CN101032597B - Medicine for strengthening resistance and solidifying health in the radiation treatment and chemo-treatment process of cancer patient - Google Patents
Medicine for strengthening resistance and solidifying health in the radiation treatment and chemo-treatment process of cancer patient Download PDFInfo
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- CN101032597B CN101032597B CN2007100908670A CN200710090867A CN101032597B CN 101032597 B CN101032597 B CN 101032597B CN 2007100908670 A CN2007100908670 A CN 2007100908670A CN 200710090867 A CN200710090867 A CN 200710090867A CN 101032597 B CN101032597 B CN 101032597B
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Abstract
The present invention is one kind of medicine for cancer patient in radiotherapy and chemotherapy to strengthen body's resistance. The medicine is prepared with astragalus root, ophiopogon root, American ginseng, dogwood fruit, wolfberry fruit and nutagrass flatsedge rhizome and in the form of granule, oral liquid, medicine powder, etc. It is used during radiotherapy and chemotherapy to enhance sensitivity, reduce toxicity and raise treating effect, and may be also used for preventing recurrence or metastasis after tumor resection, and for the conservation treatment of cancer in late stage to improve life quality.
Description
Technical field
The present invention relates to medicine, especially with Chinese crude drug preparation, at the medicine of cancer patient being implemented use in radiotherapy and the chemotherapy process to the cancer patient auxiliary treatment.
Background technology
Malignant tumor is as a class serious threat human life and healthy disease, and except that therapeutic method of surgery, radiotherapy and anticancer chemotherapy are the most frequently used and effective means.Radiotherapy is called for short radiotherapy, and anticancer chemotherapy is called for short chemotherapy.The a great problem of medical circle is at present, and the chemicotherapy toxicity almost takes place the cloudy damage of patient's gas bar none in implementing the chemicotherapy process, and the lighter increases patient's misery, and middle person reduces therapeutic dose, and weight person is forced to therapy discontinued.Therefore, reducing, alleviate patient is to guarantee that chemicotherapy finishes smoothly to the toxicity of chemicotherapy, improves the important measures of therapeutic effect of malignant tumour on the whole.Using various extra-nutritions, physical strength reinforcing to alleviate the medicine of chemicotherapy toxicity in China and foreign countries' medical practice, they respectively have the characteristics of oneself, but still not by medical circle generally acknowledge can be generally suitable, respond well to most cancer patients, medicine that cost is not too high again.On the other hand, strengthening the body resistance, tonifying vital QI are the chiefs of Chinese medicine.Year is devoted to the exploration and the research of Chinese medicine malignant tumor surplus the inventor 40, has obtained a series of application Chinese medicine anti-cancer and inhibiting tumors, and the human body immunity improving function reduces the chemicotherapy toxicity, regulates the inherent equilibrated technological achievement of body.The present invention is one of concrete results.
Summary of the invention
The object of the present invention is to provide a kind of medicine with the Chinese medicine composition preparation, its manufacture method is easy, economical, and is easy to use, has the function of strengthening the body resistance, and the toxicity that reduces, alleviates patient's chemicotherapy is had sure effect.
The medicine that the present invention is used for the radiation treatment and chemo-treatment process of cancer patient strengthening the body resistance is by the medicament that comprises following proportion raw material medicine preparation, included raw material medicaments in part by weight is expressed as, 40～60 parts of the Radixs Astragali, 10～30 parts of Radix Ophiopogonis, 1～3 part of Radix Panacis Quinquefolii, 5～15 parts of Fructus Corni (enucleation), 5～15 parts of Fructus Lycii, 5～15 parts of Rhizoma Cyperis (processing).
The consumption optimum weight proportioning of above-mentioned each component raw material medicine is 50 parts of the Radixs Astragali, 20 parts of Radix Ophiopogonis, 1.5 parts of Radix Panacis Quinquefoliis, 10 parts of Fructus Corni (enucleation), 10 parts of Fructus Lycii, 10 parts of Rhizoma Cyperis (processing).
Use above crude drug, can adopt common process to make said any dosage form on the pharmaceutics, comprise dosage forms such as powder, tablet, capsule, granular pattern electuary, oral liquid, preferred particulates type electuary.
