CN104474429A - Traditional Chinese medicine preparation with function of reducing hypomnesis - Google Patents
Traditional Chinese medicine preparation with function of reducing hypomnesis Download PDFInfo
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- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The invention provides a traditional Chinese medicine health preparation with the function of reducing hypomnesis, which is mainly used for reducing and treating senile dementia, and belongs to the field of traditional Chinese medicine healthcare. The traditional Chinese medicine preparation is prepared from the raw materials of rose, light wheat, rhizoma polygonati, Chinese yam, sharp leaf galangal fruit, white poria, fructus ziziphi jujubae, jujube kernel, longan aril, fructus lycii, mulberry, semen juglandis and lotus seed. The traditional Chinese medicine preparation has the effects of promoting Qi circulation and relieving depression, nourishing Yin and calming the mind, invigorating vital energy to educate heart, and replenishing blood and nourishing kidney to realize the reducing of hypomnesis of a human body. The clinical test shows that the traditional Chinese medicine preparation has an obvious effect on reducing and treating senile dementia; in addition, the clinical information shows that the traditional Chinese medicine preparation has a good conditioning effect on the memory, learning capacity and creativity reduction for the middle age; all raw materials used in the preparation are medicinal and edible Chinese herbal medicines, so that the traditional Chinese medicine preparation also has the life cultivation and health preservation effect.
Description
Technical field
The invention belongs to Chinese medicine health-care technical field, relate to and a kind of there is the Chinese medicine preparation improving human body hypomnesis function, be mainly used in improvement and the medical treatment of senile dementia.
Background technology
Senile dementia, is again Alzheimer (AD), is the nervous system degenerative disease of the Progressive symmetric erythrokeratodermia development of a kind of onset concealment.Show as feature with dysmnesia, aphasia, apraxia, agnosia, the infringement of visual space technical ability, n-back test obstacle and the generalized dementia such as personality and behavior change clinically, the cause of disease is not bright so far.Main manifestations is the decline gradually of decrease of cognitive function, mental symptom and behavior disorder, activity of daily living.Deterioration degree according to cognitive competence and physical function is divided into three periods: the first stage, is the mild dementia phase, shows as hypomnesis, gives prominence to recent amnesia; Judgement declines, and patient can not analyze event, thinks deeply, judge, is difficult to process complicated problem; Although still can do a little routine work be familiar with, show new things and be ignorantly difficult to resolve, apathy, excitation once in a while, often has suspicious; Time of occurrence disorientation, can make orientation to residing place and personage, to the directed difficulty in residing geographical position, and the visual space ability of labyrinth; Speech vocabulary is few, name difficulty.Second stage is the moderate dementia phase, and show as far and near memory and be badly damaged, the visual space ability of simple structure declines, time, disturbance of orientation to place; Grievous injury is had in process problem, the similitude distinguishing things and discrepancy; Independently can not carry out outdoor activity, wearing the clothes, Personal hygiene and keep wanting help in personal appearance; Calculating can not; There is various nervous symptoms, visible aphasia, apraxia and agnosia; Emotion becomes irritable uneasiness from indifferent, often walks about and does not stop, visible urinary incontinence.Phase III is the severe dementia phase, and patient relies on the person of looking after completely, and serious memory loss, only deposits the memory of fragment; Daily life can not be taken care of oneself, gatism, present keep silent, rigid limbs, visible pyramidal sign of having a medical check-up is positive, has Primitive reflexs such as holding by force, grope and suck.
At present, the subhealth state problems such as senile dementia are annoying the people of modern society day by day, usually administering about this kind of problem is adopt separately beneficial kidney and replenishing marrow medicine more, and the present invention is quite different, by adopt integration of edible and medicinal herbs raw material and there are promoting QI circulation for relieving depression, yin nourishing is set aside all worries, Qi-benefiting and heart-nourishing, enrich blood and contain comprehensive improvement result that the prescription of cardiac function realizes senile dementia.
