CN105106068A - Nerve soothing perfume - Google Patents
Nerve soothing perfume Download PDFInfo
- Publication number
- CN105106068A CN105106068A CN201510576560.6A CN201510576560A CN105106068A CN 105106068 A CN105106068 A CN 105106068A CN 201510576560 A CN201510576560 A CN 201510576560A CN 105106068 A CN105106068 A CN 105106068A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- perfume
- nerves
- herbal medicine
- quintessence oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
The invention provides nerve soothing perfume. Raw materials of the nerve soothing perfume include essential oil obtained from nerve soothing Chinese herbal medicine, alcohol, glycerine, distilled water, sodium alginate, Chinese herbal medicine absorption promotion agents, hydroxypropyl methyl cellulose and sodium pyrrolidone carboxylic acid. When the nerve soothing perfume is used, mood anxiety is regulated, and physical and psychological health is facilitated while fragrance is obtained.
Description
Technical field
The present invention relates to cosmetic technical field, particularly relate to one and to calm the nerves perfume.
Background technology
Perfume major part in the market uses the configuration of chemical spice to form, these chemical spice contain aromatic series benzene ring compound, evaporate with ethanol, to human organ particularly respiratory system generation stimulation, occupant is made to occur the symptoms such as cough, dizziness, vomiting, negative unhealthy.If life-time service, also may cause baryo,dmia, eyesight weaken, even become carcinogenic inducement.Meanwhile, some perfume inferior are also containing allowing the phosphorus benzene bis-acid potassium ester of lasting fragrance, and this chemical substance can cause motility of sperm step-down and even death, has become at present and has caused one of mankind spermatozoon death large killer.In addition, the purposes of this kind of perfume is more single, namely emphasizes merely its abnormal smells from the patient and does not focus on other effects, therefore, also limit its range of application.
Herbaceous plant containing a large amount of armaticity in Chinese herbal medicine, fragrant plant is compared with other general plants, unique sweetening treatment is worth, therefore be widely used in " aromatotherapy ", namely extract from these herbaceous plant and a large amount of the medicine of fragrant odour is made suitable dosage form, act on whole body or local with disease preventing and treating.Traditional Chinese medical theory thinks incense drug homology always, and the traditional Chinese medical science is except four natures and five flavors of drug.Separately there is the fragrant property of medicine, for thousands of years, the traditional Chinese medical science utilizes the fragrance ingredient of natural aromatic plant, by massage, take a shower, outer painting, the number of ways such as Wen Xiang, human body is produced and gets rid of illness and health-care effect, for refreshment, exorcise evil spirits by dirty, except pestilence epidemic disease, mosquito dispersing, also has dredge the meridian passage, the merit of crease-resistant skin protection, wound beauty treatment broader applications, therefore, employing Chinese herbal medicine extracting composition prepares the emphasis that perfume becomes current people research, it not only avoids the toxic that perfume that traditional chemical spice is made into has, and there is extra health care, effect of disease therapy.
The diseases such as the Chinese herbal medicine that stable mind is primary efficacy is mainly used in treating malaise, irritable, insomnia and dreamful sleep caused by a variety of causes such as insufficiency of heart-QI, deficiency of heart-blood, has a dizzy spell, forgetful, infantile convulsion and epilepsy.Modern study proves to be improved sleep, to promote learning and memory, anxiety, psychosis and antiepileptic pharmacological action, and wherein, employing Chinese herbal medicine anxiety is a major embodiment of stable mind.
Anxiety neurosis also known as anxiety neurosis, it be worry with persistence anxiety, frightened or ictal be the dysthymic disorder of feature in terror, with autonomic nervous system symptom with motion is uneasy waits behavior characteristics.The anxiety that anxiety patient shows or fear are not often inconsistent without flesh and blood or with real situation.Doctor trained in Western medicine mainly uses pharmaceutical intervention to the treatment of primary disease at present, but existing medicine Existence dependency, onset slowly, the problems such as untoward reaction.Desirable anxiolytic drugs should have rapid-action, can well maintainable remission and prevention of recurrence, alleviate adjoint depressive symptom, improve the quality of life of patient and reduce patient to features such as the demands of medical services.
The traditional Chinese medical science there is no the name of disease of anxiety neurosis, from clinical manifestation, primary disease belongs to emotional disorder, cardiopathia category, relevant with the disease such as the traditional Chinese medical science " melancholia ", " shying ", " fearing ", " palpitation with fear ", " cardiopalmus ", " palpitation with a distress feeling ", " being insomnia ", " hysteria ", " Bulbus Lilii syndrome ", " inferior spy disease ", " lantern disease ".Spirit feelings will activity exception or internal damage by the excessive seven emotions are pathogenic reasons, and anxiety has caused heat or hyperactivity of fire as feelings will obstacle is many by impairment of YIN, and its etiology and pathogenesis mostly is heresy and disturbs cardiopulmonary; gas the moon is impaired, god not in keep, strongly fragrant and heat-transformation; there is anxiety all diseases, closely related with the heart, stomach, gallbladder functional disorder.Wherein, gallbladder is fu-viscera with decisive character, and under physiological status, gallbladder contributes to resisting extraneous bad direct stimulation impact, maintenance energy and blood of human body normally runs to be coordinated with function, once gallbladder internal organs apraxia, adverse rising of stomach-QI, indigestion, then expectorant Re Neisheng, qi-movement disturbance, makes gallbladder internal organs lose resolution ability, thus causes abnormal anxiety to react.Be " disturbing in gallbladder discomfort in the stomach, expectorant heat " for primary disease main pathogenesis, treatment when with " activating QI to eliminate phlegm, clearing gallbladder stomach function regulating " for rule for the treatment of.