The effect of the primary raw material medicine in the present invention's prescription is respectively, and the Radix Astragali is a monarch drug, tonifying Qi and lifting yang, and benefit is defended consolidating superficial resistance; Radix Ophiopogonis, Radix Panacis Quinquefolii are ministerial drug.Wherein Radix Ophiopogonis nourishing lung-YIN, reinforcing stomach reg fluid, relieving restlessness clears away heart-fire; The Radix Panacis Quinquefolii boosting qi and nourishing yin relieves inflammation or internal heat and promotes the production of body fluid, and principal drug assistance is to set upright altogether; Fructus Corni, Fructus Lycii are adjuvant drug.Wherein the Fructus Corni liver and kidney tonifying is restrained astringent or styptic treatment for spontaneous sweating; The Fructus Lycii the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough; Rhizoma Cyperi is a messenger drug, the depressed liver-energy dispersing and QI regulating pain relieving.Full side's compatibility has invigorating the spleen and replenishing QI, YIN nourishing and the production of body fluid promoting, and nourishing the lung to arrest cough nourishes blood and adds essence, nourishing the liver and kidney, the effect of strengthening the body resistance.
Medicine of the present invention is by its strengthening the body resistance function, can be in radiotherapy, chemotherapy process the enhanced sensitivity attenuation, improve the therapeutic effect of malignant tumor.Also can be used for preventing recurrence or transfer behind the tumorectomy, the centering patients with advanced cancer alleviates patient's misery as the expectant treatment means, improves life quality, life-saving.
The specific embodiment
The invention will be further described by the following examples.
Embodiment 1 fills a prescription: the Radix Astragali 625 restrains, restrain Radix Ophiopogonis 250, Radix Panacis Quinquefolii 18.75 restrains, Fructus Corni (enucleation) 125 restrains, Fructus Lycii 125 restrains, Rhizoma Cyperi (processing) 100 restrains.
Preparation method:
(1) will fill a prescription in whole Radix Panacis Quinquefoliis and the 63 gram Radixs Astragali (take Radix Astragali amount and be equivalent to 3.33 times of Western parameter approximately) pulverize separately, cross 120 mesh sieves, mix homogeneously is standby;
(2) with Radix Ophiopogonis, Fructus Evodiae meat, Fructus Lycii, prepared RHIZOMA CYPERI and the last Radix Astragali of step 1, and the thick slag of the Radix Astragali, Radix Panacis Quinquefolii that step 1 is sifted out decocts with water 2 times together, the each decoction 2 hours, merging decoction liquor filters, be concentrated into relative density 1.30～1.35 (80 ℃), add the Radix Astragali, the Radix Panacis Quinquefolii fine powder mixing of step 1 made, add 1.5 times of dextrin and an amount of ethanol again, make granule, dry packing promptly.Finished product claims " stilbene wheat yin nourishing granule ".
Present embodiment uses crude drug totally 1268.75 grams, can be made into about 1000 grams of granular pattern electuary.Each oral 20 grams of adult patients, every day 3 times.
Embodiment 2 fills a prescription: the Radix Astragali 400 restrains, restrain Radix Ophiopogonis 300, Radix Panacis Quinquefolii 10 restrains, Fructus Corni (enucleation) 150 restrains, Fructus Lycii 50 restrains, Rhizoma Cyperi (processing) 150 restrains.
Preparation method:
(1) will fill a prescription in all Radix Panacis Quinquefoliis and the 40 gram Radix Astragali (Radix Astragali amount is equivalent to 4 times of Western parameter approximately) pulverize separately, cross 120 mesh sieves, mix homogeneously is standby;
(2) with Radix Ophiopogonis, Fructus Evodiae meat, Fructus Lycii, prepared RHIZOMA CYPERI and the last Radix Astragali of step 1, and the thick slag of the Radix Astragali, Radix Panacis Quinquefolii that step 1 is sifted out decocts with water 2 times together, the each decoction 2 hours, merging decoction liquor filters, be concentrated into relative density 1.30～1.35 (80 ℃), add the Radix Astragali, the Radix Panacis Quinquefolii fine powder mixing of step 1 made, add 1.5 times of dextrin and an amount of ethanol again, make granule, dry packing promptly.Finished product claims " stilbene wheat yin nourishing granule ".
