CN107929666A - A kind of Chinese medicine composition for treating dementia and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating dementia and preparation method thereof Download PDFInfo
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- CN107929666A CN107929666A CN201711277142.2A CN201711277142A CN107929666A CN 107929666 A CN107929666 A CN 107929666A CN 201711277142 A CN201711277142 A CN 201711277142A CN 107929666 A CN107929666 A CN 107929666A
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Abstract
The invention discloses a kind of Chinese medicine composition for treating dementia and preparation method thereof, wherein, the Chinese medicine composition, the Chinese medicine material matched by following parts by weight forms：10 20 parts of cultivated land, 10 20 parts of matrimony vine, 10 15 parts of Morinda officinalis, 10 20 parts of cassia seed, damp 10 25 parts of sunset, 10 15 parts of grass-leaved sweetflag, 10 15 parts of polygala, 10 20 parts of Radix Salviae Miltiorrhizae, 10 30 parts of hawthorn, 10 20 parts of Ligusticum wallichii, 10 15 parts of fructus alpiniae oxyphyllae, 10 25 parts of dogwood fruit, 10 25 parts of Radix Curcumae, 10 15 parts of radix pseudostellariae, 10 20 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 10 20 parts of arisaema cum bile, 69 parts of radix glycyrrhizae.The Chinese medicine composition of the treatment dementia of the present invention, compatibility is reasonable, has no toxic side effect, and can fundamentally treat dementia, especially senile dementia, quick, short treating period, stablizes, uneasy to recur, cheap.
Description
Technical field
Patent of the present invention is related to the technical field for treating dementia, especially a kind of Chinese medicine composition and its system for treating dementia
Preparation Method, belongs to the field of Chinese medicines.
Background technology
Dementia refers to that in the case where realizing waking state the acquired occupation of appearance is declined with social activities technical ability and obstacle,
Decrease of cognitive function, failure of memory and forfeiture, the infringement of visual space technical ability, directive force, computing power, judgment etc. are lost, and phase
After there are the obstacles such as personality, emotion and behavior change, and process is aggravated in progressive.Especially, senile dementia refers to old age
Degree of aging exceedes physiological aging, or premature aging, causes brain disorder, causes acquired, continuation disturbance of intelligence.
In the case of unconscious obstacle, there are memory and cognitive function disorder, with speech, visual space technical ability, emotion or personality change, and
Influence its social activities.Due to not effective medicine and means, dementia is aggravated, finally endangered because of body complication day by day
And life.
Dull-witted early symptom is failure of memory, personality change, and intelligence has declined, and spatial orientation is bad, often walks
Lose, fail to see homeward journey or initiative reduction, labile affect, but daily life can still be kept.Further development is then that cognitive function subtracts
Move back, aphasia, agnosia occur, sicken for consciousness sometimes.May occur in which the positioning sign of nervous system, daily life cannot take care of oneself,
Often there are shameless behavior, ethics behavior to have change, very occur phonism, photis, vain hope, manic or depressed symptom.
Late period then comprehensive disturbance of intelligence, bed, without autokinetic movement, keep silent and no language or give ambiguous stayements broken, can't take care of oneself at all,
Finally because complication causes death.Dull-witted most common complication is pulmonary infection, skin infection, urinary system infection contamination or slow
Sexual exhaustion, dyscrasia, multiple organ failure and threat to life.
Due to various social causes, rejuvenation trend is presented in the crowd that dementia occurs, for example, young man's appearance is stiff, big
Phenomena such as brain response is blunt, can be by CT examination, such as encephalatrophy etc..
For dementia, especially senile dementia, currently without specific medicament, common treatment mainly for suit the medicine to the illness, it is raw
Work nursing and prevention complication are come what is carried out, and still, conventional therapeutic scheme is often limited patient activity, lives and be unable to oneself
Reason, not only Quality of Life of Patients reduction, also brings heavy financial burden to personal, family and society.Based on this, how to realize
Dull-witted immunotherapy targeted autoantibody is the current technical issues that need to address of those skilled in the art.
The content of the invention
For the problems of the prior art, the purpose of the present invention is provide a kind of good effect for dementia, have no drug resistance, valency
Dull-witted Chinese medicine composition of the cheap treatment of lattice and preparation method thereof.
In order to achieve the above object, the technical scheme is that：
A kind of Chinese medicine composition for treating dementia, the Chinese medicine material matched by following parts by weight form：Cultivated land 10-20
Part, 10-20 parts of matrimony vine, 10-15 parts of Morinda officinalis, 10-20 parts of cassia seed, damp sunset 10-25 part, 10-15 parts of grass-leaved sweetflag, polygala 10-
15 parts, 10-20 parts of Radix Salviae Miltiorrhizae, 10-30 parts of hawthorn, 10-20 parts of Ligusticum wallichii, 10-15 parts of fructus alpiniae oxyphyllae, 10-25 parts of dogwood fruit, Radix Curcumae 10-
25 parts, 10-15 parts of radix pseudostellariae, 10-20 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 10-20 parts of arisaema cum bile, 6-9 parts of radix glycyrrhizae.
