CN102441103A - Medicine for treating insomnia - Google Patents
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- CN102441103A CN102441103A CN2011103832720A CN201110383272A CN102441103A CN 102441103 A CN102441103 A CN 102441103A CN 2011103832720 A CN2011103832720 A CN 2011103832720A CN 201110383272 A CN201110383272 A CN 201110383272A CN 102441103 A CN102441103 A CN 102441103A
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Abstract
The invention relates to a medicine for treating insomnia. Raw materials of the medicine comprise, by weight, 20 parts of Flos Albiziae, 20 parts of Angelica sinensis, 18 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 12 parts of Ramulus Cinnamomi, 12 parts of Ligusticum chuanxiong Hort, 15 parts of Radix Scrophulariae, 9 parts of Radix astragali, 10 parts of Anemarrhena asphodeloides, 8 parts of seed of wild jujube, 8 parts of Pinellia ternate, 9 parts of Rhizoma cyperi, 7 parts of rhizoma coptidis, 7 parts of Poria cocos and 5 parts of semen cassiae. It has been clinically verified that the medicinal composite for treating insomnia has efficacy of treating insomnia, is nontoxic and harmless to human body, can be used to treat both principal and secondary aspect of disease, has no side effect, is low-priced, is simple to prepare, and has an extensive application prospect.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, concrete, relate to pharmaceutical composition of a kind of Cure for insomnia disease and preparation method thereof.
Background technology
Insomnia is meant difficulty falling asleep, and awaken night easily, and the length of one's sleep is short, even lies awake all night, and with a series of neural mental symptoms, is common clinical, frequently-occurring disease.Insomnia is the performance of internal organs negative and positive of qi and blood imbalance, is referred to as " being insomnia " in the traditional Chinese medical science, " insomnia ", " must not crouch ", " unable to close the eyes " etc.In recent years, along with the quickening of rapid development of social economy, rhythm of life, great variety has taken place in social environment; Brought anxiety, pressure and competition for people's life, work; Directly influence people's physical and mental health, secular anxiety and fatigue state, or intensive direct stimulation; Can cause the disorder of cerebral nerve functional activity, the sickness rate that causes having a sleepless night is cumulative trend.The insomnia many by internal injury caused by excess of seven emotions, ponder over too, due to being terrified suddenly, innate deficiency or the body deficiency due to old age etc., qi-blood disharmony, imbalance of YIN and YANG, visceral dysfunction so that the mind is tired, mental derangement must not be slept.According to data statistics, adult's incidence rate of having a sleepless night has reached 38.2%, and women's number of the infected is 1.5 times of male's number of the infected, and wherein 3rd/4th, the middle-aged and elderly people of 40-59 between year.Long-term insomnia can cause the people fatigue, headache, dizziness, dreaminess, nervously breathe hard, emotion is irritable, anxiety is suspicious, other neural mental symptoms such as energy is not concentrated, hypomnesis.Though insomnia is not a critical illness; But long-term insomnia can badly influence the normal day's activities of people, causes quality of life to descend, and brings huge misery to the patient; And increase the danger of suffering from other diseases such as hypertension, heart disease greatly, become the social problem that merits attention.
Doctor trained in Western medicine is started with from following three aspects on the insomnia disease rule: 1, with the ascending reticular activating system of sedative hypnotic drug with the blocking-up reticular formation of brain stem, thereby reach the effect of tranquilizing soporific, represent medicine to have: stabilize, estazolam etc.2, central stimulants: because of the insomniac can not fall asleep night, brain can not get having a rest, and daytime is sleepy, impels daytime excited with central stimulants, represents medicine to have: caffeine etc.3, regulate the neural medicine of nutrient plant; Have suitable ratio to cause because of the autonomic nervous dysfunction in the insomnia case, the initial stage can be selected for use and regulated the neural medicine of nutrient plant, and only a few patient can obtain certain effect.Represent medicine to have: oryzanol tablets, vitamin B1, vitamin B6 sheet.In case suffer from the insomnia, some people can adopt western medicine, but in therapeutic process, tends to find own sleepy weak, unstable on foot; Hypomnesis, forgetful, thirsty etc., also excitement, impatience, inappetence can appear in the somebody, go out erythra, and hemogram abnormity can appear in a few peoples, the patient of long-term prescription is very easily caused the dependence of medicine.In case the drug withdrawal meeting produces bad dream, the appearance that this can bring mental disorder, depression for a lot of patients, often side effect is big, and is habit-forming easily, produces dependency.
