CN111304081A - 用于组织处理以及由其制备细胞悬液的系统和方法 - Google Patents
用于组织处理以及由其制备细胞悬液的系统和方法 Download PDFInfo
- Publication number
- CN111304081A CN111304081A CN201911343417.7A CN201911343417A CN111304081A CN 111304081 A CN111304081 A CN 111304081A CN 201911343417 A CN201911343417 A CN 201911343417A CN 111304081 A CN111304081 A CN 111304081A
- Authority
- CN
- China
- Prior art keywords
- tissue
- console
- processing chamber
- chamber
- applicator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006285 cell suspension Substances 0.000 title claims abstract description 88
- 238000012545 processing Methods 0.000 title claims description 101
- 238000000034 method Methods 0.000 title abstract description 56
- 238000002360 preparation method Methods 0.000 title description 2
- 210000001519 tissue Anatomy 0.000 claims abstract description 202
- 210000004027 cell Anatomy 0.000 claims description 102
- 108090000790 Enzymes Proteins 0.000 claims description 74
- 102000004190 Enzymes Human genes 0.000 claims description 74
- 239000012530 fluid Substances 0.000 claims description 58
- 239000000243 solution Substances 0.000 claims description 50
- 230000007246 mechanism Effects 0.000 claims description 42
- 239000007853 buffer solution Substances 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 238000004891 communication Methods 0.000 claims description 17
- 239000013043 chemical agent Substances 0.000 claims description 16
- 239000008223 sterile water Substances 0.000 claims description 16
- 239000000843 powder Substances 0.000 claims description 14
- 238000002054 transplantation Methods 0.000 claims description 14
- 238000003306 harvesting Methods 0.000 claims description 10
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims description 8
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims description 8
- 210000002744 extracellular matrix Anatomy 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 7
- 208000027418 Wounds and injury Diseases 0.000 abstract description 25
- 206010052428 Wound Diseases 0.000 abstract description 24
- 210000000981 epithelium Anatomy 0.000 abstract description 13
- 230000017423 tissue regeneration Effects 0.000 abstract description 10
- 208000014674 injury Diseases 0.000 abstract description 7
- 210000000056 organ Anatomy 0.000 abstract description 6
- 230000006378 damage Effects 0.000 abstract description 5
- 230000008733 trauma Effects 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 4
- 230000008439 repair process Effects 0.000 abstract description 3
- 238000002560 therapeutic procedure Methods 0.000 abstract description 3
- 230000015271 coagulation Effects 0.000 abstract description 2
- 238000005345 coagulation Methods 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 description 70
- 238000011282 treatment Methods 0.000 description 62
- 239000000872 buffer Substances 0.000 description 33
- 210000003491 skin Anatomy 0.000 description 33
- 230000008569 process Effects 0.000 description 29
- 239000000725 suspension Substances 0.000 description 24
- 239000002699 waste material Substances 0.000 description 17
- 230000033001 locomotion Effects 0.000 description 16
- 238000013461 design Methods 0.000 description 13
- 238000005086 pumping Methods 0.000 description 12
- 230000002572 peristaltic effect Effects 0.000 description 11
- 239000007787 solid Substances 0.000 description 11
- 238000001914 filtration Methods 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 7
- 210000002950 fibroblast Anatomy 0.000 description 7
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 238000012544 monitoring process Methods 0.000 description 7
- 239000007921 spray Substances 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- 239000000758 substrate Substances 0.000 description 7
- 238000011049 filling Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 230000029663 wound healing Effects 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 210000002615 epidermis Anatomy 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 4
