CN105163718B - 通过耳麻醉脑神经治疗疾病的方法 - Google Patents

通过耳麻醉脑神经治疗疾病的方法 Download PDF

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CN105163718B
CN105163718B CN201480024269.1A CN201480024269A CN105163718B CN 105163718 B CN105163718 B CN 105163718B CN 201480024269 A CN201480024269 A CN 201480024269A CN 105163718 B CN105163718 B CN 105163718B
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pharmaceutical composition
nerve
ear
pain
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CN105163718A (zh
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托马斯·M·克鲁斯
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CN201480024269.1A 2013-05-03 2014-05-05 通过耳麻醉脑神经治疗疾病的方法 Active CN105163718B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361819023P 2013-05-03 2013-05-03
US61/819,023 2013-05-03
PCT/US2014/036855 WO2014179814A1 (en) 2013-05-03 2014-05-05 Method of treating disease by auricular anesthesia of cranial nerves

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CN105163718A CN105163718A (zh) 2015-12-16
CN105163718B true CN105163718B (zh) 2020-03-17

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CN201480024269.1A Active CN105163718B (zh) 2013-05-03 2014-05-05 通过耳麻醉脑神经治疗疾病的方法
CN201680077107.3A Pending CN108430470A (zh) 2013-05-03 2016-11-02 通过颅神经的耳麻醉治疗疾病的方法

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US (5) US20140357686A1 (cg-RX-API-DMAC10.html)
EP (2) EP2991620B1 (cg-RX-API-DMAC10.html)
JP (3) JP6433985B2 (cg-RX-API-DMAC10.html)
KR (2) KR102086709B1 (cg-RX-API-DMAC10.html)
CN (2) CN105163718B (cg-RX-API-DMAC10.html)
AU (2) AU2014262148B2 (cg-RX-API-DMAC10.html)
CA (2) CA2910422C (cg-RX-API-DMAC10.html)
DK (1) DK2991620T3 (cg-RX-API-DMAC10.html)
ES (1) ES2823624T3 (cg-RX-API-DMAC10.html)
HK (1) HK1212230A1 (cg-RX-API-DMAC10.html)
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MY (2) MY180310A (cg-RX-API-DMAC10.html)
RU (2) RU2687249C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201508509XA (cg-RX-API-DMAC10.html)
WO (2) WO2014179814A1 (cg-RX-API-DMAC10.html)
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Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
CA2910422C (en) * 2013-05-03 2022-09-27 Thomas M. Crews Method of treating disease by auricular anesthesia of cranialnerves
EP3263103A4 (en) * 2015-02-26 2018-03-14 Limited Liability Company "konsortsium-pik" Pharmaceutical composition for treatment of inflammatory ear diseases, method for producing same and method for treatment using said composition
EP3509585B1 (en) 2016-09-07 2023-11-01 Glia, LLC Treatment of symptoms related to neurodegenerative disorders through pharmacological dermal activation of cranial nerves
US20220105052A1 (en) * 2016-12-26 2022-04-07 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
CN107789621A (zh) * 2017-12-15 2018-03-13 阜阳市平衡医疗保健器械有限公司 一种治疗头痛的药物及其配制方法
US11607275B2 (en) * 2019-05-20 2023-03-21 Medtronic Ireland Manufacturing Unlimited Company Selection of hypertensive patients for treatment with renal denervation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093417A (en) * 1999-01-11 2000-07-25 Advanced Medical Instruments Composition to treat ear disorders
WO2013040352A1 (en) * 2011-09-15 2013-03-21 Yoseph Yaacobi Systems and methods for treating ear disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19524691A1 (de) * 1995-07-06 1997-01-09 Liedtke Pharmed Gmbh Methode und Zusammensetzung einer topischen Therapie von Innenohr und Labyrinth-Symptomen
RU2104056C1 (ru) * 1995-07-10 1998-02-10 Александр Александрович Ланцов Способ лечения периферических поражений лицевого нерва
JPH1094613A (ja) * 1996-08-02 1998-04-14 Mieko Sato 食欲調整用具
AU5170400A (en) * 1999-05-27 2000-12-18 George F. El Khoury Topical application of muscarinic and opioid agents for treatment of tinnitus
DE10322497A1 (de) * 2003-05-19 2004-12-09 Liedtke, Rainer K., Dr. Topisch pharmakologische Vorbeugung und Therapie der Hyperakusis
US8940321B2 (en) * 2003-12-12 2015-01-27 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
US8755892B2 (en) * 2007-05-16 2014-06-17 Cardiac Pacemakers, Inc. Systems for stimulating neural targets
WO2011019954A2 (en) * 2009-08-13 2011-02-17 Yehuda Ivri Intracochlear drug delivery to the central nervous system
WO2011028915A2 (en) * 2009-09-03 2011-03-10 University Of Chicago Platelet aggregation inhibitors
CA2910422C (en) * 2013-05-03 2022-09-27 Thomas M. Crews Method of treating disease by auricular anesthesia of cranialnerves

