CN104644512A - Traditional Chinese medicine for acne removing mask - Google Patents
Traditional Chinese medicine for acne removing mask Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine for a lung meridian wind-heat type acne removing mask. The traditional Chinese medicine comprises the following raw materials: mulberry bark, radix ophiopogonis, phellodendron amurense, lalang grass rhizome, herba eupatorii heterophylli, filifoliumsibiricum, lettuce, erberry, wallich swallowwort roots, fructus arctii, radix arnebiae seu lithospermi, hairy euphorbia, semen euryales, rhizoma polygonati, radix angelicae, henbit and radix psuedostellariae. According to a traditional Chinese medicine theory, lung meridian wind-heat type acnes are moved by taking principles of strengthening a spleen, eliminating dampness, dispelling wind, clearing heat, activating blood circulation and eliminating blood stasis; the effect is significant; no side effect is exerted; and the acne removing effect of the mask can be improved better by further adding an absorbent.
Description
Technical field
The present invention relates to cosmetic technical field, particularly relate to a kind of for the Chinese medicine of medicine for treating comedo except facial film.
Background technology
Acne are commonly called as comedo, be equivalent to the acne vulgaris of modern medicine, multiplely be born in 16 ~ 35 years old adolescence face, breast, the hair follicle at back, sebaceous gland, normal with seborrhea, be occur that pimple is as thorn with places such as face, breast, the back ofs the body, can extrude white sample material of cracking rice is the dermatosis of main clinical manifestation." rosacea caused by lung-wind " recorded with ancient literature is similar.Along with living standard improves, the change of people life style, teen-age living habit and way of act also there occurs great changes, and the sickness rate of acne improves year by year.Current due to social pressure, the factors such as individual inheritance, its sickness rate is obvious ascendant trend, is up to 70% ~ 87%.
Western medicine think the morbidity of acne and smegma abnormal, androgen Metabolic disorder, pilosebaceous unit dyskeratosis, infected by microbes about % thus Western medicine by androgen antagonist, suppress sebum secretion, antiinflammatory infection to play the effect of anti-acne, but there is endocrine regulation at present, xerosis cutis is obvious, the side effect such as drug resistance increases, teratogenesis.
Different according to etiology and pathogenesis, acne are divided into wind and heat in the lung meridian, damp-heat in the spleen and stomach, Chong and Ren channel disorder, blood stasis expectorant to tie four types by the traditional Chinese medical science.Lung channel wind-heat type comedo is also called acne vulgaris, it is a kind of acne type the most common, along with lower bound time stamp, the change of human habitat, modern Chinese medicine expert thinks rhythm of life fast, sleep evening getting up early, the factors such as life stress increase easily cause the cloudy liquid consume of human body thus cause deficiency-heat, and this is also the main cause that modern's acne sickness rate raises.The pathogeny of lung channel wind-heat type comedo: lung governing skin and hair, lung meridian accumulated heat, experiences wind heat exopathogen in addition, two hot upper punches, and fumigate skin and fall ill, lung channel wind-heat type comedo main manifestations is: flush, and pimple color is red, or has pustule, or has pain of itching; Companion's thirst and liking drink, constipation, oliguria with reddish urine; Red tongue, yellow and thin fur, floating and rapid pulse.
This name of disease head sees " Waike Zhengzong, Orthodox Manual of External Diseases " and rolls up in four, it is pointed out when describing rosacea caused by lung-wind: " lung-wind syndrome, acne, rosacea three are of the same race; acne belong to lung, rosacea belongs to spleen; caused by total all heat in blood stasis is not loose; describe comparatively in detail and see Golden Mirror of Medicine rosacea caused by lung-wind; this card is formed by lung meridian heat in blood; often send out in face nose, play broken pimple, shape such as broomcorn millet is considered to be worth doing, and red complexion swells and ache, and breaks out white lead juice, with the passing of time all become white scales, visible ancient doctor think rosacea caused by lung-wind etiology and pathogenesis not from " heat in blood stasis do not fall apart ", " lung meridian heat in blood " etc.Later age, doctor had many performances around " heat in blood ", and its cause of disease is that lung-heat, damp-heat in the spleen and stomach, pyretic toxicity, blood stasis expectorant are solidifying etc. dissimilar " newly organized Dermatology of Traditional Chinese Medicine " Suo Shu, and pathogenesis is that interior-heat is flourishing, outer by caused by ailment said due to cold or exposure; This external " Zhu Ren Kang Linchuanjingyanji-skin surgery " saves in note in acne one and also says: acne, the traditional Chinese medical science claims " rosacea caused by lung-wind " or " whelk ", it is relevant with wiping in poor quality cosmetic that women has, therefore claim " acne " male and smoking and drinking and eat stimulus object relevant, therefore title " whelk ".The pathogenesis that " wind (exogenous wind), heat (lung-heat, damp-heat in the spleen and stomach), expectorant (damp-phlegm, heat-phlegm), the stasis of blood (blood stasis) " is rosacea caused by lung-wind morbidity, wherein basic for it with " lung-heat ".
" lung-heat " should be one of pathological process of wind and heat in the lung meridian acne morbidity, it can be used as the Etiological pathogenesis of wind and heat in the lung meridian just difficult logical in reason, is difficult to guidance clinical.Imbalance of YIN and YANG is the pathogenetic pathologic basis of disease: kidney essense loss will inevitably cause the appearance of kidney yang this pathological process partially high " the large opinion of Plain Questions YIN YANG classification of natural phenomena " to be said to a certain extent: " lucid YANG spreading into the body surface, turbid YIN flowing to five ZANG-organs; Lucid YANG replenishing four extremities, turbid YIN moving through six FU-organs." visible, yang-energy is mainly extremity, muscle provides nutrition, and cloudy gas is mainly inherent internal organs and provides nutrition.The partially upright and outspoken of yang-energy connects the heterotrophia affecting muscle extremity, just can cause some pathological changes of space between skin and muscles.The kidney being the origin of congenital constitution, the main the whole body negative and positive of kidney.Kidney is the residence of extreme misery, resides Kidney-Yin (life-gate water) and contains kidney-Yang (fire from the gater of life).The moon of the vital organs of the human body, non-kidney yin can not be nourished; The sun of the vital organs of the human body, non-kidney yang can not be warm: kidney yin is filled, and the moon of each internal organs of whole body also fills; The sun of each internal organs of the prosperous then whole body of kidney yang is also prosperous.So the deficiency of kidney essense also can cause the virtual loss of the cloudy essence of the internal organs such as the heart, liver, spleen, lung and occur the pathological phenomenon that sun is partially high.Therefore the Etiological pathogenesis of lung channel wind-heat type comedo should be: deficiency of kidney-YIN, YIN failing to keep YANG well, even it is dirty to involve the heart, liver, spleen, lung etc., its this genus is empty, and sick position relates to the five internal organs.Therefore, should with invigorating the spleen to clear away damp pathogen, lung heat clearing the kidney invigorating, wind and heat dispersing, blood circulation promoting and blood stasis dispelling, the knot that disappears except thorn be for principle in treatment.