As preference, the Chinese medicine composition that treatment of the present invention is dull-witted, the Chinese medicine matched by following parts by weight
Raw material forms：12-18 parts of cultivated land, 12-18 parts of matrimony vine, 12-15 parts of Morinda officinalis, 12-18 parts of cassia seed, damp sunset 15-25 part, stone Chang
13-15 parts of Pu, 12-15 parts of polygala, 12-18 parts of Radix Salviae Miltiorrhizae, 15-25 parts of hawthorn, 12-18 parts of Ligusticum wallichii, 12-15 parts of fructus alpiniae oxyphyllae, mountain cornel
15-20 parts of meat, 15-20 parts of Radix Curcumae, 12-15 parts of radix pseudostellariae, 12-16 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 12-18 parts of arisaema cum bile, 6-8 parts of radix glycyrrhizae.
As preference, the Chinese medicine composition that treatment of the present invention is dull-witted, the Chinese medicine matched by following parts by weight
Raw material forms：15 parts of cultivated land, 15 parts of matrimony vine, 13 parts of Morinda officinalis, 15 parts of cassia seed, damp 20 parts of sunset, 13 parts of grass-leaved sweetflag, polygala 13
Part, 15 parts of Radix Salviae Miltiorrhizae, 20 parts of hawthorn, 15 parts of Ligusticum wallichii, 13 parts of fructus alpiniae oxyphyllae, 22 parts of dogwood fruit, 22 parts of Radix Curcumae, 13 parts of radix pseudostellariae, stir-fry jujube
15 parts of benevolence, 15 parts of arisaema cum bile, 7 parts of radix glycyrrhizae.
Invention also provides a kind of preparation method of the dull-witted Chinese medicine composition for the treatment of as described above, including it is as follows
Step：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, river, are weighed by weight
Rhizome of chuanxiong, fructus alpiniae oxyphyllae, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, screening removal of impurities, it is big that larger raw material is cut into soya bean
Small fritter, when sterilization treatment 1 is small under ultraviolet germicidal lamp after mixing, is subsequently placed in container and is soaked with normal-temperature water
60-100 minutes；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 points
Clock, dries in the air after being down to 50-70 DEG C to temperature, takes filtrate, and the dregs of a decoction in marmite are spare, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 50-70 DEG C to temperature, filter to obtain secondary liquid；
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
Present invention also offers a kind of preparation method of the dull-witted Chinese medicine composition for the treatment of as described above, including following step
Suddenly：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, river are weighed by weight
Rhizome of chuanxiong, fructus alpiniae oxyphyllae, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, will be uniformly mixed after the medicinal material drying of acquirement；
2) medicinal material in step 1) after mixing is ground into medicinal powder；
3) medicinal powder of step 2) is crossed into 500-800 mesh sieves and traditional Chinese medicine powder is made；
4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder；
5) Chinese medicine composition medicinal powder made from step 4) is fitted into capsulae vacuus and capsule is made, obtain Chinese medicine composition glue
Capsule.
Further, the preparation method of the dull-witted Chinese medicine composition for the treatment of of the present invention, in obtaining in step 3)
The granularity of medicinal powder is 600 mesh.
The Chinese medicine composition that the treatment of the present invention is dull-witted can be prepared into the diversified forms such as Chinese medicinal tablet, particle, traditional Chinese medicine pill,
Decoction and capsule are not limited to, and suitable for a variety of therapeutic modalities, application method.
The pharmacology of various herbs of the Chinese medicine composition of the treatment dementia of the present invention is as follows：
Cultivated land：It is sweet in flavor；Slightly warm in nature；Enter liver, kidney essense.Function：Enriching yin, enriches blood；Cure mainly：It is few to control deficiency of Yin blood, waist knee flaccidity, labor
Cough hectic fever due to yin, seminal emission, uterine bleeding, irregular menstruation, quenches one's thirst, number of urinating, deaf, blurred vision.
Matrimony vine：Taste：It is sweet；Property：It is flat；Enter liver and kidney channel；Function：It is nourishing liver and kidney, benefiting shrewd head；Cure mainly：Consumption consumptive loss, waist and knee
Ache, dizziness and tinnitus, Heat Diabetes, blood deficiency chlorosis, blurred vision.
Morinda officinalis：Taste：It is sweet, pungent；Property：Temperature；Enter liver and kidney channel；Function：Kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling；Cure mainly：Impotence is lost
Essence, uterus cold infertile, irregular menstruation, few abdomen crymodynia, arthralgia pain due to rheumatism, muscles and bones impotence.
Cassia seed：Taste：It is sweet, bitter；Property：It is cool；Enter liver and kidney channel；Function：Heat-clearing improving eyesight, relaxes bowel；Cure mainly：The puckery pain of hot eyes,
The more tears of photophobia, dizziness of having a headache, mesh is secretly unknown, constipation.
