CN112826901A - Medicine for quickly relieving senile dementia symptoms - Google Patents
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Abstract
The invention discloses a medicine for rapidly relieving senile dementia symptoms, which is prepared by taking hawthorn, medlar, mulberry fruit, sharpleaf galangal fruit, perilla fruit, angelica, tall gastrodia tuber, American ginseng, spina date seed, ginseng, Chinese yam, tuckahoe, peach seed, safflower, astragalus root, sealwort, eucommia bark, dogwood, kudzu root and lucid ganoderma as raw materials according to a certain weight ratio. The medicament can be prepared into any common oral dosage form, has the functions of strengthening the spleen and replenishing qi, nourishing kidney essence, promoting blood circulation and removing blood stasis, restoring consciousness and calming the heart and the like, has good effects on relieving the symptoms of dysphoria and depression, dizziness and amnesia, reaction delay, limb weakness, apathy, expression dull stagnation, lower back and knee soreness and the like, and has particularly quick response and no toxic or side effect.
Description
Technical Field
The invention relates to a medicament for quickly relieving senile dementia symptoms, in particular to a medicament which is prepared from plant traditional Chinese medicines which are both edible and medicinal as raw materials according to a certain weight ratio and has obvious improvement effect on treating dysphoria and depression, dizziness and amnesia, slow reaction, limb weakness, apathy, expression dull stagnation, soreness and weakness in waist and knee joints and the like.
Background
Senile dementia (AD) has become an important factor seriously threatening physical and mental health and life quality of old people and seriously influencing social development, brings great disease and disability safety problems and economic burden to society and families, and has increasingly become a key topic of attention and research.
AD is a neurodegenerative disease characterized clinically by occult disease and progressive cognitive impairment. The disease is aggravated with aging of population, and has become a cause of death of adults after heart disease, tumor and cerebral apoplexy. According to relevant data statistics, the number of the ill people in China exceeds 900 thousands of people, and with the increasing trend of population aging, the number of the senile dementia in China is estimated to exceed 2200 thousands of people in 2040 years. The total number of people with the disease is considerable in all human beings. The incidence of the disease is higher in women than in men.
AD is also known as alzheimer's disease, a primary degenerative brain disease occurring in the elderly and pre-aged stages, is a persistent higher nerve functional activity disorder, and is impaired in memory, thinking, analysis and judgment, visual space recognition, mood, and the like in the state of unconscious disorder. The pathological changes are characterized by atrophy of cerebral cortex, accompanied by deposition of beta-amyloid, neurofibrillary tangles, reduction in the number of large numbers of memory neurons and the formation of senile plaques.
AD is a progressively developing lethal neurodegenerative disease, mainly manifested by a progressive deterioration in cognitive and memory functions, a progressive decline in daily living capacity, and various mental and behavioral disorders. With the intensive research on the etiology, pathogenesis and molecular biology, various hypotheses have been made to elucidate the etiology and pathogenesis of senile dementia from different sides.
AD belongs to difficult and complicated diseases, the research on the AD is expanded to the aspects of neuropathology, genetics, immunology and the like at present, people know the AD deeply to the molecular level and the gene level, but the real reason and the pathogenesis of the AD are not enough to know, and the AD is based on the fact that the AD is lack of high-efficiency and ideal prevention and treatment medicines at home and abroad. At present, most of AD treatment adopts comprehensive treatment methods, mainly comprises social, psychological, rehabilitation, medicament and other aspects, and the emphasis is on early diagnosis and early treatment, and particularly has certain clinical effect on early traditional Chinese medicine treatment.
At present, no specific therapeutic medicine for treating or reversing the disease progression exists. Currently, in terms of western medicine treatment, acetylcholinesterase inhibitors (AchEI) are mainly used, and include tacrine (Tcrine), Donepezil (Donepezil), exenergic (Exelon), and Galantamine (Galantamine); cholinergic receptor agonists, mainly M receptors and N receptors, commonly used are SR-46659A, Xanomeline, AF102B and the like; drugs for promoting neuronal metabolism, including brain-active substances (CereBroLysin), blood-active substances (avid Actovegin), estrogens; anti-inflammatory agents; a free radical scavenger; nerve regeneration (Neurogenesis) promoting agents, and the like. Although the medicines have certain curative effect, the medicines have more or less side effects, and especially for the old who needs to take the medicines for a long time, the medicine taking safety of patients is directly influenced.