Summary of the invention
The object of the invention is the problem for senile dementia, provide a kind of and there is the Chinese medicine preparation improving human body hypomnesis function.
Chinese medicine preparation of the present invention carries out compatibility with Flos Rosae Rugosae, Fructus Tritici Levis, Rhizoma Polygonati, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Poria, Fructus Jujubae, Semen Ziziphi Spinosae, Arillus Longan, Fructus Lycii, Fructus Mori, Semen Juglandis, Semen Nelumbinis for raw material, effect of each medicine is produced collaborative, gather that promoting QI circulation for relieving depression, yin nourishing are with all worries set aside altogether, Qi-benefiting and heart-nourishing, enrich blood and contain the function of the heart, thus the improvement realized human body hypomnesis and medical treatment effect.
Flos Rosae Rugosae, sweet and slightly bitter taste, slightly warm in nature, return liver, spleen, stomach warp; Function: resolving depression of regulating the flow of vital energy, and blood dissipating blood stasis.The present invention take Flos Rosae Rugosae as monarch drug, circulation of qi promoting with Fructus Alpiniae Oxyphyllae, resolving depression with Fructus Alpiniae Oxyphyllae, invigorate blood circulation with Fructus Alpiniae Oxyphyllae.
Fructus Tritici Levis, sweet, cool; Effect: only sweating due to debility, tranquilizing by nourishing the heart.The present invention take Fructus Tritici Levis as ministerial drug, by yin fluid astringing with Fructus Alpiniae Oxyphyllae, nourish heart with Fructus Alpiniae Oxyphyllae, calm the nerves with Fructus Alpiniae Oxyphyllae.
Rhizoma Polygonati, sweet, flat; Return spleen, lung, kidney channel; Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.Rhizoma Dioscoreae, sweet, flat; Return spleen, lung, kidney channel; Function: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.The present invention is with Rhizoma Polygonati, Rhizoma Dioscoreae for adjuvant drug, and extensively treating upper, middle and lower three is burnt, makes monarch-minister drug Fructus Alpiniae Oxyphyllae ability obtain guarantee.
Fructus Alpiniae Oxyphyllae, pungent, temperature; Enter spleen, kidney channel; Warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Poria, sweet, light, property is put down; GUIXIN, spleen, lung, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.Fructus Jujubae, sweet, temperature; Return spleen, stomach warp; Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Semen Ziziphi Spinosae is sweet, sour, flat; Return liver, gallbladder, heart channel; Effect: tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.Arillus Longan, sweet, temperature; GUIXIN, spleen channel; Effect: invigorating the heart and spleen, nourishing blood to tranquillize the mind.Fructus Lycii, sweet, flat; Enter liver, kidney channel; Effect: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Fructus Mori, sweet, sour, cold; GUIXIN, liver, kidney channel; Effect: YIN nourishing of enriching blood, promotes the production of body fluid and moisturizes.Semen Juglandis, sweet, temperature; Return kidney channel, lung, large intestine channel; Effect: the kidney invigorating warming the lung, loosening bowel to relieve constipation.Semen Nelumbinis are sweet, puckery, flat; Return spleen, kidney, heart channel; Function: spleen reinforcing antidiarrheal, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.The present invention for making medicine, uses traditional Fructus Alpiniae Oxyphyllae Chinese herbal medicine to strengthen intelligence development functions with Fructus Alpiniae Oxyphyllae, Poria, Fructus Jujubae, Semen Ziziphi Spinosae, Arillus Longan, Fructus Lycii, Fructus Mori, Semen Juglandis, Semen Nelumbinis, and improve supplementing QI and nourishing YIN, nourishing kidney of enriching blood realizes.