The present invention utilizes " aromatotherapy " to regulate mood anxiety in daily perfume uses, and prepares the novel perfume containing medicinal herb components.
Summary of the invention
Technical problem to be solved by this invention is to provide one and calms the nerves perfume, regulates mood anxiety, while fragrance, contribute to physical and mental health by daily perfume in being used.
For solving the problems of the technologies described above, present invention also offers one to calm the nerves perfume, its raw material comprises: the quintessence oil that Chinese herbal medicine of calming the nerves obtains, ethanol, glycerol, distilled water, sodium alginate, Chinese herbal medicine absorption enhancers, hydroxypropyl emthylcellulose and pyrrolidone sodium carboxylate.
Wherein, quintessence oil 3 weight portion ~ 6 weight portion, ethanol 15 weight portion ~ 25 weight portion, glycerol 2 weight portion ~ 5 weight portion, distilled water 95 weight portion ~ 105 weight portion, sodium alginate 1 weight portion ~ 3 weight portion, Chinese herbal medicine absorption enhancers 0.5 weight portion ~ 1.5 weight portion, hydroxypropyl emthylcellulose 0.5 weight portion ~ 1.5 weight portion, pyrrolidone sodium carboxylate 3 ~ 6 parts that Chinese herbal medicine of calming the nerves described in obtains.
Wherein, the raw material of described Chinese herbal medicine comprise Folium Ginkgo, Lignum Aquilariae Resinatum, Rhizoma Gastrodiae, Fructus Schisandrae Chinensis, Fructus Gardeniae, Pericarpium Citri Reticulatae, Herba Cymbopogonis, Herba Cistanches, Rhizoma Cimicifugae, Semen Sojae Preparatum perfume, Flos Osmanthi Fragrantis, night fragrant flower, Rhizoma Polygoni Cuspidati, Rhizoma Coptidis, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Menthae.
Described Chinese herbal medicine absorption enhancers is
n-octyl group chitosan.
Wherein, described in
nthe preparation method of-octyl group chitosan is specially: take chitosan 100g, be dissolved in 2L concentration be 2% acetic acid and 2L methanol mixed solvent in, stirred at ambient temperature 12h, thoroughly swellingly to be uniformly dispersed, nitrogen deoxygenation 15min, add octanal 200ml, 6L ethanol is added after the change of reaction 12h system is sticky, continue stirred at ambient temperature 48h, regulate reactant liquor to neutral with 1mol/L potassium hydroxide, rear employing 50g potassium borohydride configuration weak alkaline aqueous solution 60ml, be added drop-wise in reaction bulb with Dropping funnel, continue stirring at room temperature 24h, final reaction liquid 1mol/L hydrochloric acid is adjusted to neutrality, product sucking filtration, and with water, methanol, acetone washs 3 times respectively, collect product in 30 DEG C of vacuum finish-dryings, finally weigh product, obtain
n-octyl group chitosan.
The present invention also provides the preparation method of above-mentioned perfume of calming the nerves, and it comprises:
The first step, joins sodium alginate in part distilled water, is heated to 65 DEG C, and insulation limit, limit is stirred, until sodium alginate is dissolved completely in water, the amount of the distilled water that every 5g sodium alginate uses is 100ml;
Second step, mixes said herbal medicine composition, by extraction element, Chinese herbal medicine quintessence oil is carried out Isolation and purification, collects quintessence oil;
3rd step, the quintessence oil prepared by second step and Chinese herbal medicine absorption enhancers are dissolved in above-mentioned dissolve with ethanol, are stirred to and dissolve completely;
4th step, sodium alginate aqueous solution prepared by the first step, alcoholic solution, glycerol, hydroxypropyl emthylcellulose and pyrrolidone sodium carboxylate prepared by the 3rd step add in the distilled water of surplus, stir, leave standstill after 37 hours, put into sealed container, ageing is after 6 weeks.
Described second step comprises further,
2.1st step, Flos Osmanthi Fragrantis and night fragrant flower be ground into coarse powder respectively, mix, adopt carbon dioxide supercritical fluid extraction, extracting pressure 33 ~ 35MPa, extraction temperature 40 ~ 43 DEG C, extraction time 110 ~ 130min, collects the first quintessence oil;
2.2nd step, Folium Ginkgo, Rhizoma Gastrodiae, Cymbopogon distans (Nees)A. Camus are ground into coarse powder respectively, mix, and adopt carbon dioxide supercritical fluid extraction, extracting pressure 22 ~ 25MPa, extraction temperature 28 ~ 32 DEG C, extraction time 160-180min, collects the second quintessence oil;
2.3rd step, Lignum Aquilariae Resinatum, Semen Sojae Preparatum perfume, Rhizoma Coptidis, Radix Salviae Miltiorrhizae powder are broken into coarse powder, adopt carbon dioxide supercritical fluid extraction, extracting pressure 26 ~ 30MPa, extraction temperature 45 ~ 48 DEG C, extraction time 180 ~ 200min, collect the 3rd quintessence oil;
2.4th step, is ground into coarse powder respectively by remaining components, mixes, and adopts carbon dioxide supercritical fluid extraction, extracting pressure 24 ~ 27MPa, extraction temperature 51 ~ 54 DEG C, extraction time 200 ~ 220min, collects the 4th quintessence oil;
2.5th step, mixes above-mentioned quintessence oil, for subsequent use.