The traditional Chinese medicine has certain advantages in the aspect of treating AD. The traditional Chinese medicine considers that brain marrow empty is the basic pathological change of the disease, and kidney qi and kidney essence deficiency is the basic pathogenesis of the disease. The formation of kidney-qi deficiency mainly involves two aspects, namely congenital deficiency on the one hand and acquired deficiency on the other hand, and the latter has more important weight. The kidney essence is supplemented by the transformation of food essence micro substances transported and dissolved by spleen qi, and if the process is problematic, the probability of kidney qi deficiency is greatly increased.
A large number of scientific experiments and clinical researches show that most of old people with kidney deficiency have decreased brain function, decreased brain nerve cells, continuously decreased transmitter content and transmitter receptor number, further endocrine function disorder, continuously decreased immune function, increased autoimmunity and allergic reaction, gradually accumulated in vivo free radical capacity and peroxide along with age, and decreased content of substances resisting free radical damage such as SOD. Its pathogenesis is usually kidney deficiency, qi invigorating and spleen strengthening to help kidney in the future, kidney tonifying and essence replenishing to benefit marrow. In fact, the formula is designed to delay senility and prevent and treat senile dementia, and the inventor considers that the spleen and kidney are mainly regulated, so that the formula is a very important method for treating the senile dementia. It is the essential characteristic that the deficiency of spleen qi and kidney essence always goes through the whole course of senile dementia. The medicine has good curative effect of strengthening spleen and replenishing qi, tonifying kidney and replenishing essence and benefiting marrow in clinic and can be used for preventing and treating senile dementia.
Because the attack time of AD is long, the treatment period is long, and the total dosage of patients is large, the problem of medication safety is involved. At present, a special medicine for preventing and treating AD by traditional Chinese medicines with high efficiency, safety, rapidness and no toxic or side effect is still lacking clinically. Researches and develops medicaments which effectively improve the functions of spleen and kidney of human bodies, rapidly reduce the incidence rate of AD, are safe, reliable, have no toxic or side effect and can be taken for a long time, and are particularly important for vast AD patients.
Compared with western medicines, the traditional Chinese medicine has less side effect in the aspect of treating AD, is easily accepted by patients and has reliable overall curative effect. According to the pathogenesis of the patients with spleen qi deficiency and kidney essence deficiency, the traditional Chinese medicine research starts, and the traditional Chinese medicine variety which has the functions of strengthening the transportation and transformation of the spleen and the stomach and filling the kidney essence and benefiting the marrow is mainly selected, so that the traditional Chinese medicine has a good development prospect.
The invention provides a medicament which has reliable curative effect, no toxic or side effect and obvious effect of comprehensively treating the senile dementia, particularly the medicament which is developed by using medicine-food dual-purpose traditional Chinese medicines and has obvious curative effect has the characteristics of safety and effectiveness and has very important practical significance, and the invention is also the starting point and the research purpose of the inventor. The Chinese patent medicine for quickly relieving the senile dementia successfully develops and fills the blank that the medicine and food dual-purpose Chinese patent medicine can quickly and effectively treat the senile dementia.
Disclosure of Invention
A medicine for quickly relieving the senile dementia symptom has the functions of tonifying spleen and qi, increasing kidney essence filling and benefiting marrow and nourishing brain. Senile dementia belongs to the categories of 'forgetfulness', 'dull disease', 'depression', 'consumptive disease' and the like in traditional Chinese medicine, and the disease is in the brain. Most of the patients with deficiency syndrome consider the deficiency of kidney essence and the deficiency of marrow sea as the main pathogenesis of the disease. However, clinical observation shows that the patients with kidney deficiency often have a later-aged weak pathogenesis before the kidney deficiency.
The spleen and stomach are the acquired root and are the basic motive force for the functions of the viscera, qi and blood circulation, and body movement, etc., and when the spleen and stomach are damaged, the functions of transforming food essence into qi and blood and nourishing the viscera will be directly and adversely affected. Three causes' cloud: the meaning and thinking of the spleen mean to remember the former things, while the thinking of heart means … … the spleen suffers from diseases, so the spleen will be unclear, the mind will be restless and people will be forgetful. Spleen qi deficiency failing to transport and transform, abnormal water distribution, accumulation of dampness and generation of phlegm, stagnation of phlegm in meridians and collaterals obstructing normal circulation of qi and blood; the spleen qi is deficient in transportation and transformation, and the function of food essence transforming into qi and blood is reduced, which leads to deficiency of qi and blood, and the function of internal organs is adversely affected. The source of kidney essence depends on innate endowment and acquired nourishment, and neither of them is essential. Ming and jin formal mat is given by: the spiritual and mental activities of human beings all lie in the brain. Children with scanty sperm and not full brain and the elderly with deficient sperm and empty brain have few memories. The source of kidney essence depends on the transportation and transformation of spleen, and sufficient qi and blood are needed to fill kidney essence. Therefore, only tonifying the kidney and replenishing essence is incomplete, and the inventor sees through a large amount of clinical research data that the effect of tonifying the spleen and replenishing qi to strengthen the acquired foundation is far more obvious than that of tonifying the kidney and replenishing essence alone while tonifying the kidney and replenishing essence.