Each raw material of Chinese medicine preparation of the present invention carries out proportioning by following weight portion: Flos Rosae Rugosae 25-40 part, Fructus Tritici Levis 18-25 part, Rhizoma Polygonati 10-18 part, Rhizoma Dioscoreae 10-18 part, Fructus Alpiniae Oxyphyllae 4-10 part, Poria 4-10 part, Fructus Jujubae 4-10 part, Semen Ziziphi Spinosae 4-10 part, Arillus Longan 4-10 part, Fructus Lycii 4-10 part, Fructus Mori 4-10 part, Semen Juglandis 4-10 part, Semen Nelumbinis 4-10 part.
Optimum ratio: Flos Rosae Rugosae 30-35 part, Fructus Tritici Levis 20-24 part, Rhizoma Polygonati 13-16 part, Rhizoma Dioscoreae 13-16 part, Fructus Alpiniae Oxyphyllae 6-8 part, Poria 6-8 part, Fructus Jujubae 6-8 part, Semen Ziziphi Spinosae 6-8 part, Arillus Longan 6-8 part, Fructus Lycii 6-8 part, Fructus Mori 6-8 part, Semen Juglandis 6-8 part, Semen Nelumbinis 6-8 part.
Optimum proportioning: Flos Rosae Rugosae 30 parts, Fructus Tritici Levis 23 parts, Rhizoma Polygonati 15 parts, Rhizoma Dioscoreae 15 parts, Fructus Alpiniae Oxyphyllae 7.5 parts, Poria 7.5 parts, 7.5 parts, Fructus Jujubae, Semen Ziziphi Spinosae 7.5 parts, Arillus Longan 7.5 parts, Fructus Lycii 7.5 parts, 7.5 parts, Fructus Mori, Semen Juglandis 7.5 parts, 7.5 parts, Semen Nelumbinis.
Chinese medicine preparation of the present invention can be prepared into various oral preparations by the common process of pharmaceutics and adjuvant.As capsule, tablet, granule, powder, pill (comprising the watered pill, honeyed pill, dragee, soft gelatin capsule, enteric coated pill or drop pill) or oral liquid.
Below for senile dementia, by clinical data, the effect that medicine Improving memory power of the present invention goes down is described.
1, the object of observation: be diagnosed as patients of senile dementia function 120 example, wherein first stage, second stage, each 40 examples of phase III patient.Men and women has, and the age is in 70-88 year.
2, Therapeutic Method: granules medicine of the present invention (13 Fructus Alpiniae Oxyphyllae tea).Specification: 6g/ bag, 30 bags/box.Usage and dosage: each one bag sooner or later, warm water is directly taken after mixing it with water.The course for the treatment of: cycle in March 1, overview 3 cycle.
3, therapeutic effect criterion:
First stage: recovery from illness: memory, judgement and the normal person with age level are close.Effective: memory, judgement have had obvious improvement, have the ability of living on one's own life and taking action.Invalid: memory, judgement and ability to act significantly do not improve comparatively before.
Second stage: recovery from illness: memory, judgement and the normal person with age level are close.Effective: it is effective that symptom becomes mild dementia from moderate dementia.Invalid: memory, judgement and ability to act do not improve significantly.
Phase III: recovery from illness: memory, judgement and the normal person with age level are close.Effective: symptom becomes moderate dementia from severe dementia.Invalid: memory, judgement and ability to act significantly do not improve comparatively before.
4, observed result: clinical observation display is in table 1.Wherein, the effective percentage of mild dementia is 95%, and the effective percentage of moderate dementia is 77.5%, and the effective percentage of severe dementia is 57.5%.
Clinical trial shows, Chinese medicine preparation of the present invention improves significantly and medical treatment effect to senile dementia tool.Clinical data also proves, medicine of the present invention for middle age memory, study idea, intention power goes down also good opsonic action.In addition, in pharmaceutical preparation of the present invention, each crude drug all adopts the Chinese crude drug of integration of edible and medicinal herbs, thus has the effect of health preserving concurrently.
Detailed description of the invention
Below by specific embodiment, the prescription of medicine of the present invention and preparation thereof are described further.
