CN112826913A

CN112826913A - Medicine for quickly relieving spleen-kidney yang deficiency type climacteric syndrome

Info

Publication number: CN112826913A
Application number: CN201911188163.6A
Authority: CN
Inventors: 王忠民
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-24
Filing date: 2019-11-24
Publication date: 2021-05-25

Abstract

The invention discloses a medicine for rapidly relieving spleen-kidney yang deficiency type climacteric syndrome, which is prepared by taking cinnamon, longan pulp, hawthorn, mulberry, medlar, purple perilla, fructus amomi, sharpleaf galangal fruit, kudzuvine root, astragalus, dried ginger, dogwood fruit, angelica, desertliving cistanche, ginseng, spina date seed, tuckahoe, citron and orange peel as raw materials according to a certain weight ratio. The medicine can be prepared into any common oral dosage form, has the effects of strengthening the spleen and stomach, nourishing the kidney and replenishing essence, warming and invigorating the spleen and kidney, tonifying qi and arresting sweating, calming the heart and soothing the nerves, regulating endocrine and the like, has obvious relieving effects on eliminating limb weakness, dizziness, insomnia and amnesia, mental depression, chest distress and dysphoria, depression and anxiety, fear and suspicion, palpitation and shortness of breath, frequent sweating, cold limbs, hyposexuality, vaginal dryness, nocturia increase, self-confidence reduction, inattention and the like in climacteric period, and has particularly quick response and no toxic or side effect.

Description

Medicine for quickly relieving spleen-kidney yang deficiency type climacteric syndrome

Technical Field

The invention relates to a medicine for quickly relieving spleen-kidney yang deficiency type climacteric syndrome, in particular to a medicine which is prepared by taking plant traditional Chinese medicines and all traditional Chinese medicines which are used as both medicine and food as raw materials according to a certain weight ratio and is used for treating various symptoms of spleen-kidney yang deficiency type climacteric syndrome.

Background

Due to the rapid arrival of aging and the increasing pressure on life, climacteric syndrome diseases become common diseases which people pay more and more attention to. Although men and women have the symptoms of climacteric syndrome, female symptoms are particularly prominent and often directly or indirectly affect normal life and work. In women, with the dysfunction of hypothalamic-pituitary-ovarian endocrine axis, the estrogen level is reduced, and a series of syndromes of paroxysmal hot flashes, sweating, palpitation and other vegetative nerve functional disorders accompanied with psychological reactions such as fear, depression, anxiety and the like occur.

It is the double change of female physiology and psychology, and the adverse effect on patients is very obvious. With the improvement of living standard and the prolongation of life span of people, the prevention and treatment of a series of symptoms caused by climacteric symptoms are particularly important. The current study of this disease has become a focus of research and patient attention in the medical community.

The prevention and treatment of climacteric syndrome focuses on early detection and early treatment, and prevention of complications caused by climacteric syndrome, and especially has very important practical significance for preventing severe senile diseases such as osteoporosis and arteriosclerosis. At present, the climacteric syndrome is mainly treated by symptomatic treatment, and western medicines are sex hormones, sedatives, antidepressants and the like. In the aspect of traditional Chinese medicine treatment, the traditional Chinese medicine is mainly an ancient and classical prescription, such as Kunbao pill, Kuntai capsule, Jinkui Shenqi pill and the like, and a traditional Chinese medicine self-prepared prescription and the like.

Western pharmacose hormone therapy is often considered the most effective method to improve the quality of life and alleviate or eliminate the symptoms associated with climacteric syndrome. However, the traditional Chinese medicine composition has more contraindications and adverse reactions, has certain limitations, particularly some western medicines may increase the probability of suffering from breast cancer, endometrial cancer, abnormal bleeding of genital tract, liver damage, active thrombosis and the like, and some patients and doctors often worry about accidents. In the treatment of traditional Chinese medicines and Chinese patent medicines, because fewer Chinese patent medicines completely conforming to the climacteric syndrome pulse are available and no new medicine appears for years, the clinical selection and use are greatly limited.

Because the climacteric syndrome has long course and long treatment time, the problem of medication safety is involved. From the clinical research point of view, ensuring both reliable efficacy and medication safety, with little or no side effects, is the most desirable option. The inventor of the present invention has conducted intensive clinical studies for many years, based on the onset characteristics and pathogenesis of climacteric syndrome. The main symptoms of the disease are analyzed, the relationship with kidney, spleen, liver, heart and the like in the traditional Chinese medicine is considered to be the most close, the low estrogen level of the patient is found at the same time, and the diagnosis and treatment are mainly divided into yin and yang aspects, so that the inventor of the medicine carries out the research of relieving and eliminating the symptoms of the climacteric syndrome by the traditional Chinese medicine for many years.