Chinese medicine thinks that insomnia and the heart, liver,spleen,kidney are in close relations, and the main pathogenesis of insomnia is that men outnumbered women, and negative and positive are lost and handed over.Its cause of disease many with feelings will institute wound, eating and drinking without temperance, overstrain too, puerperal and prolonged illness, factor such as old be relevant, pathology character has the deficiency and excess two sides, disturbs in pathogenic fire derived from stagnation of liver-QI, the expectorant heat, irritability is reality; Deficiency of both the heart and spleen, the heart and gallbladder deficiency of vital energy, disarmony between the heart and kidney lack of preservation of spirit are empty.Generally speaking, its pathological change is how in the majority with void, but prolonged illness can show as the deficiency and excess folder of holding concurrently, or is due to the blood stasis.Chinese medicine is being brought into play huge effect aspect the insomnia medical treatment good effect being arranged.Because of its treating both the principal and secondary aspects of a disease, safe without toxic side effect and cause compatriots' extensive use and concern.Insomnia preferably will be nursed one's health with Chinese medicine comprehensively.But general Chinese medicine is because condition is limit and is difficult to reach theoretic therapeutic effect, and some belongs to cures the symptoms, not the disease, and some interrupts using owing to uncertain therapeutic efficacy is fixed in application process, in addition, also has the technical problem of specific aim difference.
The etiology and pathogenesis determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs that the present invention just falls ill according to insomnia, with reinforce insufficiency and reduce excessiveness, regulating YIN and YANG, tranquilizing the mind is a principle, and the internal organs negative and positive of qi and blood is coordinated, coordination between the heart and kidney is ataraxy, and insomnia spontaneous recovery.
Summary of the invention
The purpose of this invention is to provide a kind of treating both the principal and secondary aspects of a disease, have no side effect, safe ready, cheap pure traditional Chinese compound medicine.
The application inventor combines secret prescription handed down in the family from generation to generation according to forefathers' experience and oneself practice of practising medicine for many years, through the research to Chinese medicine, and combines dialectical demonstration; In many ways collect the length of many families, seek therapeutic regimen, from motherland's medical treasure-house; Filter out the natural Chinese medicine of enriching yin and nourishing kidney, tranquilizing by nourishing the heart,, skim the cream off milk by the theory of Chinese medical science prescription; Its performance is cleared away heart-fire, and the place is tired, YIN nourishing and the production of body fluid promoting, the effect of calming the nerves and nourishing heart, and adopts the natural Chinese medicines raw material, through systematic study, science compatibility; Be mixed with Cure for insomnia disease Chinese medicine composition of the present invention meticulously in conjunction with traditional lunar physics technique, the insomnia had the effect of rapid healing.
For realizing above-mentioned purpose, the technical scheme that the present invention adopts is following:
A kind of Chinese medicine composition of Cure for insomnia disease, it is got by following weight proportioning feedstock production,
Flos Albiziae 15-25 part, Radix Angelicae Sinensis 15-25 part, Radix Rehmanniae 15-25 part, Radix Ophiopogonis 15-25 part,
Ramulus Cinnamomi 10-15 part, Rhizoma Chuanxiong 10-12 part, Radix Scrophulariae 12-18 part, Fructus Ligustri Lucidi 8-10 part,
Radix Astragali 5-10 part, Rhizoma Anemarrhenae 5-10 part, Semen Ziziphi Spinosae 5-8 part, Rhizoma Pinelliae 8-10 part,
Rhizoma Cyperi 8-10 part, Rhizoma Coptidis 5-8 part, Poria 7-9 part, Semen Cassiae 5-8 part.