The preparation of embodiment 1, granules medicine
Proportioning raw materials: Flos Rosae Rugosae 30 parts, Fructus Tritici Levis 23 parts, Rhizoma Polygonati 15 parts, Rhizoma Dioscoreae 15 parts, Fructus Alpiniae Oxyphyllae 7.5 parts, Poria 7.5 parts, 7.5 parts, Fructus Jujubae, Semen Ziziphi Spinosae 7.5 parts, Arillus Longan 7.5 parts, Fructus Lycii 7.5 parts, 7.5 parts, Fructus Mori, Semen Juglandis 7.5 parts, 7.5 parts, Semen Nelumbinis.
Preparation technology: prepare the common process of granule by pharmaceutics and adjuvant is prepared from; Specification: 6g/ bag.
Usage and dosage: each one bag sooner or later, warm water is directly taken after mixing it with water; The course for the treatment of: cycle in March 1, overview 3 cycle.
The preparation of embodiment 2, capsule medicine
Proportioning raw materials: Flos Rosae Rugosae 35 parts, Fructus Tritici Levis 24 parts, Rhizoma Polygonati 16 parts, Rhizoma Dioscoreae 16 parts, Fructus Alpiniae Oxyphyllae 8 parts, Poria 8 parts, 8 parts, Fructus Jujubae, Semen Ziziphi Spinosae 8 parts, Arillus Longan 8 parts, Fructus Lycii 8 parts, 8 parts, Fructus Mori, Semen Juglandis 8 parts, 8 parts, Semen Nelumbinis.
Preparation technology: prepare the common process of capsule by pharmaceutics and adjuvant is prepared from; Specification: 0.3g/ grain.
Usage and dosage: each 0.9g sooner or later, warm water is directly taken after mixing it with water; The course for the treatment of: cycle in March 1, overview 3 cycle.
The preparation of embodiment 3, tablet medicine
Proportioning raw materials: Flos Rosae Rugosae 30 parts, Fructus Tritici Levis 20 parts, Rhizoma Polygonati 13 parts, Rhizoma Dioscoreae 13 parts, Fructus Alpiniae Oxyphyllae 6 parts, Poria 6 parts, 6 parts, Fructus Jujubae, Semen Ziziphi Spinosae 6 parts, Arillus Longan 6 parts, Fructus Lycii 6 parts, 6 parts, Fructus Mori, Semen Juglandis 6 parts, 6 parts, Semen Nelumbinis.
Preparation technology: prepare the common process of tablet by pharmaceutics and adjuvant is prepared from; Specification: 1.0g/ grain.
Usage and dosage: each 3.0g sooner or later, warm water is directly taken after mixing it with water; The course for the treatment of: cycle in March 1, overview 3 cycle.
The preparation of embodiment 4, pill medicine
Proportioning raw materials: Flos Rosae Rugosae 25 parts, Fructus Tritici Levis 18 parts, Rhizoma Polygonati 10 parts, Rhizoma Dioscoreae 10 parts, Fructus Alpiniae Oxyphyllae 4 parts, Poria 4 parts, 4 parts, Fructus Jujubae, Semen Ziziphi Spinosae 4 parts, Arillus Longan 4 parts, Fructus Lycii 4 parts, 4 parts, Fructus Mori, Semen Juglandis 4 parts, 4 parts, Semen Nelumbinis.
Preparation technology: prepare the common process of pill by pharmaceutics and adjuvant is prepared from; Specification: 0.05g/ bag.
Usage and dosage: each 6.0g sooner or later, warm water is directly taken after mixing it with water; The course for the treatment of: cycle in March 1, overview 3 cycle.