Beneficial effect of the present invention:
Regulate mood anxiety during described perfume of calming the nerves uses, while fragrance, contribute to physical and mental health.
Accompanying drawing explanation
Fig. 1
nthe infrared spectrum of-octyl group chitosan.
Detailed description of the invention
The invention provides the herbal composite for calming the nerves used in a kind of perfume of calming the nerves, its raw material comprise Folium Ginkgo, Lignum Aquilariae Resinatum, Rhizoma Gastrodiae, Fructus Schisandrae Chinensis, Fructus Gardeniae, Pericarpium Citri Reticulatae, Herba Cymbopogonis, Herba Cistanches, Rhizoma Cimicifugae, Semen Sojae Preparatum perfume, Flos Osmanthi Fragrantis, night fragrant flower, Rhizoma Polygoni Cuspidati, Rhizoma Coptidis, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Menthae.
Further preferably, described herbal composite is only prepared from by above-mentioned raw materials.
In described herbal composite, the weight portion of each raw material is respectively Folium Ginkgo 15 weight portion ~ 25 weight portion, Lignum Aquilariae Resinatum 20 weight portion ~ 30 weight portion, Rhizoma Gastrodiae 10 weight portion ~ 20 weight portion, Fructus Schisandrae Chinensis 15 weight portion ~ 25 weight portion, Fructus Gardeniae 10 weight portion ~ 20 weight portion, Pericarpium Citri Reticulatae 15 weight portion ~ 25 weight portion, Herba Cymbopogonis 15 weight portion ~ 25 weight portion, Herba Cistanches 25 weight portion ~ 35 weight portion, Rhizoma Cimicifugae 10 weight portion ~ 20 weight portion, fragrant 5 weight portion ~ 15 weight portions of Semen Sojae Preparatum, Flos Osmanthi Fragrantis 55 weight portion ~ 65 weight portion, fragrant flower 35 at night weight portion ~ 45 weight portion, Rhizoma Polygoni Cuspidati 20 weight portion ~ 30 weight portion, Rhizoma Coptidis 25 weight portion ~ 35 weight portion, Caulis Polygoni Multiflori 25 weight portion ~ 35 weight portion, Radix Salviae Miltiorrhizae 25 weight portion ~ 35 weight portion, Herba Menthae 15 weight portion ~ 25 weight portion.
Further preferably, in described herbal composite, the weight portion of each raw material is respectively Folium Ginkgo 15 weight portion ~ 20 weight portion, Lignum Aquilariae Resinatum 20 weight portion ~ 25 weight portion, Rhizoma Gastrodiae 10 weight portion ~ 15 weight portion, Fructus Schisandrae Chinensis 15 weight portion ~ 20 weight portion, Fructus Gardeniae 10 weight portion ~ 15 weight portion, Pericarpium Citri Reticulatae 15 weight portion ~ 20 weight portion, Herba Cymbopogonis 15 weight portion ~ 20 weight portion, Herba Cistanches 25 weight portion ~ 30 weight portion, Rhizoma Cimicifugae 15 weight portion ~ 20 weight portion, fragrant 10 weight portion ~ 15 weight portions of Semen Sojae Preparatum, Flos Osmanthi Fragrantis 60 weight portion ~ 65 weight portion, fragrant flower 40 at night weight portion ~ 45 weight portion, Rhizoma Polygoni Cuspidati 25 weight portion ~ 30 weight portion, Rhizoma Coptidis 30 weight portion ~ 35 weight portion, Caulis Polygoni Multiflori 30 weight portion ~ 35 weight portion, Radix Salviae Miltiorrhizae 30 weight portion ~ 35 weight portion, Herba Menthae 20 weight portion ~ 25 weight portion.
Most preferably, in described herbal composite the weight portion of each raw material be respectively Folium Ginkgo 20 weight portion, Lignum Aquilariae Resinatum 25 weight portion, Rhizoma Gastrodiae 15 weight portion, Fructus Schisandrae Chinensis 20 weight portion, Fructus Gardeniae 15 weight portion, Pericarpium Citri Reticulatae 20 weight portion, Herba Cymbopogonis 20 weight portion, Herba Cistanches 30 weight portion, Rhizoma Cimicifugae 15 weight portion, fragrant 10 weight portions of Semen Sojae Preparatum, Flos Osmanthi Fragrantis 60 weight portion, night fragrant flower 40 weight portion, Rhizoma Polygoni Cuspidati 25 weight portion, Rhizoma Coptidis 30 weight portion, Caulis Polygoni Multiflori 30 weight portion, Radix Salviae Miltiorrhizae 30 weight portion, Herba Menthae 20 weight portion.
Each raw material pharmacology is as follows:
Folium Ginkgo: sweet in the mouth, hardship, puckery, property is put down, and enter the heart, lung meridian, having astringes the lung relievings asthma, invigorate blood circulation nourish heart, effect of relieving diarrhea with astringents, for cough and asthma due to lung deficiency, uncomfortable in chest pained, dizziness headache, has loose bowels, the cards such as dysentery.
Lignum Aquilariae Resinatum: acrid in the mouth, hardship, warm in nature, return spleen, stomach, kidney, lung meridian, there is sending down the abnormal ascending QI warming middle-JIAO, effect of warming the kidney improving inspiration by invigorating kidney-QI, cure mainly QI rising in reverse order and pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, the cards such as man's cold sperm.
