CN105120905B - 放射性标记方法 - Google Patents
放射性标记方法 Download PDFInfo
- Publication number
- CN105120905B CN105120905B CN201480018669.1A CN201480018669A CN105120905B CN 105120905 B CN105120905 B CN 105120905B CN 201480018669 A CN201480018669 A CN 201480018669A CN 105120905 B CN105120905 B CN 105120905B
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- CN
- China
- Prior art keywords
- acid
- formula
- compound
- substituent
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/15—Saturated compounds containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1305687.4 | 2013-03-28 | ||
| GBGB1305687.4A GB201305687D0 (en) | 2013-03-28 | 2013-03-28 | Radiolabelling process |
| PCT/EP2014/056344 WO2014154886A1 (en) | 2013-03-28 | 2014-03-28 | Radiolabelling process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105120905A CN105120905A (zh) | 2015-12-02 |
| CN105120905B true CN105120905B (zh) | 2021-07-06 |
Family
ID=48444922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480018669.1A Active CN105120905B (zh) | 2013-03-28 | 2014-03-28 | 放射性标记方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9999692B2 (enExample) |
| EP (1) | EP2978456B1 (enExample) |
| JP (1) | JP6500011B2 (enExample) |
| KR (1) | KR102218249B1 (enExample) |
| CN (1) | CN105120905B (enExample) |
| AU (1) | AU2014242897B2 (enExample) |
| CA (1) | CA2908029C (enExample) |
| ES (1) | ES2864702T3 (enExample) |
| GB (1) | GB201305687D0 (enExample) |
| MX (1) | MX368061B (enExample) |
| RU (1) | RU2675371C2 (enExample) |
| WO (1) | WO2014154886A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201305687D0 (en) | 2013-03-28 | 2013-05-15 | Ge Healthcare Ltd | Radiolabelling process |
| US20220001034A1 (en) * | 2014-06-30 | 2022-01-06 | Ge Healthcare Limited | Novel formulation and method of synthesis |
| GB201621864D0 (en) * | 2016-12-21 | 2017-02-01 | Ge Healthcare Ltd | Solid phase conditioning |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2119458A1 (en) * | 2007-02-13 | 2009-11-18 | Nihon Medi-Physics Co., Ltd. | Method for production of radiation diagnostic imaging agent |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| JP4989467B2 (ja) | 2005-05-23 | 2012-08-01 | 日本メジフィジックス株式会社 | 新規有機化合物及び該化合物を利用した放射性ハロゲン標識有機化合物の製造方法 |
| JP5349960B2 (ja) | 2005-06-23 | 2013-11-20 | エモリー ユニバーシティー | 腫瘍画像化のためのアミノ酸類似体の立体選択的合成 |
| US7837982B2 (en) | 2005-06-23 | 2010-11-23 | Emory University | Imaging agents |
| RU2434846C2 (ru) * | 2006-05-11 | 2011-11-27 | Нихон Меди-Физикс Ко., Лтд. | Способ получения радиоактивного фтор-меченного органического соединения |
| RU2445120C2 (ru) | 2006-12-21 | 2012-03-20 | Нихон Меди-Физикс Ко., Лтд. | Радиоактивный агент для диагностической визуализации |
| DK2230229T3 (en) | 2007-12-19 | 2017-01-23 | Nihon Mediphysics Co Ltd | Process for the preparation of radioactive-fluoro-labeled organic compound |
| HUE030813T2 (en) | 2009-10-08 | 2017-05-29 | Ge Healthcare Ltd | Cleaning procedure |
| MX363538B (es) | 2010-12-29 | 2019-03-27 | Ge Healthcare Ltd | Solucion de eluyente. |
| IN2014DN03245A (enExample) * | 2011-12-21 | 2015-07-10 | Ge Healthcare Ltd | |
| GB201305687D0 (en) | 2013-03-28 | 2013-05-15 | Ge Healthcare Ltd | Radiolabelling process |
-
2013
- 2013-03-28 GB GBGB1305687.4A patent/GB201305687D0/en not_active Ceased
-
2014
- 2014-03-28 CN CN201480018669.1A patent/CN105120905B/zh active Active
- 2014-03-28 JP JP2016504702A patent/JP6500011B2/ja active Active
- 2014-03-28 ES ES14713479T patent/ES2864702T3/es active Active
- 2014-03-28 US US14/780,900 patent/US9999692B2/en active Active
- 2014-03-28 KR KR1020157026221A patent/KR102218249B1/ko active Active
- 2014-03-28 EP EP14713479.5A patent/EP2978456B1/en active Active
- 2014-03-28 MX MX2015013801A patent/MX368061B/es active IP Right Grant
- 2014-03-28 CA CA2908029A patent/CA2908029C/en active Active
- 2014-03-28 RU RU2015138540A patent/RU2675371C2/ru active
- 2014-03-28 WO PCT/EP2014/056344 patent/WO2014154886A1/en not_active Ceased
- 2014-03-28 AU AU2014242897A patent/AU2014242897B2/en active Active
-
2018
- 2018-02-20 US US15/900,716 patent/US20180177900A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2119458A1 (en) * | 2007-02-13 | 2009-11-18 | Nihon Medi-Physics Co., Ltd. | Method for production of radiation diagnostic imaging agent |
Non-Patent Citations (2)
| Title |
|---|
| "Degradation of acetonitrile in eluent solutions for [18F]fluoride PET chemistry:impact on radiosynthesis of [18F]FACBC and [18F]FDG";Anders Svadberg等;《Journal of labelled compounds and radiopharmaceuticals》;20111221(第55期);第97-102页 * |
| "Fully automated synthesis system of 3′-deoxy-3′-[18F]fluorothymidine";Seung Jun Oh等;《Nuclear Medicine and Biology》;20040125(第31期);标题，第807页左栏第1段，第808页左栏第2段，右栏第1段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6500011B2 (ja) | 2019-04-10 |
| MX2015013801A (es) | 2016-02-16 |
| US20160051710A1 (en) | 2016-02-25 |
| RU2015138540A (ru) | 2017-05-03 |
| KR102218249B1 (ko) | 2021-02-22 |
| RU2015138540A3 (enExample) | 2018-03-01 |
| US20180177900A1 (en) | 2018-06-28 |
| CA2908029A1 (en) | 2014-10-02 |
| BR112015024344A2 (pt) | 2017-07-18 |
| MX368061B (es) | 2019-09-18 |
| EP2978456B1 (en) | 2021-03-17 |
| KR20150136598A (ko) | 2015-12-07 |
| JP2016515564A (ja) | 2016-05-30 |
| AU2014242897A1 (en) | 2015-08-27 |
| AU2014242897B2 (en) | 2018-11-08 |
| WO2014154886A1 (en) | 2014-10-02 |
| GB201305687D0 (en) | 2013-05-15 |
| ES2864702T3 (es) | 2021-10-14 |
| CA2908029C (en) | 2021-05-04 |
| CN105120905A (zh) | 2015-12-02 |
| RU2675371C2 (ru) | 2018-12-19 |
| US9999692B2 (en) | 2018-06-19 |
| EP2978456A1 (en) | 2016-02-03 |
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Legal Events
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |