CN105189729B - 用于组织处理以及由其制备细胞悬液的系统和方法 - Google Patents
用于组织处理以及由其制备细胞悬液的系统和方法 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/06—Means for pre-treatment of biological substances by chemical means or hydrolysis
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Abstract
Description
所需细胞悬液体积(CSV) | 活检面积[BA](cm<sup>2</sup>) | 用于制备悬液的缓冲液 |
1.0 | 1 | 1.5 |
1.5 | 2 | 2.0 |
2.0 | 4 | 2.5 |
2.5 | 4 | 3.0 |
3.0 | 4 | 3.5 |
3.5 | 4 | 4.0 |
4.0 | 4 | 4.5 |
5.0 | 9 | 5.5 |
6.0 | 9 | 6.5 |
7.0 | 9 | 7.5 |
8.0 | 9 | 8.5 |
9.0 | 16 | 9.5 |
10.0 | 16 | 10.5 |
11.0 | 16 | 11.5 |
12.0 | 16 | 12.5 |
13.0 | 16 | 13.5 |
14.0 | 16 | 14.5 |
15.0 | 16 | 15.5 |
16.0 | 16 | 16.5 |
Claims (32)
Priority Applications (1)
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CN201911343417.7A CN111304081A (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
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US201361783422P | 2013-03-14 | 2013-03-14 | |
US61/783,422 | 2013-03-14 | ||
AU2013205148 | 2013-04-13 | ||
AU2013205148A AU2013205148B2 (en) | 2013-03-14 | 2013-04-13 | Systems and methods for tissue processing and preparation of cell suspension therefrom |
PCT/US2014/028944 WO2014153072A1 (en) | 2013-03-14 | 2014-03-14 | Systems and methods for tissue processing and preparation of cell suspension therefrom |
Related Child Applications (1)
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CN201911343417.7A Division CN111304081A (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
Publications (2)
Publication Number | Publication Date |
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CN105189729A CN105189729A (zh) | 2015-12-23 |
CN105189729B true CN105189729B (zh) | 2020-01-10 |
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CN201911343417.7A Pending CN111304081A (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
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CN201911343417.7A Pending CN111304081A (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
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US (2) | US10626358B2 (zh) |
EP (2) | EP2970856B1 (zh) |
JP (1) | JP6479757B2 (zh) |
CN (2) | CN105189729B (zh) |
AU (1) | AU2013205148B2 (zh) |
CA (1) | CA2906088A1 (zh) |
ES (1) | ES2759063T3 (zh) |
HK (1) | HK1219291A1 (zh) |
WO (1) | WO2014153072A1 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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AUPR298901A0 (en) | 2001-02-07 | 2001-03-08 | McComb Foundation, Inc., The | Cell suspension preparation technique and device |
AU2013205148B2 (en) | 2013-03-14 | 2014-10-30 | AVITA Medical Americas, LLC | Systems and methods for tissue processing and preparation of cell suspension therefrom |
JP6817953B2 (ja) | 2014-12-15 | 2021-01-20 | ヒューマン ブレイン ウェイブ エス.アール.エル. | 生体物質の分解装置および対応する製造方法、並びに、細胞懸濁液および組織微小移植片の調製方法 |
GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
DK3430122T3 (da) * | 2016-03-17 | 2021-08-23 | Synova Life Sciences Inc | Separering, adskillelse og/eller opdeling af celler ved hjælp af mekaniske stød |
WO2018102471A1 (en) | 2016-11-29 | 2018-06-07 | S2 Genomics, Inc. | Method and apparatus for processing tissue samples |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
US10996146B2 (en) | 2017-06-01 | 2021-05-04 | Becton, Dickinson And Company | Devices for dissociating a biological tissue sample and methods of use thereof |
SG11202009572WA (en) * | 2018-03-28 | 2020-10-29 | College Of Engineering Pune | An epidermal suspension spray device |
AU2019279085A1 (en) | 2018-06-01 | 2021-01-07 | S2 Genomics, Inc. | Method and apparatus for processing tissue samples |