Rhizoma Gastrodiae: sweet in the mouth, property are flat, enter Liver Channel, have suppressing the hyperactive liver to relieve the wind syndrome, spasmolytic, the effect of removing obstruction in the collateral to relieve pain, be mainly used in the dizzy headache of flaming up of liver-fire, the card such as strong wind tic, epilepsy that excessive rising of liver-YANG, liver-wind stirring up internally are caused.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, return lung, the heart, kidney channel, there is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming, for chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, deficient pulse of losing heart, the cards such as interior-heat is quenched one's thirst, palpitation and insomnia.
Fructus Gardeniae: latin name
gardeniaefructus, bitter in the mouth, cold in nature, enter the heart, lung, three burnt, have the effect of relieving restlessness pathogenic fire purging, dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, be mainly used in the vexed uneasiness of epidemic febrile disease heat stagnation breast gastral cavity, bother not peaceful; Stagnation of liver-QI is not relaxed or Liver Channel has having a dizzy spell of heat, pain in chest and hypochondrium, conjunctival congestion dry pharynx; Jaundice due to damp-heat; The symptoms such as the abdominal distention of qi depression to blood stasis.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, pungent loose logical temperature, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gathers around stagnant, chest and diaphragm feeling of fullness and the card such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi.
Herba Cymbopogonis: acrid in the mouth, micro-hardship, warm in nature, have and induce sweat; Dampness removing; Effect of relieving cough and asthma, cures mainly anemofrigid cold; Sunstroke; Vomit and diarrhoea and suffer from abdominal pain; Urine leaching pain; Rheumatic arthralgia; The cards such as cough and asthma.
Herba Cistanches: be the fleshy stem of Orobanchaceae Cistanche Hoffmgg. et Link plants Herba Cistanches and Cistanche Tubulosa, latin name
herbacistanches, sweet in the mouth, salty, warm in nature, enter kidney, large intestine channel, there are kidney-replenishing, benefiting essence-blood, the effect of loosening bowel to relieve constipation, for kidney yang deficiency, the impotence and premature ejaculation of asthenia of essence and blood, sterility and infertility, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, suffer from a deficiency of the kidney dryness of the intestine and puerperal blood deficiency, deficiency of body fluid after being ill the card such as constipation.
Rhizoma Cimicifugae: acrid in the mouth, micro-sweet, cold nature, enters lung, spleen, stomach, large intestine channel, has and deliver rash, heat-clearing and toxic substances removing, effect of elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle; Proctoptosis, the cards such as uterine prolapse.
Semen Sojae Preparatum is fragrant: be leaf and the peel of stem of Oleaceae Osmanthus fabric Radix Polygalae Wattersii, sweet in the mouth, bitter, and property is put down, and have heat clearing and inflammation relieving, effect of hemostasia and promoting granulation, cures mainly chronic tracheitis, and fracture is controlled in external, and the cards such as pain sprained by traumatic hemorrhage.
Flos Osmanthi Fragrantis: acrid in the mouth, warm in nature, return lung, spleen, kidney channel, have warming the lung to resolve fluid-retention, effect of dispersing cold for relieving pain, cures mainly cough due to fluid-retention, coldness and pain in the epigastrium, hemorrhoidal hamorrhage dysentery, amenorrhea dysmenorrhea, toothache, the cards such as halitosis.
Night fragrant flower: be flower, the leaf of asclepiadaceae tuberose plant Radix Oenotherae erythrosepalae, sweet in the mouth, light, property is put down, and have liver heat removing and eyesight improving, removing nebula, effect of removing toxic substances and promoting tissue regeneration, cures mainly conjunctival congestion and swelling pain, and carbuncle skin ulcer such as to be festered at the card.
Rhizoma Polygoni Cuspidati: latin name
polygoniCuspidatiRhizomaetRadix, micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian, there is heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, effect of relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus.
Rhizoma Coptidis: bitter in the mouth, cold in nature, enters the heart, lung, gallbladder, stomach, large intestine channel, has the effect of heat clearing and damp drying, eliminating fire and detoxication, cooling blood for improving eyesight, be longer than the fire of removing pathogen in the heart stomach, have preventing or arresting vomiting concurrently to disappear the merit of painful abdominal mass, can be used for the prosperous caused dysphoria and insomnia for the treatment of heart-fire, and the high fever coma of epidemic febrile disease, vexed, thirsty; Also can be used for damp and hot caused dysentery, tenesmus; The cards such as pyretic toxicity carbuncle sore, eczema, aphtha of the mouth and tongue, epidemic hemorrhagic conjunctivitis, the effect that Rhizoma Coptidis has function of gallbladder promoting, expansion thin vessels, reduces blood pressure, and can leukocytic phagocytic activity be strengthened, there is stronger bacteriostasis to staphylococcus aureus, Hemolytic streptococcus, streptococcus pneumoniae, meningococcus, vibrio cholera, anthrax bacillus, dysentery bacterium.
Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel, have effect of energy tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, the cards such as wind skin ulcer scabies.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, enters the heart, Liver Channel, has promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, and clear away heart-fire relieving restlessness, the effect of nourishing blood to tranquillize the mind, for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.
Traditional perfume is all solvent type product, and essence and flavoring agent is dissolved in ethanol or isopropyl alcohol becomes clear solution.Solvent-borne type perfume appearance looks elegant, preparing process are simple, the fast thus fragrance of the rear evaporation rate of sprinkling easily comes out, and compare and get consumer reception, be the main product in perfume always.But solvent-borne type perfume will use a large amount of ethanol and isopropyl alcohol, also bring many defects thus.Solvent itself, with the abnormal smells from the patient of oneself, although did deodorize process before using, always can not accomplish do not have abnormal smells from the patient completely.In addition, because in product, ethanol content is high, so higher to the zest of skin.
