CN105250412B - A kind of application of the Chinese medicine composition of soothing liver and strengthening spleen in the drug for preparing treatment anxiety-depression - Google Patents

A kind of application of the Chinese medicine composition of soothing liver and strengthening spleen in the drug for preparing treatment anxiety-depression Download PDF

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CN105250412B
CN105250412B CN201510764376.4A CN201510764376A CN105250412B CN 105250412 B CN105250412 B CN 105250412B CN 201510764376 A CN201510764376 A CN 201510764376A CN 105250412 B CN105250412 B CN 105250412B
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chinese medicine
medicine composition
radix
drug
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CN105250412A (en
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王笑民
杨国旺
郁仁存
于明薇
李琛
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Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital University of Medicine Sciences
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Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital University of Medicine Sciences
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Abstract

The invention discloses a kind of application of Chinese medicine composition of soothing liver and strengthening spleen in the drug for preparing treatment anxiety of breast cancer patients depression, the bulk pharmaceutical chemicals composition and parts by weight of the Chinese medicine composition are:60 200 parts of stir-baked RADIX BUPLEURI with vinegar, 100 200 parts of Poria cocos, 200 400 parts of Radix Astragali, 60 200 parts of Radix Angelicae Sinensis, 80 200 parts of Radix Paeoniae Alba, 100 220 parts of rhizoma atractylodis macrocephalae, 100 180 parts of cortex albiziae, 100 180 parts of the fruit of glossy privet, 80 180 parts of Radix Polygalae, 60 150 parts of rhodiola root.Clinical experimental study finds that Chinese medicine composition of the present invention can be used for treating the anxiety-depression of patient with breast cancer, significant effect.

