CN102406831B - Chinese medicine composition for treating insomnia and dreamful sleep and preparation method of Chinese medicine composition - Google Patents
Chinese medicine composition for treating insomnia and dreamful sleep and preparation method of Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to a Chinese medicine composition for treating insomnia and dreamful sleep, comprising the following raw materials in parts by weight: 30 parts of unprocessed rehmannia root, 20 parts of flower of silktree, 18 parts of codonopsis pilosula, 15 parts of dwarf lilyturf root, 12 parts of achyranthes bidentata, 15 parts of radix scrophulariae, 10 parts of red-rooted salvia root, 10 parts of vine of multiflower knotweed, 9 parts of astragalus mongholicus, 9 parts of glossy privet fruit, 8 parts of spina date seed, 8 parts of pinellia ternate, 9 parts of Chinese yam, 7 parts of kudzuvine root, 8 parts of liquorice root and 5 parts of poria cocos. The clinic verification proves that the Chinese medicine composition for treating insomnia and dreamful sleep has efficacy on curing insomnia, is nontoxic and harmless to the human body, treats both manifestation and root cause, has the characteristics of no side effect, low cost, wide application prospect and convenience for manufacture.
Description
Technical field
The invention belongs to the Chinese medicine technical field, concrete, relate to pharmaceutical composition of a kind of Cure for insomnia dreaminess and preparation method thereof.
Background technology
Insomnia is modal sleep disorder, and main clinical manifestation is difficulty falling asleep, sleeps rear easily awake, have difficulty in going to sleep after waking up, early awakening is with dreaminess, dizziness, headache, lethargy is depressed, the extremity fatigue and weak, the memory persistence goes down, bradykinesia etc., and the patient feels that antisecosis is not good next day, anxiety, nervous or sense of depression are even arranged, and severe patient has heart rate to accelerate, fervescence, the autonomic nerve symptoms such as peripheral vessels contraction still have after awakening that asthenia is unhappy, the sense of discomfort such as have one's head in the clouds.Its many by internal injury caused by excess of seven emotions, ponder over too, due to being terrified suddenly, innate deficiency or body deficiency due to old age etc., qi-blood disharmony, imbalance of YIN and YANG, visceral dysfunction so that the mind is tired, mental derangement must not be slept.An investigation of the U.S. 1992 is also found, 1/3 the adult dormancy of ating fault in is in the previous year arranged, World Health Organization (WHO) shows in the medical patient's of basic medical unit survey result 25916 examples in 15 bases of 14 countries, 27% people has sleeping problems, and the patient who is diagnosed as the insomnia is near half of actual diseased number.
On insomnia disease rule, doctor trained in Western medicine is started with from following three aspects:: 1, with the ascending reticular activating system of sedative hypnotic drug with the blocking-up reticular formation of brain stem, thereby reach the effect of tranquilizing soporific, represent that medicine has: stable, estazolam etc.2, central stimulants: because the insomniac can not fall asleep night, brain can not get having a rest, and daytime is sleepy, impels daytime excited with central stimulants, represents that medicine has: caffeine etc.3, regulate the medicine of nutrient plant nerve; Have suitable ratio to cause because of the autonomic nervous dysfunction in the insomnia case, the initial stage can be selected the medicine of regulating the nutrient plant nerve, and only a few patient can obtain certain effect.Represent that medicine has: oryzanol tablets, vitamin B1, Vitamin B6 Tablets.In case suffer from the insomnia, some people can adopt western medicine, but tends to find own sleepy weak, unstable on foot in therapeutic process; Hypomnesis, forgetful, thirsty etc., also excitement, impatience, inappetence can appear in the somebody, go out erythra, and hemogram abnormity can appear in a few peoples, the patient of long-term prescription is very easily caused the dependence of medicine.In case the drug withdrawal meeting produces bad dream, the appearance that this can bring mental disorder, depression for a lot of patients, often side effect is large, and is easily addicted, produces dependency.
