CN105168961A - Pharmaceutic preparation for treating hyperosteogeny - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine preparations and particularly provides a pharmaceutic preparation for treating hyperosteogeny. The pharmaceutic preparation is prepared from raw materials as follows: 28 parts of herbs of marginate rockbell, 25 parts of roots of entire micromelum, 20 parts of erect chamaerhodos, 18 parts of Polygonum rude Meissn, 26 parts of five-finger fig roots, 18 parts of Chinese angelica, 20 parts of Chinese clematis roots, 25 parts of dendrobium, 25 parts of suberect spatholobus stems, 20 parts of myrrh, 20 parts of fortune's drynaria rhizomes, 20 parts of scorpions, 25 parts of trberculate speranskia Herbs, 20 parts of danshen roots, 15 parts of Chinese gall, 15 parts of cassia bark and 5 parts of liquorice roots. The pharmaceutic preparation can treat the hyperosteogeny.

Description

A kind of pharmaceutical preparation being used for the treatment of hyperosteogeny

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of hyperosteogeny and its preparation method and application.

Background technology

Hyperosteogeny refers to due to degeneration of joint, so that the chronic joint disease that articular cartilage is destroyed and causes.Also known as osteoarthritis, osteoarthritis and hypertrophiarthritis etc.Primary disease onset is slow, without General Symptoms, mostly is the person in middle and old age of more than 50 years old.Be often multi-joint morbidity, also have simple joint to send out patient.Affected joints can have persistence dull pain, increases the weight of during movable increase, takes a turn for the better after having a rest.Pain is often not serious, increases the weight of when air pressure reduces, relevant with climate change.Sometimes can there is acute pain episodes, have joint stiff sense simultaneously, can find that intraarticular has crunch once in a while.Sitting posterior joint is stiff to be increased the weight of, and take a turn for the better after slightly movable, someone is referred to as " rest pain ".Later stage arthroncus, increase and limitation of movement, little complete tetanus, generally shows as bone retardance and levies.For this reason, be bursting to and develop the needs that more medicines for the treatment of hyperosteogeny safely and effectively meet clinical treatment.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of hyperosteogeny disease.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of pharmaceutical preparation being used for the treatment of hyperosteogeny, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Wahlenbergiae 28 parts, Radix Micromeli Integerrimi 25 parts, Herba Chamaerhodoris Erectae 20 parts, Polygonum rude Meissn 18 parts, Radix Fici Simplicissimae 26 parts, Radix Angelicae Sinensis 18 parts, Radix Clematidis 20 parts, Herba Dendrobii 25 parts, Caulis Spatholobi 25 parts, Myrrha 20 parts, Rhizoma Drynariae 20 parts, Scorpio 20 parts, Herba speranskiae tuberculatae 25 parts, Radix Salviae Miltiorrhizae 20 parts, Galla Chinensis 15 parts, Cortex Cinnamomi 15 parts, 5 parts, Radix Glycyrrhizae.

The described pharmaceutical preparation being used for the treatment of hyperosteogeny, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of hyperosteogeny, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

The described application of pharmaceutical preparation in preparation treatment hyperosteogeny medicine being used for the treatment of hyperosteogeny.

Herba Wahlenbergiae is root or the whole herb with root of Campanulaceae Herba Wahlenbergiae.Latin name: Wahlenbergiamarginata (Thunb.) A.DC., tonify deficiency, induces sweat.Control deficient impairment caused by overstrain, hemoptysis, epistaxis, spontaneous perspiration, night sweat, women leucorrhea, the cough due to common cold, stomachache, dysentery, knife injury.Radix Micromeli Integerrimi is the root of rutaceae Radix Micromeli Integerrimi, bark or leaf.Herba Chamaerhodoris Erectae is the herb of rosaceous plant Herba Chamaerhodoris Erectae.Polygonum rude Meissn is the herb of the withered cattle of polygonaceae plant nine.Radix Fici Simplicissimae is the root of moraceae plants ficus simplicissima.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: bone matrix hyperplasia belongs to " arthromyodynia " category of the traditional Chinese medical science, also known as " rheumatism involving the bone ".The traditional Chinese medical science thinks that primary disease is relevant with wound, strain, obstruction of collaterals by blood stasis, the damp that is affected by the cold, phlegm resistance, caused by liver and kidney deficiency etc.Herba Wahlenbergiae of the present invention, Radix Micromeli Integerrimi, Herba Chamaerhodoris Erectae, Polygonum rude Meissn, Radix Fici Simplicissimae heat-clearing and toxic substances removing, dredging collateral are invigorated blood circulation as monarch drug, Radix Angelicae Sinensis, Radix Clematidis, Herba Dendrobii, Caulis Spatholobi, Myrrha, Rhizoma Drynariae, Scorpio, Herba speranskiae tuberculatae, Radix Salviae Miltiorrhizae, Galla Chinensis, Cortex Cinnamomi blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment hyperosteogeny successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

