CN105250410A - Application of traditional Chinese medicine composition soothing liver and strengthening spleen to preparation of drug treating cancer-related fatigue - Google Patents
Application of traditional Chinese medicine composition soothing liver and strengthening spleen to preparation of drug treating cancer-related fatigue Download PDFInfo
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- CN105250410A CN105250410A CN201510760456.2A CN201510760456A CN105250410A CN 105250410 A CN105250410 A CN 105250410A CN 201510760456 A CN201510760456 A CN 201510760456A CN 105250410 A CN105250410 A CN 105250410A
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Abstract
The invention discloses application of a traditional Chinese medicine composition soothing liver and strengthening spleen to preparation of a drug treating cancer-related fatigue of breast cancer patients. The traditional Chinese medicine composition is prepared from, by weight, 60-200 parts of vinegar processed radix bupleuri, 100-200 parts of poria cocos, 200-400 parts of astragali radix, 60-200 parts of angelica sinensis, 80-200 parts of white peony roots, 100-220 parts of fried rhizoma atractylodis, 100-180 parts of cortex albiziae, 100-180 parts of glossy privet fruit, 80-180 parts of polygala tenuifolia and 60-150 parts of rhodiola rosea. The clinical and trial study finds that the traditional Chinese medicine composition can be used for treating cancer-related fatigue of the breast cancer patients, and the effect is remarkable.
Description
Technical field
The present invention relates to a kind of novelty teabag of soothing the liver Chinese medicine composition, particularly a kind of pharmaceutical composition with soothing liver and strengthening spleen effect is preparing the application in the breast cancer patients medicine tired because of property.
Background technology
Breast carcinoma is modal one in female malignant, and the whole world has 1,000,000 people to be newly diagnosed as breast carcinoma every year.China city and rural area breast cancer incidence are all in obvious ascendant trend in recent years.According to statistics, Beijing-Shanghai two places female mammary gland cancer morbidity reaches 45,/10 ten thousand and 54.9/10 ten thousand respectively, is rising 23% and 31% during the decade, close to west breast carcinoma national level occurred frequently.Breast carcinoma has become and has threatened maximum disease to women's health.And in the disease progression and process of breast carcinoma, almost can there is several symptoms or complication in each patient, the complication caused due to tumor progress itself comprises tired, pain, anemia etc., or because of oncotherapy produce as Nausea and vomiting, constipation, numb hand and foot etc., the appearance of these symptoms obviously reduces patients ' life quality, some complication or even affect the independent factor of long-term prognosis, therefore breast carcinoma related complication also more and more causes the attention of domestic and international tumor educational circles.And Cancer related fatigue is a kind of common sympton perplexing each primary breast cancer patient, and there is obvious relation between persistence with the spirit of patient, emotion, had a strong impact on the quality of life of patient.At present except the interference methods such as motion, psychology, the clinical drug therapy method of specification is not still had to improve the Cancer related fatigue of patient with breast cancer.
It is little that China's Chinese medicine has side effect, the feature of wholistic therapy and conditioning, effectively can improve the state of an illness of patient.
Summary of the invention
The object of the invention is the novelty teabag of openly a kind of Chinese medicine composition.
The present invention seeks to be achieved through the following technical solutions: the crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 60-200 part, Poria 100-200 part, Radix Astragali 200-400 part, Radix Angelicae Sinensis 60-200 part, Radix Paeoniae Alba 80-200 part, Rhizoma Atractylodis Macrocephalae (parched) 100-220 part, Cortex Albiziae 100-180 part, Fructus Ligustri Lucidi 100-180 part, Radix Polygalae 80-180 part, Radix Rhodiolae 60-150 part.
Technical solution of the present invention can be:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 80-160 part, Poria 120-180 part, Radix Astragali 220-380 part, Radix Angelicae Sinensis 80-160 part, Radix Paeoniae Alba 100-180 part, Rhizoma Atractylodis Macrocephalae (parched) 120-200 part, Cortex Albiziae 120-170 part, Fructus Ligustri Lucidi 120-170 part, Radix Polygalae 100-160 part, Radix Rhodiolae 80-120 part.
Technical solution of the present invention is preferably:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 100 parts, 150 parts, Poria, the Radix Astragali 300 parts, Radix Angelicae Sinensis 100 parts, the Radix Paeoniae Alba 150 parts, Rhizoma Atractylodis Macrocephalae (parched) 150 parts, Cortex Albiziae 150 parts, Fructus Ligustri Lucidi 150 parts, Radix Polygalae 120 parts, Radix Rhodiolae 100 parts.
