CN104435730B - A kind of external application Chinese medicine ointment for treating burn and scald skin ulcer - Google Patents

A kind of external application Chinese medicine ointment for treating burn and scald skin ulcer Download PDF

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CN104435730B
CN104435730B CN201410664672.2A CN201410664672A CN104435730B CN 104435730 B CN104435730 B CN 104435730B CN 201410664672 A CN201410664672 A CN 201410664672A CN 104435730 B CN104435730 B CN 104435730B
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radix
skin ulcer
chinese medicine
skin
wound
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向小明
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Abstract

The present invention is a kind of external application Chinese medicine ointment for treating burn and scald skin ulcer, formed by the Radix Astragali, Radix Angelicae Sinensis, golden cypress, radix scutellariae, rheum officinale, Radix zanthoxyli, Paris polyphylla, cape jasmine, the bletilla striata, radix boehmeriae, elephant hide, Selaginella tamariscina, borneol, beeswax, rapeseed oil, stearic acid, glycerine, glycerin monostearate, hexadecanol, potassium hydroxide, ethylparaben, distilled water configuration, present invention also offers a kind of above-mentioned preparation method for being used to treat the new ointment of skin ulcer.It is of the invention that there is clearing heat and detoxicating, removing necrosis, promoting granulation, eliminating stasis to subdue swelling, saprophytic removing, promoting blood circulation convergence, moisturizing analgesic, the reduction surface of a wound to ooze out, rapid wound repairing, mitigate scar growth and other effects, formula is reasonable, and making is simple, moderate, evident in efficacy, using convenient.

Description

A kind of external application Chinese medicine ointment for treating burn and scald skin ulcer
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of external application Chinese medicine ointment for treating burn and scald skin ulcer.
Background technology
Burn sore is called ulcer section by motherland's medical science, external injury and the evil infective agent of poison be cause to create ulcer it is main because Element, such as：The chemical substance such as flame, boiling water, steam, molten steel and acid, alkali, phosphorus, phenol, electrical equipment, Qiang Guang, firearm, bullet, blast etc. Skin injury can all be caused.Insect and animal biting, frostbite, dermatitis rhus, various animals and plants toxin, radioactive ray, medicine and a variety of causes cause Skin hypersensitivity damage fall within this category.Neodoxy according to professor Xu Rongxiang to burn theory, can learn this Section summarizes and is divided into following a few classes：1. fire damage class, including burn and scald, chemical burn, electric burn, electric injury；2. wound class, such as skin The damage of skin ulceration, knife wound；3. sick class of bursting, include infection and the disease of bursting of burn and scald and wound and wound surface, infected caused by skin disease And ulcer, and trauma surface infestation and ulcer as caused by inside and outside, woman, youngster, each section's disease of five official ranks.
The burns unit treatment technology that motherland's medical science is carried out is in addition to the auspicious U.S. precious moistening burn exposure methods of Xu Rong, most of masters If allowing burn wound to keep drying, prevent bacterial invasion from infecting, its deep burn wound electricity consumption baking, make local necrosis tissue Scab and skin grafting treatment are cut in implementation after drying incrustation.Western medicine is also at the outer of stagnation to burn, wound and ulcer treatment The Scientific Treatment stage.Therefore, in order that burn patient loses some benefits from modern medicine cuts scab, the pain brought of the operation such as skin-grafting And the medical expenses of great number, invention are a kind of with swelling and pain relieving is fast, short treating period, wound healing are fast, dressing no pain, either shallow are not stayed Scar, depth such as are not made skin graft at the Chinese medicine preparation of magical curative effect, significant.
The content of the invention
The problem of purpose of the present invention exists aiming at above-mentioned treatment, there is provided a kind of clearing heat and detoxicating, removing necrosis, promoting granulation, dissipate the stasis of blood Detumescence, saprophytic removing, promoting blood circulation convergence, moisturizing analgesic, the reduction surface of a wound ooze out, and rapid wound repairing, mitigate scar growth and other effects External application Chinese medicine ointment, be adapted to the treatment of various burn, wound, skin ulcer, the medicine make it is simple, it is moderate, treat Effect is notable, using convenient.