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 4
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 4
- 230000033115 angiogenesis Effects 0.000 description 4
- 239000012620 biological material Substances 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 229920002674 hyaluronan Polymers 0.000 description 4
- 229960003160 hyaluronic acid Drugs 0.000 description 4
- 210000004623 platelet-rich plasma Anatomy 0.000 description 4
- 210000004927 skin cell Anatomy 0.000 description 4
- 210000000130 stem cell Anatomy 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000002792 vascular Effects 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 3
- 206010072170 Skin wound Diseases 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 102000004142 Trypsin Human genes 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 210000003128 head Anatomy 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 210000002510 keratinocyte Anatomy 0.000 description 3
- 238000003754 machining Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 231100000241 scar Toxicity 0.000 description 3
- 229940005581 sodium lactate Drugs 0.000 description 3
- 235000011088 sodium lactate Nutrition 0.000 description 3
- 239000001540 sodium lactate Substances 0.000 description 3
- 238000012384 transportation and delivery Methods 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 206010056340 Diabetic ulcer Diseases 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010047642 Vitiligo Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 210000003560 epithelium corneal Anatomy 0.000 description 2
- 230000000762 glandular Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 239000002831 pharmacologic agent Substances 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 238000011272 standard treatment Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 208000005230 Leg Ulcer Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010050502 Neuropathic ulcer Diseases 0.000 description 1
- 208000007256 Nevus Diseases 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 108010059712 Pronase Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 108090001109 Thermolysin Proteins 0.000 description 1
- 208000020312 Thickened skin Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 230000000758 acidotic effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002491 angiogenic effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 108010007093 dispase Proteins 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000001744 histochemical effect Effects 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 210000001821 langerhans cell Anatomy 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000008263 repair mechanism Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012502 risk assessment Methods 0.000 description 1
- 238000012954 risk control Methods 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000007655 standard test method Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000008364 tissue synthesis Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 238000013024 troubleshooting Methods 0.000 description 1
- -1 trypsin-EDTA Proteins 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000010388 wound contraction Effects 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/02—Means for pre-treatment of biological substances by mechanical forces; Stirring; Trituration; Comminuting
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M45/00—Means for pre-treatment of biological substances
- C12M45/06—Means for pre-treatment of biological substances by chemical means or hydrolysis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361783422P | 2013-03-14 | 2013-03-14 | |
US61/783,422 | 2013-03-14 | ||
AU2013205148A AU2013205148B2 (en) | 2013-03-14 | 2013-04-13 | Systems and methods for tissue processing and preparation of cell suspension therefrom |
AU2013205148 | 2013-04-13 | ||