Damp sunset：Taste：It is sweet；Property：It is cold；Enter kidney, bladder warp；Function：Removing toxic substances, Li Shui, excreting dampness, expels the heat-evil；Cure mainly：Difficult urination,
Oedema turgor, vomiting, rush down dysentery, phlegm and retained fluid, tinea pedis, gonorrhoea, hematuria.
(remarks：Damp sunset：Damp sunset refers to raw rhizoma alismatis.It is raw with the person of being used as medicine for the section of active compound decontamination.Main function is to detoxify, property
Taste：It is sweet, tremble with fear.Enter kidney, bladder warp.)
Grass-leaved sweetflag：Taste：It is pungent；Property：It is bitter；Enter stomach, the heart channel of Hang-Shaoyin；Function：Dampness elimination appetizing, slit phlegm of having one's ideas straightened out, inducing resuscitation intelligence development；Cure mainly：Gastral cavity
Ruffian is not hungry, apnea, coma epilepsy, forgetfulness and deafness.
Polygala：Taste：It is pungent, bitter；Property：Temperature；Enter the heart, kidney channel；Function：Antitoxic heart-soothing and sedative；Eliminating the phlegm is had one's ideas straightened out；Removing toxicity for detumescence；Cure mainly：The heart
It is refreshing uneasy；Insomnia of palpitating with fear；It is forgetful；Frightened epilepsy；Coughing with a lot of sputum；Ulcer carbuncle on the back；Mastosis.
Radix Salviae Miltiorrhizae：Bitter, it is cold in nature, enter the heart, Liver Channel.Function：Stasis-dispelling and pain-killing, invigorate blood circulation, relieving restlessness that clears away heart-fire.Cure mainly：Menstruation is not
Adjust, closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.
Hawthorn：Taste：It is sour, sweet；Property：Temperature；Enter stomach, spleen, Liver Channel；Function：Digestion gathered food；Change the stagnant stasis of blood；Cure mainly：Eating accumulation, gastral cavity
Abdominal distention and pain, dysentery, dysmenorrhea due to blood stasis, amenorrhoea, postpartum abdominal pain；Lochiorrhagia.
Ligusticum wallichii：Taste：It is pungent；Property：Temperature；Enter liver, courage, the heart channel of Hang-Shaoyin；Function：Blood-activating and qi-promoting, wind-expelling pain-stopping；Cure mainly：Irregular menstruation, warp
Close dysmenorrhoea, abdominal mass abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Fructus alpiniae oxyphyllae：Taste：It is pungent；Property：Temperature；Enter spleen, kidney channel；Function：It is warming spleen and stopping diarrha, saliva is taken the photograph, warms up kidney, astringent sperm contracting urine；Cure mainly：
Malaria diarrhea, crymodynia in abdomen, the more salivas of mouth, enuresis with renal asthenia, frequent urination, gonorrhoea of passing out semen.
Dogwood fruit：It is sour, puckery；Slightly warm in nature, returns liver and kidney channel.Function：Tonify the liver and kidney, puckery smart prevent prolapse.Cure mainly：For dizziness
Under tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, uterine bleeding band, profuse sweating collapse, Heat Diabetes.
Radix Curcumae：Taste：It is pungent, bitter；Property：It is cool；Enter the heart, liver.Gallbladder channel；Function：Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice；It is main
Control：Closed dysmenorrhea, chest and abdomen swelling and pain, shouting pain, pyreticosis coma, epilepsy are gone mad, jaundice.
Radix pseudostellariae：Taste：It is sweet, bitter；Property：Temperature：Enter lung, the spleen channel；Function：Replenish qi to invigorate the spleen, it is promoting production of body fluid and nourishing the lung；Cure mainly：Insufficiency of the spleen body is tired,
Loss of appetite, eak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Stir-baked SEMEN ZIZIPHI SPINOSAE：Taste：It is sweet, sour；Property：It is flat；Enter liver, courage, the heart channel of Hang-Shaoyin；Function：Nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating, promotes the production of body fluid；
Cure mainly：Restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, injury thirst.
Arisaema cum bile：Taste：It is pungent, bitter；Property：It is cool；Enter lung, spleen, Liver Channel；Function：Clearing heat and eliminating phlegm, dispelling wind and relieving convulsion；Cure mainly：Phlegm heat-syndrome cough
Cough, cough up phlegm yellow thick, stroke and phlegm confusing heart, demented frightened epilepsy.
Radix glycyrrhizae：It is sweet in flavor：It is mild-natured.The thoughts of returning home, spleen, lung, stomach.Function：Invigorate the spleen and benefit qi, moisten the lung and relieve the cough, clearing heat and detoxicating, alleviation stops
Bitterly, pharmacological property is relaxed.Cure mainly：Weakness of the spleen and the stomach, shortness of breath and fatigue, palpitation and severe palpitation, cough phlegm is few, pathopyretic ulcer, medicine food poisoning, and gastral cavity abdomen is anxious
Bitterly, four limbs contraction pain.