Embodiment 1, the preparation of granule embodiment: get Herba Wahlenbergiae 28g, Radix Micromeli Integerrimi 25g, Herba Chamaerhodoris Erectae 20g, Polygonum rude Meissn 18g, Radix Fici Simplicissimae 26g, Radix Angelicae Sinensis 18g, Radix Clematidis 20g, Herba Dendrobii 25g, Caulis Spatholobi 25g, Myrrha 20g, Rhizoma Drynariae 20g, Scorpio 20g, Herba speranskiae tuberculatae 25g, Radix Salviae Miltiorrhizae 20g, Galla Chinensis 15g, Cortex Cinnamomi 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

Embodiment 2, the preparation of Tablets Example: get Herba Wahlenbergiae 28g, Radix Micromeli Integerrimi 25g, Herba Chamaerhodoris Erectae 20g, Polygonum rude Meissn 18g, Radix Fici Simplicissimae 26g, Radix Angelicae Sinensis 18g, Radix Clematidis 20g, Herba Dendrobii 25g, Caulis Spatholobi 25g, Myrrha 20g, Rhizoma Drynariae 20g, Scorpio 20g, Herba speranskiae tuberculatae 25g, Radix Salviae Miltiorrhizae 20g, Galla Chinensis 15g, Cortex Cinnamomi 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

Embodiment 3, the preparation of capsule embodiment: get Herba Wahlenbergiae 28g, Radix Micromeli Integerrimi 25g, Herba Chamaerhodoris Erectae 20g, Polygonum rude Meissn 18g, Radix Fici Simplicissimae 26g, Radix Angelicae Sinensis 18g, Radix Clematidis 20g, Herba Dendrobii 25g, Caulis Spatholobi 25g, Myrrha 20g, Rhizoma Drynariae 20g, Scorpio 20g, Herba speranskiae tuberculatae 25g, Radix Salviae Miltiorrhizae 20g, Galla Chinensis 15g, Cortex Cinnamomi 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, pharmaceutical preparation treatment hyperosteogeny of the present invention clinical research

4.1 general data: this pharmaceutical preparation is applied to clinical observation hyperosteogeny case 60 example, 46 ~ 57 years old age.The shortest person of the course of disease 6 months, most elder reaches 3 years.

4.2 diagnostic criterias: (1) this patient mostly is the middle-aged and elderly people of more than 40 years old, with the stiff pain of waist or occur the symptoms such as numbness of lower limbs, visible part patient lumbar physiological-curvature of having a medical check-up is abnormal; Lumbar vertebra both sides muscle has tenderness.(2) change (normotopia, position, side, left and right loxosis) of lumbar X line sheet, can have the changes such as lumbar curvature exception, lumbar lateral curvature, lumbar vertebra gap turn narrow, lumbar vertebra and facet joint hypertrophy, lumbar spondylolisthesis, intervertebral foramina stenosis as patient.(3) the various symptoms that lumbar hyperosteogency produces should be differentiated with multiple lumbar disc disease, as prolapse of lumbar intervertebral disc, vertebral body send out the diseases such as the region between the heart and the diaphragm deformity, vertebral tumor, tuberculosis of spine.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule one month is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: recovery from illness: clinical symptom disappearance, local movement freely, is recovered normally to work, and x line check bone matrix hyperplasia does not have growth, follows up a case by regular visits to without recurrence after 1 year.Effective: clinical symptoms disappears substantially, local movement, without obviously limited, can recover original work.Effective: clinical symptoms is obviously improved, tired or can symptom be occurred after catching cold, but comparatively before alleviate to some extent, lighter work can be participated in.Invalid: 2 ~ 3 courses for the treatment of are treated in medication, clinical symptoms is improved not obvious, and joint movement disorder is unchanged, very then increases the weight of.

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	30	4	8	13	5	83.3
Blank group	30	0	1	1	28	6.7

Visible, the medicine that the present invention obtains can safe and effective treatment hyperosteogeny, and has no side effect.

Claims (4)

1. one kind is used for the treatment of the pharmaceutical preparation of hyperosteogeny, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Wahlenbergiae 28 parts, Radix Micromeli Integerrimi 25 parts, Herba Chamaerhodoris Erectae 20 parts, Polygonum rude Meissn 18 parts, Radix Fici Simplicissimae 26 parts, Radix Angelicae Sinensis 18 parts, Radix Clematidis 20 parts, Herba Dendrobii 25 parts, Caulis Spatholobi 25 parts, Myrrha 20 parts, Rhizoma Drynariae 20 parts, Scorpio 20 parts, Herba speranskiae tuberculatae 25 parts, Radix Salviae Miltiorrhizae 20 parts, Galla Chinensis 15 parts, Cortex Cinnamomi 15 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of the pharmaceutical preparation of hyperosteogeny as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of the pharmaceutical preparation of hyperosteogeny as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of pharmaceutical preparation in treatment hyperosteogeny medicine of hyperosteogeny according to claim 1.