Therefore, the present invention considers to be adopted by Chinese herbal medicine extracting volatile spirits more aqueous solvent to replace alcohol solvent, thus reduces perfume to the strong stimulation of skin.
In addition, Chinese herbal medicine extracting composition in vitro absorbing state is comparatively weak, be difficult to well play drug effect, the present invention is by providing absorption enhancers, impel the perfume with Chinese herbal medicine extracting composition sprayed to obtain on human body skin well to absorb, thus improve its drug effect, better play the effect of calming the nerves.
Present invention also offers one to calm the nerves perfume, its raw material comprises: quintessence oil 3 weight portion ~ 6 weight portion, ethanol 15 weight portion ~ 25 weight portion, glycerol 2 weight portion ~ 5 weight portion, distilled water 95 weight portion ~ 105 weight portion, sodium alginate 1 weight portion ~ 3 weight portion, Chinese herbal medicine absorption enhancers 0.5 weight portion ~ 1.5 weight portion, hydroxypropyl emthylcellulose 0.5 weight portion ~ 1.5 weight portion, pyrrolidone sodium carboxylate 3 ~ 6 parts that said herbal medicine obtains.
Further preferably, in perfume of calming the nerves, the weight of each raw material is respectively quintessence oil 5 weight portion, ethanol 20 weight portion, glycerol 4 weight portion, distilled water 100 weight portion, sodium alginate 2 weight portion, Chinese herbal medicine absorption enhancers 1 weight portion, hydroxypropyl emthylcellulose 1 weight portion, the pyrrolidone sodium carboxylate 4 parts of described Chinese herbal medicine acquisition.
Described Chinese herbal medicine absorption enhancers is modification of chitosan, and chitosan is the product of de-acetyl chitin, and its framing structure passes through β-1 by D-glucosamine; 4-glycosidic bond combines and is formed, and dissolves in acidic aqueous solution, nontoxic; nonirritant, has good biocompatibility and biodegradability.It is generally acknowledged, chitosan is urged mechanism of absorption and is, the positive charge that its molecule carries and cell membrane produce electrostatic interaction, the protein-bonded structure of biomembrane is changed, thus causes the opening of transmembrane channel.Modification of chitosan provided by the invention is
n-octyl group chitosan.
Described
nthe preparation method of-octyl group chitosan is specially: take chitosan 100g, be dissolved in 2L concentration be 2% acetic acid and 2L methanol mixed solvent in, stirred at ambient temperature 12h, thoroughly swellingly to be uniformly dispersed, nitrogen deoxygenation 15min, add octanal 200ml, 6L ethanol is added after the change of reaction 12h system is sticky, continue stirred at ambient temperature 48h, regulate reactant liquor to neutral with 1mol/L potassium hydroxide, rear employing 50g potassium borohydride configuration weak alkaline aqueous solution 60ml, be added drop-wise in reaction bulb with Dropping funnel, continue stirring at room temperature 24h, final reaction liquid 1mol/L hydrochloric acid is adjusted to neutrality, product sucking filtration, and with water, methanol, acetone washs 3 times respectively, collect product in 30 DEG C of vacuum finish-dryings, finally weigh product, obtain
n-octyl group chitosan.
The present invention also provides the preparation method of above-mentioned perfume of calming the nerves, and it comprises:
The first step, joins sodium alginate in part distilled water, is heated to 65 DEG C, and insulation limit, limit is stirred, until sodium alginate is dissolved completely in water, the amount of the distilled water that every 5g sodium alginate uses is 100ml;
Second step, mixes said herbal medicine composition, by extraction element, Chinese herbal medicine quintessence oil is carried out Isolation and purification, collects quintessence oil;
3rd step, the quintessence oil prepared by second step and Chinese herbal medicine absorption enhancers are dissolved in above-mentioned dissolve with ethanol, are stirred to and dissolve completely;
4th step, sodium alginate aqueous solution prepared by the first step, alcoholic solution, glycerol, hydroxypropyl emthylcellulose and pyrrolidone sodium carboxylate prepared by the 3rd step add in the distilled water of surplus, stir, leave standstill after 37 hours, put into sealed container, ageing is after 6 weeks.