Present embodiment uses crude drug totally 1060 grams, can be made into about 830 grams of granular pattern electuary.Each oral 15～30 grams of adult patients, every day 2～4 times.
Embodiment 3 fills a prescription: the Radix Astragali 1200 restrains, restrain Radix Ophiopogonis 200, Radix Panacis Quinquefolii 60 restrains, Fructus Corni (enucleation) 100 restrains, Fructus Lycii 300 restrains, Rhizoma Cyperi (processing) 100 restrains.
Preparation method:
(1) will fill a prescription in all Radix Panacis Quinquefoliis and the 150 gram Radix Astragali (Radix Astragali amount is equivalent to 2.5 times of Western parameter approximately) pulverize separately, cross 120 mesh sieves, mix homogeneously is standby;
(2) with Radix Ophiopogonis, Fructus Evodiae meat, Fructus Lycii, prepared RHIZOMA CYPERI and the last Radix Astragali of step 1, and the thick slag of the Radix Astragali, Radix Panacis Quinquefolii that step 1 is sifted out decocts with water 2 times together, the each decoction 2 hours, merging decoction liquor filters, be concentrated into relative density 1.30～1.35 (80 ℃), add the Radix Astragali, the Radix Panacis Quinquefolii fine powder mixing of step 1 made, add 1.5 times of dextrin and an amount of ethanol again, make granule, dry packing promptly.Finished product claims " stilbene wheat yin nourishing granule ".
Present embodiment uses crude drug totally 1960 grams, can be made into about 1545 grams of granular pattern electuary.Each oral 20～40 grams of adult patients, every day 3～4 times.
Experimental example clinical drug of the present invention is used observation of curative effect
One. physical data
This organizes 100 routine malignant tumor patients from all over China.Wherein 62 examples are from Beijing, and all the other 38 examples are from other provinces and cities that comprise Hong Kong, Taiwan.All cases are all once at hospital admission more than three grades, and are diagnosed as malignant tumor through inspections such as CT, pathology.
(1) sex distributes: male's 53 examples, women's 47 examples.
(2) age distribution: minimum 4 years old, maximum 77 years old.The case age distribution sees Table 1.
The age distribution of table 1 case
| Age | 1～10 | 11～20 | 21～30 | 31～40 | 41～50 | 51～60 | 61～70 | 71～80 | Add up to |
| The example number | 6 | 0 | 1 | 7 | 22 | 23 | 28 | 13 | 100 |
Wherein, the patient was totally 73 in 41～70 years old, 73% of some case sum; 6 examples youngster below 10 years old is the child's bladder cancer patients for making a definite diagnosis through the BJ Children's Hospital heavily.
(3) course of disease: calculate the initial state of an illness of finding to the time of using between the medicine of the present invention, the shortest 1 month, the longest 3 years.
(4) the sick kind distributes: see Table 2.
The sick kind of table 2 case distributes
Annotate: alleged in the table " tumor " is the malignant tumor of medical science classification.Wherein, digestive system tumor comprises esophageal carcinoma, gastric cancer, intestinal cancer, hepatocarcinoma, cancer of pancreas; Urologic neoplasms comprises renal carcinoma, bladder cancer; Gynecological tumor comprises cervical cancer, carcinoma of endometrium, ovarian cancer; Other tumor comprises carcinoma of submaxilary gland, external auditory meatus cancer, temporal lobe glioma.
Organize among the 100 routine patients at this, belong to simple chemotherapy person's 33 examples, carry out chemotherapy person's 49 examples after the operation, not only make chemotherapy but also make radiotherapy person's 18 examples after the operation.
Two. administrated method
All cases are used the stilbene wheat yin nourishing granule of the present invention of pressing the preparation of embodiment 1～3 method.Put, before the chemotherapy 1～3 day or put, the chemotherapy first day begins to use medicine of the present invention.The general each 20g of case, every day 3 times.The each 40g of the person of being in a bad way, every day 2 times.The each 10g of child, every day 3 times.
The course of treatment: taking for 4 weeks continuously is a course of treatment, can not stop and continues the next course of treatment, should put, continue to use medicine of the present invention more than 20 days behind the end of chemotherapy.This organizes 100 routine medication person's one course of treatment 12 examples, medication person's two courses of treatment 54 examples, three courses of treatment of medication and three courses of treatment above person's 34 examples.Medication discontented one the course of treatment person do not include this laboratory observation statistics in.