US11033295B2 (en) * | 2019-05-06 | 2021-06-15 | Tissuemill Technologies Llc | Atraumatically formed tissue composition, devices and methods of preparation and treatment |
AU2020325201A1 (en) * | 2019-08-06 | 2022-03-10 | Bd Kiestra B.V. | Disposable device for venting a sealed container and aliquoting therefrom |
CN110639099B (zh) * | 2019-09-29 | 2024-05-17 | 中国科学院苏州生物医学工程技术研究所 | 细胞悬液雾化装置 |
CN110643495A (zh) * | 2019-10-31 | 2020-01-03 | 北京伟力新世纪科技发展股份有限公司 | 一种细胞悬浮液制备装置 |
BR112022011795A2 (pt) | 2019-12-20 | 2022-08-30 | Instil Bio Uk Ltd | Métodos para preparar e isolar uma população terapêutica de linfócitos e para tratar câncer em um indivíduo, população terapêutica de linfócitos, bolsa criopreservada, recipiente flexível, e, sistema para extração de linfócitos |
US11987787B2 (en) * | 2020-07-22 | 2024-05-21 | AVITA Medical Americas, LLC | Devices, methods, and kits for preparing a cell suspension |
CN116745400A (zh) | 2020-12-01 | 2023-09-12 | 库提斯股份公司 | 用于制备细胞悬浮液的装置和方法 |
US11879121B2 (en) | 2021-04-20 | 2024-01-23 | CisNovo | Tissue disaggregation system and methods |
DE202023002795U1 (de) | 2022-12-27 | 2024-07-15 | AVITA Medical Americas, LLC | System zur automatisierten Herstellung einer regenerativen epidermalen Suspension |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1625398A (zh) * | 2002-02-01 | 2005-06-08 | 欧里恩公司 | 一种联合治疗急性心肌梗死的方法 |
CN1878470A (zh) * | 2003-09-17 | 2006-12-13 | 马克罗珀尔生物外科公司 | 在周围血管疾病和相关病症的治疗中使用再生细胞的方法 |
WO2013019154A1 (en) * | 2011-07-29 | 2013-02-07 | General Electric Company | Systems, methods and control laws for cell harvesting |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1356794A (en) | 1919-12-27 | 1920-10-26 | Smith John Thomas | Skid-oiler |
US3647632A (en) | 1968-04-11 | 1972-03-07 | Little Inc A | Apparatus for cell culture |
US3608553A (en) | 1969-09-04 | 1971-09-28 | Ultrasonic Systems | Ultrasonic method and apparatus for tissue grafting |
JPS497414A (zh) | 1972-05-24 | 1974-01-23 | ||
US4059486A (en) | 1976-11-03 | 1977-11-22 | Monsanto Company | Cell culture process |
US4377010A (en) | 1978-11-08 | 1983-03-22 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Biocompatible material comprising a base polymer bulk graft polymerized with an ethylenically unsaturated carboxylic acid |
FR2461002A1 (fr) | 1979-07-13 | 1981-01-30 | Inst Nat Sante Rech Med | Procede pour stimuler la croissance des cellules d'epiderme humain et produits faisant application dudit procede |
US4254226A (en) | 1979-09-13 | 1981-03-03 | Sloan Kettering Institute For Cancer Research | Process for growing human epidermal cells in tissue culture |
US4304866A (en) | 1979-11-14 | 1981-12-08 | Massachusetts Institute Of Technology | Transplantable sheets of living keratinous tissue |
US4350768A (en) | 1980-09-19 | 1982-09-21 | Bristol Myers Company | Method for preparing single cell suspension |
US4510144A (en) | 1981-08-26 | 1985-04-09 | Newport Pharmaceuticals International | Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives |
US4418691A (en) | 1981-10-26 | 1983-12-06 | Massachusetts Institute Of Technology | Method of promoting the regeneration of tissue at a wound |
US4458678A (en) | 1981-10-26 | 1984-07-10 | Massachusetts Institute Of Technology | Cell-seeding procedures involving fibrous lattices |
US5328695A (en) | 1983-03-22 | 1994-07-12 | Massachusetts Institute Of Technology | Muscle morphogenic protein and use thereof |
US4649115A (en) | 1983-03-31 | 1987-03-10 | Sloan-Kettering Institute | Monoclonal antibodies to skin cells |
US5000963A (en) | 1983-06-14 | 1991-03-19 | Hefton John M | Method of treating the skin using human epidermal sheets |