Description

A kind of Chinese medicine composition of soothing liver and strengthening spleen is in the drug for preparing treatment anxiety-depression Using
Technical field
It is the present invention relates to a kind of new application of soothing the liver Chinese medicine composition, more particularly to a kind of with soothing liver and strengthening spleen effect Application of the pharmaceutical composition in the drug for preparing anxiety of breast cancer patients depression.
Background technology
Breast cancer is the most common type in female malignant, and the whole world has 1,000,000 people to be newly diagnosed as breast cancer every year.Closely The China Nian Lai city and rural area breast cancer incidence are in apparent ascendant trend.According to statistics, Beijing-Shanghai two places women with breast cancer morbidity Rate respectively reaches 45/,100,000 and 54.9/10 ten thousand, is rising 23% and 31% during the decade, occurred frequently already close to west breast cancer National level.Breast cancer has become threatens maximum disease to women's health.And in the development of the disease of breast cancer and in the process, it is several Several symptoms or complication can occur in each patient, due to tumour itself be in progress caused by complication include it is tired, Pain, anaemia etc., or such as Nausea and vomiting, constipation, numb in every limb that generates by oncotherapy, the appearance of these symptoms is apparent Patients ' life quality is reduced, certain complication even influence the independent factor of prognosis at a specified future date, therefore breast cancer related complication Also increasingly cause the attention of domestic and international tumour educational circles.And anxiety-depression is a kind of common disease for perplexing each primary breast cancer patient Shape, and have obvious relation between persistence with the spirit of patient, mood, seriously affect the quality of life of patient.At present in addition to movement, psychology Outside equal interference methods, still the clinical drug therapy method of specification does not improve the anxiety-depression of patient with breast cancer.
China's traditional Chinese medicine has the characteristics of Small side effects, wholistic therapy and conditioning, can effectively improve the state of an illness of patient.
Invention content
Present invention aims at disclose a kind of new application of Chinese medicine composition.
Purpose of the present invention is to what is be achieved through the following technical solutions:The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:Vinegar 60-200 parts of radix bupleuri, 100-200 parts of Poria cocos, 200-400 parts of Radix Astragali, 60-200 parts of Radix Angelicae Sinensis, 80-200 parts of Radix Paeoniae Alba, rhizoma atractylodis macrocephalae 100- 220 parts, 100-180 parts of cortex albiziae, 100-180 parts of the fruit of glossy privet, 80-180 parts of Radix Polygalae, 60-150 parts of rhodiola root.
Technical solution of the present invention can be:
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:80-160 parts of stir-baked RADIX BUPLEURI with vinegar, 120-180 parts of Poria cocos, Radix Astragali 220- 380 parts, 80-160 parts of Radix Angelicae Sinensis, 100-180 parts of Radix Paeoniae Alba, 120-200 parts of rhizoma atractylodis macrocephalae, 120-170 parts of cortex albiziae, fruit of glossy privet 120- 170 parts, 100-160 parts of Radix Polygalae, 80-120 parts of rhodiola root.
Technical solution of the present invention is preferably:
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:100 parts of stir-baked RADIX BUPLEURI with vinegar, 150 parts of Poria cocos, 300 parts of Radix Astragali, Radix Angelicae Sinensis 100 parts, 150 parts of Radix Paeoniae Alba, 150 parts of rhizoma atractylodis macrocephalae, 150 parts of cortex albiziae, 150 parts of the fruit of glossy privet, 120 parts of Radix Polygalae, 100 parts of rhodiola root.
Technical solution of the present invention can also be:
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:90 parts of stir-baked RADIX BUPLEURI with vinegar, 130 parts of Poria cocos, 230 parts of Radix Astragali, Radix Angelicae Sinensis 90 Part, 110 parts of Radix Paeoniae Alba, 140 parts of rhizoma atractylodis macrocephalae, 130 parts of cortex albiziae, 120 parts of the fruit of glossy privet, 130 parts of Radix Polygalae, 90 parts of rhodiola root.