The acquired constitution of tonifying can obviously enhance the functions of qi and blood, but the basic characteristics of the elderly are that the senile dementia has pathogenesis of qi and blood deficiency and also has pathogenesis characteristics of qi stagnation and blood stasis, so that the normal circulation of qi and blood can fully play the normal role of viscera only by the acquired constitution of tonifying is incomplete, and the pathogenesis of qi stagnation and blood stasis which is more likely to occur in the senile dementia due to the old qi and blood deficiency cannot be ignored in the meaning.
Through years of clinical observation, on the basis of strengthening the spleen, tonifying qi and filling kidney essence, the traditional Chinese medicine composition is supplemented with a product for promoting blood circulation and removing blood stasis, so that qi and blood can circulate freely, viscera function is normal, channels and collaterals are unobstructed, and brain and marrow can be filled normally, therefore, the traditional Chinese medicine composition is also an indispensable method for treating senile dementia. Clinical observation proves that the medicine has the advantages of invigorating spleen and replenishing qi, tonifying kidney and replenishing essence to treat senile dementia and promoting blood circulation to remove blood stasis.
The pathogenesis of spleen-qi deficiency, kidney essence deficiency, qi and blood stagnation and the like is considered to be the main factor of the senile dementia through years of exploration by traditional Chinese medicine inheritance studio instructor, Master instructor and Master TCM teacher Wang Zhong. Of course, qi and blood disorders may occur due to various factors such as excessive mental stress, emotional distress, dissimilarity in family, and physical weakness, and further, liver qi stagnation, spleen and stomach disharmony, qi and blood disorder, and kidney essence deficiency may occur. In the treatment process, the inventor achieves the effect of quickly relieving the symptoms of the senile dementia according to the treatment steps of strengthening and transporting spleen qi, regulating qi and blood, harmonize regulating viscera, tonifying kidney and replenishing essence. Clinical studies prove that the treatment method is obvious and has more effective effect than single and direct kidney tonifying and essence replenishing.
The medicine is realized by the following technical scheme. A medicine and food dual purpose medicine for rapidly relieving senile dementia symptom is characterized in that the medicine and food dual purpose medicine is prepared by the following raw materials by weight parts by the conventional process of Chinese materia medica pharmaceutics: 10-90 parts of hawthorn, 10-50 parts of wolfberry fruit, 10-90 parts of mulberry fruit, 10-60 parts of sharpleaf galangal fruit, 10-60 parts of perilla fruit, 10-90 parts of angelica, 10-60 parts of gastrodia elata, 10-90 parts of American ginseng, 10-45 parts of spina date seed, 10-90 parts of ginseng, 10-60 parts of Chinese yam, 10-90 parts of poria cocos, 10-90 parts of peach kernel, 10-60 parts of safflower, 10-90 parts of astragalus membranaceus, 10-90 parts of polygonatum, 10-90 parts of eucommia ulmoides, 10-90 parts of dogwood, 10-90 parts of radix puerariae and 10-90 parts of lucid ganoderma.
The raw material medicaments and the dosage formula are obtained by clinical tests of the inventor, and have obvious curative effect within the dosage range.
A medicine composition for quickly relieving senile dementia symptoms is prepared by selecting hawthorn, medlar, mulberry, sharpleaf galangal fruit, perilla fruit, angelica, gastrodia elata, American ginseng, spina date seed, ginseng, Chinese yam, poria cocos, peach kernel, safflower, astragalus mongholicus, rhizoma polygonati, eucommia ulmoides, dogwood, radix puerariae and lucid ganoderma to be compatible, and mutual synergistic effect is generated among the effects of the medicines, so that the medicine composition has the functions of tonifying spleen and qi, nourishing kidney essence, activating blood and dissolving stasis, restoring consciousness and calming the heart and the like, and has good effects on relieving symptoms such as dysphoria depression, dizziness and amnesia, reaction retardation, limb weakness, apathy, dull expression, waist and knee weakness, and the like, and is particularly quick in effect and free of toxic and side.