CN201480025699.5A CN105189729B (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480025699.5A Division CN105189729B (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111304081A true CN111304081A (zh) | 2020-06-19 |
Family
ID=51628587
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201911343417.7A Pending CN111304081A (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
CN201480025699.5A Active CN105189729B (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201480025699.5A Active CN105189729B (zh) | 2013-03-14 | 2014-03-14 | 用于组织处理以及由其制备细胞悬液的系统和方法 |
Country Status (9)
Country | Link |
---|---|
US (2) | US10626358B2 (zh) |
EP (2) | EP2970856B1 (zh) |
JP (1) | JP6479757B2 (zh) |
CN (2) | CN111304081A (zh) |
AU (1) | AU2013205148B2 (zh) |
CA (1) | CA2906088A1 (zh) |
ES (1) | ES2759063T3 (zh) |
HK (1) | HK1219291A1 (zh) |
WO (1) | WO2014153072A1 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPR298901A0 (en) | 2001-02-07 | 2001-03-08 | McComb Foundation, Inc., The | Cell suspension preparation technique and device |
AU2013205148B2 (en) | 2013-03-14 | 2014-10-30 | AVITA Medical Americas, LLC | Systems and methods for tissue processing and preparation of cell suspension therefrom |
AU2015365508B2 (en) | 2014-12-15 | 2021-04-01 | Human Brain Wave S.R.L. | Disgregating device of biological material and corresponding manufacturing method and method for the preparation of cell suspensions and tissue micrografts |
GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
KR102625925B1 (ko) * | 2016-03-17 | 2024-01-16 | 시노바 라이프 사이언시즈 인코포레이티드 | 충격파 또는 기계적 충격을 사용한 세포의 분리, 해리 및/또는 탈응집 |
US11231347B2 (en) * | 2016-11-29 | 2022-01-25 | S2 Genomics, Inc. | Method and apparatus for processing tissue samples |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
CN110799826B (zh) | 2017-06-01 | 2023-02-28 | 贝克顿·迪金森公司 | 用于解离生物组织样品的装置以及其使用方法 |
WO2019186588A1 (en) * | 2018-03-28 | 2019-10-03 | College Of Engineering, Pune | An epidermal suspension spray device |
JP2021525550A (ja) | 2018-06-01 | 2021-09-27 | エス2 ゲノミクス インコーポレイテッド | 組織サンプルを処理するための方法および装置 |
US11033295B2 (en) * | 2019-05-06 | 2021-06-15 | Tissuemill Technologies Llc | Atraumatically formed tissue composition, devices and methods of preparation and treatment |
CN114364783A (zh) * | 2019-08-06 | 2022-04-15 | Bd科斯特公司 | 用于给密封容器通风并且从其中取样的一次性装置 |
CN110639099B (zh) * | 2019-09-29 | 2024-05-17 | 中国科学院苏州生物医学工程技术研究所 | 细胞悬液雾化装置 |
CN110643495A (zh) * | 2019-10-31 | 2020-01-03 | 北京伟力新世纪科技发展股份有限公司 | 一种细胞悬浮液制备装置 |
MX2022007598A (es) | 2019-12-20 | 2022-09-23 | Instil Bio Uk Ltd | Dispositivos y métodos para el aislamiento de linfocitos infiltrantes de tumores y usos de los mismos. |
US11987787B2 (en) * | 2020-07-22 | 2024-05-21 | AVITA Medical Americas, LLC | Devices, methods, and kits for preparing a cell suspension |
CN116745400A (zh) | 2020-12-01 | 2023-09-12 | 库提斯股份公司 | 用于制备细胞悬浮液的装置和方法 |
US11879121B2 (en) | 2021-04-20 | 2024-01-23 | CisNovo | Tissue disaggregation system and methods |
US20240209296A1 (en) * | 2022-12-27 | 2024-06-27 | AVITA Medical Americas, LLC | Tissue healing |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999023199A1 (en) * | 1997-10-31 | 1999-05-14 | Baxter International Inc. | Closed system for processing primary tissue |
WO2002062358A1 (en) * | 2001-02-07 | 2002-08-15 | Mccomb Foundation Inc. | Cell suspension preparation technique and device |
GB0520757D0 (en) * | 2005-10-12 | 2005-11-23 | Vuppalapati Gunasekar | Delivery device |
WO2006014159A2 (en) * | 2004-07-01 | 2006-02-09 | Macropore Biosurgery Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
US20080014181A1 (en) * | 2002-03-29 | 2008-01-17 | Ariff Gregory D | Cell separation apparatus and methods of use |
CN101423820A (zh) * | 2008-11-28 | 2009-05-06 | 浙江大学 | 基于骨髓间充质干细胞的骨组织分阶段灌流培养方法 |
CN102387824A (zh) * | 2008-12-24 | 2012-03-21 | 奥古斯蒂努斯·巴德 | 快速制备和使用工程化组织和支架作为个体的植入物 |
Family Cites Families (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1356794A (en) | 1919-12-27 | 1920-10-26 | Smith John Thomas | Skid-oiler |