The present invention provides a kind of Chinese medicine eliminating facial film for lung channel wind-heat type comedo on the basis of this theory of Chinese medical science, and it for principle, effectively can eliminate rosacea caused by lung-wind with invigorating the spleen to clear away damp pathogen, wind and heat dispersing, blood circulation promoting and blood stasis dispelling.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine eliminating facial film for lung channel wind-heat type comedo, according to theory of Chinese medical science, lung channel wind-heat type comedo is eliminated for principle with invigorating the spleen to clear away damp pathogen, wind and heat dispersing, blood circulation promoting and blood stasis dispelling, Be very effective, and have no side effect, the elimination acne effect of facial film better can be improved further by interpolation absorption enhancers.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine eliminating facial film for lung channel wind-heat type comedo, its crude drug comprises Cortex Mori, Radix Ophiopogonis, Cortex Phellodendri, Rhizoma Imperatae, red stalk grass, rabbit hair Artemisia, Caulis et Folium Lactucae sativae, Ramulus Sambuci Williamsii, Radix cynanchi wallichii, Fructus Arctii, Radix Arnebiae (Radix Lithospermi), Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Rhizoma Polygonati, the Radix Angelicae Dahuricae, Herba Lamii Amplexicaulis and Radix Pseudostellariae.
Wherein, each crude drug weight of described Chinese medicine be respectively Cortex Mori 20g ~ 30g, Radix Ophiopogonis 35g ~ 45g, Cortex Phellodendri 40g ~ 50g, Rhizoma Imperatae 15g ~ 25g, red stalk grass 10g ~ 20g, rabbit hair Artemisia 10g ~ 20g, Caulis et Folium Lactucae sativae 15g ~ 25g, Ramulus Sambuci Williamsii 10g ~ 20g, Radix cynanchi wallichii 20g ~ 30g, Fructus Arctii 15g ~ 25g, Radix Arnebiae (Radix Lithospermi) 15g ~ 25g, Ramulus et Folium Bauhiniae Faberi 20g ~ 30g, Semen Euryales 20g ~ 30g, Rhizoma Polygonati 35g ~ 45g, Radix Angelicae Dahuricae 10g ~ 20g, Herba Lamii Amplexicaulis 15g ~ 25g and Radix Pseudostellariae 25g ~ 35g.
Wherein, each crude drug weight of described Chinese medicine be respectively Cortex Mori 25g ~ 30g, Radix Ophiopogonis 40g ~ 45g, Cortex Phellodendri 45g ~ 50g, Rhizoma Imperatae 20g ~ 25g, red stalk grass 15g ~ 20g, rabbit hair Artemisia 15g ~ 20g, Caulis et Folium Lactucae sativae 20g ~ 25g, Ramulus Sambuci Williamsii 15g ~ 20g, Radix cynanchi wallichii 25g ~ 30g, Fructus Arctii 15g ~ 20g, Radix Arnebiae (Radix Lithospermi) 15g ~ 20g, Ramulus et Folium Bauhiniae Faberi 20g ~ 25g, Semen Euryales 20g ~ 25g, Rhizoma Polygonati 40g ~ 45g, Radix Angelicae Dahuricae 15g ~ 20g, Herba Lamii Amplexicaulis 20g ~ 25g and Radix Pseudostellariae 30g ~ 35g.
Wherein, each crude drug weight of described Chinese medicine be respectively Cortex Mori 25g, Radix Ophiopogonis 40g, Cortex Phellodendri 45g, Rhizoma Imperatae 20g, red stalk grass 15g, rabbit hair Artemisia 15g, Caulis et Folium Lactucae sativae 20g, Ramulus Sambuci Williamsii 15g, Radix cynanchi wallichii 25g, Fructus Arctii 20g, Radix Arnebiae (Radix Lithospermi) 20g, Ramulus et Folium Bauhiniae Faberi 25g, Semen Euryales 25g, Rhizoma Polygonati 40g, Radix Angelicae Dahuricae 15g, Herba Lamii Amplexicaulis 20g and Radix Pseudostellariae 30g.
Wherein, described Chinese drug preparation becomes volatile oil clathrate compound.
Wherein, the preparation method of described Chinese medicine specifically comprises:
A walks, and gets above-mentioned each crude drug and pulverizes respectively, mix by weight, add 8 times of water gagings, soaked overnight, with volatile oil extractor extraction by steam distillation volatile oil 5 hours routinely, then after anhydrous sodium sulfate dehydration, obtains volatile oil;
B walks, and gets above-mentioned volatile oil, adds dehydrated alcohol, be made into volume ratio volatile oil: dehydrated alcohol=1: the mixed solution of 1; Get beta-schardinger dextrin-4 weight portion, add distilled water, be made into percentage by weight 4%-cyclodextrin solution, stir, 55 ~ 65 DEG C of heating in water bath make dissolving, are cooled to 50 DEG C, the mixed solution of above-mentioned volatile oil and dehydrated alcohol is added under stirring condition, sealing, temperature control 40 DEG C stirs 4 hours, cold preservation 12 ~ 24h, sucking filtration, precipitation, 30 ~ 50 DEG C of vacuum dryings, obtain volatile oil clathrate compound.
The present invention also provides a kind of facial film, and it comprises above-mentioned Chinese medicine and absorption enhancers.
Wherein, described absorption enhancers can adopt chitosan,
Wherein, described absorption enhancers can adopt chitosan derivatives, is specially the glycosyl galactose palmityl chitosan shown in following formula,
In formula,
Beneficial effect of the present invention:
The invention provides a kind of Chinese medicine of the facial film for eliminating lung channel wind-heat type comedo, according to theory of Chinese medical science, lung channel wind-heat type comedo is eliminated for principle with invigorating the spleen to clear away damp pathogen, wind and heat dispersing, blood circulation promoting and blood stasis dispelling, Be very effective, and have no side effect, the elimination acne effect of facial film better can be improved further by interpolation absorption enhancers.
Accompanying drawing explanation
Fig. 1 is the infrared spectrum of absorption enhancers.