In a medicament for rapidly relieving senile dementia symptoms, hawthorn has the effects of strengthening spleen and stomach, promoting blood circulation to remove blood stasis, reducing blood wax and the like, reducing blood pressure, resisting myocardial ischemia and cerebral ischemia, improving blood rheology, protecting endothelial cells from being damaged, resisting oxidation and aging, and has good prevention and treatment effects on senile diseases; the medlar has the functions of nourishing liver and kidney, replenishing vital essence, improving eyesight and delaying senility, has the functions of enhancing immunity, resisting oxidation, mutation and tumor, reducing blood pressure, blood fat and blood sugar, and is a commonly used fine product for tonifying kidney and replenishing essence; the mulberry has the effects of nourishing liver and kidney, nourishing blood, promoting fluid production, enhancing immunity, resisting oxidation, aging, mutation, tumor and the like, reducing blood sugar and blood fat, and has a certain protection effect on the cerebral nervous system due to the resveratrol; the fructus alpiniae oxyphyllae has the effects of warming spleen, checking diarrhea, absorbing saliva, warming kidney, securing essence and reducing urination, has the effects of resisting inflammation, resisting tumor, resisting oxidation, resisting aging, resisting allergy, relieving pain and the like, and animal experiments prove that the fructus alpiniae oxyphyllae volatile oil has the treatment effect on Parkinson's disease, the effect is realized by protecting nerves, the fructus alpiniae oxyphyllae can enhance the learning memory of mice, and has the effect of protecting striate dopamine neurons; perilla seed has the effects of depressing qi and reducing phlegm, relieving cough and asthma, relaxing bowel, and has the effects of resisting bacteria, allergy, arteriosclerosis, aging, tumors, depression and free radicals, the perilla seed oil can obviously reduce the total malondialdehyde content in the brain, can obviously improve the activity of superoxide dismutase in red blood cells, further improve the brain function and enhance the memory, and has good resistance to the memory decline of the senile dementia; the Chinese angelica has the effects of enriching and nourishing blood, promoting blood circulation to stop pain, moistening dryness and relaxing bowels, can enhance immunity, has anticoagulation, anti-inflammation, anti-allergy, anti-oxidation, anti-aging, anti-tumor and anti-injury effects, and has good protection effect on cerebral ischemia injury, animal experiments prove that the Chinese angelica can relieve apoptosis of cells after cerebral ischemia, can promote nerve growth of rats with middle cerebral artery embolism models after cerebral ischemia injury, repair expression of related protein cyclin D1 and growth related protein, reduce apoptosis, and further play a role in protecting cerebral nerves; the gastrodia elata sedative hypnotic, wind-calming and pain-relieving has the effects of resisting convulsion, dizziness, bacteria and aging and the like, animal experiments prove that the gastrodia elata can reduce the concentration of serum lipid peroxide, has the effects of improving memory and intelligence, and clinical application proves that the gastrodin has the potential effect of preventing and treating senile dementia; the American ginseng has the effects of tonifying qi and yin, clearing heat and promoting fluid, enhancing immunity, resisting fatigue, aging, tumor and hemorrhagic shock and the like, can enhance the learning and memory functions and enhance the hypoxia tolerance, and has the central nerve protection capability; semen Ziziphi Spinosae has effects in nourishing liver, calming heart, promoting fluid production, arresting sweating, enhancing immunity, tranquilizing mind, enhancing immunity, relieving convulsion, anxiety, depression, platelet aggregation, aging, myocardial ischemia, arrhythmia, radiation, tumor, and free radical; the ginseng can greatly tonify primordial qi, has the effects of enhancing memory, improving immunity, improving cardiovascular and cerebrovascular functions, resisting tumor, aging, oxidation and the like, can improve the cognitive function of people, increase memory and learning capacity, regulate a nervous system, excite the function of a hematopoietic system and improve the microcirculation of the old, and has good effect on senile dementia proved by clinical reports; the Chinese yam has the effects of tonifying spleen and qi, promoting the production of body fluid and benefiting lung, reducing blood sugar and blood fat, resisting oxidation, mutation, tumor and aging, enhancing immunity and has a certain effect on improving the constitution of the old; the tuckahoe has the effects of strengthening spleen and replenishing qi, excreting dampness and promoting diuresis, calming heart and tranquilizing mind, has the effects of enhancing immunity, resisting inflammation, tumors, aging, leukemia and the like, and has a certain effect on improving the constitution of the old; peach kernel has the effects of activating blood circulation to dissipate blood stasis, relaxing bowel, relieving cough and asthma, improving immunity of organisms, resisting allergy, tumor and the like, has anticoagulation, antithrombotic and other effects on cardiovascular and cerebrovascular diseases, can increase cerebral blood flow, reduce cerebrovascular resistance, improve