Technical solution of the present invention can also be:
The bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:150 parts of stir-baked RADIX BUPLEURI with vinegar, 150 parts of Poria cocos, 360 parts of Radix Astragali, Radix Angelicae Sinensis 120 parts, 160 parts of Radix Paeoniae Alba, 160 parts of rhizoma atractylodis macrocephalae, 140 parts of cortex albiziae, 160 parts of the fruit of glossy privet, 150 parts of Radix Polygalae, 110 parts of rhodiola root.
The Chinese medicine composition of the present invention, dosage form are the oral preparations such as capsule, granule, tablet, pill, powder.
The preparation method of Chinese medicine composition of the present invention is:Whole flavour of a drug add water to cook, and filter, and concentrate, dry, add auxiliary material In right amount, mixing, packing to get.
The preparation method of Chinese medicine composition of the present invention is preferably:Whole flavour of a drug add water to cook 2 times, first time 60min, the 2 30min are filtered, and are concentrated, dry, add right amount of auxiliary materials, mixing, granulation, packing to get.
The preparation method of Chinese medicine composition of the present invention can be:Whole flavour of a drug add water to cook 2 times, first time 60min, the 2 30min, filter, concentrate, spray drying, packing to get.
The preparation method of Chinese medicine composition of the present invention can also be:Whole flavour of a drug add water to cook, and filter, and concentration adds second Alcohol, alcohol precipitation, supernatant fling to ethyl alcohol, and concentration adds right amount of auxiliary materials, dry, mixing, granulation, packing to get.
The card of the present invention that cure mainly that is formulated is caused by liver depression, and Shuganjianpi Formula is hepatic depression and blood deficiency, the card of the dysfunction of the spleen in transport And it sets.Liver is the viscus of storing blood, and property happiness, which is adjusted, to be reached and main catharsis, body the moon sun.If seven feelings pent-ups, liver can be made to lose item and reached, irritability is not defeated, Mood irritability rises therewith demonstrate,proving.Cloudy blood secretly consumes or the source of vital function is insufficient, and liver body, which loses, supports, and insomnia and dreamful sleep can all risen therewith demonstrate,proving. Body tiredness is tired, is the powerless event of spleen deficiency transporting.Soothing liver-qi stagnation at this time, tonifying Qi and blood are also generally applicable.The existing stir-baked RADIX BUPLEURI with vinegar of we is soothing the liver Xie Yu, and have Radix Angelicae Sinensis, Radix Paeoniae Alba nourishing blood and liver.Especially the fragrance of Radix Angelicae Sinensis can promoting the circulation of qi, it is sweet in flavor can emergency, even more hepatic depression and blood deficiency wants Medicine.Rhizoma Atractylodis Macrocephalae, Poria cocos invigorating the spleen dehumidifying, make transporting have the right, and qi and blood is active, Radix Astragali and Rhizoma Atractylodis Macrocephalae compatibility, can invigoration spleen qi, match with Radix Angelicae Sinensis 5, it can qi-supplementing, blood-engendering.Cortex albiziae, Radix Polygalae, antitoxic heart-soothing and sedative solution are strongly fragrant.The fruit of glossy privet tonifies the liver and kidney.Rhodiola root, strengthening healthy qi, tonifying Qi are supported Blood, modern pharmacological studies have shown that having antifatigue, antioxidation.The five tastes on this have the work(supported and assist in though being allowed to product for assistant. Such compatibility, liver and spleen are simultaneously controlled, and qi and blood is taken into account, and legislation is comprehensive, and medication is thoughtful.
Chinese medicine composition of the present invention has the drug of the anxiety-depression for the treatment of patient with breast cancer, significant effect.
Specific implementation mode
Following experimental examples and embodiment are for further illustrating but being not limited to the present invention.
Experimental example 1:Treat the anxiety-depression clinical research of patient with breast cancer
1.1 test method:Multicenter, random, double blind, placebo controlled clinical trial, total sample size are 118, treatment Group 59, control group 59.Group technology:Research is used and is compareed between group between treatment group and control group;Before treatment and after treatment Itself cross-reference.