Described second step comprises further,
2.1st step, Flos Osmanthi Fragrantis and night fragrant flower be ground into coarse powder respectively, mix, adopt carbon dioxide supercritical fluid extraction, extracting pressure 33 ~ 35MPa, extraction temperature 40 ~ 43 DEG C, extraction time 110 ~ 130min, collects the first quintessence oil;
2.2nd step, Folium Ginkgo, Rhizoma Gastrodiae, Cymbopogon distans (Nees)A. Camus are ground into coarse powder respectively, mix, and adopt carbon dioxide supercritical fluid extraction, extracting pressure 22 ~ 25MPa, extraction temperature 28 ~ 32 DEG C, extraction time 160-180min, collects the second quintessence oil;
2.3rd step, Lignum Aquilariae Resinatum, Semen Sojae Preparatum perfume, Rhizoma Coptidis, Radix Salviae Miltiorrhizae powder are broken into coarse powder, adopt carbon dioxide supercritical fluid extraction, extracting pressure 26 ~ 30MPa, extraction temperature 45 ~ 48 DEG C, extraction time 180 ~ 200min, collect the 3rd quintessence oil;
2.4th step, is ground into coarse powder respectively by remaining components, mixes, and adopts carbon dioxide supercritical fluid extraction, extracting pressure 24 ~ 27MPa, extraction temperature 51 ~ 54 DEG C, extraction time 200 ~ 220min, collects the 4th quintessence oil;
2.5th step, mixes above-mentioned quintessence oil, for subsequent use.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 essential oil of traditional Chinese medicine
By Flos Osmanthi Fragrantis 60g and night fragrant flower 40g be ground into coarse powder respectively, mix, adopt carbon dioxide supercritical fluid extraction, extracting pressure 35MPa, extraction temperature 43 DEG C, extraction time 130min, collects the first quintessence oil, by Folium Ginkgo 20g, Rhizoma Gastrodiae 15g, Cymbopogon distans (Nees)A. Camus 20g is ground into coarse powder respectively, mixes, and adopt carbon dioxide supercritical fluid extraction, extracting pressure 25MPa, extraction temperature 32 DEG C, extraction time 180min, collects the second quintessence oil, by Lignum Aquilariae Resinatum 25g, the fragrant 10g of Semen Sojae Preparatum, Rhizoma Coptidis 30g, Radix Salviae Miltiorrhizae 30g is ground into coarse powder, adopts carbon dioxide supercritical fluid extraction, extracting pressure 30MPa, extraction temperature 48 DEG C, extraction time 200min, collects the 3rd quintessence oil, by Fructus Schisandrae Chinensis 20g, Fructus Gardeniae 15g, Pericarpium Citri Reticulatae 20g, Herba Cistanches 30g, Rhizoma Cimicifugae 15g, Rhizoma Polygoni Cuspidati 25g, Caulis Polygoni Multiflori 30 weight portion, Herba Menthae 20 weight portion is ground into coarse powder respectively, mixes, and adopts carbon dioxide supercritical fluid extraction, extracting pressure 27MPa, extraction temperature 54 DEG C, extraction time 220min, collects the 4th quintessence oil, is mixed by above-mentioned quintessence oil, for subsequent use.
Toxicology detects
(1) rat acute percutaneous toxicity test
1, tested material: essential oil of traditional Chinese medicine prepared by embodiment 1, takes tested material 50g adding distil water modulation finished product 50% pastel for subsequent use.
2, laboratory animal: SD rat 20, male and female half and half, body weight 180-220g.
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.
4, test method: test first 24 hours, in back part of animal spinal column both sides unhairing, unhairing scope is about body surface area 10%.By the dosage (coating amount 1.0g/100g.bw) of 5000mg/kg.bw, examination Mus unhairing position is applied and fixed, after 24 hours, the residual tested material of warm water removing, Continuous Observation 7 days.
5, result of the test: have no examination Mus whole body ANOMALOUS VARIATIONS in the observation period, also have no dead, is coated with the reactions such as tested material local has no red and swollen, festers, inflammation, necrosis.Therefore, to white mouse percutaneous LD female, great and mighty or powerful
50all be greater than 5000mg/kg.bw.
6, evaluate: according to acute dermal toxicity grade scale in DB61-267-1998 " health product Toxicological evaluation program and test method ", this essential oil of traditional Chinese medicine is to the nontoxic level in the true border of rat acute percutaneous toxicity.
(2) repeatedly Skin Irritation Test
1, tested material: essential oil of traditional Chinese medicine prepared by embodiment 1, taking tested material quintessence oil 10g adding distil water, to be modulated into 50% pastel for subsequent use.
2, laboratory animal: Japanese white big ear rabbit 4, male and female half and half, body weight 2.5-3.0kg.
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.
4, test method: test first 24 hours, in every rabbit back spinal column both sides cropping preserved skin, each 3 × 6cm of unhairing scope
2.Only respectively get tested material 0.5g/, be coated on the skin of every rabbit side after modulation, smear every day once, offside all makes solvent control.Smear 14 days continuously.Cropping before being coated with every day, must not injured skin, ensures that tested material fully contacts with skin.Observe dermoreaction and marking every day.Off-test.Get and smear area skin and carry out histopathologic examination.
5, result of the test: repeatedly the highest stimulation index of skin irritation and pathological tissue integration are 0, according to skin irritation strength grading standard in DB61267-1998 " health product Toxicological evaluation program and test method ", this essential oil of traditional Chinese medicine repeatedly skin irritation intensity belongs to nonirritant.
(3) skin anaphylactic test
1, tested material: essential oil of traditional Chinese medicine prepared by embodiment 1, taking tested material quintessence oil 10g adding distil water, to be modulated into 50% pastel for subsequent use.
Positive control: 2,4-dinitro-chloro-benzene (DNCB), produces in Xing Jin chemical plant, Beijing.
2, laboratory animal: Cavia porcellus 30, male and female half and half, body weight 250-300g.
3, animal housing's environment: temperature 22-25 DEG C, relative humidity: 45-55%.
4, test method: test Cavia porcellus is divided into three groups at random, often organize 10, male and female half and half, are respectively tested material group, negative control group and positive controls.
Sensitization contact: guinea pig back left of spine hair was removed in first 24 hours to tested material, unhairing scope about 3 × 3cm.Get tested material 0.2g/ only, after modulation, even application loses hair or feathers district on the left of back part of animal, continues 6 hours.7th day and the 14th day, use the same method and repeat once, positive controls is coated with 1%DNCB, and negative control group does not deal with.
