CN105164100B - 用于合成手性犬尿氨酸化合物的方法 - Google Patents

用于合成手性犬尿氨酸化合物的方法 Download PDF

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Publication number
CN105164100B
CN105164100B CN201480023992.8A CN201480023992A CN105164100B CN 105164100 B CN105164100 B CN 105164100B CN 201480023992 A CN201480023992 A CN 201480023992A CN 105164100 B CN105164100 B CN 105164100B
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compound
formula
amino
chloro
phenyl
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Chinese (zh)
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CN105164100A (zh
Inventor
斯蒂芬·阿贝尔
克劳斯·劳厄
罗兰·A·布瑞坦莫瑟
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Vistagen Therapeutics Inc
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Vistagen Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01014—Aminoacylase (3.5.1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201480023992.8A 2013-03-14 2014-03-14 用于合成手性犬尿氨酸化合物的方法 Expired - Fee Related CN105164100B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710718531.8A CN107417558A (zh) 2013-03-14 2014-03-14 用于合成手性犬尿氨酸化合物的方法

Applications Claiming Priority (3)

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US201361785807P 2013-03-14 2013-03-14
US61/785,807 2013-03-14
PCT/US2014/027694 WO2014152752A1 (en) 2013-03-14 2014-03-14 Methods for the synthesis of chiral kynurenine compounds

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US (2) US9834801B2 (enExample)
EP (1) EP2970097B1 (enExample)
JP (2) JP6340409B2 (enExample)
CN (2) CN105164100B (enExample)
CA (1) CA2941559A1 (enExample)
WO (1) WO2014152752A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2941559A1 (en) 2013-03-14 2014-09-25 Vistagen Therapeutics, Inc. Methods for the synthesis of chiral kynurenine compounds
SI3297619T1 (sl) 2015-05-22 2023-02-28 Vistagen Therapeutics, Inc., Terapevtske uporabe L-4-klorokinurenina
EP3347346A1 (en) * 2015-09-08 2018-07-18 Cephalon, Inc. Prodrugs of chlorokynurenines
US20190201360A1 (en) 2016-08-31 2019-07-04 Ampio Pharmaceuticals, Inc. Treatment of disease with n-acetyl kynurenine
WO2018180116A1 (ja) 2017-03-29 2018-10-04 富士フイルム株式会社 構造体および光センサ
CA3127220C (en) * 2018-02-09 2024-11-19 Vistagen Therapeutics Inc SYNTHESIS OF 4-CHLOROKYNURENINS AND INTERMEDIARIES
CN113549661B (zh) * 2020-04-26 2022-08-30 赤壁生合元科技有限公司 生物催化合成L-4-Cl-犬尿氨酸或L-4-Br-犬尿氨酸的方法及应用
CN113549662B (zh) * 2020-04-26 2022-06-03 赤壁市高质量发展研究院有限公司 一种用MOF载酶技术高效制备抗抑郁药前药L-4-Cl-犬尿氨酸的方法及应用
AU2023300118A1 (en) 2022-06-30 2025-01-09 A-Clip Institute, Co., Ltd. Method for testing diseased state of vasculitis or exacerbation risk of COVID-19, testing kit, companion diagnostic agent, and testing marker

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3702255A (en) * 1970-08-21 1972-11-07 Us Agriculture Kynurenine derivatives as sweetening agents
US6323240B1 (en) * 1995-11-03 2001-11-27 Pharmacia & Upjohn S.P.A. 4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
CN101528689A (zh) * 2006-10-03 2009-09-09 纽里姆药品(1991)有限公司 作为治疗剂的取代芳基吲哚化合物及它们的犬尿氨酸/犬尿胺类代谢物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766261A (en) 1970-08-21 1973-10-16 Us Agriculture Process of producing kynurenine
US3765261A (en) * 1973-01-02 1973-10-16 Hurst Performance Unitary stick transfer case shifter
US5519055A (en) 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation
US5789434A (en) * 1994-11-15 1998-08-04 Bayer Corporation Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors
ITMI20041626A1 (it) 2004-08-06 2004-11-06 Roberto Pellicciari Inibitori della chinurenina-ammino-trasferasi
WO2010067613A1 (ja) * 2008-12-11 2010-06-17 東洋紡績株式会社 Ｌ－サクシニルアミノアシラーゼ、およびこれを用いたｌ－アミノ酸の製造方法
CA2941559A1 (en) 2013-03-14 2014-09-25 Vistagen Therapeutics, Inc. Methods for the synthesis of chiral kynurenine compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3702255A (en) * 1970-08-21 1972-11-07 Us Agriculture Kynurenine derivatives as sweetening agents
US6323240B1 (en) * 1995-11-03 2001-11-27 Pharmacia & Upjohn S.P.A. 4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
CN101528689A (zh) * 2006-10-03 2009-09-09 纽里姆药品(1991)有限公司 作为治疗剂的取代芳基吲哚化合物及它们的犬尿氨酸/犬尿胺类代谢物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase;Varasi, M.等;《European Journal of Medicinal Chemistry》;19961231;第31卷(第1期);第11-21页 *

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US20180171372A1 (en) 2018-06-21
US10294502B2 (en) 2019-05-21
EP2970097A1 (en) 2016-01-20
JP6340409B2 (ja) 2018-06-06
EP2970097A4 (en) 2016-11-16
HK1218414A1 (zh) 2017-02-17
WO2014152752A1 (en) 2014-09-25
JP2018139608A (ja) 2018-09-13
CA2941559A1 (en) 2014-09-25
CN105164100A (zh) 2015-12-16
EP2970097B1 (en) 2018-10-31
CN107417558A (zh) 2017-12-01
US9834801B2 (en) 2017-12-05
JP6618569B2 (ja) 2019-12-11
JP2016513709A (ja) 2016-05-16
US20160032334A1 (en) 2016-02-04

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