US4769317A (en) | 1983-06-14 | 1988-09-06 | Hefton John M | Process for growing human epidermis, product thereof |
US5441539A (en) | 1985-06-06 | 1995-08-15 | Thomas Jefferson University | Endothelial cell deposition device |
US5035708A (en) | 1985-06-06 | 1991-07-30 | Thomas Jefferson University | Endothelial cell procurement and deposition kit |
US5460939A (en) | 1986-04-18 | 1995-10-24 | Advanced Tissue Sciences, Inc. | Temporary living skin replacement |
US5079160A (en) | 1987-06-08 | 1992-01-07 | Lacy Paul E | Method to isolate clusters of cell subtypes from organs |
US5015584A (en) | 1987-10-14 | 1991-05-14 | Board Of Regents, The University Of Texas System | Epidermal graft system |
JPH0372872A (ja) | 1988-07-12 | 1991-03-28 | Bio Kagaku Kenkyusho:Kk | 無血清培地及びそれを用いた哺乳類細胞の培養法 |
GB8816516D0 (en) | 1988-07-12 | 1988-08-17 | Welsh Water Authority | Portable incubator and incubating kit |
US5292655A (en) | 1990-01-29 | 1994-03-08 | Wille Jr John J | Method for the formation of a histologically-complete skin substitute |
EP0444270A1 (en) | 1990-02-26 | 1991-09-04 | Thomas Jefferson University | Endothelial cell deposition device |
US5145770A (en) | 1990-06-04 | 1992-09-08 | Biosurface Technology, Inc. | Cryopreservation of cultured epithelial sheets |
CA2106955C (en) | 1991-03-26 | 2003-05-06 | Robert E. Burgeson | Product and method for improving keratinocyte adhesion to the dermis |
US5556783A (en) | 1991-03-27 | 1996-09-17 | Trustees Of Univ. Of Penna | Methods of culturing and modulating the growth of hair follicular stem cells |
DK0615545T3 (da) | 1991-11-20 | 2000-10-30 | Innogenetics Nv | Lysater hidrørende fra keratinocytter til brug som sårhelingsmidler |
AU672006B2 (en) | 1992-04-17 | 1996-09-19 | Abbott Laboratories | Taxol derivatives |
US5955343A (en) | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
CA2158159A1 (en) | 1993-05-05 | 1994-11-10 | David F. Negrotti | Modular laboratory equipment and coupling system |
US5507385A (en) | 1994-08-12 | 1996-04-16 | Rubbermaid Incorporated | Multipurpose storage bin |
US5518612A (en) | 1994-08-30 | 1996-05-21 | Becton, Dickinson And Company | Cell strainer assembly and method of use |
US5650317A (en) | 1994-09-16 | 1997-07-22 | Michigan State University | Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics |
US5851522A (en) | 1995-06-07 | 1998-12-22 | Trustees Of Tufts College | Enhancing keratinocyte migration |
US6238908B1 (en) | 1995-06-07 | 2001-05-29 | Aastrom Biosciences, Inc. | Apparatus and method for maintaining and growth biological cells |
AU730222B2 (en) | 1995-12-21 | 2001-03-01 | Societe Des Produits Nestle S.A. | Improved immortalized human skin cell lines and novel serum-free medium useful for the production thereof |
US6432666B1 (en) | 1996-05-29 | 2002-08-13 | The Corporation Of The Trustees Of The Sisters Of Mercy In Queensland | Dendritic cell receptor |
AU3990197A (en) | 1996-10-04 | 1998-04-09 | Metropolitan Health Service Board | Method of engraftment of cultured cells |
IL120909A0 (en) | 1997-05-26 | 1997-09-30 | Lrr & D Ltd | Compositions and means for the treatment of burns and other cutaneous traumas |
US5786207A (en) | 1997-05-28 | 1998-07-28 | University Of Pittsburgh | Tissue dissociating system and method |
IT1293484B1 (it) | 1997-06-11 | 1999-03-01 | Fidia Advanced Biopolymers Srl | Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile |
WO1999012555A1 (en) | 1997-09-11 | 1999-03-18 | Purdue Research Foundation | Galactosidase modified submucosal tissue |
WO1999021963A1 (en) | 1997-10-25 | 1999-05-06 | Roche Diagnostics Gmbh | Autodegradable microcarriers and their use |