The traditional Chinese medical science about be insomnia, i.e. the cause of disease of insomnia thinks for a long time: being insomnia is because a variety of causes has influence on and defends gas and enter the moon by sun, make negative and positive intercept therefore.Chinese medicine is being brought into play great function aspect the insomnia medical treatment, good effect being arranged.Because of its treating both the principal and secondary aspects of a disease, safe without toxic side effect and cause compatriots' extensive use and concern.Insomnia preferably will be nursed one's health with Chinese medicine comprehensively.But general Chinese medicine is because condition is limit and is difficult to reach theoretic therapeutic effect, and some belongs to cures the symptoms, not the disease, and some interrupts using because uncertain therapeutic efficacy is fixed in application process, in addition, also has the poor technical problem of specific aim.
Summary of the invention
The purpose of this invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease, have no side effect, safe ready, cheap pure traditional Chinese compound medicine.
the present application people in conjunction with secret prescription handed down in the family from generation to generation according to forefathers' experience and oneself practice of practising medicine for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect the length of many families, seek therapeutic regimen, from motherland's medical treasure-house, filter out enriching yin and nourishing kidney, the natural Chinese medicine of tranquilizing by nourishing the heart, by the theory of Chinese medical science prescription, skim the cream off milk, its performance is cleared away heart-fire locate to be tired of, YIN nourishing and the production of body fluid promoting, the effect of calming the nerves and nourishing heart, adopt the natural Chinese medicines raw material, through systematic study, the science compatibility, meticulously be mixed with the Chinese medicine composition for insomnia and dreamful sleep of the present invention in conjunction with the Traditional Chinese Medicine technology, the effect that insomnia and dreamful sleep is had rapid healing.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of Chinese medicine composition of Cure for insomnia dreaminess, it is got by the preparation of following weight proportioning raw material,
Radix Rehmanniae 20-35 part, Flos Albiziae 18-30 part, Radix Codonopsis 15-30 part, Radix Ophiopogonis 12-25 part,
Radix Achyranthis Bidentatae 10-18 part, Radix Scrophulariae 10-18 part, Radix Salviae Miltiorrhizae 8-10 part, Caulis Polygoni Multiflori 8-10 part,
Radix Astragali 8-10 part, Fructus Ligustri Lucidi 5-10 part, Semen Ziziphi Spinosae 5-10 part, Rhizoma Pinelliae 5-8 part,
Rhizoma Dioscoreae 8-10 part, Radix Puerariae 5-10 part, Radix Glycyrrhizae 8-10 part, Poria 5-8 part.
A kind of Chinese medicine composition of Cure for insomnia dreaminess, it is preferably got by the preparation of following weight proportioning raw material,
30 parts of Radix Rehmanniae, 20 parts of Flos Albiziaes, 18 parts of Radix Codonopsis, 15 parts of Radix Ophiopogonis,
12 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Scrophulariaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Caulis Polygoni Multiflori,
9 parts of the Radixs Astragali, 9 parts of Fructus Ligustri Lucidi, 8 parts of Semen Ziziphi Spinosaes, 8 parts of the Rhizoma Pinelliaes,
9 parts of Rhizoma Dioscoreaes, 7 parts of Radix Puerariaes, 8 parts, Radix Glycyrrhizae, 5 parts, Poria.
Dosage form and usage: our pharmaceutically dosage form is decoction.Be decocted in water for oral dose, potion on the one, 15 days is a course for the treatment of.
Decoct twice, (proportioning unit: gram), first use 500ml cold water soaks said medicine 2 hours, changes slow fire boiling after intense fire boils 30 minutes, gets the 150ml medicine juice to take according to the above ratio each component medical material; Second time heating water 400ml changed slow fire boiling 4050 minutes after intense fire boils, get the 150ml medicine juice, and twice medicine juice mixed, and sooner or later respectively took 150ml, warm water delivery service in 2 hours after meal.Period in a medicine avoids pungent food and cold and cool food, avoids feelings will to stimulate, and life is regular.
The excellent results of Chinese medicine composition of Cure for insomnia dreaminess of the present invention and preparation method thereof is:
1. medicament of the present invention is made by pure Chinese medicine, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of, and does not contain chemical components, does not contain hormone, has no side effect, and treating both the exterior and interior reaches better enriching yin and nourishing kidney, tranquilizing by nourishing the heart effect;
2. this medicament short treating period, total effective rate is high, is difficult for recurrence after more.
3. technique of the present invention is simple, has reduced production cost, has alleviated patient's financial burden.
The specific embodiment
Below will describe the present invention in detail by correlation step.It will be understood by those skilled in the art that the following method that illustrates for example and step are only for explaining the present invention but not for it is made any restriction.
