CN112641912A - Medicine for quickly treating attention deficit hyperactivity disorder - Google Patents
Medicine for quickly treating attention deficit hyperactivity disorder Download PDFInfo
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Abstract
The invention discloses a medicine for quickly treating attention deficit hyperactivity disorder, which is prepared from Chinese yam, orange peel, ginger, fingered citron, sharpleaf galangal fruit, lotus plumule, tall gastrodia tuber, desertliving cistanche, lucid ganoderma, spina date seed, dried longan pulp, lily bulb, peach kernel, hawthorn and poria cocos in a certain weight ratio. The medicine can be prepared into any common oral dosage form, has the functions of strengthening spleen and replenishing qi, tonifying kidney and replenishing essence, soothing liver and relieving depression, tranquilizing mind, calming heart and relieving restlessness and the like, has obvious curative effect on eliminating the symptoms of excessive activity, inattention, involuntary impulsion, learning difficulty, dysphoria, insufficient sleep, disordered hand and foot movement, difficult sitting and the like caused by the hyperkinetic syndrome of children, and has no toxic or side effect.
Description
Technical Field
The invention relates to a medicine for quickly treating attention deficit hyperactivity disorder, in particular to a medicine which is prepared by taking plant traditional Chinese medicines which are both edible and medicinal as raw materials according to a certain weight ratio and is used for treating attention deficit hyperactivity disorder and a series of discomfort symptoms caused by attention deficit hyperactivity disorder.
Background
Hyperkinetic childhood is a disease that is quite common in clinical settings. The morbidity is 1.3% -13.4%, the average morbidity is 3%, the morbidity of boys is obviously higher than that of girls and is about 4.9: 1, and the disease is a behavior disorder in a childhood period and brings a lot of troubles to the mental health of parents and sick children. The onset of the disease is characterized by attention disorder, restlessness, irritability, good motivation, and a series of psychological disorders accompanied by learning difficulty, conduct disorder, tic disorder and certain emotional disorders.
Modern medicine thinks that hyperkinetic syndrome of children is caused by slight disorder of brain function, and the onset age is mostly 5-12 years old, and the symptom gradually disappears with age. The research proves that the main cause of the disease is insufficient effective concentration of noradrenaline in synaptic cleft of noradrenaline neurons of brain, which causes poor impulse, conception and self-control capability, excessive activity and inattention of children patients. The learning achievement is reduced after the disease occurs, the classroom discipline is poor, the emotion is not stable enough and the disease is easy to be excited, but the disease occurs and the learning achievement is irrelevant to the intelligence quotient.
Clinical observation proves that the western medicine methylphenidate can improve the concentration of norepinephrine in synaptic cleft and enable dopamine to participate in effective regulation, the medicine becomes the first choice medicine for western medicine treatment, and the medicine takes effect generally in 2 weeks after administration, and symptoms are obviously improved or disappeared. However, the side effects of the medicine are obvious, and insomnia, dizziness, headache, nausea, anorexia, palpitation and other symptoms are often caused after the medicine is taken. Because it has been reported to inhibit growth and development, it has more obvious side effects when children take it for a long time, and it is generally considered that children under 6 years old are avoided to use as much as possible, which limits the treatment of some children with hyperkinetic syndrome.
The increase of the incidence rate of the disease already brings great pain to the sick children and families of the sick children. How to effectively treat the attention deficit hyperactivity disorder is a significant task and a medical problem of medical public relations. Traditional Chinese medicine is a great treasury, and should be developed and improved in an effort. The traditional Chinese medicine also should exert the due advantages in the aspect of treating children's hyperkinetic syndrome.
In the aspect of traditional Chinese medicine treatment, although the control advantage on symptoms is relatively slow, the curative effect is more reliable, no toxic or side effect exists, and the traditional Chinese medicine has certain advantages on improvement of the whole condition. In view of the long treatment time of the attention deficit hyperactivity disorder, the age of the patient is small, and the infant yin and yang belong to the body of the infant yin and the infant yang, the traditional Chinese medicine specially used for treating the attention deficit hyperactivity disorder is few and few in the aspect of the whole traditional Chinese medicine market at present, and the traditional Chinese medicine with the traditional Chinese medicine formula of both medicine and food is still blank at present.
