CN105169019A - Pharmaceutical composition for curing pustulosis, scabies, tinea favosa or old sodden leg - Google Patents
Pharmaceutical composition for curing pustulosis, scabies, tinea favosa or old sodden leg Download PDFInfo
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- CN105169019A CN105169019A CN201510556097.9A CN201510556097A CN105169019A CN 105169019 A CN105169019 A CN 105169019A CN 201510556097 A CN201510556097 A CN 201510556097A CN 105169019 A CN105169019 A CN 105169019A
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Abstract
The invention discloses a pharmaceutical composition for curing pustulosis, scabies, tinea favosa or old sodden leg. The composition comprises liquorice, angelica sinensis, musk, salvia miltiorrhiza, leonurus, herba patriniae, pulsatilla chinensis, edible tulip, herba andrographitis, sangusis draconis, lithospermum, underleaf pearls, lophatherum gracile, sargentgloryvine stems, cnidium monnieri, resin of sweetgum, azedarach and raspberry. The composition provided by the invention is added with conventional auxiliary materials according to the conventional process and is prepared to be an ointment. The pharmaceutical composition provided by the invention has the efficacies of clearing heat, detoxifying, sterilizing and relieve itching, can promote cell recovery and growth, has a remarkable effect of curing pustulosis, scabies, tinea favosa or old sodden leg, and has no toxic or side effects.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of impetigo, scabies, tinea alba or sticky sore leg.
Background technology
Impetigo refers to impetigo, pemphigus, is a kind of sending out in skin, infectious suppurative dermatosis.Impetigo often forms because of contaminations such as pediculosis, scabies, eczema, insect bite dermatitis, and pustule wall is thicker, caves in into nest, form thick crust after broken.
Scabies parasitizes by human-like acaricide the chronic infection dermatoses caused in human body skin top layer, and primary disease infectiousness is strong, infects mainly through close contact, also can through medicated clothing indirect infection, can be popular in family or grouped population.Sarcoptic mite parasitizes in skin, excavates in " tunnel " and produces mechanical stimulus, and secretions and Excreta cause allergic reaction, and cause the infected's skin acutely scratchy, night more so (because of sarcoptic mite night energy stronger).Primary disease is multiple is born in winter, and the course of disease is different in size, the delayed several months had.
Tinea alba is again tinea capitis, and life, on head, from the beginning of white crust, is scratched where it itches unbearably, and spread in flakes, then dried and withered hairs comes off for a long time, forms bald spot, but rear hair is often renewable.How to be infected by unclean hair dressing tools or comb, cap etc. and to be caused.Be similar to tinea alba.
Sticky sore leg is always rotten lower limb again, is stood by prolonged or carried on a shoulder pole thing heavy burden, so that lower limb channels loses smooth, local QI and blood stasis, and multiple because of damp invasion of lower energizer, coagulation of QI-blood, rotten skin and flesh forms.Skin of lower extremity is injured, insect bite and eczema etc., often for bringing out the general knowledge cause of disease of sticky sore leg.Be characterized in ulcer prolonged be difficult to close up, though or through close up, easily recur because of damage.
Also do not have medicine can treat impetigo, scabies, tinea alba or sticky sore leg at present simultaneously, some medicines be also only can treat wherein one or both, and be much oral medicine, oral drugs side effect is large, can affect the function of the internal organs such as digestive tract, gastrointestinal tract and Liver and kidney.The deficiencies such as treatment by Chinese herbs effect is undesirable, and treatment time is long.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of impetigo, scabies, tinea alba or sticky sore leg.
The present invention is achieved through the following technical solutions:
The crude drug of the present composition consists of:
The crude drug composition of the present composition is preferably:
The crude drug composition of the present composition is more preferably:
The crude drug composition of the present composition is more preferably:
The crude drug composition of the present composition is more preferably:
The present composition conveniently technique adds the ointment that customary adjuvant makes clinical acceptance.