Technical solution of the present invention can also be:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 90 parts, 130 parts, Poria, the Radix Astragali 230 parts, Radix Angelicae Sinensis 90 parts, the Radix Paeoniae Alba 110 parts, Rhizoma Atractylodis Macrocephalae (parched) 140 parts, Cortex Albiziae 130 parts, Fructus Ligustri Lucidi 120 parts, Radix Polygalae 130 parts, Radix Rhodiolae 90 parts.
Technical solution of the present invention can also be:
The crude drug of this Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 150 parts, 150 parts, Poria, the Radix Astragali 360 parts, Radix Angelicae Sinensis 120 parts, the Radix Paeoniae Alba 160 parts, Rhizoma Atractylodis Macrocephalae (parched) 160 parts, Cortex Albiziae 140 parts, Fructus Ligustri Lucidi 160 parts, Radix Polygalae 150 parts, Radix Rhodiolae 110 parts.
Chinese medicine composition of the present invention, its dosage form is the oral formulations such as capsule, granule, tablet, pill, powder.
The preparation method of Chinese medicine composition of the present invention is: all flavour of a drug decoct with water, and filters, concentrated, dry, adds right amount of auxiliary materials, and mixing, subpackage, to obtain final product.
The preparation method of Chinese medicine composition of the present invention is preferably: all flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filters, concentrated, dry, adds right amount of auxiliary materials, mixing, and granulation, subpackage, to obtain final product.
The preparation method of Chinese medicine composition of the present invention can be: all flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filters, and concentrated, spraying dry, subpackage, to obtain final product.
The preparation method of Chinese medicine composition of the present invention can also be: all flavour of a drug decoct with water, and filters, and concentrated, add ethanol, precipitate with ethanol, supernatant flings to ethanol, concentrated, adds right amount of auxiliary materials, dry, mixing, and granulate, subpackage, to obtain final product.
The card that formula of the present invention cures mainly is caused by stagnation of liver-QI, and Shuganjianpi Formula is hepatic depression and blood deficiency, the card of dysfunction of the spleen in transportation and establishing.Liver is the viscus of storing blood, and property happiness tune reaches and main catharsis, body the moon sun.If seven emotions pent-up, liver can be made to lose bar and reach, irritability is not defeated, and emotion irritability rises thereupon demonstrate,proving.Cloudy blood secretly consumes, or the source of vital function is not enough, and liver body loses supports, and insomnia and dreamful sleep all can be made to rise thereupon demonstrate,proving.Body tiredness is tired, is the unable event of insufficiency of the spleen transporting.Now dispersing the stagnated live-QI to relieve the stagnation of QI, benefiting vital QI and blood also can be general.The existing Radix Bupleuri (processed with vinegar) dispersing the stagnated live-QI to relieve the stagnation of QI of we, has again Radix Angelicae Sinensis, Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver.Especially the fragrance of Radix Angelicae Sinensis can circulation of qi promoting, and sweet in the mouth can emergency, the especially key medicine of hepatic depression and blood deficiency.The Rhizoma Atractylodis Macrocephalae, Poria spleen invigorating dehumidifying, transporting is had the right, and QI and blood is active, the Radix Astragali and Rhizoma Atractylodis Macrocephalae compatibility, can invigoration spleen qi, with Radix Angelicae Sinensis compatibility, can qi-supplementing, blood-engendering.Cortex Albiziae, Radix Polygalae, mind tranquilizing and the heart calming resolving depression.Fructus Ligustri Lucidi, liver and kidney tonifying.Radix Rhodiolae, strengthening healthy qi, benefiting qi and nourishing blood, modern pharmacological research shows to have resisting fatigue, antioxidation.The five tastes on this, though make it product for assistant, have the merit supported and assist in.Compatibility like this, liver spleen is also controlled, and QI and blood is taken into account, and comprehensively, medication is thoughtful in legislation.
Chinese medicine composition of the present invention has the medicine of the Cancer related fatigue for the treatment of patient with breast cancer, Be very effective.
Detailed description of the invention
Following experimental example and embodiment are used for further illustrating but are not limited to the present invention.
Experimental example 1: the Cancer related fatigue clinical research for the treatment of patient with breast cancer
1.1 test methods: multicenter, random, double blinding, placebo controlled clinical trial, total sample size is 118 examples, treatment group 59 example, matched group 59 example.Group technology: research adopts treatment group to contrast with between group between matched group.
1.2, case selection
1.2.1 diagnosis and staging scale: with reference to NCCN breast carcinoma clinical practice guideline.