The invention provides a medicament which has reliable curative effect, no toxic or side effect and obvious effect of comprehensively treating the attention deficit hyperactivity disorder, particularly the medicament which is developed by using medicine-food dual-purpose traditional Chinese medicines and has obvious curative effect has the characteristics of safety and effectiveness and very important practical significance, and is also the starting point and the research purpose of an inventor. The successful development of a Chinese medicinal preparation for quickly treating the attention deficit hyperactivity disorder fills the blank that a Chinese medicinal preparation used as both medicine and food can quickly and effectively treat the attention deficit hyperactivity disorder.
Disclosure of Invention
A medicine for quickly treating hyperkinetic syndrome of children is mainly used for carrying out targeted medicine regulation on physical and psychological injuries of patients caused by hyperkinetic syndrome of children. This regulation is based on the holistic concept and is based on the symptoms to treat the disease, resulting in the regulation of visceral function and the alleviation of various symptoms.
The pathogenesis of the childhood hyperkinetic syndrome is unknown, and the internal cause of the child patient is generally considered to be related to the existence of brain frontal lobe hypoevolutism, and the external cause is related to the fact that parents suffer from mental or behavioral problems, are alone in family, are amiable, or are exposed to high-level lead environment in early childhood, and are related to factors such as parent smoking or alcoholism and the like.
The study proves that the children with the hyperactivity are often accompanied with impaired mental development or delayed maturation, and have the characteristics of juvenile behaviors, clumsy actions and relatively poor coordination. Some children with the same disease have more complications during pregnancy or perinatal period, genetic and diathesis factors may exist, parents and parents of the children with the same disease have the same hyperkinetic symptoms in the young period, and some children with the same disease have abnormal manifestations of good movement, crying after birth, difficulty in falling asleep, poor eating and the like in the fetal period. Some children may have biochemical and metabolic factors, and researches show that central monoamine receptors of children with hyperactivity are slowly updated, while some children have vitamin deficiency or metabolic disorder caused by certain food additives and pigments. It has also been found that hyperactivity is associated with elemental metal poisoning, with lead poisoning being thought to be associated with hyperactivity. Social, household, psychological factors have an influence on hyperactivity. Poor social environment, broken families, poor parental character, accidental mental stimulation and the like all easily cause the inattention and hyperactivity of children.
According to the pathogenic factors and the relevant characteristics of the attention deficit hyperactivity disorder, systematic research is carried out from the aspect of traditional Chinese medicine, and the research is very meaningful work. Traditional Chinese medicine has certain advantages in aspects of holistic concept, treatment based on syndrome differentiation and the like, and especially has the effects of improving physique, eliminating symptoms and the like by conditioning according to the overall condition of children.
The traditional Chinese medicine inheritance studio instructor, Master instructor and Master traditional Chinese medicine teacher king loyalty in Tianjin city are explored for many years and believe that the cause of children's hyperkinetic syndrome is the congenital deficiency of viscera functions, the physical weakness of the young yin and yang, some functions are not sound, and the hyperkinetic syndrome can be caused once suffering from adverse mental stimulation and the like. Clinical tonifying of acquired constitution can help the source of qi and blood generation to restore to normal, lays a solid material foundation for the normal function of viscera, and simultaneously conditions congenital deficiency to ensure that kidney qi is full and kidney essence is full, so that brain and marrow are full, and the function is restored to normal. For chronic diseases with excessive phlegm and blood stasis, the herbs of clearing damp and resolving phlegm, promoting blood circulation and removing blood stasis are emphasized when using herbs, the phlegm-damp can be eliminated without the obstruction of the transportation and transformation functions of the spleen and stomach, and the blood stasis can be removed to circulate qi and blood as usual. Free transportation and transformation, smooth qi and blood circulation and no visceral dysfunction, the children hyperkinetic syndrome can be automatically removed. The treatment idea is to condition viscera, and the treatment method starts with strengthening spleen and replenishing qi, tonifying kidney and replenishing essence, soothing liver and relieving depression, calming nerves and relieving restlessness, and achieves the purpose of curing the attention deficit hyperactivity disorder.
The medicine is realized by the following technical scheme. The medicine for quickly treating the attention deficit hyperactivity disorder is characterized by being prepared from a medicine-food dual-purpose traditional Chinese medicine formula by using a traditional Chinese medicine pharmaceutics conventional process according to the following raw materials in parts by weight: 10-90 parts of Chinese yam, 10-50 parts of orange peel, 10-90 parts of ginger, 10-60 parts of fingered citron, 10-60 parts of fructus alpiniae oxyphyllae, 10-90 parts of lotus plumule, 10-90 parts of gastrodia elata, 10-60 parts of cistanche, 10-90 parts of lucid ganoderma, 10-90 parts of spina date seed, 10-90 parts of longan aril, 10-90 parts of lily, 10-60 parts of peach kernel, 10-90 parts of hawthorn and 10-90 parts of poria cocos.