hemodynamics, and has a protective effect on cerebral functions; the safflower has the functions of promoting blood circulation and removing blood stasis, resisting coagulation, oxidation, aging, tumor and blood fat, and animal experiments prove that the safflower has the functions of protecting brain tissues, obviously inhibiting focal cerebral ischemia and relieving cerebral infarction area and nerve dysfunction of rats; astragalus root, radix astragali raises yang and invigorates qi, strengthens exterior and suppresses sweating, promotes production of body fluid and nourishes blood, moves stagnation and removes arthralgia, induces diuresis and reduces edema, expels toxin and pus, and heals sore and promotes tissue regeneration, which is one of the most commonly used medicines for treating deficiency syndrome. The astragalus is the best of all qi tonifying medicines in the Chinese herbal Zhenzhen, has the effects of improving immunity, resisting oxidation, mutation, tumor, virus, aging and arteriosclerosis, reducing blood fat, blood pressure and blood sugar, can effectively protect heart and cerebral vessels, and has a certain protection effect on senile dementia; rhizoma polygonati has the effects of removing rheumatism, calming the five internal organs, losing weight after long-term taking and resisting hunger for a long time (from famous medical records), can tonify qi and nourish blood, invigorate spleen and tonify qi, nourish kidney and moisten lung, has the effects of enhancing immunity, resisting bacteria, viruses, oxidation, aging, tumors and the like, has the effects of improving learning, enhancing memory and the like, and has better curative effect on hypomnesis of patients with senile dementia; eucommia bark has the functions of tonifying liver and kidney, strengthening tendons and bones, preventing miscarriage, enhancing immunity, resisting aging, oxidation, tumor, inflammation and virus, reducing blood sugar, blood pressure and blood fat, strengthening physique and the like, and the extract has the potential function of treating neurodegenerative diseases and has the nerve protection function on learning and memory disorder mice; the dogwood has the effects of tonifying liver and kidney, arresting seminal emission, relieving depletion, astringing and arresting sweating, improving immunity, resisting oxidation, resisting aging, resisting tumors, resisting inflammation, relieving pain and the like, and animal experiments prove that the dogwood has a protection effect on cortical neuron cells, has a potential protection effect on cerebral ischemic injury, has a treatment effect on focal cerebral ischemia, has an improvement effect on cerebral infarction, has obvious effects of improving and improving cognitive competence and has a protection effect on nerve injury caused by oxidative stress; kudzu vine root has the functions of expelling pathogenic factors from muscles, allaying fever, promoting the production of body fluid, quenching thirst, invigorating yang and relieving diarrhea, contains isoflavone compounds such as daidzein and the like, can improve blood circulation, resist arrhythmia, myocardial ischemia, oxidation, tumors, blood pressure, blood fat and blood sugar, protect cranial nerves, resist oxidation and the like, and animal experiments prove that the puerarin can inhibit the expression of related proteins of brain tissues and the aggregation of platelets so as to protect the brain tissues and prevent cerebral infarction; the lucid ganoderma has the effects of tonifying qi, soothing the nerves, relieving cough and asthma, and strengthening the body resistance to consolidate the constitution, has the effects of enhancing immunity, resisting oxidation, aging, mutation, tumor and the like, and has obvious curative effects of resisting insomnia and neurasthenia.
A Chinese medicine for quickly relieving the senile dementia, which has the functions of promoting the transformation of spleen and stomach, invigorating kidney, replenishing essence, benefiting marrow and delaying senility. Moreover, the medicines are not the superposition of the effects of single traditional Chinese medicines, but are scientifically prepared on the basis of the treatment based on syndrome differentiation of the traditional Chinese medicine, and the formula effect of 1+1 to more than 2 is realized. The traditional Chinese medicine has the functions mainly reflected in the aspects of strengthening spleen and replenishing qi, nourishing kidney and replenishing essence, relieving symptoms and the like, and has particularly obvious curative effect on relieving the symptoms of dysphoria and depression, dizziness and amnesia, reaction retardation, limb weakness, apathy, expression dull expression, soreness and weakness in waist and knee joints and the like.
Moreover, the pharmacological actions of the drugs have the conclusion of relevant pharmacological research or animal experiments.
The medicine can be prepared into oral administration dosage forms by adopting a conventional method of Chinese medicine preparations. The medicine of the invention can be prepared by grinding the raw materials into powder and uniformly mixing the powder into powder, granules, oral liquid and beverage. Or decocting the raw materials with water, concentrating into paste, drying to obtain effective components, and preparing into various oral preparations according to the requirements, but the invention is not limited in scope of protection.