Detailed description of the invention
The invention provides a kind of elimination facial film of lung channel wind-heat type comedo, its raw material comprises Chinese medicine composition extract, absorption enhancers, polyvinyl alcohol, titanium dioxide, sodium carboxymethyl cellulose, glycerol, ethanol, essence, methyl hydroxybenzoate, deionized water.
Further preferably, described facial film is only made up of above-mentioned raw materials.
In described facial film, the weight of each raw material is respectively: in every 100g raw mixture, Chinese medicine composition extract 3 ~ 5g, absorption enhancers 1 ~ 2g, polyvinyl alcohol 8 ~ 12g, titanium dioxide 1 ~ 2g, sodium carboxymethyl cellulose 2 ~ 4g, glycerol 2 ~ 5g, ethanol 10 ~ 15g, essence 0.5 ~ 0.8g, methyl hydroxybenzoate 0.1 ~ 0.3g, balance deionized water.
Further preferably, in described facial film, the weight of each raw material is respectively: in every 100g raw mixture, Chinese medicine composition extract 5g, absorption enhancers 2g, polyvinyl alcohol 10g, titanium dioxide 1g, sodium carboxymethyl cellulose 3g, glycerol 3g, ethanol 12g, essence 0.6g, methyl hydroxybenzoate 0.2g, balance deionized water.
Present invention also offers the preparation method of above-mentioned facial film, comprising:
The first step, prepares described Chinese medicine composition extract;
Second step, prepares absorption enhancers;
3rd step, by weight weighing polyvinyl alcohol, uses a small amount of ethanol wet, leave standstill 10min, then add 70 DEG C ~ 80 DEG C appropriate hot water, be placed in 80 DEG C ± 5 DEG C water-baths and fully stir, dissolve completely, take titanium dioxide, sodium carboxymethyl cellulose and glycerol, add in appropriate amount of deionized water, be placed in 80 DEG C ± 5 DEG C water-baths and fully mix, until dissolve, while hot by above-mentioned 2 kinds of solution mix homogeneously, obtain viscous solution;
4th step, takes Chinese medicine composition extract prepared by the first step, absorption enhancers, methyl hydroxybenzoate and essence prepared by second step by weight, is dissolved in remaining ethanol;
5th step, when the viscous solution that the 3rd step obtains is cooled to 40 DEG C ~ 50 DEG C, adds the alcoholic solution that the 4th step obtains, stirs, obtain facial film.
The crude drug of described Chinese medicine composition extract comprises Cortex Mori, Radix Ophiopogonis, Cortex Phellodendri, Rhizoma Imperatae, red stalk grass, rabbit hair Artemisia, Caulis et Folium Lactucae sativae, Ramulus Sambuci Williamsii, Radix cynanchi wallichii, Fructus Arctii, Radix Arnebiae (Radix Lithospermi), Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Rhizoma Polygonati, the Radix Angelicae Dahuricae, Herba Lamii Amplexicaulis and Radix Pseudostellariae.
Fang Zhong, Cortex Mori eliminating pathogen from the lung for relieving asthma, Radix Ophiopogonis nourishing YIN and moistening the lung, heat clearing away is nourished heart, the careless promoting blood flow to regulate menstruation of red stalk, Cortex Phellodendri heat clearing and damp drying, eliminating fire and detoxication, Rhizoma Imperatae cooling blood for hemostasis, clearing away heat and promoting diuresis, Herba Murdanniae Divergentis lung heat clearing is defended, expelling pathogenic factors from muscles table scorching hot, rabbit hair Artemisia mind tranquilizing and the heart calming, Caulis et Folium Lactucae sativae heat-clearing and toxic substances removing, Ramulus Sambuci Williamsii expelling wind and activating blood circulation, Radix cynanchi wallichii invigorating the kidney and strengthening the bones, Herba clinopodii confinis (Herba Clinopodii Gracilis) promoting flow of QI and blood, removing toxic substances and promoting subsidence of swelling, Fructus Arctii heat-clearing and toxic substances removing rash, Radix Arnebiae (Radix Lithospermi) removing heat from blood and promoting blood circulation, removing toxic substances rash, Ramulus et Folium Bauhiniae Faberi heat-clearing and toxic substances removing, Semen Euryales supplementing the kidney to control the nocturnal, Rhizoma Polygonati spleen invigorating lung moistening, the Radix Angelicae Dahuricae induces sweat cold expelling, wind-expelling pain-stopping, Herba Lamii Amplexicaulis promoting blood circulation to remove obstruction in the collateral, removing toxic substances and promoting subsidence of swelling, Radix Pseudostellariae the lung moistening and production of body fluid promoting, all medicines share, play invigorating the spleen to clear away damp pathogen altogether, wind and heat dispersing, the merit of blood circulation promoting and blood stasis dispelling.
Further preferably, the crude drug of described Chinese medicine composition extract is only made up of above-mentioned raw materials medicine.
Cortex Mori: latin name Mori Cortex, sweet in the mouth, cold in nature, enter lung meridian, there is eliminating pathogen from the lung for relieving asthma, effect of inducing diuresis to remove edema, for lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.
Radix Ophiopogonis: latin name Ophiopogonis Radix, sweet in the mouth, micro-hardship, cold nature, enter the heart, lung, stomach warp, there is nourishing YIN and moistening the lung, effect that preventing phlegm from forming and stopping coughing, heat clearing away are nourished heart, cure mainly pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN has the dry cough expectorant of heat to stick, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, thermal burn stomach-Yin or the dry mouth and throat caused by deficiency of stomach-Yin, the few tongue of red tongue, vague epigastralgia, interior-heat is quenched one's thirst, constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and dryly wait card.
Cortex Phellodendri: latin name Phellodendri Chinensis Cortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the cards such as eczema pruritus.
Rhizoma Imperatae: sweet in the mouth, cold in nature, enter lung, stomach, urinary bladder channel, have the effect of cooling blood for hemostasis, clearing away heat and promoting diuresis, be mainly used in haematemesis, hemoptysis that lung stomach has accumulated heat; Damp invasion of lower energizer pents up the hematuria of bladder; Calentura excessive thirst taking fluids profusely; Gastropyretic vomiting; The cards such as jaundice due to damp-heat.
Red stalk grass: be the herb of the different leaf Herba Lycopi of Compositae feverwort, sweet in the mouth, hardship, slightly warm in nature, returns liver, kidney channel, has promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, effect of dehumidifying row water, cures mainly menoxenia, amenorrhea, stomachache, disease that postpartum lochia can't go, edema, traumatic injury, the cards such as fracture.