Excite contact: Yu Weici was to after tested material 14 days, and by tested material 0.2g/ only, even application loses hair or feathers district on the right side of guinea pig back after modulation, removes tested material, at once observe anaphylaxis situation, then again observed in 1,24,48,72 hour after 6 hours.Positive controls is coated with 0.1%DNCB, and negative control group does not deal with.Observational technique is with tested group.Result is evaluated according to sensitization of skin evaluation criterion relevant in DB61-267-1998 " health product Toxicological evaluation program and test method ".
5, result of the test: tested group without sensitization negative control without sensitization positive control extremely sensitization
6, evaluate: according to sensitization of skin standard relevant in DB61-267-1998 " health product Toxicological evaluation program and test method ", this essential oil of traditional Chinese medicine belongs to without sensitization.Test proves: tested material group sensitization rate is 0.
Embodiment 2
n-octyl group chitosan
Take chitosan 100g, be dissolved in 2L concentration be 2% acetic acid and 2L methanol mixed solvent in, stirred at ambient temperature 12h, thoroughly swellingly to be uniformly dispersed, nitrogen deoxygenation 15min, add octanal 200ml, 6L ethanol is added after the change of reaction 12h system is sticky, continue stirred at ambient temperature 48h, regulate reactant liquor to neutral with 1mol/L potassium hydroxide, rear employing 50g potassium borohydride configuration weak alkaline aqueous solution 60ml, be added drop-wise in reaction bulb with Dropping funnel, continue stirring at room temperature 24h, final reaction liquid 1mol/L hydrochloric acid is adjusted to neutrality, product sucking filtration, and with water, methanol, acetone washs 3 times respectively, collect product in 30 DEG C of vacuum finish-dryings, finally weigh product, obtain
n-octyl group chitosan.
nthe infrared spectrum of-octyl group chitosan as shown in Figure 1.
Embodiment 3 is calmed the nerves perfume
Joined in 400ml distilled water by sodium alginate 20g, be heated to 65 DEG C, insulation limit, limit is stirred, until sodium alginate is dissolved completely in water, and essential oil of traditional Chinese medicine mixing prepared by 50g embodiment 1, and Chinese herbal medicine absorption enhancers prepared by embodiment 2
n-octyl group chitosan is dissolved in 200g ethanol, be stirred to and dissolve completely, obtain alcoholic solution, to sodium alginate aqueous solution above, alcoholic solution, 40g glycerol, 10g hydroxypropyl emthylcellulose and 40g pyrrolidone sodium carboxylate add in the distilled water of surplus, stir, leave standstill after 37 hours, put into sealed container, ageing is after 6 weeks.
Embodiment 4 mouse experiment
Animal and grouping: Male Kunming strain mice 60, weight (20+2) g.Mice adaptability is divided into 2 groups after raising 1 week at random: matched group 30 and perfume group 30 of calming the nerves.Matched group does not carry out any operation, and perfume group of calming the nerves uses perfume of calming the nerves to be covered with whole space in experimentation.
Experimental technique: mice is put into the center district of the associating open field test case of the 16 hole plates that 40cm × 40cm is housed by behavioral value, starts timing simultaneously.Be mounted with RF transmitter and camera head in associating open field test case, effectively can record various spontaneous activity behavior and the exploratory heading behavior of mice simultaneously.The degree of depth in hole is 2.2cm, is mounted with infrared ray in 1cm depths, and when the exploratory heading degree of depth of mice is more than 1cm, owing to being blocked by infrared ray, instrument will record an exploratory heading behavior automatically, and accumulative exploratory heading number of times.Every mice carries out 6min record continuously, keeps external environment quiet, clean out the Excreta in case at every turn, ensure every batch of objectivity detected as far as possible before putting people mice during operation.
Statistical method
Measurement data adopts
± s represents, compares and adopt χ between group
2inspection, all data all adopt the process of SPSS12.0 statistical software.
Result
Each group of mice central area activity time, activity distance and the time of shuttling back and forth compare, in table 1.
Table 1 respectively compare by group mice central area activity time, activity distance and the time of shuttling back and forth
Table 1 can be found out, no matter be the central area activity time, central area activity distance or shuttle back and forth the time, perfume group of calming the nerves is compared with matched group, and all there were significant differences, p<0.01.
Each group of mice exploratory heading number of times compares, and the results are shown in Table 2.
Table 2 respectively group mice exploratory heading number of times compares
As can be seen from Table 2, perfume group of calming the nerves mice exploratory heading number of times comparatively matched group significant difference, p<0.01.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (7)
1. to calm the nerves a perfume, it is characterized in that: raw material comprises quintessence oil, ethanol, glycerol, distilled water, sodium alginate, Chinese herbal medicine absorption enhancers, hydroxypropyl emthylcellulose and the pyrrolidone sodium carboxylate that Chinese herbal medicine of calming the nerves obtains.
2. to calm the nerves as claimed in claim 1 perfume, it is characterized in that: described in calm the nerves quintessence oil 3 weight portion ~ 6 weight portion, ethanol 15 weight portion ~ 25 weight portion, glycerol 2 weight portion ~ 5 weight portion, distilled water 95 weight portion ~ 105 weight portion, sodium alginate 1 weight portion ~ 3 weight portion, Chinese herbal medicine absorption enhancers 0.5 weight portion ~ 1.5 weight portion, hydroxypropyl emthylcellulose 0.5 weight portion ~ 1.5 weight portion, pyrrolidone sodium carboxylate 3 ~ 6 weight portion that Chinese herbal medicine obtains.