The medicine can also be used for extracting effective components by adopting methods such as semi-bionic extraction (SBE), Supercritical Fluid Extraction (SFE), microwave extraction (MAE), enzyme extraction (ETE), ultrasonic extraction (UAE), semi-bionic extraction (SEB), squeezing extraction (PE), Continuous Countercurrent Extraction (CCE), tissue disruption extraction (STE), heating-free extraction (HFE), normal-temperature ultrahigh-pressure extraction (UHPE), Air Explosion Extraction (AEE) and the like, and the extraction methods are all in the protection range of the medicine.
The following capsule formulations are preferred for use in the present invention.
The preparation method of the medicine comprises the following steps:
(1) weighing the raw materials in proportion for later use;
(2) 20 traditional Chinese medicines of hawthorn, medlar, mulberry, sharpleaf galangal fruit, perilla fruit, angelica, tall gastrodia tuber, American ginseng, spina date seed, ginseng, yam, tuckahoe, peach kernel, safflower, astragalus root, rhizoma polygonati, eucommia bark, dogwood, kudzuvine root and lucid ganoderma in the weight ratio are delivered to a professional traditional Chinese medicine pharmaceutical factory for extraction after being accepted;
(3) extracting by a pharmaceutical factory according to a conventional method and a conventional program for extracting traditional Chinese medicines;
(4) packaging the extracted medicinal powder into bottled capsules, wherein each bottle contains 60 capsules, and each capsule contains 0.45g of the Chinese medicinal extract powder;
(5) or making the extracted medicine into granules, wherein each bag contains 6g of traditional Chinese medicine extraction powder;
(6) the finished product is delivered to clinical experiments by a pharmaceutical factory.
The clinical use results show that the medicine of the invention has the following advantages:
1. the invention selects natural edible plant medicines as raw materials, and each component accords with the regulation of a pharmaceutical law and the principle of a traditional Chinese medicine prescription, and highlights the basic characteristics of the combination of traditional Chinese medicine syndrome differentiation and western medicine disease differentiation and the combination of etiology treatment and symptomatic treatment;
2. the medicine of the invention does not need to be decocted after being extracted, has good taste and convenient taking, is nontoxic and harmless before and after the prescription of each medicine, and has no side effect after being taken with normal dosage;
3. the medicine has good treatment effect on the low immune function of patients and various symptoms caused by the low immune function of the patients, has good prevention and health care effects, and has wide application range;
4. the medicine is selected from the varieties which can be used as both medicine and food and are regulated by Ministry of health, the safety is higher, and the medicine can be taken by patients with low immunity for a long time in treatment;
5. the medicine has good compatibility, and has certain treatment effect on the symptoms of dysphoria and depression, dizziness and amnesia, slow reaction, limb weakness, apathy, expression dull stagnation, lumbar and knee soreness and the like which are easy to appear in patients;
6. the medicine of the invention treats both principal and secondary aspect of disease, and has quick effect.
Detailed Description
The effect of the present invention will be further illustrated by the following examples and clinical application statistics.
Example 1: capsule preparation
15kg of hawthorn, 20kg of medlar, 20kg of mulberry fruit, 20kg of sharpleaf galangal fruit, 15kg of perilla fruit, 15kg of angelica, 20kg of gastrodia elata, 20kg of American ginseng, 15kg of spina date seed, 20kg of ginseng, 20kg of Chinese yam, 15kg of poria cocos, 18kg of peach kernel, 20kg of safflower, 18kg of astragalus membranaceus, 20kg of rhizoma polygonati, 20kg of eucommia ulmoides, 20kg of cornus officinalis, 20kg of kudzu root and 15kg of lucid ganoderma are extracted and processed by a professional Chinese medicine factory and are prepared into capsules, wherein each capsule is 0.45g, 4 capsules at a time and 3 times a day.
Example 2: preparation of granules
15kg of hawthorn, 20kg of medlar, 20kg of mulberry fruit, 20kg of sharpleaf galangal fruit, 15kg of perilla fruit, 15kg of angelica, 20kg of gastrodia elata, 20kg of American ginseng, 15kg of spina date seed, 20kg of ginseng, 20kg of Chinese yam, 15kg of poria cocos, 18kg of peach kernel, 20kg of safflower, 18kg of astragalus membranaceus, 20kg of rhizoma polygonati, 20kg of eucommia ulmoides, 20kg of cornus officinalis, 20kg of kudzu root and 15kg of lucid ganoderma are extracted and processed by a professional Chinese medicine factory, and are prepared into granules, wherein 6g of each bag is taken with water 1 bag and 3 times a day.