Rabbit hair Artemisia: be the herb of Compositae line Dendranthema Filifolium sibiricum (Linn.) Kitam., bitter in the mouth, cold in nature, there is heat-clearing and toxic substances removing, anti-inflammation, calm the nerves relieving convulsion, effect of regulating menstruation, hemostasis, cure mainly the high heat of infectious disease, heart beating, insomnia, neurasthenia, menorrhagia, the cards such as menoxenia.
Herba Murdanniae Divergentis: be root or the herb of Commeline communis section water leaf spp plant purple back of the body Herba Pyrolae, sweet in the mouth, micro-hardship, property is put down, and have clearing away lung-heat to relieve cough, invigorating the lung and the kidney, effect of regulating menstruation, hemostasis, cures mainly cough due to lung-heat, and the deficiency of vital energy is breathed with cough, dizziness and tinnitus, fracture, spits blood.
Caulis et Folium Lactucae sativae: be stem and the leaf of Compositae Herba Lactucae Indicae platymiscium Caulis et Folium Lactucae sativae, bitter in the mouth, sweet, cool in nature, return stomach, small intestine meridian, there is diuresis, lactogenesis, the cards such as effect of heat-clearing and toxic substances removing, cures mainly dysuria, hematuria, galactostasis, worm venom.
Radix cynanchi wallichii: sweet in the mouth, micro-hardship, warm in nature, have Bu Shen Zhuang waist, bone and muscle strengthening, effect of removing toxic substances, cures mainly lumbago due to renal deficiency, the foot and knee being feeble, traumatic injury, fracture, the cards such as lyssodexis.
Herba clinopodii confinis (Herba Clinopodii Gracilis): be the herb of Labiatae Clinopodium plant C. gracile and C. confine, bitter in the mouth, pungent, cool in nature, there is expelling wind and clearing away heat, promoting flow of QI and blood, effect of removing toxic substances and promoting subsidence of swelling, cure mainly cold, fever, abdominal pain due to retention of food, vomiting, have loose bowels, dysentery, diphtheria, laryngopharynx swelling and pain, carbuncle erysipelas, urticaria, venom, treating swelling and pain by traumatic injury, the cards such as traumatic hemorrhage.
Ramulus Sambuci Williamsii: be the stem branch of Caprifoliaceae Sambucus plant Ramulus Sambuci Williamsii, sambucus buergeriana Blume and Sambucus nigra L., sweet in the mouth, hardship, property is put down, return Liver Channel, there is expelling wind and removing dampness, effect of promoting blood circulation and hemostasis, cure mainly rheumatic arthralgia, gout, Kaschin-Beck disease, acute and chronic nephritis, rubella, traumatic injury, the cards such as fracture swells and ache, traumatic hemorrhage.
Fructus Arctii: acrid in the mouth is bitter; Cold in nature, return lung, stomach warp, has dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, and lung qi dispersing sore-throat relieving falls apart swollen effect, cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; The card such as sore swollen toxin and mumps.
Radix Arnebiae (Radix Lithospermi): cold in nature, sweet in the mouth, one-tenth, GUIXIN, Liver Channel, have removing heat from blood and promoting blood circulation, effect of removing toxic substances rash.Contain for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood, for measles, calentura skin eruption, eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, the cards such as constipation with heat retention.
Ramulus et Folium Bauhiniae Faberi: latin name Euphorbiae Hirate Herba, mildly bitter flavor, micro-acid, cool in nature, there is heat-clearing and toxic substances removing, effect that dampness removing is antipruritic, for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; The cards such as eczema, dermatitis, skin pruritus are controlled in external.
Semen Euryales: sweet in the mouth, puckery, property is put down.Return spleen, kidney channel.Have supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, the function of damp eliminating leukorrhagia stopping, cures mainly emission, diarrhea due to hypofunction of the spleen, and insufficiency of the spleen nebulousurine is with inferior card.
Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, has enriching qi and yin, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature, enter lung, spleen, stomach warp, there is the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.
Herba Lamii Amplexicaulis: be the herb of Labiatae lamium plant Herba Lamii Amplexicaulis, acrid in the mouth, hardship, slightly warm in nature, has promoting blood circulation to remove obstruction in the collateral, and effect of removing toxic substances and promoting subsidence of swelling, cures mainly traumatic injury, bones and muscles pain, numb limbs and tense tendons, hemiplegia, facial paralysis, jaundice, nasal sinusitis, toxic swelling, the cards such as impetigo.
Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down, and enters spleen, lung meridian, there is air making-up and spleen enlivening, the effect of the lung moistening and production of body fluid promoting, for the lack of appetite asthenia of deficiency-weakness of spleen-QI, deficiency of stomach-Yin, energy strengthening the spleen gas, nourishing stomach-YIN, for deficiency of the lung cough caused by dryness and cardiopalmus sleeplessness, the deficiency-heat hyperhidrosis of deficiency of vital energy Tianjin wound, energy supplementing QI for promoting the production of body fluid, control deficiency of vital energy xeropulmonary cough, the card such as cardiopalmus sleeplessness, hyperhidrosis of deficiency of both QI and YIN, Radix Pseudostellariae can improve myocardial contraction, stops Ca
2+interior stream is to reduce the generation of tachy-arrhythmia.
Each crude drug weight of described Chinese medicine composition extract be respectively Cortex Mori 20g ~ 30g, Radix Ophiopogonis 35g ~ 45g, Cortex Phellodendri 40g ~ 50g, Rhizoma Imperatae 15g ~ 25g, red stalk grass 10g ~ 20g, rabbit hair Artemisia 10g ~ 20g, Caulis et Folium Lactucae sativae 15g ~ 25g, Ramulus Sambuci Williamsii 10g ~ 20g, Radix cynanchi wallichii 20g ~ 30g, Fructus Arctii 15g ~ 25g, Radix Arnebiae (Radix Lithospermi) 15g ~ 25g, Ramulus et Folium Bauhiniae Faberi 20g ~ 30g, Semen Euryales 20g ~ 30g, Rhizoma Polygonati 35g ~ 45g, Radix Angelicae Dahuricae 10g ~ 20g, Herba Lamii Amplexicaulis 15g ~ 25g and Radix Pseudostellariae 25g ~ 35g.