Embodiment 1
A kind of Chinese medicine composition of Cure for insomnia dreaminess, it is got by the preparation of following weight proportioning raw material,
30 parts of Radix Rehmanniae, 20 parts of Flos Albiziaes, 18 parts of Radix Codonopsis, 15 parts of Radix Ophiopogonis,
12 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Scrophulariaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Caulis Polygoni Multiflori,
9 parts of the Radixs Astragali, 9 parts of Fructus Ligustri Lucidi, 8 parts of Semen Ziziphi Spinosaes, 8 parts of the Rhizoma Pinelliaes,
9 parts of Rhizoma Dioscoreaes, 7 parts of Radix Puerariaes, 8 parts, Radix Glycyrrhizae, 5 parts, Poria.
Embodiment 2
(proportioning unit: gram), first use 500ml cold water soaks said medicine 2 hours, changes slow fire boiling after intense fire boils 30 minutes, gets the 150ml medicine juice to take each component medical material in the described ratio of embodiment 1; Second time heating water 400ml changed slow fire boiling 40 minutes after intense fire boils, get the 150ml medicine juice, and twice medicine juice mixed, and sooner or later respectively took 150ml, warm water delivery service in 2 hours after meal.
Potion on the one, two weeks were a course for the treatment of, and period in a medicine avoids pungent food and cold and cool food, avoids feelings will to stimulate, and life is regular.
Embodiment 3
Clinical data
The selected reference of case " insomnia definition, diagnosis and Drug therapy Consensus of experts (draft) " and " Chinese Spirit Obstacles classification and diagnostic criteria (CCMD-3) " formulate following standard: 1. Sleep latency is long: time for falling asleep surpasses 30min; 2. obstacle is kept in sleep: the number of times of awakening night is greater than 2 times; 3. sleep quality descends: shallow, the dreaminess of sleeping; 4. total sleep time shortens: be less than 5 hours; 5. residual effect is large in the daytime: sensation giddy in inferior morning, lassitude, drowsiness, weak etc.
Exclusion standard:
1. the age is under-18s, over-65s person; 2. serious body illness and principal characteristic mental sickness person; 3. and with other drug and antipsychotic drug person; 4. serious suicidal attempt and actor are arranged; 5. gestation and women breast-feeding their children; 6. mismatch therapist.
Random to select clinic case 105 examples be treatment group, male 58 examples, female's 47 examples, age 18-60 year, 40 years old mean age, the course of disease 6 months-11 years; Select 78 examples the same period as a control group, male 36 examples, female's 42 examples, age 25-64 year, the course of disease 1 year-10 years.Learn by statistics processing at aspects such as sex, age, the course of disease, the state of an illness for two groups, there was no significant difference (P＞0.05) has comparability.
Therapeutic Method:
Treatment group 105 examples are taken medicine of the present invention, potion on the one, and two weeks were a course for the treatment of; Matched group 78 examples are taken estazolam, and 2mg is each, once-a-day, take every night warm boiled water before the sleep on time.Two groups all take continuously surrounding, do not take other drug during treatment.
Efficacy assessment standard:
Draft in conjunction with clinical with reference to " traditional Chinese medical science disease Standardization of diagnosis and curative effect " that State Administration of Traditional Chinese Medicine formulates.Insomnia primary symptom before and after two groups of patient treatments is scored.Score standard: severe: the difficulty of falling asleep, wake up more, dreaminess, wake up early morning, and be lasting appearance, and residual effect is obvious in the daytime, remembers 3 minutes; Moderate: above disease is interrupted and is occurred, and residual effect is slight in the daytime, remembers 2 minutes; Slightly: disease is light, or occurs once in a while, remembers 1 minute; Remember 0 minute without associated conditions.Cure: the insomnia primary symptom disappears; Produce effects: insomnia primary symptom integration reduces＞2/3; Effectively: insomnia primary symptom integration reduces 1/3-2/3; Invalid: insomnia primary symptom integration reduces＜1/3.
