltration technology or adsorbing material process, then uses water and graded ethanol solutions eluting successively, collect required treatment fluid or eluent, be drying to obtain.
Adsorbing material can be a kind or 2 kinds in macroporous resin series, polyamide, polydextran gel and agarose gel etc.
Embodiment 13:
1. get required Fructus Cannabis 1000g, marine microalgae 1000g, Ganoderma 1000g, Semen Juglandis 100g, obtain miscella by expresser squeezing, for subsequent use.
2. by above-mentioned residue and required leaf of Camellia nitidissima Chi 500g, JINHUA Flos Camelliae Japonicae 200g, Camellia nitidissima Chi seed 50g, Black Grape 1000g, Fructus Lycii 100g, Fructus Jujubae 1000g, add 70% ethanol of mixture weight 10 ~ 20 times, 70 ~ 80 DEG C of decompressions or heating in vacuum reflux 2 times, each 1h, gained extracting solution filters, medicinal residues are added 10 ~ 20 times of water reflux, extract, 2 times, each 1h, gained extracting solution filters, merge extracted twice liquid, filtrate is also concentrated through 60 ~ 70 DEG C of decompression recycling ethanols, and spraying dry, obtains extract powder.
3. get said extracted thing powder and the mixing of appropriate microcrystalline Cellulose, slowly add above-mentioned 1. miscella, make abundant absorption, then add appropriate amount of starch mixing, dry powder is filled, adjustment loading amount, obtained 1000.
Embodiment 14:
The routine clinical observation of compound recipe bar horse fructus cannabis capsules treatment senile dementia 20.
1, clinical data:
Choose patients of senile dementia 40 example made a definite diagnosis in August, 2012 ~ in August, 2015, age is all more than 60 years old, tcm diagnosis all meets " the diagnosis of dementia evaluation criteria " that Gerontological Society of Chinese Chinese medicine association works out, and Western medicine diagnose standard is with reference to the international Disease Diagnosis Standard about alzheimer disease of 1992 the tenth time revision (ICD-10).Treatment group and matched group is divided into, each 20 examples according to random digits table.Wherein, man 26 example, female 14 example, 60 ~ 79 years old age, the mean age (62.55 ± 4.95) year; Body weight 50 ~ 120kg, average (58.5 ± 7.2) kg.Through coherence check, get rid of coronary heart disease, hypertension, acute cerebrovascular disease, diabetes, various acute and chronic Organ Failures and other organic disease persons, born fathead etc.Ensure that the sex of two groups of cases, age, course of disease distribution all have comparability.
2, method:
Matched group adopts citicoline treatment, intramuscular injection, 100 ~ 500mg/ time, 1 ~ 2 time/d.Treatment group adopts compound recipe bar horse fructus cannabis capsules, every day 3 times, each 4, continuous use 3 months.
3, observation index, method and curative effect evaluation
According to Gerontological Society of the Chinese association of traditional Chinese medicine " senile dementia efficacy assessment standard ", with the method for classification score observe intelligence before and after patient treatment, activity of daily living, cognitive function change and Behavioral and psychological symptom change into Outcome measure index, Outcome measure is carried out in the score change according to indices before and after patient treatment.Effective: cardinal symptom is recovered substantially, conscious, accurate positioning, answers a question correct, is quick on the draw, takes care of oneself, can carry out mass society activity; Effective: main spirits symptom alleviates or partial disappearance to some extent, life is taken care of oneself substantially, answers a question and is in the main true, but bradykinesia, intelligence, personality still have obstacle; Control: main spirits symptom is without increasing the weight of, and situation of taking care of oneself change is not obvious, bradykinesia, intelligence, personality still have obstacle but nothing increases the weight of; Invalid: cardinal symptom is without change, or the state of an illness has development, can't take care of oneself, answer a question incorrect, mental dementia is treated.
And measure all cases by doctor trained in Western medicine scale, adopt 3 scales: mini mental state examination (MMSE), Chang Gu river Dementia scale (HDS), daily life scale (ADL).And blood fat and hemorheological change.The data obtained is adopted SPSS17.0 process, between group, count ratio comparatively adopts χ
2inspection, ranked data application Ridit analyzes, and measurement data adopts
represent, compare use paired t-test before and after treatment, P < 0.05 has significance for significant difference.