A kind of Chinese medicine composition of Cure for insomnia disease, it is preferably got by following weight proportioning feedstock production,
20 parts of Flos Albiziaes, 20 parts of Radix Angelicae Sinensis, 18 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis,
12 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs, 15 parts of Radix Scrophulariaes, 9 parts of Fructus Ligustri Lucidi,
9 parts of the Radixs Astragali, 10 parts of the Rhizoma Anemarrhenaes, 8 parts of Semen Ziziphi Spinosaes, 8 parts of the Rhizoma Pinelliaes,
9 parts of Rhizoma Cyperis, 7 parts of Rhizoma Coptidis, 7 parts in Poria, 5 parts of Semen Cassiaes.
Pharmaceutical composition of the present invention can adopt respectively the distinguish the flavor of medical material of conventional method in will writing out a prescription to carry out compatibility in proportion, processes various clinical suitable dosage forms by existing preparation process, and the used medical material of respectively distinguishing the flavor of is the Chinese crude drug that commercially available process is up to the standards.
Preparation of pharmaceutical compositions method of the present invention comprises the steps:
(1) it is subsequent use to get above-mentioned each bulk drugs;
(2) add 6～10 times of water gagings and decoct 2～4 times, each 2-4 hour, filter, merging filtrate is condensed into the extractum that density is 1.1-1.2g/ml;
(3) after 50-60 ℃ of drying, be crushed to 100-120 purpose medicated powder, incapsulate, sterilization makes capsule preparations.
The preferred version of method for preparing of the present invention comprises the steps:
(1) it is subsequent use to get above-mentioned each bulk drugs;
(2) add 8 times of water gagings and decoct 3 times, each 2 hours, filter, merging filtrate is condensed into the extractum that density is 1.12g/ml;
(3) after 50-60 ℃ of drying, be crushed to 120 purpose medicated powder, incapsulate, sterilization makes capsule preparations.
Dosage form and usage: our pharmaceutically dosage form is a capsule formulation, and three times on the one, each 5,2 weeks were a course of treatment.
Period in a medicine avoids pungent food and cold and cool food, avoids feelings will to stimulate, and life is regular.
The excellent results of Chinese medicine composition of Cure for insomnia disease of the present invention and preparation method thereof is:
1. medicament of the present invention is processed by pure Chinese medicine, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of, and does not contain chemical components, does not contain hormone, has no side effect, and treating both the exterior and interior reaches better enriching yin and nourishing kidney, tranquilizing by nourishing the heart effect;
2. this medicament short treating period, total effective rate is high, and more the back is difficult for recurrence.
3. technology of the present invention is simple, has reduced production cost, has alleviated patient's financial burden.
The specific embodiment
Below will describe the present invention in detail through correlation step.It will be understood by those skilled in the art that following method that illustrates for example and step only are used to explain the present invention but not are used for it is made any restriction.
Embodiment 1
A kind of pharmaceutical composition of Cure for insomnia disease, it is got by following weight proportioning feedstock production,
20 parts of Flos Albiziaes, 20 parts of Radix Angelicae Sinensis, 18 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis,
12 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs, 15 parts of Radix Scrophulariaes, 9 parts of Fructus Ligustri Lucidi,
9 parts of the Radixs Astragali, 10 parts of the Rhizoma Anemarrhenaes, 8 parts of Semen Ziziphi Spinosaes, 8 parts of the Rhizoma Pinelliaes,
9 parts of Rhizoma Cyperis, 7 parts of Rhizoma Coptidis, 7 parts in Poria, 5 parts of Semen Cassiaes.
Embodiment 2
It is subsequent use to get above-mentioned each bulk drugs in the ratio of embodiment 1;
Add 8 times of water gagings and decoct 3 times, each 2 hours, filter, merging filtrate is condensed into the extractum that density is 1.12g/ml;
After the 50-60 ℃ of drying, be crushed to 120 purpose medicated powder, incapsulate, sterilization makes capsule preparations.
Three times on the one, each 5,2 weeks were a course of treatment.Period in a medicine avoids pungent food and cold and cool food, avoids feelings will to stimulate, and life is regular.
