CN102198220B - Medicine for fatigue resistance and memory enhancement - Google Patents
Medicine for fatigue resistance and memory enhancement Download PDFInfo
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- CN102198220B CN102198220B CN2010101331094A CN201010133109A CN102198220B CN 102198220 B CN102198220 B CN 102198220B CN 2010101331094 A CN2010101331094 A CN 2010101331094A CN 201010133109 A CN201010133109 A CN 201010133109A CN 102198220 B CN102198220 B CN 102198220B
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Abstract
The invention discloses a medicine for fatigue resistance and memory enhancement. Materials of wolfberry, mulberry, Chinese date, rhizome polygonati, longan aril, spine date seed, perilla, root of kudzu vine and chrysanthemum are decocted according to a certain weight proportion, and then extracted so as to obtain the medicine that can be made into any oral dosage form in common use. With the functions of tonifying kidney and replenishing essence, strengthening spleen and replenishing qi, tranquilizing the mind, invigorating brain and benefiting wisdom and the like, the medicine has a good curative effect for mental weariness, myasthenia of limbs, insomnia and dreaminess, poor memory and the like, with rapid effect and little toxic side-effect.
Description
Technical field
The present invention relates to the medicine of a kind of resisting fatigue and memory reinforcing, particularly relate to a kind of with botanical herbs and all be that the Chinese medicine of medicine-food two-purpose is raw material medicine that process, that have special efficacy.
Background technology
Fatigue and hypomnesis are the modal symptoms of brain worker.Now, because study, work equal pressure constantly increases, the overlong time of requiring mental skill occurs feeling exhausted, hypomnesis, insomnia, dreaminess, agitation etc., is perplexing large quantities of mental workers always.In fact, these symptoms all are the performances of subhealth state, and untimely treatment will influence operate as normal and study.
This disease is shown effect repeatedly, also can produce a series of complication, and resistance against diseases is descended, and work efficiency is low, and school grade is not good, and lethargy is depressed, even some serious functional diseases occur.But, still lack the specific medicament of special for treating for this symptom common, occurred frequently.
Aspect medical above-mentioned symptom, generally use calm Western medicine and nutrient drug, but downern is prone to the generation dependency, and many side effect are arranged.And the effect of Chinese medicine usually is comprehensive, and relieving fatigue, nourishing the brain and tranquilizing the mind, promotion memory, enhance immunity then can be held concurrently through the compound recipe form and control it, have certain prescription advantage, and it is rarely seen to cherish such medicine.
How dispeling fatigue fast, improve sleep quality, effectively inspire enthusiasm, is the prerequisite that improves memory function, leans on downern to improve sleep merely and obviously is unfavorable for improving memory ability, is unfavorable for that more removing the brain worker feels exhausted.
The inventor is through clinical verification for many years, and filtering out can fatigue alleviating, and single medicinal material that again can the hypermnesis double effects is formed the medicine that has resisting fatigue and hypermnesis function and do not have toxic and side effects, is the inventor's purpose.Make a general survey of Chinese medicine and western medicine market, such medicine still belongs to blank.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of resisting fatigue and memory reinforcing.Prescription is a criterion with traditional determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, and QI invigorating is held concurrently with spleen invigorating, and the assistant that nourishes blood is to calm the nerves; Brain-strengthening is aided with supports essence, and monarch is clearly demarcated, and it is apt to fill a prescription; Dialectically combine with differential diagnosis of diseases, Chinese and Western medicine is closed ginseng, and all it has produce effects property and reliability of resisting fatigue, enhance immunity, promotion memory to institute's medicament through the relevant pharmacological evaluation proof of modern medicine; And every herbal medicine all points out and do not have toxic and side effects, is the tired good medicine with hypomnesis of a kind of Comprehensive Treatment brain worker.
The present invention realizes with following technical scheme.The medicine of a kind of resisting fatigue and memory reinforcing is characterized in that it is to be processed with conventional method for preparing by following raw medicaments in portion by weight:
Fructus Lycii 10-30 part, Fructus Mori 10-30 part, Fructus Jujubae 15-30 part, Rhizoma Polygonati 12-30 part, Arillus Longan 10-30 part, Semen Ziziphi Spinosae 10-30 part, Folium Perillae 10-30 part, Radix Puerariae 12-30 part, Flos Chrysanthemi 10-30 part.