1.2.2 inclusive criteria:
The 2.1 women with breast cancer out-patient treatment patients having a clear and definite pathological diagnosis
After 2.2 mammary cancer radical operation excisions within 5 years, terminate radiotherapy or chemotherapy more than 1 month
2.3 confirm without tumor recurrence or transfer through clinical and iconography.
2.4ECOG marks as 0-2 divides
1.3 administrated method
Chinese drug-treated group: use sample prepared by the method for embodiment 1, morning and evening every day is each once, each one bag (4g), warm boiled water.The treatment surrounding course for the treatment of.
Matched group: placebo granulation, morning and evening every day is each once, each one bag, warm boiled water.The treatment surrounding course for the treatment of.
2 index of assessment of curative effects compare:
2.1 baseline characteristic
Baseline characteristic main contents are age of patient, education degree, marital status, operating time, histological type, clinical scale, Therapeutic Method.Because 3 routine object of study do not include statistical analysis in, we carry out baseline characteristic analysis to 115 routine patients.In Baseline Data, measurement data adopts two sample t-test, and classification and ranked data adopt X 2 test.Statistical result showed, feature has comparability (P > 0.05) substantially.
Tired Chinese edition revision scale (RPFS-CV) of 2.2Piper: in table 1
3, result of the test:
The results are shown in Table 2
A table 2 liang group RPFS-CV compares
Statistics display, total score and each dimension (behavior dimension, emotion dimension, sensation dimension, cognitive dimension) two groups of baselines have comparability (P > 0.05).No matter treat after 2 weeks, 4 weeks, be total score, or each dimension treatment group comparatively matched group improve obviously, two groups of differences have statistical significance (P < 0.05).
Embodiment 1
1, prescription:
Radix Bupleuri (processed with vinegar) 100g, Poria 150g, Radix Astragali 300g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 150g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Cortex Albiziae 150g, Fructus Ligustri Lucidi 150g, Radix Polygalae 120g, Radix Rhodiolae 100g.
2. method for making:
Whole flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filter, concentrated, dry, add right amount of auxiliary materials, mixing, granulation, in point pack, obtain granule.
Embodiment 2
1, prescription:
Radix Bupleuri (processed with vinegar) 90g, Poria 130g, Radix Astragali 230g, Radix Angelicae Sinensis 90g, Radix Paeoniae Alba 110g, Rhizoma Atractylodis Macrocephalae (parched) 140g, Cortex Albiziae 130g, Fructus Ligustri Lucidi 120g, Radix Polygalae 130g, Radix Rhodiolae 90g.
2. method for making:
Whole flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filter, and concentrated, spraying dry, subpackage, to obtain final product.
Embodiment 3
1, prescription:
Radix Bupleuri (processed with vinegar) 150g, Poria 150g, Radix Astragali 360g, Radix Angelicae Sinensis 120g, Radix Paeoniae Alba 160g, Rhizoma Atractylodis Macrocephalae (parched) 160g, Cortex Albiziae 140g, Fructus Ligustri Lucidi 160g, Radix Polygalae 150g, Radix Rhodiolae 110g.
2. method for making:
Whole flavour of a drug decoct with water, and filter, and concentrated, add ethanol, precipitate with ethanol, supernatant flings to ethanol, concentrated, add right amount of auxiliary materials, dry, mixing, and granulate, subpackage, to obtain final product.
Embodiment 4
1, prescription:
Radix Bupleuri (processed with vinegar) 100g, Poria 150g, Radix Astragali 300g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 150g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Cortex Albiziae 150g, Fructus Ligustri Lucidi 150g, Radix Polygalae 120g, Radix Rhodiolae 100g.
2. method for making:
Whole flavour of a drug decoct with water 2 times, filter, and concentrated, add ethanol to 60%, precipitate with ethanol, supernatant flings to ethanol, concentrated, add right amount of auxiliary materials, dry, mixing, and granulate, subpackage, to obtain final product.
Claims (10)
1. the Chinese medicine composition of a soothing liver and strengthening spleen treats the application in the breast cancer patients medicine tired because of property in preparation, the crude drug of described Chinese medicine composition and weight portion are: Radix Bupleuri (processed with vinegar) 60-200 part, Poria 100-200 part, Radix Astragali 200-400 part, Radix Angelicae Sinensis 60-200 part, Radix Paeoniae Alba 80-200 part, Rhizoma Atractylodis Macrocephalae (parched) 100-220 part, Cortex Albiziae 100-180 part, Fructus Ligustri Lucidi 100-180 part, Radix Polygalae 80-180 part, Radix Rhodiolae 60-150 part.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 80-160 part, Poria 120-180 part, Radix Astragali 220-380 part, Radix Angelicae Sinensis 80-160 part, Radix Paeoniae Alba 100-180 part, Rhizoma Atractylodis Macrocephalae (parched) 120-200 part, Cortex Albiziae 120-170 part, Fructus Ligustri Lucidi 120-170 part, Radix Polygalae 100-160 part, Radix Rhodiolae 80-120 part.