Embodiment 3
Clinical data
Following standard is formulated in the selected reference of case " insomnia definition, diagnosis and Drug therapy expert common recognition (draft) " and " Chinese mental disorder classification and diagnostic criteria (CCMD-3) ": the incubation period of 1. sleeping is long: time for falling asleep surpasses 30min; 2. obstacle is kept in sleep: the number of times of awakening night is greater than 2 times; 3. sleep quality descends: shallow, the dreaminess of sleeping; 4. total sleep time shortens: be less than 5 hours; 5. residual effect is big in the daytime: sensation giddy in inferior morning, lassitude, drowsiness, weak etc.
Exclusion standard:
1. the age is under-18s, over-65s person; 2. serious body illness and principal characteristic mental sickness person; 3. and with other drug and antipsychotic drug person; 4. serious suicidal attempt and actor are arranged; 5. gestation and women breast-feeding their children; 6. mismatch therapist.
Select clinic case 97 example to be the treatment group at random, male 39 examples, women 58 examples, age 19-65 year, 43 years old mean age, the course of disease 1 year-11 years
Therapeutic Method:
Take the medicament composition capsule preparation of Cure for insomnia disease of the present invention, three times on the one, each 5,2 weeks were a course of treatment.Take two courses of treatment continuously, do not obey other drug during the treatment.
Efficacy assessment standard:
" traditional Chinese medical science disease diagnosis criterion of therapeutical effect " formulated with reference to State Administration of Traditional Chinese Medicine combines clinical drafting.Insomnia primary symptom before and after two groups of patient treatments is scored.Score standard: severe: the difficulty of falling asleep, wake up more, dreaminess, wake up early morning, and be lasting appearance, and residual effect is obvious in the daytime, remembers 3 fens; Moderate: above disease is interrupted appearance, and residual effect is slight in the daytime, remembers 2 fens; Slightly: disease is light, or occurs once in a while, remembers 1 fen; No associated conditions note 0 minute.Cure: the insomnia primary symptom disappears; Produce effects: insomnia primary symptom integration reduces＞2/3; Effectively: insomnia primary symptom integration reduces 1/3-2/3; Invalid: insomnia primary symptom integration reduces＜1/3.
Therapeutic outcome:
Cure 90 examples (93%), produce effects 3 examples (3%), effective 2 examples (2%), invalid 2 examples (2%), total effective rate 98%;
Embodiment 4
Exemplary embodiments
Case 1: the field, the man, the student, 19 years old, long-term insomnia caused physical weakness; Realization is fallen asleep for being difficult to, and can not sleep soundly after falling asleep, and has a dream again and again, and the length of one's sleep of every day, generally about 5 hours, energy did not have recovery after sleeping; Distraction on class, school grade seriously descends, and father and mother also so very worry, have bought the medicine of a little Cure for insomnias, but also cured the symptoms, not the disease; The medical treatment effect is bad, and the pharmaceutical composition of taking Cure for insomnia disease of the present invention is after course of treatment, and sleep quality obviously improves, and has a dream no longer again and again; Energy is good more a lot of than in the past after waking up, and continues to use medicine of the present invention, after two courses of treatment, extends to 7 hours the length of one's sleep; After continuing to take a course of treatment, feel hale and hearty, the insomnia also gradually far away he and go, study also be improved.Follow up a case by regular visits to half a year, do not have recurrence.
Case 2: Liu, the woman, secondary school teachers, 45 years old, suffer from insomnia 5 years, difficulty falling asleep is tossed about, and bad dream is diverse and confused, awakening constantly, the cardiopalmus severe palpitation is feared all day, and the companion is dizzy weak, lassitude, hypomnesis, pale tongue, pulse condition stringy and thready pulse.The multi-treatment poor effect, the pharmaceutical composition of taking Cure for insomnia disease of the present invention is after two courses of treatment, and sleep quality obviously improves, and continues to take two courses of treatment, and all cards are basic to disappear, and follows up a case by regular visits to half a year, does not have recurrence.
Case 3: Cao, the woman, 50 years old, be in climacteric, be prone to agitation, often be with anger sleeping, have only 3-4 hour the length of one's sleep, bad dream again and again.Look into: red tongue, yellow and greasy fur, thready pulse and counting.Dialectical is heart-liver blood deficiency, type of phlegm-heat attacking the heart.Take medicine of the present invention after course of treatment, the length of one's sleep, irritated emotion is eased; Sleep quality has had large increase; No longer often have horrible nightmares, extend to 5 hours the length of one's sleep, continues to use medicine to the of the present invention during four courses of treatment; Can reach 7-8 hour the length of one's sleep, and involutional symptom there be alleviating to a certain degree.Followed up a case by regular visits to six months, and do not have recurrence.