US3647632A (en) | 1968-04-11 | 1972-03-07 | Little Inc A | Apparatus for cell culture |
US3608553A (en) | 1969-09-04 | 1971-09-28 | Ultrasonic Systems | Ultrasonic method and apparatus for tissue grafting |
JPS497414A (zh) | 1972-05-24 | 1974-01-23 | ||
US4059486A (en) | 1976-11-03 | 1977-11-22 | Monsanto Company | Cell culture process |
US4377010A (en) | 1978-11-08 | 1983-03-22 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Biocompatible material comprising a base polymer bulk graft polymerized with an ethylenically unsaturated carboxylic acid |
FR2461002A1 (fr) | 1979-07-13 | 1981-01-30 | Inst Nat Sante Rech Med | Procede pour stimuler la croissance des cellules d'epiderme humain et produits faisant application dudit procede |
US4254226A (en) | 1979-09-13 | 1981-03-03 | Sloan Kettering Institute For Cancer Research | Process for growing human epidermal cells in tissue culture |
US4304866A (en) | 1979-11-14 | 1981-12-08 | Massachusetts Institute Of Technology | Transplantable sheets of living keratinous tissue |
US4350768A (en) | 1980-09-19 | 1982-09-21 | Bristol Myers Company | Method for preparing single cell suspension |
US4510144A (en) | 1981-08-26 | 1985-04-09 | Newport Pharmaceuticals International | Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives |
US4458678A (en) | 1981-10-26 | 1984-07-10 | Massachusetts Institute Of Technology | Cell-seeding procedures involving fibrous lattices |
US4418691A (en) | 1981-10-26 | 1983-12-06 | Massachusetts Institute Of Technology | Method of promoting the regeneration of tissue at a wound |
US5328695A (en) | 1983-03-22 | 1994-07-12 | Massachusetts Institute Of Technology | Muscle morphogenic protein and use thereof |
US4649115A (en) | 1983-03-31 | 1987-03-10 | Sloan-Kettering Institute | Monoclonal antibodies to skin cells |
US4769317A (en) | 1983-06-14 | 1988-09-06 | Hefton John M | Process for growing human epidermis, product thereof |
US5000963A (en) | 1983-06-14 | 1991-03-19 | Hefton John M | Method of treating the skin using human epidermal sheets |
US5035708A (en) | 1985-06-06 | 1991-07-30 | Thomas Jefferson University | Endothelial cell procurement and deposition kit |
US5441539A (en) | 1985-06-06 | 1995-08-15 | Thomas Jefferson University | Endothelial cell deposition device |
US5460939A (en) | 1986-04-18 | 1995-10-24 | Advanced Tissue Sciences, Inc. | Temporary living skin replacement |
US5079160A (en) | 1987-06-08 | 1992-01-07 | Lacy Paul E | Method to isolate clusters of cell subtypes from organs |
US5015584A (en) | 1987-10-14 | 1991-05-14 | Board Of Regents, The University Of Texas System | Epidermal graft system |
JPH0372872A (ja) | 1988-07-12 | 1991-03-28 | Bio Kagaku Kenkyusho:Kk | 無血清培地及びそれを用いた哺乳類細胞の培養法 |
GB8816516D0 (en) | 1988-07-12 | 1988-08-17 | Welsh Water Authority | Portable incubator and incubating kit |
US5292655A (en) | 1990-01-29 | 1994-03-08 | Wille Jr John J | Method for the formation of a histologically-complete skin substitute |
EP0444270A1 (en) | 1990-02-26 | 1991-09-04 | Thomas Jefferson University | Endothelial cell deposition device |
US5145770A (en) | 1990-06-04 | 1992-09-08 | Biosurface Technology, Inc. | Cryopreservation of cultured epithelial sheets |
EP0579742A4 (en) | 1991-03-26 | 1994-07-13 | Oregon State | Product and method for improving keratinocyte adhesion to the dermis |
US5556783A (en) | 1991-03-27 | 1996-09-17 | Trustees Of Univ. Of Penna | Methods of culturing and modulating the growth of hair follicular stem cells |
EP0615545B1 (en) | 1991-11-20 | 2000-05-17 | N.V. Innogenetics S.A. | Lysates derived from keratinocytes for use as wound healing substances |
DK0639186T3 (da) | 1992-04-17 | 1999-12-13 | Abbott Lab | Taxolderivater |
US5955343A (en) | 1992-12-28 | 1999-09-21 | Massachusetts Institute Of Technology | Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor |
CA2158159A1 (en) | 1993-05-05 | 1994-11-10 | David F. Negrotti | Modular laboratory equipment and coupling system |