Further preferably, each crude drug weight of described Chinese medicine composition extract be respectively Cortex Mori 25g ~ 30g, Radix Ophiopogonis 40g ~ 45g, Cortex Phellodendri 45g ~ 50g, Rhizoma Imperatae 20g ~ 25g, red stalk grass 15g ~ 20g, rabbit hair Artemisia 15g ~ 20g, Caulis et Folium Lactucae sativae 20g ~ 25g, Ramulus Sambuci Williamsii 15g ~ 20g, Radix cynanchi wallichii 25g ~ 30g, Fructus Arctii 15g ~ 20g, Radix Arnebiae (Radix Lithospermi) 15g ~ 20g, Ramulus et Folium Bauhiniae Faberi 20g ~ 25g, Semen Euryales 20g ~ 25g, Rhizoma Polygonati 40g ~ 45g, Radix Angelicae Dahuricae 15g ~ 20g, Herba Lamii Amplexicaulis 20g ~ 25g and Radix Pseudostellariae 30g ~ 35g.
The rightest choosing, each crude drug weight of described Chinese medicine composition extract be respectively Cortex Mori 25g, Radix Ophiopogonis 40g, Cortex Phellodendri 45g, Rhizoma Imperatae 20g, red stalk grass 15g, rabbit hair Artemisia 15g, Caulis et Folium Lactucae sativae 20g, Ramulus Sambuci Williamsii 15g, Radix cynanchi wallichii 25g, Fructus Arctii 20g, Radix Arnebiae (Radix Lithospermi) 20g, Ramulus et Folium Bauhiniae Faberi 25g, Semen Euryales 25g, Rhizoma Polygonati 40g, Radix Angelicae Dahuricae 15g, Herba Lamii Amplexicaulis 20g and Radix Pseudostellariae 30g.
Present invention also offers the extracting mode of above-mentioned Chinese medicine composition extract, comprising:
The first step, gets above-mentioned each crude drug and pulverizes respectively, mix by weight, add 8 times of water gagings, soaked overnight, with volatile oil extractor extraction by steam distillation volatile oil 5 hours routinely, then after anhydrous sodium sulfate dehydration, obtains volatile oil;
Second step, gets above-mentioned volatile oil, adds dehydrated alcohol, is made into volume ratio volatile oil: dehydrated alcohol=1: the mixed solution of 1; Get beta-schardinger dextrin-4 weight portion, add distilled water, be made into percentage by weight 4%-cyclodextrin solution, stir, 55 ~ 65 DEG C of heating in water bath make dissolving, are cooled to 50 DEG C, the mixed solution of above-mentioned volatile oil and dehydrated alcohol is added under stirring condition, sealing, temperature control 40 DEG C stirs 4 hours, cold preservation 12 ~ 24h, sucking filtration, precipitation, 30 ~ 50 DEG C of vacuum dryings, obtain volatile oil clathrate compound.
Cyclodextrin derives by starch a kind of cyclic oligosaccharide obtained, there is the tubular hollow structure of rigidity, because cyclodextrin interior cavity surface is hydrophobic, surface and hydrophilic outer, there is certain bioadhesive, can enclose insoluble drug, improve dissolubility and the bioavailability of medicinal herb components, the bad smell of Chinese herbal medicine can be covered simultaneously, improve stability, therefore, Chinese medicine composition extract provided by the invention adopts volatile oil clathrate compound, better can promote that it is eliminating the effect in acne process.
Chitosan-phospholipid complex is be connected on cell membrane with the positive charge that its molecule carries as the mechanism of action of penetration enhancement agent, the protein-bonded structure of intercellular tight is changed, thus cause the opening of transmembrane channel, and this effect is reversible, damage can not be caused to the tight structure of mucosal epithelium, the present invention impels Effective Component of Chinese Medicine to be better absorbed by the skin by adopting the agent of specific chitosan penetration enhancement, improves the effect eliminating acne.
Absorbent of the present invention can adopt commercially available chitosan, also can adopt chitosan derivatives, is specially the glycosyl galactose palmityl chitosan shown in following formula,
In formula,
Present invention also offers the preparation method of above-mentioned glycosyl galactose palmityl chitosan, comprising:
The first step, takes 10g chitosan, slowly stirs and is dissolved in 250mL methanesulfonic acid, be transferred in 1L three-necked bottle, put up device, add the Hexadecanoyl chloride relative to chitosan mole 2 times, react 1h at 20 DEG C, after having reacted, add excessive distilled water, with the acyl chloride reaction do not reacted, generate fatty acid, add the amino deprotection that 250mL ammonia makes to become sulfonate, filter, with excessive acetone reflux to remove fatty acid, sucking filtration, filtering residue acetone drip washing 3 times, dry 12h;
Second step, 8g lactobionic acid and 8g 1-ethyl-(3-dimethylaminopropyl) phosphinylidyne diimmonium salt hydrochlorate (EDCHCl) are dissolved in 200mL DMSO, obtain colourless transparent solution, in reaction vessel, product prepared by the 4g first step is dissolved in 200mL DMSO, adds clear solution above, 24h is reacted at 30 DEG C, reactant liquor distill water dialysis 24h, lyophilization, to obtain final product.
It is pointed out that the consumption in preparation process is herein only a citing, according to the size of weight doing the product needed, adjust corresponding data at double.
The proportionate relationship occurred in the present invention unless otherwise indicated, is all part by weight relation.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition extract 1
Get Cortex Mori 25g, Radix Ophiopogonis 40g, Cortex Phellodendri 45g, Rhizoma Imperatae 20g, the careless 15g of red stalk, rabbit hair Artemisia 15g, Caulis et Folium Lactucae sativae 20g, Ramulus Sambuci Williamsii 15g, Radix cynanchi wallichii 25g, Fructus Arctii 20g, Radix Arnebiae (Radix Lithospermi) 20g, Ramulus et Folium Bauhiniae Faberi 25g, Semen Euryales 25g, Rhizoma Polygonati 40g, Radix Angelicae Dahuricae 15g, Herba Lamii Amplexicaulis 20g and Radix Pseudostellariae 30g pulverizes respectively, mixing, add 8 times of water gagings, soaked overnight, with volatile oil extractor extraction by steam distillation volatile oil 5 hours routinely, again after anhydrous sodium sulfate dehydration, obtain volatile oil, get above-mentioned volatile oil, add dehydrated alcohol, be made into volume ratio volatile oil: dehydrated alcohol=1: the mixed solution of 1, get beta-schardinger dextrin-4 weight portion, add distilled water, be made into percentage by weight 4%-cyclodextrin solution, stir, 60 DEG C of heating in water bath make dissolving, are cooled to 50 DEG C, the mixed solution of above-mentioned volatile oil and dehydrated alcohol is added under stirring condition, sealing, temperature control 40 DEG C stirs 4 hours, cold preservation 24h, sucking filtration, precipitation, 30 DEG C of vacuum dryings, obtain volatile oil clathrate compound.