Pharmaceutical composition of the present invention has heat clearing away, removing toxic substances, sterilization, antipruritic effect, can promote the recovery of cell, growth, to treatment impetigo, scabies, tinea alba or sticky sore leg Be very effective, has no side effect.
Experimental example is used for further illustrating the present invention below, but is not limited to the present invention.
Experimental example one: clinical trial
1, clinical observation
Capsule of the present invention (according to the preparation of embodiment 1 method) is to treatment impetigo, scabies, tinea alba and sticky sore leg patient 400 example, wherein male 200 example, and women 200 is routine.
2, medicament selection
Treatment group anthology invention ointment (according to the preparation of embodiment 1 method), wipes for twice on the one in trouble sheet.
3, diagnostic criteria
3.1 impetigo diagnostic criterias
Routine blood test display total white blood cells and neutrophilic granulocyte, percentage of lymphocyte all can increase.General originator, erythrocyte sedimentation rate raises.By streptococcus causer, anti-" O " can obviously raise.
Chickenpox impetigo is mainly in winter-spring season, and common with trunk, Head And Face, oral mucosa is also often got involved, and skin lesion is mainly the shinny vesicle differed in size, around obvious blush, and vesicle central authorities are in omphalos shape.Do not merge, centration distributes, and the various different skin lesion and visible erythema, herpes, knot are crazy about etc., can have obvious General Symptoms.
The morbidity of pustular eczema had nothing to do with season, age, and also without certain predilection site, skin lesion is pleomorphism, has pustule phenomenon, oozed out obviously.Obscure boundary, the chronic course of disease, conscious play is itched, easy recurrent exerbation.
The diagnostic criteria of 3.2 scabies
1) have scabies contact history, scabies is a kind of infectious disease, has scabies patient around.
2) night pruritus clearly
3) there is the large small red dot of needle point, pimple in the thin tender place of skin, and finger seam, shirtfront, back, femoribus internus can occur, and adult does not generally occur in facial area, and child also can occur on the face.
4) there is scabies tuberosity: occur at men and women's genital area the hard pimple that Semen Glycines is large or Semen phaseoli radiati is large.
3.3 tinea alba
1) the many overhead portions of skin lesion, rounded white squama speckle is as large in coin or bean, and boundary is clear.In focus, hair is matt, fractures, do not stay cicatrix after being ill apart from scalp 2 ~ 5 millimeters of places.Conscious pruritus.
2) be apt to occur in school age population, man is more than female, and the unit of collective that is everlasting is popular.Have with same patient or with sick cat, dog close contact history.
3) Fungus examination: see bright green fluorescence under filtering Burdick lamp, fungal culture has the pathogenic bacterium such as Microsporon, trichophyta genus.
3.4 sticky sore leg
0 grade: skin is without open focus; Show as acra blood supply insufficiency, color cyanosis or pale, acra send out cool, numb, insensitive or lose.Acra twinge or causalgia, often with the deformity etc. of toes or foot.
One-level: acra skin has open focus; Always rotten lower limb patient has vesicle, blood blister, clavus or callus, cold injury or scald and the shallow table ulcer caused by other skin injurys, but focus not yet involves deep tissue.
Secondary: infection focus invades deep muscle tissue; Always rotten lower limb often has slight cellulitis, multiple pus stove and tunnel, or infects and expand along spatium intermusculare, and cause vola, instep connectivity ulcer or gangrene, purulent secretion is more, foot or refer to skin of toe stove dry gangrene, but tendon ligament there is no destruction.
Three grades: tendon ligament tissue destroys; Cellulitis merges and forms large vomica, and purulent secretion and slough increase, always rotten lower limb patient foot or minority toes dry gangrene, but bone destruction is still not obvious.
Level Four: always rotten lower limb is severe infections; Cause bone destruction, osteomyelitis, osteoarthrosis destroys or has formed pseudarthrosis, and the moist or serious gangrene or downright bad of dryness occurs for part toes or part brothers.