Through years of clinical observation, the climacteric syndrome is divided into two main categories of yin and yang by adopting a method of grasping main contradictions, yin deficiency patients begin to nourish yin essence of liver and kidney, yang deficiency patients mainly nourish yang qi of spleen and kidney, and other corresponding symptoms are regulated by different emphasis in medicines. Clinical research results show that the scheme has reliable treatment effect and no toxic or side effect, and is superior to the treatment of common medicines.

The invention relates to a novel medicine for treating climacteric syndrome, which has reliable curative effect without toxic or side effect and can quickly treat, relieve or eliminate related symptoms, in particular to a medicine with obvious curative effect developed by using medicine-food dual-purpose traditional Chinese medicines, which has the characteristics of safety and effectiveness and very important practical significance, and is the starting point and the research purpose of leading master of traditional Chinese medicine doctors and leading of a traditional Chinese medicine inheritance studio in Tianjin city to master and master the loyalty of the traditional Chinese medicine inventor. The successful development of a Chinese patent medicine for quickly relieving the spleen-kidney yang deficiency type climacteric syndrome fills the blank that the medicine and food dual-purpose Chinese patent medicine can quickly treat the climacteric syndrome.

Disclosure of Invention

A medicine for quickly relieving climacteric syndrome caused by spleen and kidney yang deficiency mainly aims at the symptoms of limb weakness, dizziness, insomnia, amnesia, mental depression, chest distress, dysphoria, depression, anxiety, suspicion of fear, palpitation, shortness of breath, frequent sweating, cold and cold limbs, hyposexuality, vaginal dryness, nocturia, self-confidence reduction, attention deficit and the like, and quickly relieves or relieves the symptoms by treating the symptoms of spleen and stomach strengthening, kidney nourishing and essence replenishing, spleen and kidney warming and tonifying, qi replenishing and arresting sweating, heart calming and nerves calming, endocrine regulation and the like.

The traditional Chinese medicine considers that the climacteric syndrome belongs to the symptoms of perimenopause, depression, consumptive disease, hysteria, sweating syndrome, palpitation and the like, and mainly solves the main contradiction for patients with the pathogenesis mainly including spleen and kidney yang deficiency according to the main clinical pulse syndrome, and if the treatment is carried out inversely, the traditional Chinese medicine is more effective and quicker.

According to years of clinical research of the inventor, some traditional Chinese medicines are found to have the basic characteristics of conforming to the syndrome differentiation treatment of the traditional Chinese medicine and also conform to the medication principle of pharmacological research. According to the characteristic that the pathogenesis of the climacteric syndrome is low in estrogen level, on the basis of clinically conforming to the treatment based on syndrome differentiation of traditional Chinese medicine, the traditional Chinese medicine which has the effects of nourishing liver and kidney, relieving related symptoms, supplementing plant estrogen and relieving diseases caused by estrogen deficiency is selected, and the clinical application proves that the traditional Chinese medicine has the effect of getting twice the result with little effort.

In traditional Chinese medicine, there are many varieties containing plant estrogen. Phytoestrogens are plant components that bind to and activate estrogen receptors in mammals and humans, and thus have some estrogen-like and/or antiestrogenic activity. Pharmacological studies have confirmed that these chemical molecules include flavones, isoflavones, flavanones, flavonols, coumarins, lignans, and the like.

The mechanism of the plant estrogen is similar to that of steroid hormone, so that the plant estrogen can be combined with two estrogen receptors ER alpha and Er beta in a human body, and the plant estrogen contained in some traditional Chinese medicines can be one of the material bases of the traditional Chinese medicines for preventing and treating diseases. The inventor finds that some traditional Chinese medicines containing plant estrogen can effectively improve the estrogen level in the body of a patient and has particularly obvious effect of relieving climacteric syndrome through clinical research.

According to the pulse symptoms of the spleen-kidney yang deficiency type female climacteric syndrome, medicines which meet the syndrome differentiation requirements and supplement plant estrogen are selected, and medicines for tonifying kidney, strengthening spleen, tonifying yang, nourishing blood and the like in the dual purposes of medicine and food are combined, so that the treatment effect is greatly improved, and the disease course is effectively shortened.