The dull-witted Chinese medicine composition for the treatment of provided by the invention, using enriching yin, the cultivated land enriched blood as monarch drug in a prescription；With nourishing liver and kidney,
The matrimony vine of benefiting shrewd head, kidney-replenishing, strengthening the bones and muscles, the Morinda officinalis of wind-damp dispelling, heat-clearing improving eyesight, the cassia seed to relax bowel are ministerial drug；
With Li Shui, excreting dampness, the damp sunset to expel the heat-evil, dampness elimination appetizing, slit phlegm of having one's ideas straightened out, grass-leaved sweetflag, the antitoxic heart-soothing and sedative of inducing resuscitation intelligence development；Eliminating the phlegm is had one's ideas straightened out；
The polygala of removing toxicity for detumescence, stasis-dispelling and pain-killing, invigorate blood circulation, the Radix Salviae Miltiorrhizae of relieving restlessness that clears away heart-fire, digestion gathered food；Change hawthorn, the blood-activating and qi-promoting of the stagnant stasis of blood,
It is the Ligusticum wallichii of wind-expelling pain-stopping, warming spleen and stopping diarrha, saliva is taken the photograph, warms up kidney, the fructus alpiniae oxyphyllae of astringent sperm contracting urine, tonify the liver and kidney, the mountain cornel of puckery smart prevent prolapse
Meat, regulating qi to disperse stagnation, heart fire-clearing upset-relieving, the Radix Curcumae of normalizing gallbladder to cure jaundice, replenish qi to invigorate the spleen, promoting production of body fluid and nourishing the lung radix pseudostellariae, nourishing heart tonifying liver, calming heart peace
God, arrest sweating, the stir-baked SEMEN ZIZIPHI SPINOSAE to promote the production of body fluid, clearing heat and eliminating phlegm, the arisaema cum bile of dispelling wind and relieving convulsion is adjutant；To invigorate the spleen and benefit qi, moisten the lung and relieve the cough, heat-clearing
Removing toxic substances, alleviates analgesic, and the radix glycyrrhizae for relaxing pharmacological property is to make medicine.The Chinese medicine composition of the treatment dementia of the present invention, compatibility is reasonable, nontoxic
Side effect, can fundamentally treat dementia, especially senile dementia, quick, short treating period, stablizes, uneasy to recur, price
It is cheap.
Embodiment
Below in conjunction with embodiment, technical scheme is clearly and completely described.Obviously, it is described
Embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this area
Those of ordinary skill's all other embodiments obtained without making creative work, belong to protection of the present invention
Scope.
Embodiment one：
A kind of Chinese medicine composition for treating dementia, the Chinese medicine material matched by following parts by weight form：10 parts of cultivated land, Chinese holly
10 parts of Qi, 10 parts of Morinda officinalis, 10 parts of cassia seed, damp 10 parts of sunset, 10 parts of grass-leaved sweetflag, 10 parts of polygala, 10 parts of Radix Salviae Miltiorrhizae, 10 parts of hawthorn,
10 parts of Ligusticum wallichii, 10 parts of fructus alpiniae oxyphyllae, 10 parts of dogwood fruit, 10 parts of Radix Curcumae, 10 parts of radix pseudostellariae, 10 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 10 parts of arisaema cum bile, radix glycyrrhizae
6 parts.
The present embodiment provides a kind of preparation method of the dull-witted Chinese medicine composition for the treatment of as described above at the same time, including such as
Lower step：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, river are weighed by weight
Rhizome of chuanxiong, fructus alpiniae oxyphyllae, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, are put into marmite after mixing, into marmite
1000ml water is added, is soaked 45 minutes；
2) after boiling by intense fire, being heated 25 minutes with slow boiling, after temperature slightly drops, take filtrate, the dregs of a decoction in marmite are spare, and
Filtrate is poured into container, obtains first time liquid；
3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then slow boiling heating
About 30 minutes, treat that temperature is cooled to room temperature, take filtrate, obtain second of liquid；
4) it well-done liquid will be put into same container, and be uniformly mixed twice, it is filling close after obtained liquid is sterilized
Envelope, obtains Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time
Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first pico- heating when taking.
Embodiment two：
A kind of Chinese medicine composition for treating dementia, the Chinese medicine material matched by following parts by weight form：12 parts of cultivated land, Chinese holly
12 parts of Qi, 12 parts of Morinda officinalis, 12 parts of cassia seed, damp 15 parts of sunset, 13 parts of grass-leaved sweetflag, 12 parts of polygala, 12 parts of Radix Salviae Miltiorrhizae, 15 parts of hawthorn,
12 parts of Ligusticum wallichii, 12 parts of fructus alpiniae oxyphyllae, 15 parts of dogwood fruit, 15 parts of Radix Curcumae, 12 parts of radix pseudostellariae, 12 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 12 parts of arisaema cum bile, radix glycyrrhizae
7 parts.