Pyatyi: all infect; The large portion of foot or all infect or ischemia, causes serious moist or dry gangrene, acra blackening, ordinary wave and ankle joint and shank.
4, criterion of therapeutical effect
" in cure the desease Standardization of diagnosis and curative effect " of implementing with reference to State Administration of Traditional Chinese Medicine 1994 drafts as follows:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear;
Effective: tcm clinical practice symptom, sign obviously change;
Effective: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all not improved;
5, therapeutic outcome
| Group | Case | Cure in one week | Cure in two weeks | Cure in three weeks |
| Treatment impetigo group | 100 examples | 56 examples | 42 examples | 2 examples |
| Treatment scabies group | 100 examples | 49 examples | 48 examples | 3 examples |
| Treatment tinea alba group | 100 examples | 51 examples | 47 examples | 2 examples |
| Treatment sticky sore leg group | 100 examples | 48 examples | 47 examples | 5 examples |
6, conclusion
Show according to above-mentioned therapeutic outcome, it is 100% that the present invention treats impetigo clinical cure rate, and wherein in two weeks, cure rate is that in 98%, one week, cure rate is 56%; The clinical cure rate that the present invention treats scabies is 100%, and wherein in two weeks, cure rate 97%, one week interior cure rate is 49%; The clinical cure rate that the present invention treats tinea alba is 100%, and wherein in two weeks, cure rate is that in 98%, one week, cure rate is 51%; It is 100% that the present invention controls the clinical cure rate treating Yan skin ulcer lower limb, and wherein in two weeks, cure rate is that in 95%, one week, cure rate is 48%.
Experimental example two: model case
Case 1: Lee so-and-so, man 8 years old, in July, 2011 here go to a doctor.The raw skin ulcer in head many places, type is as large in soybean grain, and flowing yellow fluid after bursting, is impetigo after diagnosing, use ointment of the present invention (according to the preparation of embodiment 1 method), every day is applied to affected part twice, and after three days, symptom obviously alleviates, the incrustation of part affected part, continued after four days, recovery from illness.Check after 1 year, do not recur.
Case 2: king so-and-so, man 23 years old, at factory work, bimester before do not know what is because of whole skin pruritus, patient facial region and the little pimple of the multiple redness of chest, band pus head; Back and waist have large stretch of erythema, and that touches is in the way; The multiple tuberosity of buttocks, has desquamation; Penis and scrotum has lesser tubercle, is scabies after diagnosing, and use ointment of the present invention (according to the preparation of embodiment 2 method), every day is applied to affected part twice, and after 5 days, symptom obviously alleviates, and continues use after 5 days, recovery from illness, 1 year afterwards check do not recur.
Case 3: Zhang, female, 10 years old, bimester front scalp on visible well-defined circular canescence speckle, be covered with thicker canescence squama above, hair becomes canescence, tarnishes.Affected part uneven the breaking of visible height is sent out, and residual disconnected sending out is drawn out easily very much, and affected part scalp has pruritus in various degree.After diagnosing for being tinea capitis, have another name called tinea alba, use ointment of the present invention (according to the preparation of embodiment 3 method), every day is applied to affected part twice, and after one week, symptom alleviates, and white speckle and squama obviously reduce, continue use after one week, recovery from illness, white speckle and canescence squama completely without, hair is glossy.Check after 1 year, do not recur.
Case 4: Zhao so-and-so, man, 63 years old, in patient's left leg, hypomere skin festered hemorrhage repeatedly, cause out-of-bed activity difficulty, had a strong impact on quality of life, patient also suffers from varicose veins of the lower extremity and has the more than ten years, and in the shank of left side, festering appears in hypomere repeatedly closely during the last ten years, hemorrhage, prolonged being difficult to fully recovers, and toss about in bed Liao Duojia hospital and all do not obtain definite therapeutic scheme, the state of an illness is further serious.This year is when celebrating the New Year or the Spring Festival, the skin of leg ulceration again of Mr. Chen, bleed more than, by being passed on after local hospital emergency treatment, I treats at institute, uses ointment of the present invention (according to the preparation of embodiment 4 method), every day twice, after one week, symptom obviously alleviates, rotten position is formed a scab gradually, continues use recovery from illness after two weeks, can orthobiosis.Check after 1 year, do not recur.