The raw material medicaments and the dosage formula are obtained by the inventor through combined clinical tests of many medical institutions for many years, and have obvious curative effect within the dosage range.
The Chinese yam, orange peel, ginger, fingered citron, sharpleaf galangal fruit, lotus plumule, gastrodia elata, cistanche salsa, lucid ganoderma, spina date seed, longan pulp, lily, peach kernel, hawthorn and poria are selected for compatibility, and the effects of the Chinese yam, the orange peel, the ginger, the fingered citron, the sharpleaf galangal fruit, the lotus plumule, the gastrodia elata, the cistanche salsa, the lucid ganoderma, the spina date seed, the longan pulp, the lily, the peach kernel, the hawthorn and the poria are mutually synergistic, so that the Chinese medicinal composition has the functions of tonifying spleen and qi, tonifying kidney and replenishing.
Chinese yam, tuckahoe and ginger in a medicine prescription for quickly treating children hyperkinetic syndrome can strengthen spleen and replenish qi, transport and resolve water dampness and tonify acquired constitution; the orange peel and the fingered citron can regulate qi, soothe the liver, regulate qi activity and relieve emotional depression of children patients; fructus Alpinae Oxyphyllae and Cistanchis herba have effects of invigorating kidney, replenishing essence, and tonifying congenital deficiency; the lotus plumule, the lucid ganoderma, the spina date seed, the longan pulp and the lily can calm the nerves and calm the mind, calm the heart and relieve restlessness, and effectively relieve mental stress; peach kernel and hawthorn fruit can promote blood circulation to remove blood stasis, promote blood circulation and regulate the functions of internal organs.
A medicine for quickly treating hyperkinetic syndrome of children has the functions of improving the physique of a child patient, relieving a plurality of symptoms of the child patient, promoting the physical health of the patient and the like in different degrees by using one medicine. Moreover, the medicines are not the superposition of the effects of single traditional Chinese medicines, but are scientifically prepared on the basis of the treatment based on syndrome differentiation of the traditional Chinese medicine, and the formula effect of 1+1 to more than 2 is realized. The traditional Chinese medicine is mainly embodied in the aspects of strengthening the spleen and replenishing qi, tonifying the kidney and replenishing essence, soothing the liver and relieving depression, soothing the nerves and calming the mind, relieving restlessness and the like.
The medicine can be prepared into oral administration dosage forms by adopting a conventional method of Chinese medicine preparations. The medicine of the invention can be prepared by grinding the raw materials into powder and uniformly mixing the powder into powder, granules, oral liquid and beverage. The active ingredients can be obtained by decocting the raw materials in water and then concentrating the decoction, and then various oral preparations can be prepared, but the protection scope of the invention is not limited by the active ingredients.
The medicine can also be used for extracting effective components by adopting methods such as semi-bionic extraction (SBE), Supercritical Fluid Extraction (SFE), microwave extraction (MAE), enzyme extraction (ETE), ultrasonic extraction (UAE), semi-bionic extraction (SEB), squeezing extraction (PE), Continuous Countercurrent Extraction (CCE), tissue disruption extraction (STE), heating-free extraction (HFE), normal-temperature ultrahigh-pressure extraction (U HPE), Air Explosion Extraction (AEE) and the like, and the extraction methods are all in the protection range of the medicine.
The following capsule formulations are preferred for use in the present invention.
The preparation method of the medicine comprises the following steps:
(1) weighing the raw materials in proportion for later use;
(2) 15 traditional Chinese medicines of Chinese yam, orange peel, ginger, fingered citron, sharpleaf galangal fruit, lotus plumule, tall gastrodia tuber, desertliving cistanche, lucid ganoderma, spina date seed, dried longan pulp, lily, peach seed, hawthorn and tuckahoe in the weight ratio are delivered to a professional traditional Chinese medicine pharmaceutical factory for extraction after being checked and accepted;
(3) extracting by a pharmaceutical factory according to a conventional method and a conventional program for extracting traditional Chinese medicines;
(4) packaging the extracted medicinal powder into bottled capsules, wherein each bottle contains 60 capsules, and each capsule contains 0.45g of the Chinese medicinal extract powder;
(5) or making the extracted medicine into granules, wherein each bag contains 6g of traditional Chinese medicine extraction powder;
(6) the finished product is delivered to clinical trials by the pharmaceutical factory.