The medicine is realized by the following technical scheme. A medicine and food dual purpose medicine for rapidly relieving spleen and kidney yang deficiency type climacteric syndrome is characterized in that the medicine and food dual purpose medicine is prepared by the following raw materials by the conventional process of traditional Chinese medicine pharmaceutics in parts by weight: 10-90 parts of cinnamon, 10-50 parts of arillus longan, 10-90 parts of hawthorn, 10-60 parts of mulberry, 10-60 parts of wolfberry, 10-90 parts of perilla, 10-60 parts of fructus amomi, 10-90 parts of fructus alpiniae oxyphyllae, 10-45 parts of radix puerariae, 10-90 parts of astragalus membranaceus, 10-60 parts of dried ginger, 10-90 parts of cornus officinalis, 10-90 parts of angelica sinensis, 10-60 parts of cistanche deserticola, 10-90 parts of ginseng, 10-90 parts of spina date seed, 10-90 parts of poria cocos, 10-90 parts of citron and 10-90 parts of orange peel.

The raw material medicaments and the dosage formula are obtained by clinical experiments of the inventor, and have obvious curative effect within the dosage range.

The medicine composition for quickly relieving spleen-kidney yang deficiency type climacteric syndrome is prepared by selecting cinnamon, arillus longan, hawthorn, mulberry, wolfberry fruit, purple perilla, fructus amomi, fructus alpiniae oxyphyllae, radix puerariae, radix astragali, rhizoma zingiberis, dogwood fruit, angelica sinensis, cistanche, ginseng, spina date seed, poria cocos, citron and orange peel for compatibility, and mutual synergistic effect is generated among the efficacies of the medicines, so that a plurality of spleen-kidney yang deficiency symptoms of the climacteric syndrome are effectively controlled, and the medicine composition is particularly quick in effect and free of toxic and side effects.

Cinnamon in the medicine for rapidly relieving the spleen-kidney yang deficiency type climacteric syndrome warms and tonifies kidney yang, dispels cold to relieve pain, warms channels and activates blood, and induces fire to return to original qi, and is a main medicine for treating kidney yang deficiency; the longan pulp has the effects of tonifying heart and spleen, nourishing blood and soothing nerves, and can effectively relieve neurasthenia, palpitation, amnesia, insomnia and the like caused by climacteric syndrome; the hawthorn can remove qi and blood, remove blood stasis without damaging new blood, remove stagnation without damaging healthy qi, and has a treatment effect on climacteric syndrome of multiple blood stasis; the mulberry has the effects of tonifying liver and kidney, nourishing blood, promoting the production of body fluid and relaxing bowel, and has good treatment effect on kidney deficiency symptoms in menopause; the medlar has the effects of nourishing liver and kidney, replenishing vital essence, improving eyesight, moistening lung, relieving cough and prolonging life, contains a certain amount of plant estrogen, and has a treatment effect on relieving the low estrogen level of the climacteric syndrome; purple perilla regulates qi and dispels cold, promotes qi circulation and harmonizes stomach, regulates qi movement, warms yang and eliminates dampness, and is good at treating diseases such as stagnation of liver-qi, phlegm-qi stagnation and the like; fructus amomi is capable of resolving dampness and promoting qi circulation, pungent and dispersing and warming middle energizer, tonifying spleen and regulating qi, warm in nature but not dry, and promoting qi circulation without breaking qi, and is particularly suitable for symptoms of qi stagnation of spleen and stomach and deficiency-cold of spleen and stomach; fructus alpiniae oxyphyllae warms and tonifies spleen and kidney, fixes essence and reduces urination, can restrict cold and cool medicine from passing, and has good effects of relieving symptoms of nocturia increase and the like of climacteric patients; kudzu vine root has the functions of expelling pathogenic factors from muscles, allaying fever, promoting the production of body fluid to quench thirst, and invigorating yang to arrest diarrhea, puerarin of the kudzu vine root has the function of plant estrogen, and animal experiments prove that the kudzu vine root has the function of protecting diseases caused by estrogen deficiency; astragalus root, radix astragali has effects of invigorating qi and invigorating yang, consolidating superficial resistance and arresting sweating, and is especially suitable for the elderly with asthenia and deficiency of middle-warmer energy; the lily has the effects of nourishing yin and moistening dryness, calming heart and tranquilizing mind, tonifying spleen and invigorating stomach, and has good relieving effect on symptoms such as neurasthenia and the like caused by climacteric syndrome; the dried ginger has the effects of warming channels for dispelling cold, restoring yang to dredge collaterals, warming lung and dissolving fluid, and has good effects of tonifying yang and dispelling cold; the dogwood fruit has the effects of nourishing liver and kidney, controlling nocturnal emission and stopping sweating, and can relieve dizziness, lumbar soreness, weakness in the lower and knee joints, frequent micturition and spontaneous sweating and the like caused by climacteric syndrome; the angelica has the functions of enriching and activating blood, contains plant estrogen, and has treatment effect on relieving various symptoms caused by low estrogen level; the cistanche has the effects of tonifying kidney and strengthening yang, relaxing bowel and delaying senility, contains plant estrogen, and has obvious effect of relieving climacteric syndrome; ginseng radix has effects of invigorating primordial qi, invigorating spleen and lung, promoting fluid production to quench thirst, ginsenoside can promote memory, resist nerve cell apoptosis, has good effects of resisting aging, oxidation and fatigue, enhancing immunity, regulating nervous system, exciting hemopoietic system function, improving microcirculation of the elderly, improving memory, and improving learning ability; the spina date seed has the effects of nourishing the heart, soothing the nerves, tonifying yin and arresting sweating, and has good effects on insomnia, amnesia, spontaneous sweating, night sweat and other symptoms commonly seen in climacteric syndrome; the tuckahoe has the effects of tonifying qi, calming heart and tranquilizing mind, and promoting diuresis and eliminating dampness, and has good effects on symptoms such as weak constitution, insufficiency of spleen-qi, stagnation of water-dampness and the like; citron can promote diaphragmatic function to stop vomiting, regulate the middle warmer to reduce phlegm, sooth the liver and regulate qi, and can be used for treating liver depression and spleen deficiency, water damp indigestion, turbid phlegm obstruction in the middle warmer and other symptoms; the orange peel has the good effects of regulating qi, invigorating stomach, eliminating dampness and phlegm, strengthening spleen and stomach, promoting digestion and the like.