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6093417A (en) * 1999-01-11 2000-07-25 Advanced Medical Instruments Composition to treat ear disorders
WO2013040352A1 (en) * 2011-09-15 2013-03-21 Yoseph Yaacobi Systems and methods for treating ear disorders

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"安替比林-苯佐卡因滴耳液对儿童急性中耳炎耳痛的治疗";Hoberman A;《国外医学耳鼻喉科学分册》;19991231;第23卷(第3期);第168-169页 *
"罗哌卡因迷走神经阻滞预防术中哮喘发作的效果";孟岚等;《齐鲁医学杂志》;20061031;第21卷(第5期);第413-414页 *

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ES2823624T3 (es) 2021-05-07
JP7512317B2 (ja) 2024-07-08
AU2014262148B2 (en) 2018-11-22
JP2016522819A (ja) 2016-08-04
IL242339B (en) 2020-05-31
ZA201508782B (en) 2017-08-30
BR112018008893A8 (pt) 2019-02-26
MX2018005625A (es) 2018-12-06
AU2014262148A1 (en) 2015-11-05
RU2701548C1 (ru) 2019-09-30
WO2014179814A1 (en) 2014-11-06
MX2015015194A (es) 2016-02-11
BR112018008893A2 (pt) 2018-11-06
HK1212230A1 (en) 2016-06-10
EP3370716A4 (en) 2019-04-17
NZ713746A (en) 2021-01-29
JP6433985B2 (ja) 2018-12-05
JP2022065015A (ja) 2022-04-26
NZ742076A (en) 2024-12-20
AU2016349784B2 (en) 2019-06-06
CA3004160A1 (en) 2017-05-11
US20160051516A1 (en) 2016-02-25
ZA201803483B (en) 2019-08-28
US20220387307A1 (en) 2022-12-08
CA3004160C (en) 2023-03-14
MX381106B (es) 2025-03-04
RU2687249C2 (ru) 2019-05-08
EP2991620A4 (en) 2017-01-11
MX390998B (es) 2025-03-21
KR20160003012A (ko) 2016-01-08
EP3370716A1 (en) 2018-09-12
AU2016349784A1 (en) 2018-05-17
MY180310A (en) 2020-11-28
CN108430470A (zh) 2018-08-21
US20260083666A1 (en) 2026-03-26
US20140357686A1 (en) 2014-12-04
US20180360745A1 (en) 2018-12-20
JP2018536709A (ja) 2018-12-13
IL259019A (en) 2018-06-28
US11123284B2 (en) 2021-09-21
WO2017079270A1 (en) 2017-05-11
DK2991620T3 (da) 2020-10-12
CA2910422C (en) 2022-09-27
KR20180088408A (ko) 2018-08-03
EP2991620A1 (en) 2016-03-09
MY196979A (en) 2023-05-16
CN105163718A (zh) 2015-12-16
IL259019B (en) 2021-06-30
KR102086709B1 (ko) 2020-03-09
KR102796310B1 (ko) 2025-04-16
RU2015148757A (ru) 2017-06-08
CA2910422A1 (en) 2014-11-06
US9968589B2 (en) 2018-05-15
EP2991620B1 (en) 2020-07-08
SG11201508509XA (en) 2015-11-27

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