Clinical observation of the drug of the invention
One, general data
In order to prove the clinical efficacy of the medicine, 132 patients with senile dementia are treated by the traditional Chinese medicine outpatient service in 7-2019 in 2018 and the age is 55-85 years; 49 men and 83 women; the observed group and the control group were divided into 66 cases each by the digital random Chart method. In the observation group, 24 men and 42 women were observed; the age is 55-85 years, and the average age is 72.71 +/-6.39 years; the course of the disease (28.11 +/-13.77) months. 66 control groups, 25 men and 41 women; the age is 55-84 years, and the average age is 72.97 +/-6.42 years; the course of the disease (27.91 + -14.16) months. The general clinical data of two groups, such as sex, age, course of disease, etc., have no significant difference after statistical treatment and are comparable (P is more than 0.05).
Western diagnostic criteria: the diagnosis of AD meets the diagnostic criteria of dementia and senile dementia, which are revised by American psychiatric Association in 1994 as the diagnostic Manual of mental disorders of American psychiatric society and the Standard of statistical work Manual, fourth edition. There is objective evidence to indicate short-term and long-term memory impairment; at least 1 of the following items are provided: impairment of abstract thinking; impaired judgment; disorders of other cortical higher functions such as aphasia, disuse, agnosia, "structural" difficulties; the personality changes. Wherein the first and second disorders significantly interfere with professional and daily social activities or interpersonal relationships; not only in the course of delirium.
The traditional Chinese medicine diagnosis standard is as follows: the traditional Chinese medicine syndrome diagnosis standard refers to the traditional Chinese medicine syndrome diagnosis standard (the Chinese people's republic of China standardized traditional Chinese medicine clinical diagnosis and treatment term-syndrome part GB/T16751.2-1997) and is diagnosed as the marrow deficiency syndrome due to kidney deficiency. The main symptoms are: deficiency of kidney essence and insufficiency of essence and marrow are the common symptoms of growth retardation, or chronic fracture, or soreness of waist and bones, dizziness, tinnitus, amnesia, dementia, etc.
And (3) inclusion standard: the age is 55-85 years old, and the diagnosis standard of the senile dementia is met. Adopting a simple and easy quick-check table (MMSE) of mental states to totally divide the patients with mild and moderate senile dementia into 13-24 divisions; male or female aged more than or equal to 50 years old; no major somatic disease; excluding brain trauma and other mental disorders. The patients who have not used psychotropic drugs or vasoactive drugs in 2 months before the study have no major consumptive diseases, have good compliance and voluntarily sign informed consent.
Exclusion criteria: patients suffering from vascular dementia or dementia due to other causes; patients with severe diseases of the heart, liver, kidney and hematopoietic system (sinus bradycardia and conduction block, ALT and AST are 2 times higher than the upper limit of normal value, urea nitrogen is 1.5 times higher than the upper limit of normal value in renal function examination, creatinine is higher than normal value); those with allergic constitution or who are allergic to the present therapeutic agent; those with critical illness and difficulty in self-care; hypertension with difficult control; diseases with interfering cognitive tests, such as aphasia, hemiplegia, or severe hearing impairment, visual deficits, speech communication limitation; patients with a history of syncope, asthma and chronic obstructive pulmonary disease; those who are participating in other drug clinical trials; the critical illness state can not make a definite appraiser on the effectiveness and the safety of the research medicine; poor compliance and failure to complete the whole course of treatment; the comprehensive evaluation proves that the clinical observers are not suitable to participate.
Second, test method
Comparison medication: both groups were administered for 2 months. The observation group takes the medicinal granules of the invention with 6g per bag, 1 bag per time and 3 times per day after being taken with water; the huperzine A tablet (made by Henan Tailong pharmaceutical industry Co., Ltd., Chinese medicine standard H10940156) is administered orally 0.15mg each time 2 times a day, and other neurotrophic agents are not administered during western medicine administration period, and small dose of anxiolytic medicine such as alprazolam tablet can be administered if necessary, 0.4-0.8 mg per day. The duration of continuous treatment in 2 groups was 3 months.
The evaluation standard of curative effect is as follows: before and at the end of 3 months of treatment, the ChangGuchuan dementia modification scale (HDS-R) is adopted to evaluate the clinical performance, and the brief mental state scale (MMSE) is adopted to evaluate the cognitive function and the curative effect.
