CA2908029C - Radiolabelling process - Google Patents
Radiolabelling process Download PDFInfo
- Publication number
- CA2908029C CA2908029C CA2908029A CA2908029A CA2908029C CA 2908029 C CA2908029 C CA 2908029C CA 2908029 A CA2908029 A CA 2908029A CA 2908029 A CA2908029 A CA 2908029A CA 2908029 C CA2908029 C CA 2908029C
- Authority
- CA
- Canada
- Prior art keywords
- formula
- acid
- compound
- substituent
- facbc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/15—Saturated compounds containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1305687.4A GB201305687D0 (en) | 2013-03-28 | 2013-03-28 | Radiolabelling process |
| GB1305687.4 | 2013-03-28 | ||
| PCT/EP2014/056344 WO2014154886A1 (en) | 2013-03-28 | 2014-03-28 | Radiolabelling process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2908029A1 CA2908029A1 (en) | 2014-10-02 |
| CA2908029C true CA2908029C (en) | 2021-05-04 |
Family
ID=48444922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2908029A Active CA2908029C (en) | 2013-03-28 | 2014-03-28 | Radiolabelling process |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9999692B2 (enExample) |
| EP (1) | EP2978456B1 (enExample) |
| JP (1) | JP6500011B2 (enExample) |
| KR (1) | KR102218249B1 (enExample) |
| CN (1) | CN105120905B (enExample) |
| AU (1) | AU2014242897B2 (enExample) |
| CA (1) | CA2908029C (enExample) |
| ES (1) | ES2864702T3 (enExample) |
| GB (1) | GB201305687D0 (enExample) |
| MX (1) | MX368061B (enExample) |
| RU (1) | RU2675371C2 (enExample) |
| WO (1) | WO2014154886A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201305687D0 (en) | 2013-03-28 | 2013-05-15 | Ge Healthcare Ltd | Radiolabelling process |
| US20220001034A1 (en) * | 2014-06-30 | 2022-01-06 | Ge Healthcare Limited | Novel formulation and method of synthesis |
| GB201621864D0 (en) * | 2016-12-21 | 2017-02-01 | Ge Healthcare Ltd | Solid phase conditioning |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5808146A (en) | 1995-11-09 | 1998-09-15 | Emory University | Amino acid analogs for tumor imaging |
| JP4989467B2 (ja) * | 2005-05-23 | 2012-08-01 | 日本メジフィジックス株式会社 | 新規有機化合物及び該化合物を利用した放射性ハロゲン標識有機化合物の製造方法 |
| EP1893244A4 (en) | 2005-06-23 | 2009-06-24 | Univ Emory | AGENTS FOR IMAGING |
| CA2612187C (en) | 2005-06-23 | 2013-05-07 | Emory University | Stereoselective synthesis of amino acid analogs for tumor imaging |
| ES2380372T3 (es) * | 2006-05-11 | 2012-05-11 | Nihon Medi-Physics Co., Ltd. | Procedimiento para la producción de compuesto orgánico marcado con flúor radioactivo |
| KR101497406B1 (ko) | 2006-12-21 | 2015-03-02 | 니혼 메디피직스 가부시키가이샤 | 방사성 화상 진단제 |
| JP5258583B2 (ja) | 2007-02-13 | 2013-08-07 | 日本メジフィジックス株式会社 | 放射性画像診断剤の製造方法 |
| JP5732198B2 (ja) | 2007-12-19 | 2015-06-10 | 日本メジフィジックス株式会社 | 放射性フッ素標識有機化合物の製造方法 |
| EP2509637B1 (en) | 2009-10-08 | 2016-08-10 | GE Healthcare Limited | Purification method |
| EP2793954B1 (en) * | 2011-12-21 | 2020-10-21 | GE Healthcare Limited | 18f-fluciclovine compositions in citrate buffers |
| AU2011351550B2 (en) | 2010-12-29 | 2017-02-02 | Ge Healthcare Limited | Eluent solution |
| GB201305687D0 (en) | 2013-03-28 | 2013-05-15 | Ge Healthcare Ltd | Radiolabelling process |
-
2013
- 2013-03-28 GB GBGB1305687.4A patent/GB201305687D0/en not_active Ceased
-
2014
- 2014-03-28 AU AU2014242897A patent/AU2014242897B2/en active Active
- 2014-03-28 WO PCT/EP2014/056344 patent/WO2014154886A1/en not_active Ceased
- 2014-03-28 US US14/780,900 patent/US9999692B2/en active Active
- 2014-03-28 KR KR1020157026221A patent/KR102218249B1/ko active Active
- 2014-03-28 RU RU2015138540A patent/RU2675371C2/ru active
- 2014-03-28 JP JP2016504702A patent/JP6500011B2/ja active Active
- 2014-03-28 CA CA2908029A patent/CA2908029C/en active Active
- 2014-03-28 ES ES14713479T patent/ES2864702T3/es active Active
- 2014-03-28 EP EP14713479.5A patent/EP2978456B1/en active Active
- 2014-03-28 MX MX2015013801A patent/MX368061B/es active IP Right Grant
- 2014-03-28 CN CN201480018669.1A patent/CN105120905B/zh active Active
-
2018
- 2018-02-20 US US15/900,716 patent/US20180177900A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2978456A1 (en) | 2016-02-03 |
| KR20150136598A (ko) | 2015-12-07 |
| ES2864702T3 (es) | 2021-10-14 |
| CA2908029A1 (en) | 2014-10-02 |
| CN105120905B (zh) | 2021-07-06 |
| KR102218249B1 (ko) | 2021-02-22 |
| US20180177900A1 (en) | 2018-06-28 |
| AU2014242897A1 (en) | 2015-08-27 |
| JP2016515564A (ja) | 2016-05-30 |
| MX368061B (es) | 2019-09-18 |
| US20160051710A1 (en) | 2016-02-25 |
| BR112015024344A2 (pt) | 2017-07-18 |
| RU2015138540A3 (enExample) | 2018-03-01 |
| GB201305687D0 (en) | 2013-05-15 |
| EP2978456B1 (en) | 2021-03-17 |
| AU2014242897B2 (en) | 2018-11-08 |
| CN105120905A (zh) | 2015-12-02 |
| JP6500011B2 (ja) | 2019-04-10 |
| WO2014154886A1 (en) | 2014-10-02 |
| RU2675371C2 (ru) | 2018-12-19 |
| RU2015138540A (ru) | 2017-05-03 |
| US9999692B2 (en) | 2018-06-19 |
| MX2015013801A (es) | 2016-02-16 |
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| CA2953641C (en) | Novel formulation and method of synthesis | |
| CA2908029C (en) | Radiolabelling process | |
| EP2793954B1 (en) | 18f-fluciclovine compositions in citrate buffers | |
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| NZ624250A (en) | 18f-fluciclovine compositions in citrate buffers | |
| NZ624250B2 (en) | 18f-fluciclovine compositions in citrate buffers | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190314 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 11TH ANNIV.) - STANDARD Year of fee payment: 11 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250227 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20250227 |