The cinnamon and the dried ginger warmly tonify yang qi, and relieve the climacteric syndrome of cold limbs; the medlar, the mulberry, the cornus, the cistanche, the sharpleaf galangal fruit, the kudzuvine root and the Chinese angelica have the effects of tonifying the kidney, replenishing essence, benefiting yin and nourishing blood so as to supplement the innate root; hawthorn, purple perilla, fructus amomi, citron and orange peel can sooth the liver and regulate qi, strengthen the spleen and stomach to supplement acquired constitution; radix astragali and radix Ginseng can reinforce primordial qi and relieve fatigue to improve immunity; the longan pulp, the spina date seed and the tuckahoe are capable of calming the nerves and calming the heart and relieving restlessness so as to eliminate amnesia and depression. The medicines are matched, and the traditional Chinese medicine composition has obvious and rapid relieving effect on symptoms of climacteric syndrome.

The selected medicines have the efficacies of strengthening the spleen and stomach, nourishing the kidney and replenishing essence, warming and invigorating the spleen and the kidney, tonifying qi and arresting sweating, calming the heart and soothing the nerves, regulating endocrine and the like in different degrees. Moreover, the medicines are not the superposition of the effects of single traditional Chinese medicines, but are scientifically prepared on the basis of the treatment based on syndrome differentiation of the traditional Chinese medicine, and the formula effect of 1+1 to more than 2 is realized. The functions of the traditional Chinese medicine are mainly reflected in that the traditional Chinese medicine has obvious curative effects on the symptoms of limb weakness, dizziness, insomnia, amnesia, mental depression, chest distress, dysphoria, depression, anxiety, suspicion of fear, palpitation, shortness of breath, frequent sweating, cold limbs, hyposexuality, vaginal dryness, nocturia, reduction of self-confidence, inattention and the like caused by the spleen-kidney yang deficiency type climacteric syndrome caused by various diseases.

Moreover, the pharmacological actions of the drugs have the conclusion of relevant pharmacological research or animal experiments.

The medicine can be prepared into oral administration dosage forms by adopting a conventional method of Chinese medicine preparations. The medicine of the invention can be prepared by grinding the raw materials into powder and uniformly mixing the powder into powder, granules, oral liquid and beverage. Or decocting the raw materials with water, concentrating into paste, drying to obtain effective components, and preparing into various oral preparations according to the requirements, but the invention is not limited in scope of protection.