Three. result and efficacy analysis
Efficacy evaluation is divided into produce effects, effective, invalid three grades.Its standard is:
Produce effects:
(1) put, the toxicity of chemotherapy is slight, finishes radiotherapy, chemotherapy full course of treatment smoothly;
(2) leukocyte remains on normal level in radiotherapy, chemotherapy overall process.
Effectively:
(1) put, the toxicity of chemotherapy in may command, can stand in the scope, adhere to finishing radiotherapy, chemotherapy full course of treatment;
(2) put, leukocyte decreases in the chemotherapy process, finishing to put, returning to normal level in 2 weeks after the chemotherapy.
Invalid:
(1) put, chemotherapy toxic side effect is obvious, cause not finish radiotherapy, chemotherapy full course of treatment;
(2) put, leukocyte is reduced to below the normal level in the chemotherapy process, does not return to normal level after taking medicine of the present invention.
Above-mentioned " put, chemotherapy toxic side effect " comprises that the soreness of waist is weak, loss of appetite, xerostomia, feel sick, vomiting; Alopecia etc.
This group 100 examples are used stilbene wheat yin nourishing granule total effective rate of the present invention and are reached 84%.Efficacy analysis sees Table 3.
Table 3 efficacy analysis
Four. conclusion
Clinical observation shows, pharmaceutical composition of the present invention can obviously be alleviated malignant tumor patient at the toxicity of implementing to put, taking place in the chemotherapy journey, auxiliaryly puts, chemotherapy safety finishes smoothly, thereby improves the curative effect to malignant tumor.Simultaneously show that in clinical observation stilbene wheat yin nourishing granule of the present invention is without any side effects, taking convenience is the active drug of adjuvant therapy of malignant tumor.
Claims (3)
1. medicine that is used for the radiation treatment and chemo-treatment process of cancer patient strengthening the body resistance, it is characterized in that it is made by following raw materials by weight proportions: 40～60 parts of the Radixs Astragali, 10～30 parts of Radix Ophiopogonis, 1～3 part of Radix Panacis Quinquefolii, 5～15 parts of enucleation Fructus Corni, 5～15 parts of Fructus Lycii, 5～15 parts of prepared RHIZOMA CYPERIs.
2. medicine according to claim 1 is characterized in that, the weight proportion of raw materials used medicine is 50 parts of the Radixs Astragali, 20 parts of Radix Ophiopogonis, 1.5 parts of Radix Panacis Quinquefoliis, 10 parts of enucleation Fructus Corni, 10 parts of Fructus Lycii, 10 parts of prepared RHIZOMA CYPERIs.
3. medicine according to claim 1 and 2 is characterized in that, the pharmaceutical dosage form of using described crude drug making is the granular pattern electuary.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100908670A CN101032597B (en) | 2007-04-10 | 2007-04-10 | Medicine for strengthening resistance and solidifying health in the radiation treatment and chemo-treatment process of cancer patient |
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| CN2007100908670A CN101032597B (en) | 2007-04-10 | 2007-04-10 | Medicine for strengthening resistance and solidifying health in the radiation treatment and chemo-treatment process of cancer patient |
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| CN101032597A CN101032597A (en) | 2007-09-12 |
| CN101032597B true CN101032597B (en) | 2010-12-22 |
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| CN104721546B (en) * | 2015-03-20 | 2018-05-08 | 张波 | A kind of Chinese medicine composition for preventing postoperative recurrence of cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1421238A (en) * | 2002-12-23 | 2003-06-04 | 丁铁岭 | Natural bioreaction regulator with the functions of resisting cancer, resisting free radical damage and regulating immunity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1421238A (en) * | 2002-12-23 | 2003-06-04 | 丁铁岭 | Natural bioreaction regulator with the functions of resisting cancer, resisting free radical damage and regulating immunity |
Non-Patent Citations (2)
| Title |
|---|
| 郑显明.扶正培本法在癌症治疗中的应用和地位.云南中医中药杂志 4.1994,(4),4-6. |
| 郑显明.扶正培本法在癌症治疗中的应用和地位.云南中医中药杂志 4.1994,(4),4-6. * |
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