The present embodiment provides a kind of preparation method of the dull-witted Chinese medicine composition for the treatment of as described above at the same time, including such as
Lower step：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, river are weighed by weight
Rhizome of chuanxiong, fructus alpiniae oxyphyllae, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, will be uniformly mixed after the medicinal material drying of acquirement；
2) medicinal material in step 1) after mixing is ground into medicinal powder；
3) medicinal powder of step 2) is crossed into 600 mesh sieves and traditional Chinese medicine powder is made；
4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder；
5) Chinese medicine composition medicinal powder made from step 4) is fitted into capsulae vacuus and capsule is made, obtain Chinese medicine composition glue
Capsule.
Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take in three times within 1 day, 15 grams every time (3).
Embodiment three：
A kind of Chinese medicine composition for treating dementia, the Chinese medicine material matched by following parts by weight form：15 parts of cultivated land, Chinese holly
15 parts of Qi, 13 parts of Morinda officinalis, 15 parts of cassia seed, damp 20 parts of sunset, 13 parts of grass-leaved sweetflag, 13 parts of polygala, 15 parts of Radix Salviae Miltiorrhizae, 20 parts of hawthorn,
15 parts of Ligusticum wallichii, 13 parts of fructus alpiniae oxyphyllae, 22 parts of dogwood fruit, 22 parts of Radix Curcumae, 13 parts of radix pseudostellariae, 15 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 15 parts of arisaema cum bile, radix glycyrrhizae
7 parts.
The present embodiment provides a kind of dull-witted Chinese medicine composition for the treatment of as described above at the same time
Preparation method, include the following steps：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, river are weighed by weight
Rhizome of chuanxiong, fructus alpiniae oxyphyllae, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, are put into marmite after mixing, into marmite
1100ml water is added, is soaked 45 minutes；
2) after boiling by intense fire, being heated 25 minutes with slow boiling, after temperature slightly drops, take filtrate, the dregs of a decoction in marmite are spare, and
Filtrate is poured into container, obtains first time liquid；
3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then slow boiling heating
About 30 minutes, treat that temperature is cooled to room temperature, take filtrate, obtain second of liquid；
4) it well-done liquid will be put into same container, and be uniformly mixed twice, it is filling close after obtained liquid is sterilized
Envelope, obtains Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time
Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first pico- heating when taking.
Example IV：
A kind of Chinese medicine composition for treating dementia, the Chinese medicine material matched by following parts by weight form：18 parts of cultivated land, Chinese holly
18 parts of Qi, 15 parts of Morinda officinalis, 18 parts of cassia seed, damp 25 parts of sunset, 15 parts of grass-leaved sweetflag, 15 parts of polygala, 18 parts of Radix Salviae Miltiorrhizae, 25 parts of hawthorn,
18 parts of Ligusticum wallichii, 15 parts of fructus alpiniae oxyphyllae, 20 parts of dogwood fruit, 20 parts of Radix Curcumae, 15 parts of radix pseudostellariae, 16 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 18 parts of arisaema cum bile, radix glycyrrhizae
8 parts.
The present embodiment provides a kind of preparation of the Chinese medicine composition for the treatment of functional dyspepsia FD as described above at the same time
Method, includes the following steps：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, river are weighed by weight
Rhizome of chuanxiong, fructus alpiniae oxyphyllae, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, are put into marmite after mixing, into marmite
1500ml water is added, is soaked 60 minutes；
2) after boiling by intense fire, being heated 30 minutes with slow boiling, after temperature slightly drops, take filtrate, the dregs of a decoction in marmite are spare, and
Filtrate is poured into container, obtains first time liquid；
3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then slow boiling heating
About 30 minutes, treat that temperature is cooled to room temperature, take filtrate, obtain second of liquid；
4) it well-done liquid will be put into same container, and be uniformly mixed twice, it is filling close after obtained liquid is sterilized
Envelope, obtains Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time
Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first pico- heating when taking.
Embodiment five：
A kind of Chinese medicine composition for treating dementia, the Chinese medicine material matched by following parts by weight form：20 parts of cultivated land, Chinese holly
20 parts of Qi, 15 parts of Morinda officinalis, 20 parts of cassia seed, damp 25 parts of sunset, 15 parts of grass-leaved sweetflag, 15 parts of polygala, 20 parts of Radix Salviae Miltiorrhizae, 30 parts of hawthorn,
20 parts of Ligusticum wallichii, 15 parts of fructus alpiniae oxyphyllae, 25 parts of dogwood fruit, 25 parts of Radix Curcumae, 15 parts of radix pseudostellariae, 20 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 20 parts of arisaema cum bile, radix glycyrrhizae
9 parts.
The present embodiment provides a kind of preparation of the Chinese medicine composition for the treatment of functional dyspepsia FD as described above at the same time
Method, includes the following steps：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, river are weighed by weight
Rhizome of chuanxiong, fructus alpiniae oxyphyllae, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, will be uniformly mixed after the medicinal material drying of acquirement；
2) medicinal material in step 1) after mixing is ground into medicinal powder；
3) medicinal powder of step 2) is crossed into 600 mesh sieves and traditional Chinese medicine powder is made；
4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder.
Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take at twice within 1 day, 10 grams every time (2).
The dull-witted Chinese medicine composition for the treatment of provided by the invention, using enriching yin, the cultivated land enriched blood as monarch drug in a prescription；With nourishing liver and kidney,
The matrimony vine of benefiting shrewd head, kidney-replenishing, strengthening the bones and muscles, the Morinda officinalis of wind-damp dispelling, heat-clearing improving eyesight, the cassia seed to relax bowel are ministerial drug；
With Li Shui, excreting dampness, the damp sunset to expel the heat-evil, dampness elimination appetizing, slit phlegm of having one's ideas straightened out, grass-leaved sweetflag, the antitoxic heart-soothing and sedative of inducing resuscitation intelligence development；Eliminating the phlegm is had one's ideas straightened out；
The polygala of removing toxicity for detumescence, stasis-dispelling and pain-killing, invigorate blood circulation, the Radix Salviae Miltiorrhizae of relieving restlessness that clears away heart-fire, digestion gathered food；Change hawthorn, the blood-activating and qi-promoting of the stagnant stasis of blood,
It is the Ligusticum wallichii of wind-expelling pain-stopping, warming spleen and stopping diarrha, saliva is taken the photograph, warms up kidney, the fructus alpiniae oxyphyllae of astringent sperm contracting urine, tonify the liver and kidney, the mountain cornel of puckery smart prevent prolapse
Meat, regulating qi to disperse stagnation, heart fire-clearing upset-relieving, the Radix Curcumae of normalizing gallbladder to cure jaundice, replenish qi to invigorate the spleen, promoting production of body fluid and nourishing the lung radix pseudostellariae, nourishing heart tonifying liver, calming heart peace
God, arrest sweating, the stir-baked SEMEN ZIZIPHI SPINOSAE to promote the production of body fluid, clearing heat and eliminating phlegm, the arisaema cum bile of dispelling wind and relieving convulsion is adjutant；To invigorate the spleen and benefit qi, moisten the lung and relieve the cough, heat-clearing
Removing toxic substances, alleviates analgesic, and the radix glycyrrhizae for relaxing pharmacological property is to make medicine.The Chinese medicine composition of the treatment dementia of the present invention, compatibility is reasonable, nontoxic
Side effect, can fundamentally treat dementia, especially senile dementia, quick, short treating period, stablizes, uneasy to recur, price
It is cheap.
The present invention has carried out clinical efficacy tracking with the data given by embodiment 2 at the same time, and curative effect is summarized as follows：
1. choosing dementia patients 60, two groups for the treatment of group and control group are divided into using single blind randomized, wherein, treatment group 40
Example, man 27, female 13, average age 55 years old；Control group 20, man 12, female 8, average age 56 years old.Two groups in year
Difference that age, gender, the course of disease, state of an illness weight etc. compare that there are no significant, is comparable.
2. diagnostic criteria：
1) cognition dysfunction：
1. memory disorders：For most prominent early symptom, especially AD, two kinds of forms of antidromicity and anterograde are shown as
Forget, such as lose ordinary articles, forget the food boiled on stove, forget appointment etc., disorientation occurs in late period, does not remember even
Derived from oneself birthday, kinsfolk and the name of oneself.
2. aphasis or aphasia：It is difficult to show as name, speech cavity, burden, the understanding to language, writes and repeat
Also there is obstacle, late period is then hypologia or echo-speech occurs.
3. idea appraxia：Motor activity cannot be performed by, which showing as, does some simple actions, such as combs one's hair, wears the clothes.
4. agnosia：To understanding the object even Disability of household, also tactile agnosia, i.e., cannot lean in tactile recognition hand
Object (such as coin).
5. locomitivity is disorderly：Refer to the obstacle for performing more complicated task or completing to occur during more complicated behavioral activity,
This is also one of most common symptom of dementia patients, is also one of performance of social adaptation's decline.
2) non-cognition dysfunction：
1. space disturbance in cognition：That is spatial orientation and the obstacle of execution space recognition activities.
2. judge and anticipation ability obstacle：Show as ability and the status of excessive estimation oneself, or some work of underestimation
Dynamic danger.
3. personality change：Such as pay no attention to hygiene, it is untidy and unsuitable excessively intimate etc. to stranger.
4. gait changes：Often fall, can be also common in the performance of other not cleer and peaceful pathological changes of basal ganglia of ambivalence
The dementia that VaD, Lewy body dementia (DLB) and parkinsonism (PD) and amyotrophia lateral sclerosis (ALS) merge.
5. spirit and behavior disorder：This is one of dull-witted protrusion symptom, especially in DLB and frontotemporal dementia (FTD) more
Prominent, common sympton has anxiety, depressed, and abnormal feeling, spirit and abnormal behavior, the latter include illusion, vainly hopes, irritability, is attacked
Behavior (language and action) is hit, morbid state collects valueless object etc..