The preparation of embodiment 5, oral medicine liquid of the present invention
Proportioning raw materials: Flos Rosae Rugosae 40 parts, Fructus Tritici Levis 25 parts, Rhizoma Polygonati 18 parts, Rhizoma Dioscoreae 18 parts, Fructus Alpiniae Oxyphyllae 10 parts, Poria 10 parts, 10 parts, Fructus Jujubae, Semen Ziziphi Spinosae 10 parts, Arillus Longan 4 parts, Fructus Lycii 10 parts, 10 parts, Fructus Mori, Semen Juglandis 10 parts, 10 parts, Semen Nelumbinis.
Preparation technology: prepare the common process of oral liquid by pharmaceutics and adjuvant is prepared from.Specification: 10ml/ bottle.
Usage and dosage: each 20ml sooner or later, warm water is directly taken after mixing it with water or is directly swallowed; The course for the treatment of: cycle in March 1, overview 3 cycle.
In the various embodiments described above, each proportioning raw materials is all with parts by weight.
Claims (5)
1. one kind has Improving memory power and to go down the Health-protection traditional Chinese medicinal preparation of function, with Flos Rosae Rugosae, Fructus Tritici Levis, Rhizoma Polygonati, Rhizoma Dioscoreae, Fructus Alpiniae Oxyphyllae, Poria, Fructus Jujubae, Semen Ziziphi Spinosae, Arillus Longan, Fructus Lycii, Fructus Mori, Semen Juglandis, Semen Nelumbinis for raw material, the oral preparations be prepared into by customary adjuvant and the technique of pharmaceutics.
2. there is Improving memory power as claimed in claim 1 to go down the Health-protection traditional Chinese medicinal preparation of function, it is characterized in that: described each raw material carries out proportioning by following weight portion:
Flos Rosae Rugosae 25-40 part, Fructus Tritici Levis 18-25 part, Rhizoma Polygonati 10-18 part, Rhizoma Dioscoreae 10-18 part, Fructus Alpiniae Oxyphyllae 4-10 part, Poria 4-10 part, Fructus Jujubae 4-10 part, Semen Ziziphi Spinosae 4-10 part, Arillus Longan 4-10 part, Fructus Lycii 4-10 part, Fructus Mori 4-10 part, Semen Juglandis 4-10 part, Semen Nelumbinis 4-10 part.
3. there is Improving memory power as claimed in claim 1 to go down the Health-protection traditional Chinese medicinal preparation of function, it is characterized in that: described each raw material carries out proportioning by following weight portion:
Flos Rosae Rugosae 30-35 part, Fructus Tritici Levis 20-24 part, Rhizoma Polygonati 13-16 part, Rhizoma Dioscoreae 13-16 part, Fructus Alpiniae Oxyphyllae 6-8 part, Poria 6-8 part, Fructus Jujubae 6-8 part, Semen Ziziphi Spinosae 6-8 part, Arillus Longan 6-8 part, Fructus Lycii 6-8 part, Fructus Mori 6-8 part, Semen Juglandis 6-8 part, Semen Nelumbinis 6-8 part.
4. there is Improving memory power as claimed in claim 1 to go down the Health-protection traditional Chinese medicinal preparation of function, it is characterized in that: described each raw material carries out proportioning by following weight portion:
Flos Rosae Rugosae 30 parts, Fructus Tritici Levis 23 parts, Rhizoma Polygonati 15 parts, Rhizoma Dioscoreae 15 parts, Fructus Alpiniae Oxyphyllae 7.5 parts, Poria 7.5 parts, 7.5 parts, Fructus Jujubae, Semen Ziziphi Spinosae 7.5 parts, Arillus Longan 7.5 parts, Fructus Lycii 7.5 parts, 7.5 parts, Fructus Mori, Semen Juglandis 7.5 parts, 7.5 parts, Semen Nelumbinis.