WO1999023199A1 (en) * | 1997-10-31 | 1999-05-14 | Baxter International Inc. | Closed system for processing primary tissue |
US20010048917A1 (en) | 1998-03-09 | 2001-12-06 | Warren Hoeffler | Skin equivalent and methods of forming and using same |
US6080581A (en) | 1998-07-02 | 2000-06-27 | Charles Daniel Anderson | Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same |
US6207451B1 (en) | 1998-09-15 | 2001-03-27 | The Regents Of The University Of Michigan | Mammalian muscle construct and method for producing same |
AU764347B2 (en) | 1998-12-02 | 2003-08-14 | Vivolution A/S | Spray delivery of cells |
JP2002537851A (ja) | 1999-03-09 | 2002-11-12 | アコルディス インダストリアル ファイバース ゲゼルシャフト ミット ベシュレンクテル ハフツング | 作用物質のインビトロテスト法、その装置および使用 |
JP4022069B2 (ja) * | 1999-05-28 | 2007-12-12 | シーフィード | 細胞破壊装置および方法 |
US7081240B1 (en) | 2000-06-28 | 2006-07-25 | Zimmer Orthobiologics, Inc. | Protein mixtures for wound healing |
US6673603B2 (en) | 2000-09-01 | 2004-01-06 | Modex Therapeutiques, S.A. | Cell paste comprising keratinocytes and fibroblasts |
US6660853B2 (en) | 2000-12-15 | 2003-12-09 | Al Prescott | Method for purifying high molecular weight hyaluronic acid |
AUPR298901A0 (en) | 2001-02-07 | 2001-03-08 | McComb Foundation, Inc., The | Cell suspension preparation technique and device |
JP5214085B2 (ja) | 2001-02-07 | 2013-06-19 | アヴィータ・メディカル・リミテッド | 細胞懸濁液の作製方法及び細胞懸濁液 |
WO2002066598A1 (de) | 2001-02-20 | 2002-08-29 | Max-Delbrück-Centrum für Molekulare Medizin | System zur automatischen isolierung von lebenden zellen aus tierischen geweben |
US7585670B2 (en) * | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
AU2752P (en) | 2002-03-01 | 2005-06-02 | Vletter & Den Haan Beheer B V | WINDSOR Lilium hybrid |
ITPD20020064A1 (it) | 2002-03-12 | 2003-09-12 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
US9144583B2 (en) * | 2002-03-29 | 2015-09-29 | Tissue Genesis, Inc. | Cell separation apparatus and methods of use |
US20050026275A1 (en) * | 2003-06-23 | 2005-02-03 | Andrej Bahoric | Device, system and method for receiving, processing and dispersing cells |
JP2005043617A (ja) * | 2003-07-28 | 2005-02-17 | Konica Minolta Business Technologies Inc | 画像形成装置 |
EP2298863B1 (en) | 2004-03-22 | 2015-07-22 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
WO2005121323A2 (en) | 2004-06-07 | 2005-12-22 | Massachusetts Institute Of Technology | Methods for ex vivo propagation of somatic hair follicle stem cells |
EP2980206A1 (en) * | 2004-07-01 | 2016-02-03 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
WO2006014156A1 (en) | 2004-07-02 | 2006-02-09 | Macropore Biosurgery, Inc. | Systems and methods for isolating and using clinically safe adipose derived regenerative cells |
US8568761B2 (en) | 2005-07-15 | 2013-10-29 | Cormatrix Cardiovascular, Inc. | Compositions for regenerating defective or absent myocardium |
US8216528B2 (en) * | 2005-09-29 | 2012-07-10 | Sysmex Corporation | Sample preparation kit, sample preparation container, and sample processing device |
GB0520757D0 (en) * | 2005-10-12 | 2005-11-23 | Vuppalapati Gunasekar | Delivery device |
JP5269612B2 (ja) | 2006-02-07 | 2013-08-21 | スパイナルサイト, エルエルシー | インビボバイオリアクターを使用する軟骨の修復のための方法および組成物 |
US9259445B2 (en) | 2006-06-07 | 2016-02-16 | Universidad Tecnica Federico Santa Maria | Integrated implant system (IIS) biocompatible, biodegradable and bioactive, comprising a biocompatible sterile porous polymeric matrix and a gel, integrating in situ the tridimensional matrix structure |
US20070286880A1 (en) | 2006-06-08 | 2007-12-13 | Andrey Vasiliev | Inoculated spongiform scaffold for transplantation and tissue regeneration |