4, result
4.1 liang of groups Clinical efficacy comparison (see table 1)
Table 1 liang group Clinical efficacy comparison example (%)
Note: two groups of total effective rates compare, * P < 0.05.
Treatment group total effective rate compares with matched group, has notable difference (P < 0.05), shows that compound recipe bar horse fructus cannabis capsules improves patients of senile dementia clinical symptoms and is better than matched group.Before and after two groups of treatments, blood pressure, blood glucose, heart rate, pulse etc. are all without significant change, and have no adverse reaction.
After 4.2 liang of group treatments, memory recovery situation compares (see table 2)
Memory recovery situation comparative example (%) after table 2 liang group treatment
Note: compare with matched group, * P < 0.05
Treatment group total effective rate compares with matched group, has notable difference (P < 0.05), shows that compound recipe bar horse fructus cannabis capsules improves patients of senile dementia and has good memory in matched group.
4.3 liang of group MMSE, HDS, ADL scale score compare (see table 3)
Table 3 liang group MMSE, HDS, ADL scale score compares
Note: compared with matched group, * P < 0.05; Compared with before treatment,
Treatment group compares with matched group, MMSE, HDS and ADL integration curative effect all has significant difference (P < 0.05), shows that compound recipe bar horse fructus cannabis capsules improves the intelligence of patients of senile dementia and activity of daily living effect is obviously better than matched group.
Blood fat, hemorheological comparison (see table 4) before and after 4.4 liang of group treatments
Before and after table 4 liang group treatment, blood fat, hemorheology change are compared
Note: with this group before treatment, * P < 0.05.
Blood fat, hemorheology index is measured before and after two groups of treatments.Compare before and after treatment group treatment and there is significant difference (P < 0.05), no significant difference (P > 0.05) is compared before and after treatment of control group, show that compound recipe bar horse fructus cannabis capsules also has reduction blood fat, improve hemorheology effect, produce thus and reduce blood pressure, strengthen capillary resistance, reduce capillary fragility, coronary artery dilator, increase coronary flow, improve the effect such as brain blood circulation and brain tissue metabolism, thus to senile dementia prevention and cure, the parkinson disease that cerebrovascular causes, cardiovascular and cerebrovascular disease etc. are significant.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the embodiment described.
Claims (10)
1. a compound recipe fructus cannabis capsules, it is characterized in that, make primarily of the following raw material with parts by weight: Fructus Cannabis 500-1000 part, marine microalgae 500-1000 part, Ganoderma 500-1000 part, leaf of Camellia nitidissima Chi 250-500 part, JINHUA Flos Camelliae Japonicae 100-200 part, Camellia nitidissima Chi seed 25-50 part, Black Grape 500-1000 part, Semen Juglandis 50-100 part, Fructus Lycii 50-100 part and Fructus Jujubae 500-1000 part.
2. compound recipe fructus cannabis capsules as claimed in claim 1, it is characterized in that, make primarily of the following raw material with parts by weight: Fructus Cannabis 700-800 part, marine microalgae 700-800 part, Ganoderma 700-800 part, leaf of Camellia nitidissima Chi 350-400 part, JINHUA Flos Camelliae Japonicae 140-160 part, Camellia nitidissima Chi seed 35-40 part, Black Grape 700-800 part, Semen Juglandis 70-80 part, Fructus Lycii 70-80 part and Fructus Jujubae 700-800 part.
3. a preparation method for compound recipe fructus cannabis capsules as claimed in claim 1, is characterized in that, comprise the following steps:
Step one, by after the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma, JINHUA Flos Camelliae Japonicae, leaf of Camellia nitidissima Chi, Camellia nitidissima Chi seed, Black Grape, Semen Juglandis, Fructus Lycii and Fructus Jujubae drying, pulverize respectively, mixed powder is obtained after mixing, adding volume fraction is that the ethanol of 50%-95% carries out alcohol extraction, filters to obtain the first medicinal liquid and the first medicinal residues;
Step 2, described first medicinal residues are added water and carry out water extraction, after filtration the second medicinal liquid;
Step 3, by described first medicinal liquid and described second medicinal liquid mixing, after concentrating under reduced pressure, spraying dry obtains extract powder;
Step 4, described extract powder and pharmaceutically acceptable mixed with excipients is even, granulate, fill, obtain described compound recipe fructus cannabis capsules.