Embodiment 2 Chinese medicine composition extract 2
Get Cortex Mori 30g, Radix Ophiopogonis 45g, Cortex Phellodendri 50g, Rhizoma Imperatae 25g, the careless 20g of red stalk, rabbit hair Artemisia 20g, Caulis et Folium Lactucae sativae 25g, Ramulus Sambuci Williamsii 20g, Radix cynanchi wallichii 30g, Fructus Arctii 20g, Radix Arnebiae (Radix Lithospermi) 20g, Ramulus et Folium Bauhiniae Faberi 25g, Semen Euryales 25g, Rhizoma Polygonati 45g, Radix Angelicae Dahuricae 20g, Herba Lamii Amplexicaulis 25g and Radix Pseudostellariae 35g pulverizes respectively, mixing, add 8 times of water gagings, soaked overnight, with volatile oil extractor extraction by steam distillation volatile oil 5 hours routinely, again after anhydrous sodium sulfate dehydration, obtain volatile oil, get above-mentioned volatile oil, add dehydrated alcohol, be made into volume ratio volatile oil: dehydrated alcohol=1: the mixed solution of 1, get beta-schardinger dextrin-4 weight portion, add distilled water, be made into percentage by weight 4%-cyclodextrin solution, stir, 60 DEG C of heating in water bath make dissolving, are cooled to 50 DEG C, the mixed solution of above-mentioned volatile oil and dehydrated alcohol is added under stirring condition, sealing, temperature control 40 DEG C stirs 4 hours, cold preservation 24h, sucking filtration, precipitation, 30 DEG C of vacuum dryings, obtain volatile oil clathrate compound.
Embodiment 3 Chinese medicine composition extract 3
Get Cortex Mori 25g, Radix Ophiopogonis 40g, Cortex Phellodendri 45g, Rhizoma Imperatae 20g, the careless 15g of red stalk, rabbit hair Artemisia 15g, Caulis et Folium Lactucae sativae 20g, Ramulus Sambuci Williamsii 15g, Radix cynanchi wallichii 25g, Fructus Arctii 15g, Radix Arnebiae (Radix Lithospermi) 15g, Ramulus et Folium Bauhiniae Faberi 20g, Semen Euryales 20g, Rhizoma Polygonati 40g, Radix Angelicae Dahuricae 15g, Herba Lamii Amplexicaulis 20g and Radix Pseudostellariae 30g pulverizes respectively, mixing, add 8 times of water gagings, soaked overnight, with volatile oil extractor extraction by steam distillation volatile oil 5 hours routinely, again after anhydrous sodium sulfate dehydration, obtain volatile oil, get above-mentioned volatile oil, add dehydrated alcohol, be made into volume ratio volatile oil: dehydrated alcohol=1: the mixed solution of 1, get beta-schardinger dextrin-4 weight portion, add distilled water, be made into percentage by weight 4%-cyclodextrin solution, stir, 60 DEG C of heating in water bath make dissolving, are cooled to 50 DEG C, the mixed solution of above-mentioned volatile oil and dehydrated alcohol is added under stirring condition, sealing, temperature control 40 DEG C stirs 4 hours, cold preservation 24h, sucking filtration, precipitation, 30 DEG C of vacuum dryings, obtain volatile oil clathrate compound.
Embodiment 4 absorption enhancers
Take 100g chitosan, slow stirring is dissolved in 2.5L methanesulfonic acid, be transferred in 5L three-necked bottle, put up device, add the Hexadecanoyl chloride relative to chitosan mole 2 times, 1h is reacted at 20 DEG C, excessive distilled water is added after having reacted, with the acyl chloride reaction do not reacted, generate fatty acid, add the amino deprotection that 2.5L ammonia makes to become sulfonate, filter, with excessive acetone reflux to remove fatty acid, sucking filtration, filtering residue acetone drip washing 3 times, dry 12h, obtain intermediate product, 80g lactobionic acid and 80g 1-ethyl-(3-dimethylaminopropyl) phosphinylidyne diimmonium salt hydrochlorate (EDCHCl) are dissolved in 2L DMSO, obtain colourless transparent solution, in reaction vessel, the intermediate product prepared above by 40g is dissolved in 2L DMSO, add clear solution above, 24h is reacted at 30 DEG C, reactant liquor distill water dialysis 24h, lyophilization, obtain.
The infrared spectrum of product is shown in Fig. 1.Along with an OH is substituted, wide and strong weakening through base peak originally, emerging 2926cm
-1, 2856cm
-1place is the secondary contracting vibration absorption peak of saturated C-H, 1744cm
-1place is the contracting second month in a season vibration absorption peak of ester carbonyl group, 1402cm
-1represent the in-plane bending vibration of saturated C-H, 721cm
-1place is the correlation absorption band of long-chain methylene, proves that fatty acyl group successfully grafts in chitosan molecule.
Embodiment 5 facial film 1
Weighing polyvinyl alcohol 10g by weight, use a small amount of ethanol wet, leave standstill 10min, then 70 DEG C of appropriate hot water are added, be placed in 80 DEG C ± 5 DEG C water-baths fully to stir, dissolve completely, take titanium dioxide 1g, sodium carboxymethyl cellulose 3g and glycerol 3g, add in appropriate amount of deionized water, be placed in 80 DEG C ± 5 DEG C water-baths fully to mix, until dissolve, while hot by above-mentioned 2 kinds of solution mix homogeneously, obtain viscous solution, take volatile oil clathrate compound 5g prepared by embodiment 1, absorption enhancers 2g prepared by embodiment 4, methyl hydroxybenzoate 0.2g and essence 0.6g, be dissolved in remaining ethanol, obtain alcoholic solution, when the viscous solution obtained above is cooled to 45 DEG C, add the alcoholic solution obtained below, stir, obtain facial film 1.
Embodiment 6 facial film 2
Weighing polyvinyl alcohol 10g by weight, use a small amount of ethanol wet, leave standstill 10min, then 70 DEG C of appropriate hot water are added, be placed in 80 DEG C ± 5 DEG C water-baths fully to stir, dissolve completely, take titanium dioxide 1g, sodium carboxymethyl cellulose 3g and glycerol 3g, add in appropriate amount of deionized water, be placed in 80 DEG C ± 5 DEG C water-baths fully to mix, until dissolve, while hot by above-mentioned 2 kinds of solution mix homogeneously, obtain viscous solution, take volatile oil clathrate compound 5g prepared by embodiment 1, methyl hydroxybenzoate 0.2g and essence 0.6g, be dissolved in remaining ethanol, obtain alcoholic solution, when the viscous solution obtained above is cooled to 45 DEG C, add the alcoholic solution obtained below, stir, obtain facial film 2.