Therapeutic outcome:
Treatment group 105 examples are cured 98 examples (93.33%), produce effects 3 examples (2.86%), effective 2 examples (1.90%), invalid 2 examples (1.90%), total effective rate 98%; Matched group 78 examples are cured 25 examples (31.25%), produce effects 29 examples (36.25%), effective 10 examples (12.5%), invalid 14 examples (17.5%), total effective rate 82.5%.Two groups of curative effects are relatively checked through X2, and treatment group obviously is better than matched group, has significant difference (P＜0.01).
Embodiment 4
Exemplary embodiments
Case 1: Chen, the man, 28 years old, the irregular serious insomnia that causes of long-term operating pressure and daily schedule showed as 2:00 AM and substantially has difficulty in going to sleep before, can not sleep soundly after falling asleep, again and again have a dream, the length of one's sleep of every day, generally about 4 hours, after sleeping, energy did not recover, once use a variety of Drug therapys, had no effect.Use medicine of the present invention after course for the treatment of, sleep quality obviously improves, and no longer again and again has a dream, and after waking up, energy is than good a lot of in the past, continue to use medicine of the present invention, after two courses for the treatment of, extend to 7 hours the length of one's sleep, after using again two courses for the treatment of, extend to 8 hours the length of one's sleep, sleep quality obviously improves, and energy is also vigorous, and work efficiency has had large increase.Followed up a case by regular visits to six months, without recurrence.
Case 2: consolidate certain, the female, 51 years old, needed just can fall asleep night in 2-3 hour, wake up 2-3 time at least after falling asleep, conscious dizziness on daytime, weak.Look into: red tongue, yellow and greasy fur, thready pulse and counting.Dialectical is heart-liver blood deficiency, type of phlegm-heat attacking the heart.Give decoction of the present invention and take a course for the treatment of, symptom subtracts greatly, continues and takes a course for the treatment of, falls asleep normal, and daytime is full of physical strength.Follow up a case by regular visits to half a year, not recurrence again.
Case 3: Wu, the female, 58 years old, suffered from the insomnia companioned with headache nearly 10 years, sleep rear easily awake, be difficult to fall asleep again after waking up, very lie awake all night, headache as split, the time heavy when light, being irritable and irascible, anorexia, thirst and liking drink, red eyes and bitter taste in the mouth, yellowish or reddish urine, constipation, red tongue, yellow and thin fur, wiry and frequent pulse.Repeatedly capable electroencephalogram, cranium brain CT examination, show no obvious abnormalities, and the state of an illness day by day increases the weight of.Through taking medicine of the present invention after two courses for the treatment of, the symptom of easily waking up is obviously improved, even if early awakening can also reenter and sleep 1-2 hour, then after taking a course for the treatment of, sleep is basic recovers normal, the transference cures such as headache.Followed up a case by regular visits to 1 year, without recurrence.
Above-mentioned each Chinese medicine that the present invention adopts is made compatibility mutually, can bring into play its collaborative effect of curing the disease, having drug effect between each composition of raw material of Chinese medicine used is interweaved and mutually promotes and coordinate usefulness, through clinical verification, insomnia and dreamful sleep there is good therapeutic effect, in the applicant's medical practice of nearly ten years, the case number of curing is numerous, all obtain good effect, and with low cost, alleviate patient's burden.
The application be used for insomnia and dreamful sleep Chinese medicine composition with low cost, evident in efficacy, have broad application prospects.
Claims (2)
1. Chinese medicine composition that is used for insomnia and dreamful sleep, it gets 30 parts of Radix Rehmanniae, 20 parts of Flos Albiziaes, 18 parts of Radix Codonopsis, 15 parts of Radix Ophiopogonis, 12 parts of Radix Achyranthis Bidentataes, 15 parts of Radix Scrophulariaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Caulis Polygoni Multiflori, 9 parts of the Radixs Astragali, 9 parts of Fructus Ligustri Lucidi, 8 parts of Semen Ziziphi Spinosaes, 8 parts of the Rhizoma Pinelliaes, 9 parts of Rhizoma Dioscoreaes, 7 parts of Radix Puerariaes, 8 parts, Radix Glycyrrhizae, 5 parts, Poria by the preparation of following weight proportioning raw material.
2. the purposes of Chinese medicine composition claimed in claim 1 in preparation Cure for insomnia dreaminess medicine.
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| CN103977247A (en) * | 2014-05-31 | 2014-08-13 | 全椒县尹氏油脂有限公司 | Chinese medicine for treating excessive night dream |
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