US5507385A (en) | 1994-08-12 | 1996-04-16 | Rubbermaid Incorporated | Multipurpose storage bin |
US5518612A (en) | 1994-08-30 | 1996-05-21 | Becton, Dickinson And Company | Cell strainer assembly and method of use |
US5650317A (en) | 1994-09-16 | 1997-07-22 | Michigan State University | Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics |
US5851522A (en) | 1995-06-07 | 1998-12-22 | Trustees Of Tufts College | Enhancing keratinocyte migration |
US6238908B1 (en) | 1995-06-07 | 2001-05-29 | Aastrom Biosciences, Inc. | Apparatus and method for maintaining and growth biological cells |
WO1997023602A1 (en) | 1995-12-21 | 1997-07-03 | Societe Des Produits Nestle S.A. | Improved immortalized human skin cell lines and novel serum-free medium useful for the production thereof |
JP2000512490A (ja) | 1996-05-29 | 2000-09-26 | デレク ナイジェル ジョン ハート | 樹状細胞のレセプター |
AU3990197A (en) | 1996-10-04 | 1998-04-09 | Metropolitan Health Service Board | Method of engraftment of cultured cells |
IL120909A0 (en) | 1997-05-26 | 1997-09-30 | Lrr & D Ltd | Compositions and means for the treatment of burns and other cutaneous traumas |
US5786207A (en) | 1997-05-28 | 1998-07-28 | University Of Pittsburgh | Tissue dissociating system and method |
IT1293484B1 (it) | 1997-06-11 | 1999-03-01 | Fidia Advanced Biopolymers Srl | Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile |
WO1999012555A1 (en) | 1997-09-11 | 1999-03-18 | Purdue Research Foundation | Galactosidase modified submucosal tissue |
WO1999021963A1 (en) | 1997-10-25 | 1999-05-06 | Roche Diagnostics Gmbh | Autodegradable microcarriers and their use |
US20010048917A1 (en) | 1998-03-09 | 2001-12-06 | Warren Hoeffler | Skin equivalent and methods of forming and using same |
US6080581A (en) | 1998-07-02 | 2000-06-27 | Charles Daniel Anderson | Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using same |
US6207451B1 (en) | 1998-09-15 | 2001-03-27 | The Regents Of The University Of Michigan | Mammalian muscle construct and method for producing same |
DK1143983T3 (da) | 1998-12-02 | 2006-04-10 | Bristol Myers Squibb Co | Sprayafgivelse af celler |
JP2002537851A (ja) | 1999-03-09 | 2002-11-12 | アコルディス インダストリアル ファイバース ゲゼルシャフト ミット ベシュレンクテル ハフツング | 作用物質のインビトロテスト法、その装置および使用 |
JP4078073B2 (ja) * | 1999-05-28 | 2008-04-23 | シーフィード | 流体試料分析装置および方法 |
US7081240B1 (en) | 2000-06-28 | 2006-07-25 | Zimmer Orthobiologics, Inc. | Protein mixtures for wound healing |
US6673603B2 (en) | 2000-09-01 | 2004-01-06 | Modex Therapeutiques, S.A. | Cell paste comprising keratinocytes and fibroblasts |
US6660853B2 (en) | 2000-12-15 | 2003-12-09 | Al Prescott | Method for purifying high molecular weight hyaluronic acid |
AUPR298901A0 (en) | 2001-02-07 | 2001-03-08 | McComb Foundation, Inc., The | Cell suspension preparation technique and device |
WO2002066598A1 (de) | 2001-02-20 | 2002-08-29 | Max-Delbrück-Centrum für Molekulare Medizin | System zur automatischen isolierung von lebenden zellen aus tierischen geweben |
US7585670B2 (en) * | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
FI20020197A0 (fi) * | 2002-02-01 | 2002-02-01 | Orion Corp | Yhdistelmä akuutin myokardiilisen infarktin hoitoon |
AU2752P (en) | 2002-03-01 | 2005-06-02 | Vletter & Den Haan Beheer B V | WINDSOR Lilium hybrid |
ITPD20020064A1 (it) | 2002-03-12 | 2003-09-12 | Fidia Advanced Biopolymers Srl | Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem |
US20050026275A1 (en) * | 2003-06-23 | 2005-02-03 | Andrej Bahoric | Device, system and method for receiving, processing and dispersing cells |
JP2005043617A (ja) * | 2003-07-28 | 2005-02-17 | Konica Minolta Business Technologies Inc | 画像形成装置 |
CA2539346A1 (en) | 2003-09-17 | 2005-04-21 | Macropore Biosurgery, Inc. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
EP3461884A1 (en) | 2004-03-22 | 2019-04-03 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
WO2005121323A2 (en) | 2004-06-07 | 2005-12-22 | Massachusetts Institute Of Technology | Methods for ex vivo propagation of somatic hair follicle stem cells |