Following embodiment all can realize the effect of above-mentioned experimental example.
Detailed description of the invention
embodiment 1
Said medicine conveniently technique adds customary adjuvant and makes ointment, and often prop up 15g, every day is applied to affected part twice.
embodiment 2
Said medicine conveniently technique adds customary adjuvant and makes ointment, and often prop up 10g, every day is applied to affected part twice.
embodiment 3
Said medicine conveniently technique adds customary adjuvant and makes ointment, and often prop up 20g, every day is applied to affected part twice.
embodiment 4
Said medicine conveniently technique adds customary adjuvant and makes ointment, and often prop up 15g, every day is applied to affected part twice.
embodiment 5
Said medicine conveniently technique adds customary adjuvant and makes ointment, and often prop up 15g, every day is applied to affected part twice.
Claims (9)
1. treat a pharmaceutical composition for impetigo, scabies, tinea alba or sticky sore leg, it is characterized in that, the crude drug of said composition consists of:
2. compositions as claimed in claim 1, is characterized in that the crude drug of said composition consists of:
3. compositions as claimed in claim 1 or 2, is characterized in that the crude drug of said composition consists of:
4. compositions as claimed in claim 1, is characterized in that the crude drug of said composition consists of:
5. compositions as claimed in claim 1, is characterized in that the crude drug of said composition consists of:
6. the compositions as described in claim 1,2,4 or 5, it is characterized in that said composition conveniently technique add the ointment that customary adjuvant makes clinical acceptance.
7. compositions as claimed in claim 3, it is characterized in that said composition conveniently technique add the ointment that customary adjuvant makes clinical acceptance.
8. the application of the compositions as described in claim 1,2,4 or 5 in the medicine of preparation treatment impetigo, scabies, tinea alba or sticky sore leg.
9. the application of compositions as claimed in claim 3 in the medicine of preparation treatment impetigo, scabies, tinea alba or sticky sore leg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510556097.9A CN105169019A (en) | 2015-09-02 | 2015-09-02 | Pharmaceutical composition for curing pustulosis, scabies, tinea favosa or old sodden leg |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510556097.9A CN105169019A (en) | 2015-09-02 | 2015-09-02 | Pharmaceutical composition for curing pustulosis, scabies, tinea favosa or old sodden leg |
Publications (1)
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| CN105169019A true CN105169019A (en) | 2015-12-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510556097.9A Pending CN105169019A (en) | 2015-09-02 | 2015-09-02 | Pharmaceutical composition for curing pustulosis, scabies, tinea favosa or old sodden leg |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262943A (en) * | 1999-02-09 | 2000-08-16 | 夏进 | Skin ointment with functions of relieving inflammation, alleviating pain and inhibiting cicatrization |
| CN103349677A (en) * | 2013-07-14 | 2013-10-16 | 孙喜范 | Tinea manuum treatment unguent and preparation method |
-
2015
- 2015-09-02 CN CN201510556097.9A patent/CN105169019A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1262943A (en) * | 1999-02-09 | 2000-08-16 | 夏进 | Skin ointment with functions of relieving inflammation, alleviating pain and inhibiting cicatrization |
| CN103349677A (en) * | 2013-07-14 | 2013-10-16 | 孙喜范 | Tinea manuum treatment unguent and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 刘再朋: "皮肤常见疾病治法简介（续）", 《江苏中医》 * |
| 李祥农: "黄水疮验方6则", 《中国中医药报》 * |
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Application publication date: 20151223 |