1.2, case selection
1.2.1 diagnosis and staging scale:With reference to NCCN breast cancer clinical practice guidelines.
1.2.2 inclusion criteria:
2.1 have the women with breast cancer treat-and-release patient of clear pathological diagnosis
After 2.2 mammary cancer radical operation resections within 5 years, terminate radiotherapy or chemotherapy 1 month or more
2.3 confirm through clinical and iconography without tumor recurrence or transfer.
2.4ECOG scorings are 0-2 points
1.3 administrated method
Chinese medicine group:The sample prepared using the method for embodiment 1, each primary daily morning and evening, one bag (4g) every time, warm water It takes after mixing it with water.Treatment course surrounding.
Control group:Placebo granulation, it is each primary daily morning and evening, one bag every time, warm boiled water.Treatment course surrounding.
2 test results:
2.1 baseline characteristic
Baseline characteristic main contents are the age of patient, education degree, marital status, operating time, histological type, clinic Classification, therapy.Since 3 research objects are not included in statistical analysis, we carry out baseline characteristic analysis to 115 patients. Measurement data uses two sample t-tests, classification and ranked data that Chi-square Test, wherein theoretical frequency is used to be more than in Baseline Data 5 data uses Wilcoxon rank sum tests.Statistical result showed, feature are comparable (P > 0.05) substantially.
2.2 general hospital's anxiety-depression scales (HADS)
3 test results:
2 two groups of HADS-A of table compare
3 two groups of HADS-D of table compare
HADS-A:When baseline, Chinese medicine group compared with the control group (P > 0.05), treatment 4 weeks after, Chinese medicine group and control group phase Than statistics has statistical significance, and follow-up 4 weeks, difference has statistical significance.
HADS-D:When baseline, Chinese medicine group compared with the control group (P > 0.05), treatment 4 weeks after, Chinese medicine group and control group phase Than statistics has statistical significance, and follow-up 4 weeks, difference has statistical significance.
Embodiment 1
1, prescription:
Stir-baked RADIX BUPLEURI with vinegar 100g, Poria cocos 150g, Radix Astragali 300g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 150g, rhizoma atractylodis macrocephalae 150g, cortex albiziae 150g, Fruit of glossy privet 150g, Radix Polygalae 120g, rhodiola root 100g.
2. preparation method:
Whole flavour of a drug add water to cook 2 times, first time 60min, the 2nd 30min, filter, and concentrate, dry, add right amount of auxiliary materials, Mixing, granulation dispense in bag to get granule.
Embodiment 2
1, prescription:
Stir-baked RADIX BUPLEURI with vinegar 90g, Poria cocos 130g, Radix Astragali 230g, Radix Angelicae Sinensis 90g, Radix Paeoniae Alba 110g, rhizoma atractylodis macrocephalae 140g, cortex albiziae 130g, female Loyal sub- 120g, Radix Polygalae 130g, rhodiola root 90g.
2. preparation method:
Whole flavour of a drug add water to cook 2 times, first time 60min, the 2nd 30min, filter, and concentrate, and are spray-dried, packing, i.e., .
Embodiment 3
1, prescription:
Stir-baked RADIX BUPLEURI with vinegar 150g, Poria cocos 150g, Radix Astragali 360g, Radix Angelicae Sinensis 120g, Radix Paeoniae Alba 160g, rhizoma atractylodis macrocephalae 160g, cortex albiziae 140g, Fruit of glossy privet 160g, Radix Polygalae 150g, rhodiola root 110g.
2. preparation method:
Whole flavour of a drug add water to cook, and filter, and concentration adds ethyl alcohol, alcohol precipitation, supernatant to fling to ethyl alcohol, concentrates, and add auxiliary material suitable Amount, dry, mixing, granulation, packing to get.
Embodiment 4
1, prescription:
Stir-baked RADIX BUPLEURI with vinegar 100g, Poria cocos 150g, Radix Astragali 300g, Radix Angelicae Sinensis 100g, Radix Paeoniae Alba 150g, rhizoma atractylodis macrocephalae 150g, cortex albiziae 150g, Fruit of glossy privet 150g, Radix Polygalae 120g, rhodiola root 100g.
2. preparation method:
Whole flavour of a drug add water to cook 2 times, filter, and concentration adds ethyl alcohol to 60%, and alcohol precipitation, supernatant flings to ethyl alcohol, concentration, Add right amount of auxiliary materials, dry, mixing, granulation, packing to get.