WO2006014156A1 (en) | 2004-07-02 | 2006-02-09 | Macropore Biosurgery, Inc. | Systems and methods for isolating and using clinically safe adipose derived regenerative cells |
US8568761B2 (en) | 2005-07-15 | 2013-10-29 | Cormatrix Cardiovascular, Inc. | Compositions for regenerating defective or absent myocardium |
US8216528B2 (en) * | 2005-09-29 | 2012-07-10 | Sysmex Corporation | Sample preparation kit, sample preparation container, and sample processing device |
US7850983B2 (en) | 2006-02-07 | 2010-12-14 | Spinalcyte, Llc | Methods and compositions for repair of cartilage using an in vivo bioreactor |
US9259445B2 (en) | 2006-06-07 | 2016-02-16 | Universidad Tecnica Federico Santa Maria | Integrated implant system (IIS) biocompatible, biodegradable and bioactive, comprising a biocompatible sterile porous polymeric matrix and a gel, integrating in situ the tridimensional matrix structure |
US20070286880A1 (en) | 2006-06-08 | 2007-12-13 | Andrey Vasiliev | Inoculated spongiform scaffold for transplantation and tissue regeneration |
US8022037B2 (en) | 2007-01-08 | 2011-09-20 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
US8309342B2 (en) * | 2007-12-04 | 2012-11-13 | Ingeneron, Inc. | Apparatus and methods for cell isolation |
US8580564B2 (en) | 2008-05-07 | 2013-11-12 | Ucl Business Plc | Biomimetic cell scaffolds |
EP2329246A2 (en) * | 2008-09-17 | 2011-06-08 | Pressure Biosciences, Inc. | Shredder for mechanical disruption by gentle controlled compressive rotation |
US9057064B1 (en) * | 2009-02-25 | 2015-06-16 | Ag-Defense Systems, Inc. | Method and apparatus for extracting DNA from a biological sample |
AU2010242780B2 (en) * | 2009-05-01 | 2016-04-21 | Puregraft Llc | Systems, methods and compositions for optimizing tissue and cell enriched grafts |
US8207118B2 (en) | 2009-07-17 | 2012-06-26 | University Of Southern California | Skin wound healing compositions and methods of use thereof |
US8921103B2 (en) | 2009-08-28 | 2014-12-30 | Board Of Regents, The University Of Texas System | Laminar construct for tissue-engineered dermal equivalent |
FR2950074B1 (fr) | 2009-09-16 | 2017-10-06 | Oreal | Equivalent de peau in vitro et procede de preparation |
AU2010303414B2 (en) | 2009-10-07 | 2016-01-07 | Genogen, Inc. | Methods and compositions for skin regeneration |
CN101914495A (zh) | 2010-07-22 | 2010-12-15 | 吉林大学 | 用于体外大量扩增毛囊干细胞的培养方法 |
US8162247B2 (en) * | 2010-08-17 | 2012-04-24 | Biomedical Polymers, Inc. | Grinding system |
US9150826B2 (en) * | 2011-03-14 | 2015-10-06 | Zymo Research Corporation | Portable sample disruptor apparatus, kits, and methods |
ES2963341T3 (es) | 2011-03-22 | 2024-03-26 | Cartiregen B V | Un sistema de procesamiento de células de cartílago |
US10934519B2 (en) * | 2011-07-29 | 2021-03-02 | Global Life Sciences Solutions Usa Llc | Systems, methods and control laws for cell harvesting |
AU2012303719B2 (en) * | 2011-08-29 | 2016-05-26 | Stempeutics Research Private Limited | A system for isolating stromal vascular fraction (SVF) cells from the adipose tissue and a method thereof |
ES2725564T3 (es) * | 2011-11-08 | 2019-09-24 | Auxocell Laboratories Inc | Sistemas y métodos de procesamiento celular |
EP3896152A1 (en) | 2012-03-22 | 2021-10-20 | Avita Medical Ltd | Cell suspension and use thereof |
FR2991690B1 (fr) | 2012-06-07 | 2020-02-28 | Laboratoires Genevrier | Utilisation d'une chaufferette pour favoriser une reaction biologique |
AU2013205148B2 (en) | 2013-03-14 | 2014-10-30 | AVITA Medical Americas, LLC | Systems and methods for tissue processing and preparation of cell suspension therefrom |
US10436680B2 (en) * | 2013-10-15 | 2019-10-08 | Kianoosh Peyvan | Capture, disruption, and extraction apparatus and method |
-
2013
- 2013-04-13 AU AU2013205148A patent/AU2013205148B2/en active Active
-
2014
- 2014-03-14 ES ES14770177T patent/ES2759063T3/es active Active
- 2014-03-14 CA CA2906088A patent/CA2906088A1/en active Pending
- 2014-03-14 EP EP14770177.5A patent/EP2970856B1/en active Active