4. the preparation method of compound recipe fructus cannabis capsules as claimed in claim 3, it is characterized in that, in step, after above-mentioned raw materials is pulverized, first the Fructus Cannabis of above-mentioned weight portion, marine microalgae, Ganoderma and Semen Juglandis are obtained miscella and press residue through squeezing, again the leaf of Camellia nitidissima Chi of described press residue and above-mentioned weight portion, JINHUA Flos Camelliae Japonicae, Camellia nitidissima Chi seed, Black Grape, Fructus Lycii and Fructus Jujubae are mixed to get described mixed powder, carry out alcohol extraction;
In described step 4, described extract powder, described miscella and pharmaceutically acceptable mixed with excipients is even, obtained described compound recipe fructus cannabis capsules.
5. the preparation method of compound recipe fructus cannabis capsules as claimed in claim 3, is characterized in that, in step one, described drying refers to low-temperature reduced-pressure drying or vacuum drying, and baking temperature is lower than 70 DEG C.
6. the preparation method of compound recipe fructus cannabis capsules as claimed in claim 3, it is characterized in that, in step 2, described water extraction is specially and adds water reflux, extract, 2 times, each 1h, and amount of water is 10-20 times of described first medicinal residues weight.
7. the preparation method of compound recipe fructus cannabis capsules as claimed in claim 3, it is characterized in that, in step, described alcohol extraction is specially: add volume fraction be 70% ethanol 70-80 DEG C decompression or heating in vacuum reflux 2 times, each 1h, wherein, the 10-20 of described volume fraction to be the addition of the ethanol of 70% be described mixed powder weight doubly.
8. the preparation method of compound recipe fructus cannabis capsules as claimed in claim 3, it is characterized in that, in step one, described alcohol extraction is specially:
A, in described mixed powder, add the ethanol that volume fraction is 95%, its addition is 10 times of described mixed powder weight, and 60-100 DEG C of heating and refluxing extraction 1-2 time, each 1-2h, by extracting liquid filtering, obtains filtrate and filtering residue;
B, in described filtering residue, add the ethanol that volume fraction is 50%, its addition is 10 times of described filtering residue weight, 60-100 DEG C of heating and refluxing extraction 1-2 time, each 1-2h, by extracting liquid filtering, obtain described first medicinal residues, the filtrate of alcohol extraction is merged to obtain described first medicinal liquid.
9. the preparation method of compound recipe fructus cannabis capsules as claimed in claim 3, it is characterized in that, in step one, described alcohol extraction is specially: in described mixed powder, add ethanol ultrasonic extraction 1-3 time that volume fraction is 50%, its addition be the 10-20 of described mixed powder weight doubly.
10. the application of the compound recipe fructus cannabis capsules as described in claim 1 or 2 any one or the compound recipe fructus cannabis capsules prepared by claim 3-9 any one, it is characterized in that, described compound recipe fructus cannabis capsules is in the application of Improving memory power and senile dementia prevention and cure.
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| CN107802697A (en) * | 2017-11-15 | 2018-03-16 | 裴春鹏 | A kind of medicine for treating senile dementia and preparation method thereof and detection method |
| CN108079130A (en) * | 2018-01-12 | 2018-05-29 | 广西天昌投资有限公司 | A kind of pharmaceutical composition of the tea polyphenols containing golden flower and preparation method thereof |
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| CN103393821A (en) * | 2013-08-05 | 2013-11-20 | 杨心洁 | Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof |
| CN103749782A (en) * | 2014-01-01 | 2014-04-30 | 廖少波 | Camellia nitidissima/fructus cannabis health-preserving tea |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393821A (en) * | 2013-08-05 | 2013-11-20 | 杨心洁 | Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof |
| CN103749782A (en) * | 2014-01-01 | 2014-04-30 | 廖少波 | Camellia nitidissima/fructus cannabis health-preserving tea |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107802697A (en) * | 2017-11-15 | 2018-03-16 | 裴春鹏 | A kind of medicine for treating senile dementia and preparation method thereof and detection method |
| CN108079130A (en) * | 2018-01-12 | 2018-05-29 | 广西天昌投资有限公司 | A kind of pharmaceutical composition of the tea polyphenols containing golden flower and preparation method thereof |
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