Above-mentioned raw materials medicine and consumption prescription are inventor's warps and how tame medical institutions associating clinical trials just draws, and in above-mentioned amount ranges, all have significant curative effect.
Fructus Lycii nourishing the liver and kidney in the side, tonifying YIN is supported smart, resisting fatigue, defying age, antioxidation, radioprotective, promotion immunologic function; The Fructus Mori kidney tonifying, essence replenishing, the yin nourishing of enriching blood, antioxidation, defying age, antimutagenic, promotion immunologic function; The two closes it, mends congenital essence, the merit of strong internal organs.The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, antioxidation, mutation, raise immunity; The Rhizoma Polygonati benefiting qi and nourishing blood, nourishing YIN and moistening the lung, reinforce spleen and kidney together, resisting fatigue, defying age; The two compatibility is mended the gas of the day after tomorrow, helps the spleen lung strong.The Arillus Longan invigorating the heart and spleen, nourishing blood to tranquillize the mind, anti-stress, resisting fatigue, raise immunity; Semen Ziziphi Spinosae tonifying liver mind calming, tonifying YIN promotes the production of body fluid, anoxia enduring, defying age, raise immunity; The two is collaborative, supports the heart tired out, and tonifying YIN blood loses, the god of peaceful uneasiness.Folium Perillae regulating functional activities of vital QI, lung moistening and asthma relieving, modern pharmacological research confirm to have the ability of learning and memory of raising and antidotal effect; The Radix Puerariae born fluid, Yiyang gas, defying age, anoxia enduring is separated scorchingly hotly, and modern pharmacological research confirms that the memory process is had obvious facilitation; Flos Chrysanthemi suppressing the hyperactive liver removing heat from blood, the clear sharp head, defying age, resisting fatigue is useful to improving memory; The three helps mutually, the machine of regulating the flow of vital energy, Yiyang gas, resisting fatigue, and hypermnesia is recalled.The all medicines in full side cooperate curative effect to bring out the best in each other, and meet the basic principle of tcm treatment according to syndrome differentiation, meet the prescription thinking of the combination of Chinese and Western medicine.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to process dosage form for oral administration.Medicine of the present invention can be ground into powder with crude drug and be mixed into powder, pill, tablet, granule, oral liquid.Can get active ingredient with being condensed into decocting liquid behind each crude drug decocting, refabrication becomes various oral agents, does not all influence therapeutic effect, does not also limit protection scope of the present invention.
The present invention preferably adopts following capsule formulation and granule.
The method for preparing of said medicine, carry out as follows:
(1) take by weighing raw material in proportion, subsequent use;
(2) with the Fructus Lycii of said weight ratio, Fructus Mori, Fructus Jujubae, Rhizoma Polygonati, Arillus Longan, Semen Ziziphi Spinosae, Folium Perillae, Radix Puerariae, Flos Chrysanthemi 9 flavor medicine decocte with water 5 times, merge decocting liquid then 5 times;
(3) step (2) gained decocting liquid is condensed into extractum;
(4) with extractum dry dry extract;
(5) pulverize the dry extract powdering;
(6) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;
(7) incapsulate.
Each amount of water of described step (2) was not advisable to have powder, decocted 30 minutes at every turn.
Described step (5) gained medicated powder and tablet adjuvant commonly used is mixed, and tabletting becomes tablet.
Medicine of the present invention shows that through clinical use result following advantage is arranged:
1, to select the natural edible-plant medicine for use be raw material in the present invention, and each component meets Medicine Act regulation and tcm prescription principle, gives prominence to the basic characteristic that Chinese medical discrimination combines with the doctor trained in Western medicine differential diagnosis of diseases, etiological treatment combines with symptomatic treatment;
2, medicine of the present invention need not decoct, good mouthfeel, and taking convenience, all nontoxic before and after each herbal medicine prescription, normal dose is taken and do not found any side effect, and is all-ages;
3, medicine of the present invention to feel exhausted, lassitude, hypomnesis, poor sleeping quality etc. not only have excellent curative, and the good preventing health-care effect is also arranged, the scope of application is extensive;
4, all selected but safety is higher in the kind of Ministry of Public Health regulation medicine-food two-purpose for medicine of the present invention, and treatment is tired can take earlier with memory the long period;
Symptoms such as 5, medicine of the present invention has the good property taken into account, and constipation, dreaminess, the blood fat that occurs easily for brain worker, management personnel is higher have certain therapeutical effect of taking into account;
6, medicine of the present invention has good anti-subhealth state effect, has actively reliable curative effect for the initial stage prevention of the treatment of many functional diseases, many diseases, immunologic hypofunction etc.;
7, medicine treating both the principal and secondary aspects of a disease of the present invention takes effect rapidly.