This ointment is that inventor uses TCM surgery sore theoretical foundation, with reference to the successive dynasties it is handed down from the older generations of the family and it is modern burn medical technologies essence Marrow, unique treatment through being devoted for years to draw in the academic thought of Ulcerated Burn Wounds Treated treatment and the accumulation of clinical research for many years Method.Rheum officinale, radix scutellariae, Paris polyphylla, cape jasmine, golden cypress, Radix zanthoxyli, Selaginella tamariscina have clearing heat and detoxicating in side, detumescence promoting blood circulation, the work(of analgesic and scar eliminating Effect.According to modern pharmacological research and clinical observation for many years in person, find above medicine to local challenge septicopyemia sense of burning Stronger anti Bacillus pyocyaneu Flugge, staphylococcus aureus, pyococcus, a variety of Gram-negatives are infected with, positive bacteria has obvious suppression System is killed and stronger removing toxic substances is anti-infective and prevents to mitigate the preventive and therapeutic effects such as scar growth；The Radix Astragali in side, Radix Angelicae Sinensis, the bletilla striata, elephant hide, There is benefiting qi and nourishing blood, moisturizing to dispel the effect that the ulcer such as rotten, expelling pus and promoting granulation analgesic do not close up long altogether for borneol, beeswax, rapeseed oil；This hair Bright is a kind of ointment, and it can protect skin wound, regulation transepidermal water to dry, so as to match somebody with somebody in the ointment with traditional Chinese herb medicine 5, surface of a wound dressing can be made, carry medicine non-greasy, skin is not glued in dressing, not viscous clothing, dressing without pain, and few bleeding is excellent without remaining medicine scab etc. Point.
The present invention is made up by weight ratio of following traditional Chinese medicines：Radix Astragali 450-550g, Radix Angelicae Sinensis 400-600g, golden cypress 400- 600g, radix scutellariae 450-550g, rheum officinale 450-550g, Radix zanthoxyli 350-550g, Paris polyphylla 400-600g, cape jasmine 480-600g, the bletilla striata 450-600g, radix boehmeriae 450-550g, elephant hide 100-300g, Selaginella tamariscina 400-600g, borneol 25-30g, beeswax 250-400g, dish Seed oil 2000-3000g, stearic acid 450-550g, glycerine 450-550g, glycerin monostearate 50-100g, hexadecanol 100- 200g, potassium hydroxide 45-55g, ethylparaben 20-30g, distilled water 3700-3800g.
Optimal weight proportion：Radix Astragali 500g, Radix Angelicae Sinensis 500g, golden cypress 500g, radix scutellariae 500g, rheum officinale 500g, Radix zanthoxyli 500g, Paris polyphylla 500g, cape jasmine 500g, bletilla striata 500g, radix boehmeriae 500g, elephant hide 200g, Selaginella tamariscina 500g, borneol 20g, beeswax 350g, vegetable seed Oily 2500g, stearic acid 500g, glycerine 500g, glycerin monostearate 75g, hexadecanol 150g, potassium hydroxide 50g, nipalgin second Ester 25g, distilled water 3750g.
Embodiment is as follows：
(1) each parts by weight are weighed：Radix Astragali 500g, Radix Angelicae Sinensis 500g, golden cypress 500g, radix scutellariae 500g, rheum officinale 500g, Radix zanthoxyli 500g, Paris polyphylla 500g, cape jasmine 500g, bletilla striata 500g, radix boehmeriae 500g, elephant hide 200g, Selaginella tamariscina 500g, borneol 20g, beeswax 350g, rapeseed oil 2500g, stearic acid 500g, glycerine 500g, glycerin monostearate 75g, hexadecanol 150g, potassium hydroxide 50g, ethylparaben 25g, distilled water 3750g.
(2) above-mentioned stearic acid, glycerine, glycerin monostearate, hexadecanol are taken in beaker, heating water bath makes thing to 90 DEG C Material fusing, it is uniformly dissolved as oil phase, then potassium hydroxide, ethylparaben is added in distilled water water and dissolved as aqueous phase, Aqueous phase is slowly added into oil phase under 90 DEG C of stirrings, high-speed stirred carries out emulsion reaction 20min, and being cooled to room temperature, to obtain emulsifying agent standby With.
(3) take the above-mentioned Radix Astragali, Radix Angelicae Sinensis, golden cypress, radix scutellariae, rheum officinale, Radix zanthoxyli, Paris polyphylla, cape jasmine, the bletilla striata, radix boehmeriae, elephant hide, Selaginella tamariscina is soaked with clear water, rapeseed oil is entered after decoction, then tortured with slow fire and float filtering of removing slag to the dried-up Huang of medicine.
(4) concentrated medicament of filtering and borneol, yellow wax and emulsifying agent obtained above are dissolved to foam and moved back only from fire, Semi-solid mixed type ointment is formed after condensation, basin bottling is standby.