Safety evaluatio
Acute dermal toxicity is tested
Albino guinea-pig 40, male and female half and half.Weight 272.4 ± 8.89, is divided into matrix group and facial film group (5 times) at random.Experiment before 24h shave except animal trunk back intend contamination region by hair, be about 30-40cm
2.By tested material (gl) even application in back part of animal, closing contact 24h.The activity of Continuous Observation 1d5 endogenous murine, diet.The toxic reaction of body weight change and death condition and local skin and whole body.At skin sensibiligen duration of test, freely, diet is good, fur gloss in mice activity, and feces is normal, and no significant difference between the rheological parameters' change with time group of weight, also end sees that whole body acute poisoning is reacted.
Acute skin irritation test
Get albino guinea-pig 16 that is adult, healthy, skin zero damage, male and female half and half, weight 304.7 ± 0.89.Before experiment, 24h conventional method shaves hair.Employing own control designs, and left side gives facial film (5 times), and right side gives substrate (each gl).Preservative film parcel 24h.Warm water is removed after tested material, at once observe 1h, 24,48h, 72h to 7d be coated with the dermoreaction holding position, carries out the evaluation of dermoreaction anomalous integral stimulus intensity.The vestige of the visible local immobilization with adhesive tape of removing tested material, the irritant reaction of facial film 5 multiple dose group, only has 1/8, and is inadequate visible erythema, disappears after 6h.According to skin irritation reaction standards of grading, calculating its stimulus intensity is 0.2.
Comparative example 1 facial film 3
Weighing polyvinyl alcohol 10g by weight, use a small amount of ethanol wet, leave standstill 10min, then 70 DEG C of appropriate hot water are added, be placed in 80 DEG C ± 5 DEG C water-baths fully to stir, dissolve completely, take titanium dioxide 1g, sodium carboxymethyl cellulose 3g and glycerol 3g, add in appropriate amount of deionized water, be placed in 80 DEG C ± 5 DEG C water-baths fully to mix, until dissolve, while hot by above-mentioned 2 kinds of solution mix homogeneously, obtain viscous solution, take methyl hydroxybenzoate 0.2g and essence 0.6g, be dissolved in remaining ethanol, obtain alcoholic solution, when the viscous solution obtained above is cooled to 45 DEG C, add the alcoholic solution obtained below, stir, obtain facial film 3.
Effect data
240 routine patients are all in August, 2012 ~ in JIUYUE, 2013 to the medical acne patient of Dermatology Outpatient Department.15 ~ 30 years old age.Diagnosis meets the diagnostic criteria (with reference to beauty treatment Chinese medicine the 2nd edition) of doctor trained in Western medicine unusual acne diagnostic criteria (with reference to " new Chinese medicine guideline of clinical investigations " 2001 editions) and traditional Chinese medical science lung channel wind-heat type comedo.Wherein, male patient 129 example, female patient 151 example; Age is between 16 years old ~ 32 years old.240 routine patients are divided into three groups at random, are respectively treatment 1 group, treat 2 groups and matched group.
Disease Diagnosis Standard
Disease Diagnosis Standard
Diagnostic criteria with reference to seat skin ulcer in " traditional Chinese medical science Clinical Researches of New Drugs guideline ": pubarche falls ill, be apt to occur in and the flourishing position of the sebaceous gland such as portion, upper breast and back, antimere, skin lesion is pityriasis rubra pimple, fester, tuberosity, cyst, blackhead and paralysed trace, overflow, in chronic process with sebaceous gland.
Differentiation of symptoms and signs for classification of syndrome standard
Diagnostic criteria with reference to lung channel wind-heat type comedo in " beauty treatment Chinese medicine ": and portion's flushing, pimple color is red, or has fester, or has pain of itching; Companion's thirst and liking drink, constipation, oliguria with reddish urine; Red tongue, yellow and thin fur, floating and rapid pulse.
Grading and efficacy assessment standard
Close to learn with reference to Chinese medical and hold credit and can close " unusual acne classification of severity and the efficacy assessment standard " that hold group and formulate for 1997 by skin, the classification of (1) state of an illness weight with closing: gently, in, weigh three degree, 1-9 level; (1-3 level is slight, and 4-6 level is moderate, and 7-9 level is severe.) wherein: 1 grade of acne, pimple, fester are less than 25; 2 grades 25-50; 3 grades 51-75; 4 grades 76-100; 5 grades of > 100; 6 grades with 1-2 tuberosity or cyst; 7 grades with 3-5 tuberosity or cyst; 8 grades with 6 with superior thyroid tubercle or cyst; 9 grades of tuberositys, the hypertrophica paralysed traces of cyst companion.
(2) mark: 1. before treatment: 3 degree 9 grades, every 1 grade of scoring is 1 point; 2., after treatment: often reduce by 1 grade and deduct 1 point, if all disappearances, it is 2 points; 3. mark × 100% before therapeutic index=(before treatment the rear mark of mark-treatment)/treatment; If be 4. still simple after treatment, but alleviate to some extent, then can calculate little point, often improvement 10% can deduct 0.1 point.
(3) efficacy assessment standard: 1. clinical cure: therapeutic index reaches more than 95%; 2. effective: therapeutic index 60-95%; 3. effective: therapeutic index 20-59%; 4. invalid: therapeutic index < 20%.
(4) exclusion standard: 1. do not meet diagnostic criteria; 2. uncooperatively maybe therapist can not be adhered to; 3. the Chinese and western drugs person for the treatment of seat skin ulcer was used in 2 weeks; 4. merge Liver and kidney, cardiovascular and cerebrovascular disease, malignant tumor, infectious disease, psychosis, other severe primary diseases and have bleeding tendency person; 5. gestation or women breast-feeding their children; 6. severe allergy or paralysed trace body constitution person.
Therapeutic Method
Treat 1 group, treat 2 combined therapy 3 groups all carry out face cleaning, subsequently adopt embodiment 5 prepare facial film 1, embodiment 6 prepare facial film 2 and comparative example 1 prepare facial film 3 treat, using facial film every day 2 times, each 40 minutes, 6 weeks is 1 course for the treatment of.Last therapeutic terminates Effect of follow-up visit by telephone after 4 weeks.
Statistical procedures
Follow-up Data is organized into grade frequency table form, adopts two independent sample non parametric testss (rank test) in statistic software SPSS 13.0 to carry out statistical procedures.
Result
Three groups of effectiveness comparison, the results are shown in Table 1.