- 2014-03-14 CN CN201911343417.7A patent/CN111304081A/zh active Pending
- 2014-03-14 JP JP2016502942A patent/JP6479757B2/ja active Active
- 2014-03-14 US US14/776,038 patent/US10626358B2/en active Active
- 2014-03-14 CN CN201480025699.5A patent/CN105189729B/zh active Active
- 2014-03-14 EP EP19208169.3A patent/EP3674396A1/en active Pending
- 2014-03-14 WO PCT/US2014/028944 patent/WO2014153072A1/en active Application Filing
-
2016
- 2016-06-23 HK HK16107310.0A patent/HK1219291A1/zh unknown
-
2020
- 2020-02-11 US US16/787,882 patent/US11124752B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999023199A1 (en) * | 1997-10-31 | 1999-05-14 | Baxter International Inc. | Closed system for processing primary tissue |
WO2002062358A1 (en) * | 2001-02-07 | 2002-08-15 | Mccomb Foundation Inc. | Cell suspension preparation technique and device |
US20080014181A1 (en) * | 2002-03-29 | 2008-01-17 | Ariff Gregory D | Cell separation apparatus and methods of use |
WO2006014159A2 (en) * | 2004-07-01 | 2006-02-09 | Macropore Biosurgery Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
GB0520757D0 (en) * | 2005-10-12 | 2005-11-23 | Vuppalapati Gunasekar | Delivery device |
CN101423820A (zh) * | 2008-11-28 | 2009-05-06 | 浙江大学 | 基于骨髓间充质干细胞的骨组织分阶段灌流培养方法 |
CN102387824A (zh) * | 2008-12-24 | 2012-03-21 | 奥古斯蒂努斯·巴德 | 快速制备和使用工程化组织和支架作为个体的植入物 |
Non-Patent Citations (2)
Title |
---|
无锡轻工大学 北京:中国轻工业出版社: "食品分析", 30 June 2008, pages: 128 - 129 * |
禹邦超: "《应用酶学导论》", 31 December 1994, 华中师范大学出版社, pages: 296 - 299 * |
Also Published As
Publication number | Publication date |
---|---|
US20160024450A1 (en) | 2016-01-28 |
US11124752B2 (en) | 2021-09-21 |
EP2970856B1 (en) | 2019-11-13 |
EP2970856A4 (en) | 2016-10-26 |
JP6479757B2 (ja) | 2019-03-06 |
EP2970856A1 (en) | 2016-01-20 |
HK1219291A1 (zh) | 2017-03-31 |
WO2014153072A1 (en) | 2014-09-25 |
US10626358B2 (en) | 2020-04-21 |
AU2013205148B2 (en) | 2014-10-30 |
US20200208086A1 (en) | 2020-07-02 |
CA2906088A1 (en) | 2014-09-25 |
JP2016512689A (ja) | 2016-05-09 |
CN105189729A (zh) | 2015-12-23 |
AU2013205148A1 (en) | 2014-10-02 |
CN105189729B (zh) | 2020-01-10 |
ES2759063T3 (es) | 2020-05-07 |
EP3674396A1 (en) | 2020-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105189729B (zh) | 用于组织处理以及由其制备细胞悬液的系统和方法 | |
CA2939115A1 (en) | A system for tissue manipulation | |
US20210121901A1 (en) | Modular device for cell spraying | |
US5786207A (en) | Tissue dissociating system and method | |
EP2604680A1 (en) | Automatic culture device | |
CN114144207A (zh) | 无创伤地形成的组织组合物、装置、制备方法和治疗方法 | |
JP2020506682A (ja) | 組織凍結保存および回復のためのデバイス | |
CN108079363A (zh) | 一种用于动物组织脱细胞处理的试剂盒及其应用 | |
CN211066646U (zh) | 一种多功能干细胞组织采集装置 | |
CN211096304U (zh) | 一种新型的内科护理消毒箱 | |
CN112961820A (zh) | 一种皮肤组织采集、提取并制备细胞悬液的方法和装置 | |
CN211535828U (zh) | 器官支架制备装置 | |
CN110553984A (zh) | 一种自动化肝脏检验设备 | |
CN111658827A (zh) | 器官支架制备装置和器官支架制备方法 | |
WO2023209039A2 (en) | Tissue structure isolation using a micro-cutting device and uses of resulting micro-cubes of tissue | |
CN118593143A (zh) | 一种心内科手术辅助架 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40032292 Country of ref document: HK |
|
CB02 | Change of applicant information |
Country or region after: Australia Address after: California, USA Applicant after: AVITA MEDICAL LTD. Address before: Cambridge County, England Applicant before: AVITA MEDICAL LTD. Country or region before: United Kingdom Country or region after: Australia Address after: California, USA Applicant after: Evita Medical Holdings Ltd. Address before: California, USA Applicant before: AVITA MEDICAL LTD. Country or region before: Australia |
|
CB02 | Change of applicant information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20240327 Address after: California, USA Applicant after: Evita Medical USA LLC Country or region after: U.S.A. Address before: California, USA Applicant before: Evita Medical Holdings Ltd. Country or region before: Australia |
|
TA01 | Transfer of patent application right |