5. there is Improving memory power as claimed in claim 1 to go down the Health-protection traditional Chinese medicinal preparation of function, it is characterized in that: described oral preparations is capsule, tablet, granule, pill or oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410838890.3A CN104474429B (en) | 2014-12-30 | 2014-12-30 | It is a kind of that there is the Chinese medicine preparation for improving failure of memory function |
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| CN201410838890.3A CN104474429B (en) | 2014-12-30 | 2014-12-30 | It is a kind of that there is the Chinese medicine preparation for improving failure of memory function |
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| CN104474429A true CN104474429A (en) | 2015-04-01 |
| CN104474429B CN104474429B (en) | 2017-12-01 |
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| CN105168507A (en) * | 2015-09-10 | 2015-12-23 | 无限极（中国）有限公司 | Combination with memory-improving function and preparation method and application thereof |
| CN105192076A (en) * | 2015-08-25 | 2015-12-30 | 山东省农业科学院畜牧兽医研究所 | Yoghourt beverage capable of improving memory ability and preparing method thereof |
| CN105395643A (en) * | 2015-12-16 | 2016-03-16 | 甘肃东方天润玫瑰科技发展有限公司 | Rose-angelica sinensis composition for treating Alzheimer's disease and application thereof |
| CN106822739A (en) * | 2017-01-19 | 2017-06-13 | 湖北大顶山制药有限公司 | A kind of integration of drinking and medicinal herbs prevents and treats the particle of senile dementia |
| CN108991529A (en) * | 2018-08-22 | 2018-12-14 | 湖南中医药大学 | The food compositions and preparation method thereof of member are supported in a kind of invigorating the spleen |
| CN110025702A (en) * | 2019-04-04 | 2019-07-19 | 甘肃大整健康管理股份有限公司 | It is a kind of to have both the Chinese medicine composition for improving memory and effect of weight reducing |
| CN110522872A (en) * | 2019-08-23 | 2019-12-03 | 湖北中医药大学 | A kind of cream taste composition and preparation method thereof for raising body |
| CN112826901A (en) * | 2019-11-24 | 2021-05-25 | 王忠民 | Medicine for quickly relieving senile dementia symptoms |
| US11779626B2 (en) | 2018-01-05 | 2023-10-10 | Cosmax Ns, Inc. | Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes |
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| CN106974285B (en) * | 2017-03-31 | 2020-12-08 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition and application thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105192076A (en) * | 2015-08-25 | 2015-12-30 | 山东省农业科学院畜牧兽医研究所 | Yoghourt beverage capable of improving memory ability and preparing method thereof |
| CN105168507A (en) * | 2015-09-10 | 2015-12-23 | 无限极（中国）有限公司 | Combination with memory-improving function and preparation method and application thereof |
| CN105395643A (en) * | 2015-12-16 | 2016-03-16 | 甘肃东方天润玫瑰科技发展有限公司 | Rose-angelica sinensis composition for treating Alzheimer's disease and application thereof |
| CN105395643B (en) * | 2015-12-16 | 2018-01-05 | 甘肃东方天润玫瑰科技发展有限公司 | A kind of rose Radix Angelicae Sinensis composition for treating Alzheimer's disease and its application |
| CN106822739A (en) * | 2017-01-19 | 2017-06-13 | 湖北大顶山制药有限公司 | A kind of integration of drinking and medicinal herbs prevents and treats the particle of senile dementia |
| US11779626B2 (en) | 2018-01-05 | 2023-10-10 | Cosmax Ns, Inc. | Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes |
| CN108991529A (en) * | 2018-08-22 | 2018-12-14 | 湖南中医药大学 | The food compositions and preparation method thereof of member are supported in a kind of invigorating the spleen |
| CN110025702A (en) * | 2019-04-04 | 2019-07-19 | 甘肃大整健康管理股份有限公司 | It is a kind of to have both the Chinese medicine composition for improving memory and effect of weight reducing |
| CN110522872A (en) * | 2019-08-23 | 2019-12-03 | 湖北中医药大学 | A kind of cream taste composition and preparation method thereof for raising body |
| CN112826901A (en) * | 2019-11-24 | 2021-05-25 | 王忠民 | Medicine for quickly relieving senile dementia symptoms |
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