3. to calm the nerves as claimed in claim 1 or 2 perfume, it is characterized in that: described in calm the nerves the raw material of Chinese herbal medicine comprise Folium Ginkgo, Lignum Aquilariae Resinatum, Rhizoma Gastrodiae, Fructus Schisandrae Chinensis, Fructus Gardeniae, Pericarpium Citri Reticulatae, Herba Cymbopogonis, Herba Cistanches, Rhizoma Cimicifugae, Semen Sojae Preparatum perfume, Flos Osmanthi Fragrantis, night fragrant flower, Rhizoma Polygoni Cuspidati, Rhizoma Coptidis, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Herba Menthae.
4. the perfume of calming the nerves as described in claims 1 to 3, is characterized in that: described Chinese herbal medicine absorption enhancers is
n-octyl group chitosan.
5. the perfume of calming the nerves as described in Claims 1-4, is characterized in that: described in
nthe preparation method of-octyl group chitosan is specially: take chitosan 100g, be dissolved in 2L concentration be 2% acetic acid and 2L methanol mixed solvent in, stirred at ambient temperature 12h, thoroughly swellingly to be uniformly dispersed, nitrogen deoxygenation 15min, add octanal 200ml, 6L ethanol is added after the change of reaction 12h system is sticky, continue stirred at ambient temperature 48h, regulate reactant liquor to neutral with 1mol/L potassium hydroxide, rear employing 50g potassium borohydride configuration weak alkaline aqueous solution 60ml, be added drop-wise in reaction bulb with Dropping funnel, continue stirring at room temperature 24h, final reaction liquid 1mol/L hydrochloric acid is adjusted to neutrality, product sucking filtration, and with water, methanol, acetone washs 3 times respectively, collect product in 30 DEG C of vacuum finish-dryings, finally weigh product, obtain
n-octyl group chitosan.
6. to calm the nerves described in claim 1 to 5 preparation method of perfume, it is characterized in that, comprising:
The first step, joins sodium alginate in part distilled water, is heated to 65 DEG C, and insulation limit, limit is stirred, until sodium alginate is dissolved completely in water, the amount of the distilled water that every 5g sodium alginate uses is 100ml;
Second step, mixes said herbal medicine composition, by extraction element, Chinese herbal medicine quintessence oil is carried out Isolation and purification, collects quintessence oil;
3rd step, the quintessence oil prepared by second step and Chinese herbal medicine absorption enhancers are dissolved in above-mentioned dissolve with ethanol, are stirred to and dissolve completely;
4th step, sodium alginate aqueous solution prepared by the first step, alcoholic solution, glycerol, hydroxypropyl emthylcellulose and pyrrolidone sodium carboxylate prepared by the 3rd step add in the distilled water of surplus, stir, leave standstill after 37 hours, put into sealed container, ageing is after 6 weeks.
7. to calm the nerves described in claim 6 preparation method of perfume, it is characterized in that: described second step comprises further,
2.1st step, Flos Osmanthi Fragrantis and night fragrant flower be ground into coarse powder respectively, mix, adopt carbon dioxide supercritical fluid extraction, extracting pressure 33 ~ 35MPa, extraction temperature 40 ~ 43 DEG C, extraction time 110 ~ 130min, collects the first quintessence oil;
2.2nd step, Folium Ginkgo, Rhizoma Gastrodiae, Cymbopogon distans (Nees)A. Camus are ground into coarse powder respectively, mix, and adopt carbon dioxide supercritical fluid extraction, extracting pressure 22 ~ 25MPa, extraction temperature 28 ~ 32 DEG C, extraction time 160-180min, collects the second quintessence oil;
2.3rd step, Lignum Aquilariae Resinatum, Semen Sojae Preparatum perfume, Rhizoma Coptidis, Radix Salviae Miltiorrhizae powder are broken into coarse powder, adopt carbon dioxide supercritical fluid extraction, extracting pressure 26 ~ 30MPa, extraction temperature 45 ~ 48 DEG C, extraction time 180 ~ 200min, collect the 3rd quintessence oil;
2.4th step, is ground into coarse powder respectively by remaining components, mixes, and adopts carbon dioxide supercritical fluid extraction, extracting pressure 24 ~ 27MPa, extraction temperature 51 ~ 54 DEG C, extraction time 200 ~ 220min, collects the 4th quintessence oil;
2.5th step, mixes above-mentioned quintessence oil, for subsequent use.
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| CN106137833A (en) * | 2016-07-14 | 2016-11-23 | 唐虎 | The preparation method of perfume |
| CN111249181A (en) * | 2019-10-11 | 2020-06-09 | 深圳市越昌科技有限公司 | Long-acting slow-release perfume and preparation method thereof |
| CN113082184A (en) * | 2021-04-08 | 2021-07-09 | 安徽宝华药业有限公司 | Traditional Chinese medicine composition for resisting cancer and preparation method thereof |
| CN113181414A (en) * | 2021-01-25 | 2021-07-30 | 福建路合环保科技有限公司 | Natural odor-expelling agent and preparation method and application thereof |
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Denomination of invention: Nerve soothing perfume Effective date of registration: 20181228 Granted publication date: 20180209 Pledgee: Mingguang Company limited by guarantee financing Pledgor: GOLD ONYX PERFUME (MINGGUANG) Co.,Ltd. Registration number: 2018340000773 |
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Denomination of invention: Soothing perfume Effective date of registration: 20231201 Granted publication date: 20180209 Pledgee: Mingguang Company limited by guarantee financing Pledgor: GOLD ONYX PERFUME (MINGGUANG) Co.,Ltd. Registration number: Y2023980068976 |