The clinical use results show that the medicine of the invention has the following advantages:
1. the invention selects natural edible plant medicines as raw materials, and each component accords with the regulation of a pharmaceutical law and the principle of a traditional Chinese medicine prescription, and highlights the basic characteristics of the combination of traditional Chinese medicine syndrome differentiation and western medicine disease differentiation and the combination of etiology treatment and symptomatic treatment;
2. the medicine of the invention does not need to be decocted after being extracted, has good taste and convenient taking, is nontoxic and harmless before and after the prescription of each medicine, and has no side effect after being taken with normal dosage;
3. the medicine has good treatment effect on the attention deficit hyperactivity disorder and various symptoms of the attention deficit hyperactivity disorder, has good prevention and health care effects, and has wide application range;
4. the medicine is selected from the varieties which can be used as both medicine and food and specified in Weijian Wei, has higher safety, and can be taken by patients with uric acid increase for a long time in treatment;
5. the medicine has good compatibility, and has certain compatibility of treatment on the symptoms such as complication, low immunity, sub-health and the like which are easy to appear in patients;
6. the medicine of the invention treats both principal and secondary aspect of disease, and has quick effect.
Detailed Description
The effect of the present invention will be further illustrated by the following examples and clinical application statistics.
Example 1: capsule preparation
15kg of Chinese yam, 20kg of orange peel, 20kg of ginger, 20kg of fingered citron, 15kg of sharpleaf galangal fruit, 15kg of lotus plumule, 20kg of gastrodia elata, 20kg of cistanche, 15kg of lucid ganoderma, 20kg of spina date seed, 15kg of arillus longan, 20kg of lily, 15kg of peach kernel, 20kg of hawthorn and 20kg of poria cocos, and the Chinese medicinal herbs are extracted and processed by a professional Chinese medicinal herb factory to prepare capsules, wherein each capsule is 0.45g, 2-4 capsules each time, and 3 times a day.
Example 2: beverage preparation
15kg of Chinese yam, 20kg of orange peel, 20kg of ginger, 20kg of finger citron, 15kg of sharpleaf galangal fruit, 15kg of lotus plumule, 20kg of gastrodia elata, 20kg of cistanche, 15kg of lucid ganoderma, 20kg of spina date seed, 15kg of longan pulp, 20kg of lily, 15kg of peach kernel, 20kg of hawthorn and 20kg of poria cocos are extracted and processed by a professional traditional Chinese medicine pharmacy factory, and are prepared into granules, 6g of each bag is taken 3 times a day, and the specific taking dosage is determined according to the age.
Clinical observation of the drug of the invention
One, general data
In order to prove the clinical curative effect of the medicine, 96 cases of patients with hyperkinetic syndrome of children, 77 cases of men and 19 cases of women are treated by the outpatient clinic of the traditional Chinese medicine department in 7 months to 5 months of 2019 in 2018; the minimum age is 5 years, the maximum age is 13 years, and the average age is (7.9 +/-3.1); the shortest disease course is 7 months, the longest course is 5 years and 3 months, and the average (3.3 +/-1.2) years. The samples were randomly divided into 2 groups of 48 cases according to the numerical method. Statistical analysis shows that the 2 groups of patients have no significant difference in sex, age, disease course and condition of hyperactivity, and have comparability (P is more than 0.05).
Diagnostic criteria: adopts CCMD-3 Western medicine diagnosis standard established by the psychiatric department of the Chinese medical society to eliminate tourette syndrome, mental retardation, epilepsy, mental diseases of children, nervous system diseases and naughty children. The syndrome differentiation standard of the traditional Chinese medicine is formulated by referring to the traditional Chinese medicine planning teaching material 'Chinese medicine science and children hyperkinetic syndrome', the symptoms of hyperkinetic impulse can last for more than 6 months, hyperkinetic action can not be automatically controlled, people are restless, run to go and run out of places without distinction, multilingual or self-speaking self-language, the children play too excitably, often busy, ask for a question and do not give a rush to answer, queue up in an instable order, pick up other people without permission, have a mental anxiety, carelessness carelessly makes people carelessly do with tigers carelessly, attention is not concentrated, interests are changeable and disorderly, the people are lazy and lacy, lose three and four, have heads and tails, have memory loss, are easy to be interfered, have anxious and irritability, constipation, have red tongue quality, thin or thin and yellowish fur, and fine and wiry pulse or string number.