3. Chinese medicine composition as claimed in claim 2, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 100 parts, 150 parts, Poria, the Radix Astragali 300 parts, Radix Angelicae Sinensis 100 parts, the Radix Paeoniae Alba 150 parts, Rhizoma Atractylodis Macrocephalae (parched) 150 parts, Cortex Albiziae 150 parts, Fructus Ligustri Lucidi 150 parts, Radix Polygalae 120 parts, Radix Rhodiolae 100 parts.
4. Chinese medicine composition as claimed in claim 2, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 90 parts, 130 parts, Poria, the Radix Astragali 230 parts, Radix Angelicae Sinensis 90 parts, the Radix Paeoniae Alba 110 parts, Rhizoma Atractylodis Macrocephalae (parched) 140 parts, Cortex Albiziae 130 parts, Fructus Ligustri Lucidi 120 parts, Radix Polygalae 130 parts, Radix Rhodiolae 90 parts.
5. Chinese medicine composition as claimed in claim 2, it is characterized in that crude drug and the weight portion of this Chinese medicine composition are: Radix Bupleuri (processed with vinegar) 150 parts, 150 parts, Poria, the Radix Astragali 360 parts, Radix Angelicae Sinensis 120 parts, the Radix Paeoniae Alba 160 parts, Rhizoma Atractylodis Macrocephalae (parched) 160 parts, Cortex Albiziae 140 parts, Fructus Ligustri Lucidi 160 parts, Radix Polygalae 150 parts, Radix Rhodiolae 110 parts.
6. the Chinese medicine composition as described in as arbitrary in claim 1 to 5, it is characterized in that, its dosage form is the oral formulations such as capsule, granule, tablet, pill, powder.
7. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1 to 5, is characterized in that the method is: all flavour of a drug decoct with water, and filters, concentrated, dry, adds right amount of auxiliary materials, and mixing, subpackage, to obtain final product.
8. the preparation method of Chinese medicine composition as claimed in claim 7, is characterized in that the method is: all flavour of a drug decoct with water 2 times, for the first time 60min, the 2nd 30min, filters, concentrated, dry, and add right amount of auxiliary materials, mixing, granulation, subpackage, to obtain final product.
9. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1 to 5, is characterized in that the method is: all flavour of a drug decoct with water 2 times, first time 60min, the 2nd 30min, filter, concentrated, spraying dry, subpackage, to obtain final product.
10. the preparation method of the Chinese medicine composition as described in as arbitrary in claim 1 to 5, is characterized in that the method is: all flavour of a drug decoct with water, and filters, concentrated, adds ethanol, precipitate with ethanol, supernatant flings to ethanol, concentrated, adds right amount of auxiliary materials, dry, mixing, granulate, subpackage, to obtain final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510760456.2A CN105250410B (en) | 2015-11-10 | 2015-11-10 | A kind of application of the Chinese medicine composition of soothing liver and strengthening spleen in the drug for preparing treatment Cancer related fatigue |
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| CN201510760456.2A CN105250410B (en) | 2015-11-10 | 2015-11-10 | A kind of application of the Chinese medicine composition of soothing liver and strengthening spleen in the drug for preparing treatment Cancer related fatigue |
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| CN105250410B CN105250410B (en) | 2018-09-18 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496865A (en) * | 2009-03-19 | 2009-08-05 | 杨颖� | Chinese medicament preparation for treating depression and anxiety as well as preparation method thereof |
| CN101961190A (en) * | 2010-10-20 | 2011-02-02 | 刘爱霞 | Drug pillow for insomnia recovery |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101496865A (en) * | 2009-03-19 | 2009-08-05 | 杨颖� | Chinese medicament preparation for treating depression and anxiety as well as preparation method thereof |
| CN101961190A (en) * | 2010-10-20 | 2011-02-02 | 刘爱霞 | Drug pillow for insomnia recovery |
Non-Patent Citations (1)
| Title |
|---|
| 卢伟: "癌症患者化疗期间癌因性疲乏中医临床辨治探讨", 《吉林中医药》 * |
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