More than all medicines be prepared into ointment, have clearing heat and detoxicating, removing necrosis, promoting granulation, eliminating stasis to subdue swelling, saprophytic removing, promoting blood circulation convergence, Moisturizing analgesic, the reduction surface of a wound ooze out, and rapid wound repairing, mitigate scar growth and other effects.
The present invention has advantages below：
(1) present invention is pure Chinese medicinal preparation, and each component meets the regulation of Pharmacopoeia of People's Republic of China, secondary to human body poison to make It is comparatively safe reliable with small.
(2) present invention can be drained the toxin of burn slough corruption separation and alluvial, can make the cell of new life Tissue fast-growth simultaneously accelerates wound healing, shortens treatment time.
(3) present invention can be acted on by medicine is improved surface of a wound blood fortune and circulation, makes to ooze out reduction, and can effectively press down System, killing bacterium make inflammation prompt resolution.
(4) present invention is adapted to the treatment of various burn, wound, skin ulcer, makes simply, and moderate, curative effect shows Write, the features such as using facilitating.
Below by way of clinical observation experiment, beneficial effects of the present invention are expanded on further
1st, patient profiles
The chronic ulcer of skin patient of our hospital's outpatient clinic, MethodsThe cases enrolled 140, male 74, women 66 are injured former Cause：Wound 28, burn 35, furuncle, abscess ulceration 26, diabetic gangrene 33, varix of lower limb 8, hemangioma note Ulcer 10 caused by penetrating therapy.
2nd, patient selection's standard
1. meeting 140 chronic ulcer of skin patients of MethodsThe cases enrolled condition, the course of disease is more than 3 weeks.2. patient temperature is just Often, blood picture is in normal range (NR), stable disease, and same disease whole body therapeutic medication is identical.3. agree to through sufferers themselves and energy is hard Hold and continue dressing change in the court's dressing room.
3rd, treatment method
140 patients are randomly divided into treatment group and each 70 of control group, the age of two groups of patients, injured reason, ulcer journey Degree, area and time, there was no significant difference, has comparativity.Treatment group patient is first cleaned with 0.9% sodium chloride solution or Iodophor The surface of a wound is sterilized, vesicle treats its absorbed themselves, and big bubble row low level after bubble oozes out the phase cuts off tapping and retains bubble skin.Depth Fire victim should remove Beancurd sheet and slough as early as possible in the tissue rotten de- liquefaction phase.It is not required to anaesthetize during debridement, follows strictly Noninvasive cleaning principle, the faster cream of sore of the present invention is then applied to the surface of a wound using the wrapping such as exposure or gauze application with spatula Therapy, daily dressing once, until wound healing.The faster cream of the sore for being applied to ulcer wound surface is only changed to moistening burn by control group Cream, remaining is identical with treatment group.
4th, curative effect judging standard
Treatment group and control group do Statistical Comparison evaluation after dressing change 30d.Total effective rate is healing added with efficiency.
Cure：Symptom, sign all disappear, and functional activity recovers normal, wound healing.
Effectively：Symptom, sign are clearly better, and the surface of a wound is obviously reduced, and yellowish pink turns red, and pus tails off.
It is invalid：Skin surface symptom is without improvement, or has exacerbation to be inclined to.
5th, treatment results
In 70 skin ulcer patients for the treatment of group, healing 59, cure rate 84.28%, effective 7, total effective rate 94.29%, invalid 4, inefficiency 5.71%.In 70 skin ulcer patients of control group group, 36 are cured, cure rate 51.43%, effective 16, total effective rate 72.29%, invalid 18, inefficiency 25.71%.
Above clinical practice proves that the ointment in burn wound treatment, can intuitively understand surface of a wound clinical healing process, energy Effectively by Medicated Permeation hypodermis；Dirt between the surface of a wound and tissue, bacteriotoxin and slough can effectively be purified Separation comes off；Local circulation is can effectively improve, the stagnant impaired local organization necrosis progrediens of the stasis of blood is prevented, infection control, makes burn bad Dead tissue is not attacked to the normal structure under the surface of a wound；And the Regeneration and Repair of surface of a wound damaged tissues can be effectively facilitated.In deep wounds In the rotten de- liquefaction exclusion of slough and growth course, because the ointment effect is unique, in the rotten flesh level flesh bud to the greatest extent of wound tissue again When raw, granulation surface can form one layer of white or faint yellow gluey diaphragm, and this tunic is to prove burn wound skin physiology again Raw and tissue growth reparation feature.Separation slough can be removed rapidly to deep two degree, 3-degree wound.Such as deep two degree of surface of a wound 4 ~5 days downright bad layers start shedding off liquefaction, liquefaction is in peak, surface of a wound basal part skin island tissue is high within 15 days or so Rise, the granulation tissue of 20 days or so projections is changed into calming down, and the epithelial tissue of visible white centered on hair bladder to four Perithelium island spreading via tissue space is closed and reaches healing.As 3-degree wound can be shown in that the surface of a wound has liquefied substance for 3~7 days, slough typically exists De- sanies terminates within 2-3 weeks.Substrate 15 days or so is in gradually " granulation " to rat, and part granulation spreads in epithelial edge While, be dispersed in skin point on the surface of a wound and gradually spread, mutually fusion and close and form wound healing.