US8022037B2 (en) | 2007-01-08 | 2011-09-20 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
US8309342B2 (en) | 2007-12-04 | 2012-11-13 | Ingeneron, Inc. | Apparatus and methods for cell isolation |
EP2291512B1 (en) | 2008-05-07 | 2015-10-07 | UCL Business PLC | Biomimetic cell scaffolds |
CN102203580A (zh) * | 2008-09-17 | 2011-09-28 | 高压生物科学公司 | 通过柔和受控压缩转动用于机械分裂的粉碎机 |
CN101423820B (zh) * | 2008-11-28 | 2012-02-01 | 浙江大学 | 基于骨髓间充质干细胞的骨组织分阶段灌流培养方法 |
WO2010072417A2 (en) * | 2008-12-24 | 2010-07-01 | Augustinus Bader | Rapid preparation and use of engineered tissue and scaffolds as individual implants |
US9057064B1 (en) * | 2009-02-25 | 2015-06-16 | Ag-Defense Systems, Inc. | Method and apparatus for extracting DNA from a biological sample |
CN102458302B (zh) | 2009-05-01 | 2015-11-25 | 比米尼技术有限责任公司 | 用于优化组织和细胞富集的移植物的系统、方法和组合物 |
US8207118B2 (en) | 2009-07-17 | 2012-06-26 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
US8921103B2 (en) | 2009-08-28 | 2014-12-30 | Board Of Regents, The University Of Texas System | Laminar construct for tissue-engineered dermal equivalent |
FR2950074B1 (fr) | 2009-09-16 | 2017-10-06 | Oreal | Equivalent de peau in vitro et procede de preparation |
CN102781463A (zh) | 2009-10-07 | 2012-11-14 | 戈诺珍公司 | 用于皮肤再生的方法和组合物 |
CN101914495A (zh) | 2010-07-22 | 2010-12-15 | 吉林大学 | 用于体外大量扩增毛囊干细胞的培养方法 |
US8162247B2 (en) * | 2010-08-17 | 2012-04-24 | Biomedical Polymers, Inc. | Grinding system |
US9150826B2 (en) * | 2011-03-14 | 2015-10-06 | Zymo Research Corporation | Portable sample disruptor apparatus, kits, and methods |
ES2746023T3 (es) | 2011-03-22 | 2020-03-04 | Cartiregen B V | Un sistema de procesamiento de células de cartílago |
EP2714887A1 (en) * | 2011-08-29 | 2014-04-09 | Stempeutics Research Private Limited | A system for isolating stromal vascular fraction (svf) cells from the adipose tissue and a method thereof |
JP6159729B2 (ja) * | 2011-11-08 | 2017-07-05 | オークソセル ラボラトリーズ, インコーポレイテッド | 細胞を処理するためのシステムおよび方法 |
WO2013142254A1 (en) | 2012-03-22 | 2013-09-26 | Avita Medical Ltd. | Cell suspension and use thereof |
FR2991690B1 (fr) | 2012-06-07 | 2020-02-28 | Laboratoires Genevrier | Utilisation d'une chaufferette pour favoriser une reaction biologique |
AU2013205148B2 (en) | 2013-03-14 | 2014-10-30 | AVITA Medical Americas, LLC | Systems and methods for tissue processing and preparation of cell suspension therefrom |
US10436680B2 (en) * | 2013-10-15 | 2019-10-08 | Kianoosh Peyvan | Capture, disruption, and extraction apparatus and method |
-
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- 2013-04-13 AU AU2013205148A patent/AU2013205148B2/en active Active
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- 2014-03-14 EP EP14770177.5A patent/EP2970856B1/en active Active
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1625398A (zh) * | 2002-02-01 | 2005-06-08 | 欧里恩公司 | 一种联合治疗急性心肌梗死的方法 |
CN1878470A (zh) * | 2003-09-17 | 2006-12-13 | 马克罗珀尔生物外科公司 | 在周围血管疾病和相关病症的治疗中使用再生细胞的方法 |
WO2013019154A1 (en) * | 2011-07-29 | 2013-02-07 | General Electric Company | Systems, methods and control laws for cell harvesting |
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CN111304081A (zh) | 2020-06-19 |
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WO2014153072A1 (en) | 2014-09-25 |
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JP6479757B2 (ja) | 2019-03-06 |
HK1219291A1 (zh) | 2017-03-31 |
AU2013205148B2 (en) | 2014-10-30 |
ES2759063T3 (es) | 2020-05-07 |
CA2906088A1 (en) | 2014-09-25 |
US20200208086A1 (en) | 2020-07-02 |
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