And (3) inclusion standard: the children are 5-13 years old, accord with the diagnosis standard of the attention deficit hyperactivity disorder, can be actively matched with medication, and sign informed consent for all patients.
Exclusion criteria: excluding those with neurodevelopmental retardation, mental disorders in children, conduct disorder or organic mental disorder and other nervous system diseases.
Second, test method
Comparison medication: the observation group is taken with the medicinal granules of the invention with water 3 times a day, and 1 bag is taken each time after 3-8 years old; 1.5 bags each time for 9-13 years old; the control group takes JINGLING oral liquid (produced by Liaoning Benxi Puji pharmaceutical Co., Ltd.) 1 time 1 bottle, 2 times per day. All 2 groups were treated continuously for 12 weeks, and the effective infant was followed for 4 weeks.
And (3) observation of curative effect: attention deficit and hyperactivity, behavioral scale (Conner's scale), hyperactivity index, and syndrome score of TCM were observed and recorded 1 time each at 3, 6, 9, and 12 weeks before and after treatment. The treatment effect of 2 groups was assessed and compared after the 12-week treatment period.
The curative effect standard is as follows: the main symptoms disappear, the soft neurosis disappears, the attention test is negative, the attention deficit hyperactivity score is reduced by more than 80 percent, the learning performance is obviously improved, and the patients are healed after taking off the medicine for 6 months without relapse; the main symptoms are obviously improved, the soft neurosis basically disappeared, the attention test is obviously improved, the attention defect multi-momentum table score is reduced by more than 50 percent, and the learning score is improved to a certain extent and is the obvious effect; the main symptoms are improved, the soft neurosis is obviously improved, the attention test is improved, the learning performance of the attention deficit hyperactivity score which is reduced by more than 30 percent is improved, but the effect is not stable; after treatment, no obvious improvement in symptoms and signs is found to be ineffective.
Statistical analysis: statistical analysis is carried out by adopting SPSS16.0 statistical software, t test is adopted for comparison among the measurement data groups, Ridit test is adopted for the grade data, and data are usedAnd (4) showing. P < 0.05 is statistically different.
And (3) analyzing the curative effect: 1)2 groups of curative effect comparative analysis. 29 of 48 observation groups are cured (60.42%), the obvious effect is 12 (25.00%), the improvement is 5 (10.42%), the ineffective effect is 2 (4.17%), and the total effective rate is 95.83%; in 48 cases of the control group, 20 cases (41.67%) were cured, 7 cases (14.58%) were significantly effective, 13 cases (27.08%) were improved, 8 cases (16.67%) were ineffective, and the total effective rate was 83.33%. Statistical analysis shows that the cure rate and the total effective rate of the two groups are significantly different, and P is less than 0.05. 2) The 2 groups were compared in the positive cases before and after treatment. In 48 observation groups, 46 cases of attention tests before treatment, 44 cases of scratch tests, 48 cases of resting tests, 47 cases of balance tests, 46 cases of backhand tests and 46 cases of finger nose tests are respectively 5, 4, 2 and 2 cases after treatment; in 48 control groups, the attention test before treatment 46, the scratch and pin test 44, the resting test 47, the balance test 47, the backhand test 46 and the finger nose test 46 are 10, 9, 11, 9, 7 and 6 respectively after treatment. The improvement condition of the observation group is better than that of the control group, and the medicine has certain clinical popularization value.
Claims (7)
2. the medicament for rapidly treating attention deficit hyperactivity disorder according to claim 1, wherein the formulation is prepared into capsules by a conventional process of Chinese materia medica pharmaceutics.
3. The medicament for rapidly treating attention deficit hyperactivity disorder according to claim 1, wherein the formulation is prepared into tablets by a conventional process of Chinese materia medica preparation.
4. The medicament for rapidly treating attention deficit hyperactivity disorder according to claim 1, wherein the formulation is prepared into powder or granules by a conventional process of Chinese medicinal preparation.
5. The medicament for rapidly treating attention deficit hyperactivity disorder according to claim 1, wherein the medicament is formulated into watered pills, honeyed pills, watered honeyed pills, concentrated pills, or dripping pills by a conventional process of Chinese medicinal preparation.
6. The medicament for rapidly treating attention deficit hyperactivity disorder according to claim 1, wherein the formulation is prepared into oral liquid by a conventional process of Chinese materia medica pharmaceutics.
7. The medicine for rapidly treating attention deficit hyperactivity disorder according to claim 1, wherein the formula of the medicine is that the medicine is prepared into tea by a conventional process of Chinese materia medica pharmaceutics.
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