AU2014242897B2 - Radiolabelling process - Google Patents

Radiolabelling process Download PDF

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Publication number
AU2014242897B2
AU2014242897B2 AU2014242897A AU2014242897A AU2014242897B2 AU 2014242897 B2 AU2014242897 B2 AU 2014242897B2 AU 2014242897 A AU2014242897 A AU 2014242897A AU 2014242897 A AU2014242897 A AU 2014242897A AU 2014242897 B2 AU2014242897 B2 AU 2014242897B2
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AU
Australia
Prior art keywords
acid
formula
compound
facbc
composition
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AU2014242897A
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English (en)
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AU2014242897A1 (en
Inventor
Torild Wickstrom
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication date
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Publication of AU2014242897A1 publication Critical patent/AU2014242897A1/en
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Publication of AU2014242897B2 publication Critical patent/AU2014242897B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/15—Saturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2014242897A 2013-03-28 2014-03-28 Radiolabelling process Active AU2014242897B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1305687.4A GB201305687D0 (en) 2013-03-28 2013-03-28 Radiolabelling process
GB1305687.4 2013-03-28
PCT/EP2014/056344 WO2014154886A1 (en) 2013-03-28 2014-03-28 Radiolabelling process

Publications (2)

Publication Number Publication Date
AU2014242897A1 AU2014242897A1 (en) 2015-08-27
AU2014242897B2 true AU2014242897B2 (en) 2018-11-08

Family

ID=48444922

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014242897A Active AU2014242897B2 (en) 2013-03-28 2014-03-28 Radiolabelling process

Country Status (12)

Country Link
US (2) US9999692B2 (enExample)
EP (1) EP2978456B1 (enExample)
JP (1) JP6500011B2 (enExample)
KR (1) KR102218249B1 (enExample)
CN (1) CN105120905B (enExample)
AU (1) AU2014242897B2 (enExample)
CA (1) CA2908029C (enExample)
ES (1) ES2864702T3 (enExample)
GB (1) GB201305687D0 (enExample)
MX (1) MX368061B (enExample)
RU (1) RU2675371C2 (enExample)
WO (1) WO2014154886A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201305687D0 (en) 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process
US20220001034A1 (en) * 2014-06-30 2022-01-06 Ge Healthcare Limited Novel formulation and method of synthesis
GB201621864D0 (en) * 2016-12-21 2017-02-01 Ge Healthcare Ltd Solid phase conditioning

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017092A1 (en) * 1995-11-09 1997-05-15 Emory University Amino acid analogs for tumor imaging
WO2006126410A1 (ja) * 2005-05-23 2006-11-30 Nihon Medi-Physics Co., Ltd. 新規有機化合物及び該化合物を利用した放射性ハロゲン標識有機化合物の製造方法
WO2007001958A2 (en) * 2005-06-23 2007-01-04 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
WO2012089594A1 (en) * 2010-12-29 2012-07-05 Ge Healthcare Limited Eluent solution

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006262502A1 (en) 2005-06-23 2007-01-04 Emory Univerisity Imaging agents
US7897811B2 (en) 2006-05-11 2011-03-01 Nihon Medi-Physics Co., Ltd. Process for production of radioactive fluorine-labeled organic compound
US8790620B2 (en) * 2006-12-21 2014-07-29 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
EP2119458B9 (en) 2007-02-13 2013-08-21 Nihon Medi-Physics Co., Ltd. Method for production of radiation diagnostic imaging agent
US8269035B2 (en) 2007-12-19 2012-09-18 Nihon Medi-Physics Co., Ltd. Process for production of radioactive-fluorine-labeled organic compound
CA2785179C (en) 2009-10-08 2018-06-05 Ge Healthcare Limited Purification method
JP6446268B2 (ja) * 2011-12-21 2018-12-26 ジーイー・ヘルスケア・リミテッド クエン酸緩衝液中の18f−フルシクロビン組成物
GB201305687D0 (en) 2013-03-28 2013-05-15 Ge Healthcare Ltd Radiolabelling process

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017092A1 (en) * 1995-11-09 1997-05-15 Emory University Amino acid analogs for tumor imaging
WO2006126410A1 (ja) * 2005-05-23 2006-11-30 Nihon Medi-Physics Co., Ltd. 新規有機化合物及び該化合物を利用した放射性ハロゲン標識有機化合物の製造方法
EP1889834A1 (en) * 2005-05-23 2008-02-20 Nihon Medi-Physics Co., Ltd. Novel organic compound and method for producing radioactive halogen-labeled organic compound using the same
WO2007001958A2 (en) * 2005-06-23 2007-01-04 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
WO2012089594A1 (en) * 2010-12-29 2012-07-05 Ge Healthcare Limited Eluent solution

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Anders Svadberg¿, ""Degradation of acetonitrile in eluent solutions for [18F]fluoride PET chemistry:impact on radiosynthesis of [18F]FACBC and [18F]FDG"", Journal of labelled compounds and radiopharmaceuticals *
J. A. NYE ET AL, THE JOURNAL OF NUCLEAR MEDICINE, (2007-06-01), vol. 48, no. 6, doi:10.2967/jnumed.107.040097, ISSN 0161-5505, pages 1017 - 1020 *
YU W ET AL, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 20, no. 7, ISSN 0960-894X, (2010-04-01), pages 2140 -2143, (2010-02-14) *

Also Published As

Publication number Publication date
CA2908029C (en) 2021-05-04
AU2014242897A1 (en) 2015-08-27
CN105120905A (zh) 2015-12-02
RU2015138540A (ru) 2017-05-03
EP2978456A1 (en) 2016-02-03
GB201305687D0 (en) 2013-05-15
CA2908029A1 (en) 2014-10-02
KR102218249B1 (ko) 2021-02-22
WO2014154886A1 (en) 2014-10-02
KR20150136598A (ko) 2015-12-07
MX2015013801A (es) 2016-02-16
CN105120905B (zh) 2021-07-06
RU2015138540A3 (enExample) 2018-03-01
JP6500011B2 (ja) 2019-04-10
US20160051710A1 (en) 2016-02-25
MX368061B (es) 2019-09-18
BR112015024344A2 (pt) 2017-07-18
US20180177900A1 (en) 2018-06-28
EP2978456B1 (en) 2021-03-17
JP2016515564A (ja) 2016-05-30
ES2864702T3 (es) 2021-10-14
RU2675371C2 (ru) 2018-12-19
US9999692B2 (en) 2018-06-19

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