Below by way of skin irritation test, excitant of the present invention to skin is further looked at
1st, experimental animal
Take 8 healthy white rabbits, female half and half, by back both sides symmetrical region unhairing 150cm2Sub-cage rearing, observation 24h.Two big groups are randomly divided into, first group of intact skin group, second group of damaged skin group (is sterilized each rabbit off hair-fields with scalpel Skin draws homalographic # words, using oozing of blood as degree, as damaged skin group).
2nd, test method
Using androgynous left and right sides own control, the left dorsal of every group of rabbit applies the faster cream 1ml of sore of the present invention, the right side back of the body MEBO 1ml is applied, is administered once daily, continuous 7d, observation and record before removing 1h after medicine every time and sticking again Situations such as erythema and oedema.After last sticks, 1h, 24h, 48h and 72h are visually observed and are recorded coating part after medicine is removed Situations such as whetheing there is erythema and oedema.
3rd, result of the test
The faster cream group of sore and the continuous 7d of MEBO control group of the present invention gives the complete and damaged skin of rabbit, Do not find obvious erythema and oedema reaction, Continuous Observation 10d, each rabbit skin health, vacuum response generation, show this hair The faster cream of bright sore has no stimulation to the complete and damaged skin of rabbit.
The toxicity profile of the present invention is further looked at below by way of skin sensibiligen experiment
1st, experimental animal
Take 12 healthy white rabbits, female half and half, by back both sides symmetrical region unhairing 150cm2 sub-cage rearings, observation 24h.2nd, test method
With reference to study of tcm new drug guide (pharmacy, pharmacology, the toxicity of the issue of bureau of drug administration of Ministry of Health of the People's Republic of China Learn) above-mentioned rabbit is randomly divided into three groups, first group of intact skin group, give sore faster 4 times of concentration of cream clinical equivalent；Second Each rabbit off hair-fields sterilization skin (is drawn homalographic # words, using oozing of blood as degree, as damaged skin by group damaged skin group with scalpel Group), give sore faster 4 times of concentration of cream clinical equivalent；3rd group of control group, gives MEBO.Dosage is 2ml/ times, It is administered intermittently in 24h 3 times altogether, by reagent is uniformly applied to left side hair removal section, after by reagent 24h, washes away residue, and in 1, 24th, 48,72h to d7, change and breathing, the central nervous system of each rabbit body weight, skin and hair, eye and mucous membrane are observed and recorded daily The situation of the systems such as system, quadruped locomotion.
3rd, result of the test
1h, 24h, 48h is administered, the skin of each group animal is observed after 72h to 7d, hair, mucous membrane, is breathed, circulation, nerve System, four limbs activity etc. is showed no anomalous variation, and no animal poisoning is dead, and damaged skin group also has no obvious inflammatory reaction and change Purulence shows.Before table 1 below observation administration and after administration 7d, each group rabbit changes of weight no significant difference.
The influence of acute toxicity test body weight of the faster cream of the sore of table 1 to family's rabbit skin
Result of the test shows that the faster cream high dose group of sore and MEBO control group are to intact skin and damaged skin Rabbit respectively observes 7d, does not occur any acute toxic reaction (P ＞ 0.05).
Sensitiveness of the present invention to skin is further looked at below by way of skin anaphylactic test.
1st, experimental animal
Extracting waste cavy 40, by its symmetrical unhairing in back both sides, area 3cm*3cm, sub-cage rearing, 1d is observed, is pressed Male and female half and half are randomly divided into 4 groups, and A groups are burnt to the faster cream low dosage of sore, B groups to the faster cream high dose of sore, C groups to moistening Cream control, D groups give positive control medicine DNF.Each group carries out sensitization contact in both sides hair removal section and excited respectively Contact administration.