The specific embodiment
Add up the effect that further specifies medicine of the present invention below in conjunction with embodiment and clinical practice.
Embodiment 1: the capsule preparation
Fructus Lycii 30kg, Fructus Mori 24kg, Fructus Jujubae 15kg, Rhizoma Polygonati 30kg, Arillus Longan 18kg, Semen Ziziphi Spinosae 20kg, Folium Perillae 15kg, Radix Puerariae 18kg, Flos Chrysanthemi 15kg add the common decoction of water 5 times; Add water was not advisable to have powder at every turn; The each decoction 30 minutes merges 5 times decocting liquid; Decocting liquid through conventional alcohol extraction, is condensed into extractum; Extractum is put into drying baker oven dry back pulverizing be fine powder, and carry out conventional high-temperature sterilization; Fine powder is incapsulated every medicated powder 0.45g.
Embodiment 2: the granule preparation
Fructus Lycii 30kg, Fructus Mori 24kg, Fructus Jujubae 15kg, Rhizoma Polygonati 30kg, Arillus Longan 18kg, Semen Ziziphi Spinosae 20kg, Folium Perillae 15kg, Radix Puerariae 18kg, Flos Chrysanthemi 15kg; Embodiment 1 said method is processed medicated powder; Be aided with granule adjuvant commonly used again and process electuary, every bag of medicine 2g of electuary.
Clinical drug of the present invention is observed
One, ordinary circumstance and test method
Be to confirm the clinical efficacy of medicine of the present invention, in March, 2008-2009 year by the end of February, the treatment group selection possesses characteristics person's 56 examples such as mental weariness, limbs fatigue, insomnia and dreamful sleep, poor memory, male's 27 examples wherein, women's 29 examples; Age 15-47 year, average 28.6 years old.Matched group 56 examples, male's 26 examples wherein, women's 30 examples; Age 14-48 year, average 29.1 years old.Two groups have comparability through statistical procedures, difference there are no significant meaning (P＞0.05).
The treatment group is all taken embodiment 1 medicament capsule, and each 5, every day 3 times.Matched group buccal Radix Panacis Quinquefolii buccal tablet, every day 3 times, each 1; The reinforcing the heart sheet of calming the nerves, each 5, every day 2 times.Two groups of period in a medicine are avoided direct stimulation, and administration time 14 days was 1 course of treatment, and treatment time is the 1-2 course of treatment.
Two, clinical observation standard
Criterion of therapeutical effect: mental weariness, limbs fatigue, insomnia and dreamful sleep, four cardinal symptoms of poor memory all disappear and are produce effects; Mental weariness, limbs fatigue, insomnia and dreamful sleep, poor memory transference cure at least more than one or above-mentioned primary symptom are obviously alleviated to effectively; The no change person is invalid before and after above-mentioned four cardinal symptoms treatment.
Three, therapeutic effect analysis
Observation group's produce effects 41 examples, effective 14 examples, invalid 1 example, obvious effective rate 73.2%; Matched group produce effects 29 examples, effective 23 examples, invalid 4 examples, obvious effective rate 51.8%.Two groups of comparing differences have statistical significance (P＜0.05).It is emphasized that the treatment group do not find side effect, continue to take and to reach the produce effects standard.
Claims (3)
1. the medicine of resisting fatigue and memory reinforcing is characterized in that it is to be processed by following raw medicaments in portion by weight:
Fructus Lycii 10-30 part Fructus Mori 10-30 part Fructus Jujubae 15-30 part Rhizoma Polygonati 12-30 part
Arillus Longan 10-30 part Semen Ziziphi Spinosae 10-30 part Folium Perillae 10-30 part Radix Puerariae 12-30 part
Flos Chrysanthemi 10-30 part.