Claims (11)

1. a kind of application of Chinese medicine composition of soothing liver and strengthening spleen in the drug for preparing treatment anxiety of breast cancer patients depression, described The bulk pharmaceutical chemicals and parts by weight of Chinese medicine composition are:60-200 parts of stir-baked RADIX BUPLEURI with vinegar, 100-200 parts of Poria cocos, 200-400 parts of Radix Astragali, Radix Angelicae Sinensis 60-200 parts, 80-200 parts of Radix Paeoniae Alba, 100-220 parts of rhizoma atractylodis macrocephalae, 100-180 parts of cortex albiziae, 100-180 parts of the fruit of glossy privet, Radix Polygalae 80- 180 parts, 60-150 parts of rhodiola root.
2. the Chinese medicine composition of soothing liver and strengthening spleen as described in claim 1 is in the drug for preparing treatment anxiety of breast cancer patients depression In application, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:80-160 parts of stir-baked RADIX BUPLEURI with vinegar, Poria cocos 120-180 Part, 220-380 parts of Radix Astragali, 80-160 parts of Radix Angelicae Sinensis, 100-180 parts of Radix Paeoniae Alba, 120-200 parts of rhizoma atractylodis macrocephalae, 120-170 parts of cortex albiziae, 120-170 parts of the fruit of glossy privet, 100-160 parts of Radix Polygalae, 80-120 parts of rhodiola root.
3. the Chinese medicine composition of soothing liver and strengthening spleen as claimed in claim 2 is in the drug for preparing treatment anxiety of breast cancer patients depression In application, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:100 parts of stir-baked RADIX BUPLEURI with vinegar, 150 parts of Poria cocos, Radix Astragali 300 parts, 100 parts of Radix Angelicae Sinensis, 150 parts of Radix Paeoniae Alba, 150 parts of rhizoma atractylodis macrocephalae, 150 parts of cortex albiziae, 150 parts of the fruit of glossy privet, 120 parts of Radix Polygalae, red scape It 100 parts.
4. the Chinese medicine composition of soothing liver and strengthening spleen as claimed in claim 2 is in the drug for preparing treatment anxiety of breast cancer patients depression In application, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:90 parts of stir-baked RADIX BUPLEURI with vinegar, 130 parts of Poria cocos, Radix Astragali 230 parts, 90 parts of Radix Angelicae Sinensis, 110 parts of Radix Paeoniae Alba, 140 parts of rhizoma atractylodis macrocephalae, 130 parts of cortex albiziae, 120 parts of the fruit of glossy privet, 130 parts of Radix Polygalae, rhodiola root 90 parts.
5. the Chinese medicine composition of soothing liver and strengthening spleen as claimed in claim 2 is in the drug for preparing treatment anxiety of breast cancer patients depression In application, it is characterised in that the bulk pharmaceutical chemicals and parts by weight of the Chinese medicine composition are:150 parts of stir-baked RADIX BUPLEURI with vinegar, 150 parts of Poria cocos, Radix Astragali 360 parts, 120 parts of Radix Angelicae Sinensis, 160 parts of Radix Paeoniae Alba, 160 parts of rhizoma atractylodis macrocephalae, 140 parts of cortex albiziae, 160 parts of the fruit of glossy privet, 150 parts of Radix Polygalae, red scape It 110 parts.
6. the Chinese medicine composition of the soothing liver and strengthening spleen as described in claim 1 to 5 is any is preparing treatment anxiety of breast cancer patients suppression Application in strongly fragrant drug, which is characterized in that Chinese medicine composition dosage form is oral preparation.
7. the Chinese medicine composition of soothing liver and strengthening spleen as claimed in claim 6 is in the drug for preparing treatment anxiety of breast cancer patients depression In application, which is characterized in that Chinese medicine composition dosage form be capsule, granule, tablet, pill, powder.
8. the Chinese medicine composition of the soothing liver and strengthening spleen as described in claim 1 to 5 is any is preparing treatment anxiety of breast cancer patients suppression Application in strongly fragrant drug, it is characterised in that the preparation method of the Chinese medicine composition is:Whole flavour of a drug add water to cook, filtration, dense Contracting, it is dry, add right amount of auxiliary materials, mixing, packing to get.
9. the Chinese medicine composition of soothing liver and strengthening spleen as claimed in claim 8 is in the drug for preparing treatment anxiety of breast cancer patients depression In application, it is characterised in that the preparation method of the Chinese medicine composition is:Whole flavour of a drug add water to cook 2 times, first time 60min, 2nd 30min is filtered, and is concentrated, dry, adds right amount of auxiliary materials, mixing, granulation, packing to get.
10. the Chinese medicine composition of the soothing liver and strengthening spleen as described in claim 1 to 5 is any is preparing treatment anxiety of breast cancer patients suppression Application in strongly fragrant drug, it is characterised in that the preparation method of the Chinese medicine composition is:Whole flavour of a drug add water to cook 2 times, and first Secondary 60min, the 2nd 30min, filter, concentrate, spray drying, packing to get.
11. the Chinese medicine composition of the soothing liver and strengthening spleen as described in claim 1 to 5 is any is preparing treatment anxiety of breast cancer patients suppression Application in strongly fragrant drug, it is characterised in that the preparation method of the Chinese medicine composition is:Whole flavour of a drug add water to cook, filtration, dense Contracting, adds ethyl alcohol, alcohol precipitation, supernatant to fling to ethyl alcohol, concentrates, adds right amount of auxiliary materials, dry, mixing, granulation, packing to get.
CN201510764376.4A 2015-11-10 2015-11-10 A kind of application of the Chinese medicine composition of soothing liver and strengthening spleen in the drug for preparing treatment anxiety-depression Active CN105250412B (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101670075A (en) * 2009-10-16 2010-03-17 蚌埠丰原涂山制药有限公司 Traditional Chinese medicine composition for treating depression

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101670075A (en) * 2009-10-16 2010-03-17 蚌埠丰原涂山制药有限公司 Traditional Chinese medicine composition for treating depression

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
中药治疗癌症伴发抑郁50例;郭雅明等;《中国中西医结合学会第七届精神疾病学术讨论会论文汇编》;20021231;191-193 *
自拟乳癌抑郁方结合中医五行音乐治疗乳腺癌术后抑郁状态60例回顾分析;刘松江等;《中国卫生产业》;20111231;第8卷(第6期);100-101 *

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