Table 1 three groups of effectiveness comparison (n)
| Group | n | Clinical cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treat 1 group | 80 | 69 | 8 | 3 | 0 | 100.00 |
| Treat 2 groups | 80 | 52 | 19 | 8 | 1 | 98.75 |
| Matched group | 80 | 0 | 0 | 0 | 80 | 0.00 |
As can be seen from Table 1, adopt Chinese medicine composition provided by the invention effectively can eliminate lung channel wind-heat type comedo, comparison therapy 1 group and treatment 2 groups, the therapeutic effect for the treatment of 1 group is better, and the absorption adopting absorption enhancers better can promote medicinal herb components is described.
By following up a case by regular visits to, treating 1 group and curing with treatment 2 groups the situations that recurrence does not all occur cases.
Model case
Patient, female, 26, year, go to a doctor in December, 2012, private prosecution face and more than 1 year of neck acne, recurrent exerbation, skin lesion often obviously increases the weight of afterwards in edible pungent stimulation, once Chinese herbal medicine was taken and the multiple external medication several months does not take effect, patient facial region's flushing, be dispersed in Semen phaseoli radiati size pimple, tuberosity, a little pustule, and form slight cicatrix, red tongue, yellow and thin fur, floating and rapid pulse, be diagnosed as acne, lung meridian wind-heat type, after routine cleaning is carried out to skin of face, use facial film 1 prepared by the embodiment of the present invention 5, use 2 every day, after 6 weeks, substantially, cure, Effect of follow-up visit by telephone, do not recur.
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. eliminate a Chinese medicine for facial film for lung channel wind-heat type comedo, it is characterized in that: crude drug comprises Cortex Mori, Radix Ophiopogonis, Cortex Phellodendri, Rhizoma Imperatae, red stalk grass, rabbit hair Artemisia, Caulis et Folium Lactucae sativae, Ramulus Sambuci Williamsii, Radix cynanchi wallichii, Fructus Arctii, Radix Arnebiae (Radix Lithospermi), Ramulus et Folium Bauhiniae Faberi, Semen Euryales, Rhizoma Polygonati, the Radix Angelicae Dahuricae, Herba Lamii Amplexicaulis and Radix Pseudostellariae.
2. Chinese medicine as claimed in claim 1, is characterized in that: each crude drug weight be respectively Cortex Mori 20g ~ 30g, Radix Ophiopogonis 35g ~ 45g, Cortex Phellodendri 40g ~ 50g, Rhizoma Imperatae 15g ~ 25g, red stalk grass 10g ~ 20g, rabbit hair Artemisia 10g ~ 20g, Caulis et Folium Lactucae sativae 15g ~ 25g, Ramulus Sambuci Williamsii 10g ~ 20g, Radix cynanchi wallichii 20g ~ 30g, Fructus Arctii 15g ~ 25g, Radix Arnebiae (Radix Lithospermi) 15g ~ 25g, Ramulus et Folium Bauhiniae Faberi 20g ~ 30g, Semen Euryales 20g ~ 30g, Rhizoma Polygonati 35g ~ 45g, Radix Angelicae Dahuricae 10g ~ 20g, Herba Lamii Amplexicaulis 15g ~ 25g and Radix Pseudostellariae 25g ~ 35g.
3. Chinese medicine as claimed in claim 1 or 2, is characterized in that: each crude drug weight be respectively Cortex Mori 25g ~ 30g, Radix Ophiopogonis 40g ~ 45g, Cortex Phellodendri 45g ~ 50g, Rhizoma Imperatae 20g ~ 25g, red stalk grass 15g ~ 20g, rabbit hair Artemisia 15g ~ 20g, Caulis et Folium Lactucae sativae 20g ~ 25g, Ramulus Sambuci Williamsii 15g ~ 20g, Radix cynanchi wallichii 25g ~ 30g, Fructus Arctii 15g ~ 20g, Radix Arnebiae (Radix Lithospermi) 15g ~ 20g, Ramulus et Folium Bauhiniae Faberi 20g ~ 25g, Semen Euryales 20g ~ 25g, Rhizoma Polygonati 40g ~ 45g, Radix Angelicae Dahuricae 15g ~ 20g, Herba Lamii Amplexicaulis 20g ~ 25g and Radix Pseudostellariae 30g ~ 35g.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that: each crude drug weight be respectively Cortex Mori 25g, Radix Ophiopogonis 40g, Cortex Phellodendri 45g, Rhizoma Imperatae 20g, red stalk grass 15g, rabbit hair Artemisia 15g, Caulis et Folium Lactucae sativae 20g, Ramulus Sambuci Williamsii 15g, Radix cynanchi wallichii 25g, Fructus Arctii 20g, Radix Arnebiae (Radix Lithospermi) 20g, Ramulus et Folium Bauhiniae Faberi 25g, Semen Euryales 25g, Rhizoma Polygonati 40g, Radix Angelicae Dahuricae 15g, Herba Lamii Amplexicaulis 20g and Radix Pseudostellariae 30g.
5. the Chinese medicine as described in Claims 1-4, is characterized in that: described Chinese drug preparation becomes volatile oil clathrate compound.
6. the preparation method of the Chinese medicine as described in claim 1 to 5, is characterized in that, comprising:
A walks, and gets above-mentioned each crude drug and pulverizes respectively, mix by weight, add 8 times of water gagings, soaked overnight, with volatile oil extractor extraction by steam distillation volatile oil 5 hours routinely, then after anhydrous sodium sulfate dehydration, obtains volatile oil;
B walks, and gets above-mentioned volatile oil, adds dehydrated alcohol, be made into volume ratio volatile oil: dehydrated alcohol=1: the mixed solution of 1; Get beta-schardinger dextrin-4 weight portion, add distilled water, be made into percentage by weight 4%-cyclodextrin solution, stir, 55 ~ 65 DEG C of heating in water bath make dissolving, are cooled to 50 DEG C, the mixed solution of above-mentioned volatile oil and dehydrated alcohol is added under stirring condition, sealing, temperature control 40 DEG C stirs 4 hours, cold preservation 12 ~ 24h, sucking filtration, precipitation, 30 ~ 50 DEG C of vacuum dryings, obtain volatile oil clathrate compound.
7. a facial film, is characterized in that: comprise the Chinese medicine described in claim 1 to 5 and absorption enhancers.
8. facial film according to claim 7, is characterized in that: described absorption enhancers can adopt chitosan.
9. the facial film described in claim 7 or 8, is characterized in that: described absorption enhancers can adopt chitosan derivatives, is specially the glycosyl galactose palmityl chitosan shown in following formula,
In formula,
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Application publication date: 20150527 |
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