2. method for preparing for preparing the said medicine of claim 1 is characterized in that it carries out as follows:
(1) take by weighing raw material in proportion, subsequent use;
(2) with the Fructus Lycii of said weight ratio, Fructus Mori, Fructus Jujubae, Rhizoma Polygonati, Arillus Longan, Semen Ziziphi Spinosae, Folium Perillae, Radix Puerariae, Flos Chrysanthemi 9 flavor medicine decocte with water 5 times, merge decocting liquid then 5 times;
(3) step (2) gained decocting liquid is condensed into extractum;
(4) with extractum dry dry extract;
(5) pulverize the dry extract powdering;
(6) after 110 ℃ keep 10 minutes down, reduce to 105 ℃ and kept 5 minutes, and then be cooled to 100 ℃, kept 5 minutes, be cooled to room temperature;
(7) incapsulate.
3. method for preparing for preparing the said medicine of claim 1 is characterized in that it carries out as follows:
(1) take by weighing raw material in proportion, subsequent use;
(2) with the Fructus Lycii of said weight ratio, Fructus Mori, Fructus Jujubae, Rhizoma Polygonati, Arillus Longan, Semen Ziziphi Spinosae, Folium Perillae, Radix Puerariae, Flos Chrysanthemi 9 flavor medicine decocte with water 5 times, merge decocting liquid then 5 times;
(3) step (2) gained decocting liquid is condensed into extractum;
(4) with extractum dry dry extract;
(5) pulverize the dry extract powdering;
(6) step (5) gained medicated powder and tablet adjuvant commonly used is mixed, tabletting becomes tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101331094A CN102198220B (en) | 2010-03-26 | 2010-03-26 | Medicine for fatigue resistance and memory enhancement |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101331094A CN102198220B (en) | 2010-03-26 | 2010-03-26 | Medicine for fatigue resistance and memory enhancement |
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| Publication Number | Publication Date |
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| CN102198220A CN102198220A (en) | 2011-09-28 |
| CN102198220B true CN102198220B (en) | 2012-07-04 |
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| CN2010101331094A Active CN102198220B (en) | 2010-03-26 | 2010-03-26 | Medicine for fatigue resistance and memory enhancement |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102640926B (en) * | 2012-04-24 | 2014-05-21 | 黄宏植 | Dietary therapy product for regulating sleep and preparation method thereof |
| CN103859379A (en) * | 2012-12-10 | 2014-06-18 | 天津红日药业股份有限公司 | Formula and preparation method of life cultivation and health preservation food helpful for improving memory |
| CN103125939A (en) * | 2013-03-07 | 2013-06-05 | 甘肃复兴厚生物医药科技有限公司 | Rhizoma polygonati and lotus seed particles |
| CN105079447A (en) * | 2014-05-14 | 2015-11-25 | 成都百草和济科技有限公司 | Health care product or medicine composition capable of relieving fatigue and enhancing immunity |
| CN105396026A (en) * | 2014-09-15 | 2016-03-16 | 北京创盈科技产业集团有限公司 | Traditional Chinese medicine preparation containing cistanche deserticola, and preparation method thereof |
| CN105596726A (en) * | 2016-01-13 | 2016-05-25 | 成都市康飞药业有限公司 | Composition for preventing and treating sub-health caused by staying up late and preparation method of composition |
| CN110624049A (en) * | 2019-11-01 | 2019-12-31 | 广西中医药大学 | Application of polygonatum sibiricum and mulberry drink in preparation of anti-fatigue composition |
| CN115737747B (en) * | 2022-10-19 | 2023-10-24 | 贵州医科大学 | Traditional Chinese medicine composition for improving memory and preventing and treating senile dementia and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112524A (en) * | 2006-07-26 | 2008-01-30 | 郁华军 | Health products having functions of invigorating qi and blood and smoothing skin |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112524A (en) * | 2006-07-26 | 2008-01-30 | 郁华军 | Health products having functions of invigorating qi and blood and smoothing skin |
Non-Patent Citations (2)
| Title |
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| 周宝宽.抗疲劳防治亚健康中药整理与研究.《中华中医药学刊》.2008,第26卷(第1期),第193-195页. * |
| 鞠宝兆.中药抗疲劳机制及方药的筛选规律.《中国临床康复》.2004,第8卷(第18期),第3656-3657页. * |
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