3. curative effect determinate standard：Reference《Chinese medical disease Standardization of diagnosis and curative effect》
1) it is effective：Primary symptom is largely recovered, and Function of memory cognition is substantially achieved improvement, and orientation is substantially sound, and question and answer are kept to the point,
Reaction is good, and life can take care of oneself；
2) effectively：Primary symptom is recovered normal or has been mitigated, and Function of memory cognition slightly improves, and question and answer are fine, but reacts slow
It is blunt to owe sensitive；
3) it is invalid：Primary symptom is without improvement or aggravation.
4. diagnostic result：
Treatment group is effective 26 (65%), effective 8 (20%), invalid 1 (3%), total effective rate 85%；Control group
Effective 12 (60%), effective 5 (20%), invalid 1 (3%), total effective rate 80%.
The Chinese medicine composition of the treatment dementia of the present invention, compatibility is reasonable, has no toxic side effect, and can fundamentally treat silly
Stay, especially senile dementia, quick, short treating period, stablize, it is uneasy to recur, it is cheap.
Toxicity test is carried out to the Chinese medicine composition of the present invention, test effect is as follows：
Select 18-22 grams of weight, the healthy mice of 10 week old (homogeneous test body heavy phase difference is no more than 2 grams).Rat 12 weeks
Age；120-150 grams of weight, homogeneous test body heavy phase difference are no more than 10g.During experiment, animal is randomly divided into 4-5 groups by volume,
Every group of at least 10 animals, to reaction of animals situation is observed after tested material at once, once, continuous observation 6 months, sees for observation daily
Toxic reaction is examined, pays attention to recording appearance, behavioral activity, the state of mind, appetite (feed consumption), stool and urine and its face of animal
Color, hair, the colour of skin, breathing, nose, eye, oral cavity secretion without exception, changes of weight etc., compared with control group, administration group small white mouse
Physical condition is normal, and has no that small white mouse is sick or dead.Prompt the medicine security good, have no toxic side effect.
The treatment case of the Chinese medicine composition of the present invention is as follows：
Case one, Mr. Wang, male, 69 years old.Before 8 months, household has found that the thing that it did is often forgetful, all garrulous daily to favore with
Favore with, no end, originally do not find that it connects dozens of minutes even several minutes of generations gradually too note that with the development of time
Thing can not all be recalled, and such as to just eating cannot recalling for dish before a few houres, also show disfluency gradually, talked about when speaking
To mouth, always the idea of oneself is not known in expression, and household is checked with city-level the People's Hospital is sent into, and is diagnosed as
Senile dementia, is admitted to hospital and carries out the treatment of Drug, and the state of an illness has the chance progressively aggravated after later six months of leaving hospital, and is carried out then to here
Treatment, takes the present invention after one month, symptom makes moderate progress, and can express clearly the idea of oneself.After adhere to taking the present invention
Three months, the symptom such as forgetful was tentatively improved.
Case two, Liu, female, 70 years old.Started somewhat uncommon, babble Chu before 3 months, also walk sometimes on foot not
Surely, memory is very poor, and sight becomes gradually dull, and thing is held in hand and does not know thing is placed on where, total to suspect that someone steals his
Thing, always gyrates in the street, and if always saying of talking endlessly of refreshing god is not understood in the mouth, others greets also not to him
Comprehend, turn everyday in outside and do not know and go home to have a meal, then treated to here, can after the present invention one month
Simply linked up, it is known that go home to have a meal, after adhere to taking the present invention always after three months, behavior is improved, and is known
Road goes home to have a meal on time, and spy can express clearly the idea of oneself.
Case three, Mr. Li, male, 28 years old.It is in hospital because traffic accident occurs, finds brain atrophy through CT examination, control in hospital
After treating a period of time, dull-witted symptom is still shown as.The Chinese medicine of the offer of the embodiment of the present invention five is taken after one month, symptom has been delayed
Solution, squeak squeak is intended by the idea of oneself, but pronounces indistinctly, and continuously takes after two months, and symptom mitigates, and adheres to taking half
Nian Hou, can normally and people's communication exchange.Visited after 1 year, no recurrence.
Case four, Liang, female, 55 years old.Husband is dead in one's early years, and sons and daughters live apart after getting married, long-term solitary, by early period
It is sparing of one's words, failure of memory, is slow in action, Later development, which becomes, loses memory, and granddaughter grandson of oneself often forgets about, also not
Remember the road gone home.The Chinese medicine of the offer of the embodiment of the present invention four is taken after one month, symptom has been alleviated, and slowly remembers family
People, but still do not speak, he continuously takes after two months, no longer forget relatives, can also simply be exchanged with household, adhere to taking
After half a year, it also can no longer forget east with people's normal communication and forget west.Visited after 1 year, no recurrence.