2nd, test method
With reference to study of tcm new drug guide (pharmacy, pharmacology, the toxicity of the issue of bureau of drug administration of Ministry of Health of the People's Republic of China Learn).
Sensitization contact：It will be burnt by different groups by the faster cream of test product low dosage sore, the faster cream of high dose sore, moistening Hinder cream control group, 0.1%2,4- dinitrofluorobenzene 0.2ml/ times, 1 times/day is applied to hair removal section on the left of guinea pig back, 7d and the 14d is respectively repeated 1 times in the same way.
Excite contact：Give 14d after by test product sensitization in last, with the faster cream of low dosage sore, the faster cream of high dose sore, MEBO, 0.1%2,4- dinitrofluorobenzene 0.2ml/ times, it is applied to respectively on the right side of corresponding tested group of cavy and goes to hair-fields, contact Residue is washed away after 6h, is observed at once, then observing skin again in 24h, 48h, 72h, to whether there is redness, oedema etc. allergic anti- Answer situation and systemic conditions.
3rd, result of the test
Sensitization test (STT) (sensitization contact) of the faster cream of the sore of table 2 to guinea pig skin
Sensitization test (STT) (excite contact) of the faster cream of the sore of table 3 to guinea pig skin
With reference to study of tcm new drug guide (pharmacy, pharmacology, the toxicity of the issue of bureau of drug administration of Ministry of Health of the People's Republic of China Learn) in " standards of grading of cutaneous anaphylaxis degree " and " hypersensitive evaluation criterion ", scoring system is carried out to original record Meter, the results are shown in Table 2 and table 3.Result of the test shows, compared with control group and positive controls, sore faster cream (high dose group, Low dose group) it is used for guinea pig skin, no allergic reaction outside.(P ＞ 0.05)
In summary, the ointment is advantageous to epithelialization and wound healing, can promote large area in burn wound treatment The corruption of deep burn slough comes off and toxin excretion, and can effectively kill bacterium, and corruption goes flesh to give birth to, and the flat skin length of skin, blood follows increasing By force, the impaired cell of effective nutrition, improve the hypoxic-ischemic and malnutrition of local organization, mitigate scar growth, make poison, it is rotten, The stasis of blood, empty pathology are effectively improved, and local gasification is recovered normal, are made damaged tissues newborn and are healed rapidly, and can reduce Burn patient loses some benefits, cuts painful and great number the financial burden that the operations such as scab, skin-grafting are brought.Trampled through clinic and zoopery table It is bright：The ointment is fast with sterilization swelling and pain relieving, and short treating period, wound healing is fast, and either shallow does not stay scar, and depth is not made skin graft, and dressing is painless Hardship, the surface of a wound and dressing such as do not adhere at the magical curative effect, and without skin irritation, the reaction of non-toxic and skin hypersensitivity, clinic Application.

Claims (2)

  1. A kind of 1. external application Chinese medicine ointment for treating burn and scald skin ulcer, it is characterised in that：The treatment burn and scald skin ulcer External application Chinese medicine ointment be made up of the raw material of following weight proportion, Radix Astragali 450-550g, Radix Angelicae Sinensis 400-600g, golden cypress 400- 600g, radix scutellariae 450-550g, rheum officinale 450-550g, Radix zanthoxyli 350-550g, Paris polyphylla 400-600g, cape jasmine 480-600g, the bletilla striata 450-600g, radix boehmeriae 450-550g, elephant hide 100-300g, Selaginella tamariscina 400-600g, borneol 25-30g, beeswax 250-400g, dish Seed oil 2000-3000g, stearic acid 450-550g, glycerine 450-550g, glycerin monostearate 50-100g, hexadecanol 100- 200g, potassium hydroxide 45-55g, ethylparaben 20-30g, distilled water 3700-3800g.
  2. A kind of 2. external application Chinese medicine ointment for treating burn and scald skin ulcer, it is characterised in that：The treatment burn and scald skin ulcer External application Chinese medicine ointment be made up of the raw material of following weight proportion, it is Radix Astragali 500g, Radix Angelicae Sinensis 500g, golden cypress 500g, radix scutellariae 500g, big Yellow 500g, Radix zanthoxyli 500g, Paris polyphylla 500g, cape jasmine 500g, bletilla striata 500g, radix boehmeriae 500g, elephant hide 200g, Selaginella tamariscina 500g, ice Piece 20g, beeswax 350g, rapeseed oil 2500g, stearic acid 500g, glycerine 500g, glycerin monostearate 75g, hexadecanol 150g, Potassium hydroxide 50g, ethylparaben 25g, distilled water 3750g.
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