The medicine can also be used for extracting effective components by adopting methods such as semi-bionic extraction (SBE), Supercritical Fluid Extraction (SFE), microwave extraction (MAE), enzyme extraction (ETE), ultrasonic extraction (UAE), semi-bionic extraction (SEB), squeezing extraction (PE), Continuous Countercurrent Extraction (CCE), tissue disruption extraction (STE), heating-free extraction (HFE), normal-temperature ultrahigh-pressure extraction (U HPE), Air Explosion Extraction (AEE) and the like, and the extraction methods are all in the protection range of the medicine.

The following capsule formulations are preferred for use in the present invention.

The preparation method of the medicine comprises the following steps:

(1) weighing the raw materials in proportion for later use;

(2) 19 traditional Chinese medicines of cinnamon, longan aril, hawthorn, mulberry, medlar, purple perilla, fructus amomi, sharpleaf galangal fruit, kudzuvine root, astragalus root, dried ginger, dogwood fruit, angelica, desertliving cistanche, ginseng, spina date seed, tuckahoe, citron and orange peel in the weight ratio are delivered to a professional traditional Chinese medicine pharmaceutical factory for extraction after being checked and accepted;

(3) extracting by a pharmaceutical factory according to a conventional method and a conventional program for extracting traditional Chinese medicines;

(4) packaging the extracted medicinal powder into bottled capsules, wherein each bottle contains 60 capsules, and each capsule contains 0.45g of the Chinese medicinal extract powder;

(5) or making the extracted medicine into granules, wherein each bag contains 6g of traditional Chinese medicine extraction powder;

(6) the finished product is delivered to clinical experiments by a pharmaceutical factory.

The clinical use results show that the medicine of the invention has the following advantages:

1. the invention selects natural edible plant medicines as raw materials, and each component accords with the regulation of a pharmaceutical law and the principle of a traditional Chinese medicine prescription, and highlights the basic characteristics of the combination of traditional Chinese medicine syndrome differentiation and western medicine disease differentiation and the combination of etiology treatment and symptomatic treatment;

2. the medicine of the invention does not need to be decocted after being extracted, has good taste and convenient taking, is nontoxic and harmless before and after the prescription of each medicine, and has no side effect after being taken with normal dosage;

3. the medicine has good treatment effect on female low estrogen level and a plurality of symptoms caused by the female low estrogen level, has good prevention and health care effects, and has wide application range;

4. the medicine is selected from the varieties which can be used as both medicine and food and are regulated by Ministry of health, the safety is higher, and the medicine can be taken by patients with low immunity for a long time in treatment;

5. the medicine has good compatibility, and has certain compatibility treatment effect on various symptoms, sub-health and the like which are easy to appear in female or male climacteric syndrome patients with spleen-kidney yang deficiency;

6. the medicine of the invention treats both principal and secondary aspect of disease, and has quick effect.

Detailed Description

The effect of the present invention will be further illustrated by the following examples and clinical application statistics.

Example 1: capsule preparation

15kg of cinnamon, 20kg of longan pulp, 20kg of hawthorn, 20kg of mulberry, 15kg of medlar, 15kg of perilla, 20kg of fructus amomi, 20kg of fructus alpiniae oxyphyllae, 15kg of radix puerariae, 20kg of radix astragali, 20kg of rhizoma zingiberis, 15kg of fructus corni, 18kg of angelica, 20kg of herba cistanche, 18kg of ginseng, 15kg of spina date seed, 25kg of poria cocos, 20kg of citron and 20kg of orange peel, and the raw materials are extracted and processed by a professional Chinese medicine pharmacy to prepare capsules, wherein each capsule is 0.45g, 4 capsules each time and 3 times a day.

Example 2: preparation of granules

15kg of cinnamon, 20kg of longan pulp, 20kg of hawthorn, 20kg of mulberry, 15kg of medlar, 15kg of perilla, 20kg of fructus amomi, 20kg of fructus alpiniae oxyphyllae, 15kg of radix puerariae, 20kg of radix astragali, 20kg of rhizoma zingiberis, 15kg of fructus corni, 18kg of angelica, 20kg of herba cistanche, 18kg of ginseng, 15kg of spina date seed, 25kg of poria cocos, 20kg of fructus citri and 20kg of orange peel, the raw materials are extracted and processed by a professional Chinese medicine pharmacy factory, and are prepared into granules, 6g of each bag is prepared, 1 bag is prepared each time, 3 times a day, and the granules are taken with.