Above-mentioned each Chinese medicine that the present invention adopts is made compatibility mutually, can bring into play its collaborative effect of curing the disease, and has drug effect between each composition of used raw material of Chinese medicine and is interweaved and mutually promotes and coordinate usefulness; Through clinical verification, the insomnia there is good therapeutic effect, in the medical practice in nearly ten years of the applicant; The case number of curing is numerous; All obtain good effect, and with low cost, alleviate patient's burden.
The application be used for the insomnia Chinese medicine composition with low cost, evident in efficacy, have broad application prospects.
Claims (4)
1. the pharmaceutical composition of a Cure for insomnia disease, it is got by following weight proportioning feedstock production,
Flos Albiziae 15-25 part, Radix Angelicae Sinensis 15-25 part, Radix Rehmanniae 15-25 part, Radix Ophiopogonis 15-25 part,
Ramulus Cinnamomi 10-15 part, Rhizoma Chuanxiong 10-12 part, Radix Scrophulariae 12-18 part, Fructus Ligustri Lucidi 8-10 part,
Radix Astragali 5-10 part, Rhizoma Anemarrhenae 5-10 part, Semen Ziziphi Spinosae 5-8 part, Rhizoma Pinelliae 8-10 part,
Rhizoma Cyperi 8-10 part, Rhizoma Coptidis 5-8 part, Poria 7-9 part, Semen Cassiae 5-8 part.
2. the pharmaceutical composition of the described Cure for insomnia disease of claim 1, it is got by following weight proportioning feedstock production,
20 parts of Flos Albiziaes, 20 parts of Radix Angelicae Sinensis, 18 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis,
12 parts of Ramulus Cinnamomi, 12 parts of Rhizoma Chuanxiongs, 15 parts of Radix Scrophulariaes, 9 parts of Fructus Ligustri Lucidi,
9 parts of the Radixs Astragali, 10 parts of the Rhizoma Anemarrhenaes, 8 parts of Semen Ziziphi Spinosaes, 8 parts of the Rhizoma Pinelliaes,
9 parts of Rhizoma Cyperis, 7 parts of Rhizoma Coptidis, 7 parts in Poria, 5 parts of Semen Cassiaes.
3. claim 1 or 2 described preparation of drug combination methods is characterized in that comprising the steps:
(1) it is subsequent use to get above-mentioned each bulk drugs;
(2) decocting that adds 8 times of weight boils 3 times, and each 2 hours, filter, merging filtrate is condensed into relative density and is 1.12 extractum;
(3) after 50-60 ℃ of drying, be crushed to 120 purpose medicated powder, incapsulate, sterilization makes capsule preparations.
4. claim 1 or the 2 described Chinese medicine compositions purposes in preparation Cure for insomnia disease drug.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186831A (en) * | 2018-03-28 | 2018-06-22 | 吕立英 | A kind of capsule for treating insomnia and preparation method thereof |
| CN111467439A (en) * | 2020-04-20 | 2020-07-31 | 谢菲莉 | A Chinese medicinal composition for treating insomnia and invigorating kidney, and its preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396512A (en) * | 2008-10-15 | 2009-04-01 | 黄建国 | Traditional Chinese medicine formulation for treating insomnia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101396512A (en) * | 2008-10-15 | 2009-04-01 | 黄建国 | Traditional Chinese medicine formulation for treating insomnia |
Non-Patent Citations (1)
| Title |
|---|
| 张轶丹等: "中药治疗失眠概况", 《云南中医学院学报》, vol. 27, no. 1, 31 March 2004 (2004-03-31), pages 52 - 55 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186831A (en) * | 2018-03-28 | 2018-06-22 | 吕立英 | A kind of capsule for treating insomnia and preparation method thereof |
| CN111467439A (en) * | 2020-04-20 | 2020-07-31 | 谢菲莉 | A Chinese medicinal composition for treating insomnia and invigorating kidney, and its preparation method |
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