The foregoing description of the disclosed embodiments, enables those skilled in the art to realize or use the present invention.To this
A variety of modifications of a little embodiments will be apparent for a person skilled in the art, and the general principles defined herein can
Without departing from the spirit or scope of the present invention, to realize in other embodiments.Therefore, the present invention will not be limited
The embodiments shown herein is formed on, and is to fit to consistent with the principles and novel features disclosed herein most wide
Scope.
Claims (7)
1. a kind of Chinese medicine composition for treating dementia, it is characterised in that the Chinese medicine material matched by following parts by weight forms：It is ripe
Ground 10-20 parts, 10-20 parts of matrimony vine, 10-15 parts of Morinda officinalis, 10-20 parts of cassia seed, damp sunset 10-25 part, 10-15 parts of grass-leaved sweetflag,
10-15 parts of polygala, 10-20 parts of Radix Salviae Miltiorrhizae, 10-30 parts of hawthorn, 10-20 parts of Ligusticum wallichii, 10-15 parts of fructus alpiniae oxyphyllae, 10-25 parts of dogwood fruit,
10-25 parts of Radix Curcumae, 10-15 parts of radix pseudostellariae, 10-20 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 10-20 parts of arisaema cum bile, 6-9 parts of radix glycyrrhizae.
2. the dull-witted Chinese medicine composition for the treatment of according to claim 1, it is characterised in that matched by following parts by weight
Chinese medicine material forms：12-18 parts of cultivated land, 12-18 parts of matrimony vine, 12-15 parts of Morinda officinalis, 12-18 parts of cassia seed, damp sunset 15-25 part,
13-15 parts of grass-leaved sweetflag, 12-15 parts of polygala, 12-18 parts of Radix Salviae Miltiorrhizae, 15-25 parts of hawthorn, 12-18 parts of Ligusticum wallichii, 12-15 parts of fructus alpiniae oxyphyllae,
15-20 parts of dogwood fruit, 15-20 parts of Radix Curcumae, 12-15 parts of radix pseudostellariae, 12-16 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 12-18 parts of arisaema cum bile, radix glycyrrhizae 6-8
Part.
3. the dull-witted Chinese medicine composition for the treatment of according to claim 1, it is characterised in that matched by following parts by weight
Chinese medicine material forms：15 parts of cultivated land, 15 parts of matrimony vine, 13 parts of Morinda officinalis, 15 parts of cassia seed, damp 20 parts of sunset, 13 parts of grass-leaved sweetflag, polygala
13 parts, 15 parts of Radix Salviae Miltiorrhizae, 20 parts of hawthorn, 15 parts of Ligusticum wallichii, 13 parts of fructus alpiniae oxyphyllae, 22 parts of dogwood fruit, 22 parts of Radix Curcumae, 13 parts of radix pseudostellariae, fry
15 parts of jujube kernel, 15 parts of arisaema cum bile, 7 parts of radix glycyrrhizae.
4. a kind of preparation method of the dull-witted Chinese medicine composition for the treatment of as any one of claim 1-3, its feature exist
In including the following steps：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, Ligusticum wallichii, benefit, are weighed by weight
Intelligence benevolence, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into soya bean size
Fritter, when sterilization treatment 1 is small under ultraviolet germicidal lamp after mixing, is subsequently placed in container and soaks 60-100 with normal-temperature water
Minute；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow boiling heats 30 minutes, dries in the air
After being down to 50-70 DEG C to temperature, filtrate is taken, the dregs of a decoction in marmite are spare, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 20 points
Clock, dries in the air after being down to 50-70 DEG C to temperature, filters to obtain secondary liquid；
4), the liquid obtained in step 2) and step 3) is merged, and is uniformly mixed, bottles or packs after drying in the air to room temperature, in obtaining
Drug composition liquid.
5. a kind of preparation method of the dull-witted Chinese medicine composition for the treatment of as any one of claim 1-3, its feature exist
In including the following steps：
1) cultivated land, matrimony vine, Morinda officinalis, cassia seed, damp sunset, grass-leaved sweetflag, polygala, Radix Salviae Miltiorrhizae, hawthorn, Ligusticum wallichii, benefit are weighed by weight
Intelligence benevolence, dogwood fruit, Radix Curcumae, radix pseudostellariae, stir-baked SEMEN ZIZIPHI SPINOSAE, arisaema cum bile, radix glycyrrhizae, will be uniformly mixed after the medicinal material drying of acquirement；
2) medicinal material in step 1) after mixing is ground into medicinal powder；
3) medicinal powder of step 2) is crossed into 500-800 mesh sieves and traditional Chinese medicine powder is made；
4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder.
6. the preparation method of the dull-witted Chinese medicine composition for the treatment of according to claim 5, it is characterised in that including following step
Suddenly：
Chinese medicine composition medicinal powder made from step 4) is fitted into capsulae vacuus capsule is made, obtain Chinese medicinal composition capsules.
7. the preparation method of the dull-witted Chinese medicine composition for the treatment of as claimed in claim 5, it is characterised in that obtained in step 3)
The granularity of traditional Chinese medicine powder be 600 mesh.
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