Clinical observation of the drug of the invention

One, general data

In order to prove the clinical curative effect of the medicine, 134 patients with the spleen-kidney yang deficiency type female climacteric syndrome are treated by the traditional Chinese medicine gynecological outpatient service in Hospital, namely 7 months to 2019 months in 2018, and the age is 45 to 55 years; the observed group and the control group were divided into 67 cases each by the digital random table method. 67 observation groups, wherein the ages are 45-55 years, and the average age (49.22 +/-3.61) is year; 67 control groups were aged 45-55 years, with the mean age (49.27. + -. 3.55) years. The general clinical data of two groups of ages and the like have no significant difference through statistical treatment and are comparable (P is more than 0.05).

Diagnostic criteria: is determined according to the clinical research guiding principle of treating the female climacteric syndrome by the new traditional Chinese medicine in the 3 rd edition of Chinese new medicine clinical research guiding principle. The aged 45-55 years old has symptoms of limb weakness, dizziness, insomnia, amnesia, mental depression, chest distress, dysphoria, depression, anxiety, fear, suspiciousness, palpitation, short breath, frequent sweating, cold body, hyposexuality, vaginal dryness, nocturia, self-confidence reduction, inattention and the like.

And (3) inclusion standard: the female is aged 45-55 years old, sexed, dialectically conforms to the traditional Chinese medicine spleen-kidney yang deficiency type female climacteric syndrome patient, conforms to the observation standard, actively participates in the clinical experiment, and voluntarily signs an informed consent.

Exclusion criteria: patients with mental system diseases, patients with serious liver and kidney function diseases, patients with serious heart diseases and other system endocrine diseases, patients taking medicaments related to climacteric syndrome without signing informed consent can not be actively matched with clinical observation and treatment patients.

Second, Experimental methods

Comparison medication: both groups were administered for 2 months. The observation group takes the medicinal granules of the invention with 6g per bag, 1 bag per time and 3 times per day after being taken with water; the control group orally administered YOUGUI pill (Zhongjing Asxi pharmaceutical Co., Ltd., Chinese medicine standard: Z41022170) for 3 times a day, 50 pills each time. Uncooked and cold stimulating food should be prohibited during the treatment period of 2 groups, and attention should be paid to harmonize emotion and avoid staying up all night and engendering qi.

Symptom score: each symptom is classified into mild, moderate and severe grade 3, which are recorded as 1, 2 and 3. Debilitation of limbs: none, 0 min; the feeling is weak, and the general physical labor can bear the feeling, 1 minute; obvious fatigue which can not surpass the manual work feeling, 2 points; obvious hypodynamia, and 3 minutes later, the feeling of hypodynamia still after the rest after the work. Spontaneous sweating often: none, 0 min; occasionally, the head is slightly sweated, and the body is slightly cool after sweating, 1 point; sweat more, cool and fond hot drink after sweating, 2 points; sweating often, cold body with preference for hot drink after sweating, 3 minutes. Increase of nocturia: none, 0 min; the number of times of getting up at night is 2 times and 1 minute; the number of times of getting up at night is 3-4, and 2 minutes; the number of times of getting up at night is more than or equal to 5 and 3 minutes. Insomnia and dreaminess: none, 0 min; occasionally, 1 point; frequently, the hypnotic is taken effectively for 2 minutes; often, taking hypnotics is ineffective for 3 points; dizziness and tinnitus: none, 0 min; (ii) a Occasionally, 1 point; often, the life is not affected, 2 points; often, it affects life by 3 points. Soreness and weakness in the lower back and knee joints: none, 0 min; occasionally, 1 point; often, the life is not affected, 2 points; often, it affects life by 3 points. Decreased libido: none, 0 min; occasionally, hyposexuality, 1 point; asexual desire in general, 2 points; there was no sexual desire or aversion to sexual life for 3 points. Cold in shape and cold in limbs: none, 0 min; feel slightly cool, 1 point; the body is cold, and the clothes and the quilt need to be slightly added for 2 minutes; obviously feel cold, need obviously increase clothing and quilt, 3 points. Tongue manifestation: normal, 0 point; the tongue is reddish with yellow coating, 1 point; red tongue with little coating, 2 points; the tongue is red and thin, dry and cracked without coating, 3 points. The pulse condition: normal, 0 point; fineness number, 1 point; number of fine and heavy, 2 minutes; decoct-thin and rapid, weak in 3 minutes.