Observation indexes are as follows: (1) change in chief complaint score before and after treatment in group 2; (2)2 pre-and post-treatment MMSE score comparisons; (3) the clinical efficacy of 2 groups of patients was compared.
Statistical analysis: statistics is carried out by adopting SPSS10.0 for windows statistical softwareThe two groups of curative effects are compared by adopting x2The test shows that P is less than 0.05, which shows that the difference is statistical.
And (3) analyzing the curative effect: group 2 clinical performance assessments were performed with HDS-R. The total score is 32.5, the near-far memory is 9.5, the directional force is 5.5, the calculation force is 5, the command obedience is 2.5 and the language comprehension is 7.5.
(1) Change in chief complaint score before and after treatment in group 2: the far and near memory before and after treatment of the observation group are respectively 5.29 +/-1.33 and 5.82 +/-1.71, the computing capacity before and after treatment are respectively 2.63 +/-1.21 and 2.85 +/-1.33, the language understanding before and after treatment are respectively 4.37 +/-1.45 and 5.92 +/-1.61, the command obedience before and after treatment are respectively 1.65 +/-0.51 and 2.33 +/-0.51, and the directional force before and after treatment are respectively 3.21 +/-1.29 and 4.39 +/-1.09; the far and near memory before and after treatment of the control group are respectively 5.32 +/-1.63 and 5.91 +/-1.82, the calculation capacity before and after treatment are respectively 2.77 +/-1.36 and 2.82 +/-1.42, the language understanding before and after treatment are respectively 4.49 +/-1.59 and 4.74 +/-1.77, the command compliance before and after treatment are respectively 1.65 +/-0.53 and 1.78 +/-0.59, and the directional force before and after treatment are respectively 3.31 +/-1.31 and 3.59 +/-1.39; the 3 aspects of language understanding, command obedience and directional force of the observation group are obviously improved after treatment, the observation group has statistical difference, and the observation group is superior to the control group. (2) Comparison of MMSE scores before and after 2 groups of treatments: the concentration of the drug in the observation group is 25.33 +/-3.03 and 31.22 +/-4.52 before and after treatment, and the concentration of the drug in the contrast group is 24.97 +/-3.09 and 29.57 +/-4.12 before and after treatment; there were statistical differences before and after treatment for cognitive function in group 2. (3) Clinical efficacy comparison of 2 groups of patients: the improvement of the fraction before and after MMSE treatment is used as a judgment curative effect standard, and the improvement of the fraction is calculated as (the score at the end of treatment-the score before treatment)/the score before treatment multiplied by 100%. The effect is shown: the improvement fraction is more than or equal to 20 percent; the method has the following advantages: the fraction is improved by 10 to 19 percent; and (4) invalidation: the improvement rate is less than 10%. 31 cases (46.97%) with obvious effect, 29 cases (43.94%) with effect, 6 cases (9.09%) with no effect and 90.91% of total effective rate in 66 cases in the observation group; in 66 cases of the control group, 17 cases (25.76%) are effective, 35 cases (53.03%) are effective, 14 cases (21.21%) are ineffective, and the total effective rate is 78.79%; the 2 groups showed statistical differences in significant efficiency. Through clinical observation and comparison, the total treatment effect of the medicine is obviously higher than that of a control group, and the medicine has certain clinical popularization significance.
Claims (7)
2. the medicine for rapidly relieving the symptoms of senile dementia as claimed in claim 1, wherein the formula is characterized in that the capsule is prepared by adopting the conventional process of Chinese materia medica pharmaceutics.
3. The medicine for rapidly relieving the symptoms of senile dementia according to claim 1, wherein the formula is characterized in that the medicine is prepared into tablets by adopting the conventional process of Chinese materia medica preparation.
4. The medicine for rapidly relieving the symptoms of senile dementia according to claim 1, wherein the formula is characterized in that the medicine is prepared into powder or granules by adopting the conventional process of Chinese materia medica preparation.
5. The medicine for rapidly relieving senile dementia as claimed in claim 1, wherein the formulation is characterized in that the traditional Chinese medicine preparation is prepared into water pills, honey pills, water honey pills, condensed pills or dripping pills by the conventional process.
6. The medicine for rapidly relieving the symptoms of senile dementia according to claim 1, wherein the formula is characterized in that the medicine is prepared into oral liquid and paste by adopting the conventional process of Chinese materia medica pharmaceutics.
7. The medicine for rapidly relieving the symptoms of senile dementia as claimed in claim 1, wherein the formula is characterized in that the medicine is prepared into tea by adopting the conventional process of Chinese materia medica pharmaceutics.
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