The curative effect standard is as follows: the curative effect evaluation is carried out according to the guiding principle of clinical research of new traditional Chinese medicine and the improved Kupperman scoring standard. The clinical cure is as follows: associated symptoms disappeared, score decreased by > 90%; the effect is shown: the clinical symptoms are obviously improved, and the score is reduced by more than or equal to 70 percent but less than 90 percent; the method has the following advantages: clinical symptoms improved, with a score reduction of > 30% but < 70%: and (4) invalidation: the clinical symptoms and physical signs are not obviously improved, and the score is less than 30%.

Observation indexes are as follows: (1) observing the treatment effect of the 2 groups; (2) observing the change condition of the traditional Chinese medicine syndrome values before and after the treatment of the group 2; (3) the side effects after taking the drug were observed.

Statistical analysis: statistical analysis is carried out by adopting SPSS10.0 for windows statistical software, and x is adopted for comparing the two groups of curative effects²The test shows that P is less than 0.05, which shows that the difference is statistical.

And (3) analyzing the curative effect: (1) the effective rate comparison of 2 groups: after 2 months of treatment, 25 clinical cases (37.31%) in 67 cases of the observation group are cured, the remarkable curative effect is 27 cases (40.30%), the effective is 11 cases (16.42%), the ineffective is 4 cases (5.97%), and the total effective rate is 94.03%; in 67 cases of the control group, 8 cases (11.94%) are clinically cured, the obvious curative effect is 21 cases (31.34%), the effective effect is 24 cases (35.82%), the ineffective effect is 14 cases (20.30%), and the total effective rate is 79.70%. The two groups of effective rates have statistical difference, and P is less than 0.05. (2)2 groups of Chinese medicine syndrome value change conditions before and after treatment: the observation group is 19.36 plus or minus 4.79 before treatment and 4.19 plus or minus 2.25 after treatment; the control group had 19.31 + -4.59 before treatment and 7.87 + -3.17 after treatment. The two groups of effective rates have statistical difference, and P is less than 0.05. (3) No clinical abnormal symptom is found in the treatment period of 2 groups, and 13 suspicious abnormal persons are respectively 6 persons in the observation group and 7 persons in the control group, and are all normal after general physical examination, hematuria routine examination, electrocardiogram, liver and kidney function examination and the like. Clinical observation results prove that the medicine has good treatment effect on the spleen-kidney yang deficiency type climacteric syndrome and has certain clinical popularization value.

Claims

1. The formula of the medicine is characterized in that the medicine is prepared from a medicine-food dual-purpose traditional Chinese medicine formula and the following raw material medicines in parts by weight:

2. the medicine for rapidly relieving the spleen-kidney yang deficiency type climacteric syndrome as claimed in claim 1, wherein the formula is characterized in that the capsule is prepared by adopting the conventional process of Chinese materia medica pharmaceutics.

3. The medicine for rapidly relieving the spleen-kidney yang deficiency type climacteric syndrome as claimed in claim 1, wherein the formula is characterized in that the medicine is prepared into tablets by adopting the conventional process of Chinese materia medica pharmaceutics.

4. The medicine for rapidly relieving the spleen-kidney yang deficiency type climacteric syndrome as claimed in claim 1, wherein the formula is characterized in that the medicine is prepared into powder or granules by adopting the conventional process of Chinese materia medica pharmaceutics.

5. The medicine for rapidly relieving the spleen-kidney yang deficiency type climacteric syndrome as claimed in claim 1, wherein the formula is characterized in that the traditional Chinese medicine preparation conventional process is adopted to prepare water pills, honey pills, water honey pills, concentrated pills or dripping pills.

6. The medicine for rapidly relieving the spleen-kidney yang deficiency type climacteric syndrome as claimed in claim 1, wherein the formula is characterized in that the oral liquid and the ointment are prepared by adopting the conventional process of Chinese materia medica pharmaceutics.

7. The medicine for rapidly relieving the spleen-kidney yang deficiency type climacteric syndrome as claimed in claim 1, wherein the formula is characterized in that the medicine is prepared into tea by adopting the conventional process of Chinese materia medica pharmaceutics.