CN105061399A - 一种含氟四嗪吡啶类化合物及其用途 - Google Patents
一种含氟四嗪吡啶类化合物及其用途 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
Abstract
本发明提供一种含氟四嗪吡啶类化合物,结构如式I所示:
Description
技术领域本发明属于农药中杀螨剂领域,涉及一种含氟四嗪吡啶类化合物及其用途。
背景技术螨类是一类常见的害虫,危害蔬菜、果树、棉花等作物,常对作物造成毁灭性的灾害。植食性螨类具有体积小、繁殖快、适应性强及易产生抗药性等特点,是公认的难防治的有害生物群落。因此,研制高效、低毒、低残留、不同作用机理的杀螨剂意义重大。US4237127及US5455237报道了四嗪类化合物及其在农业防治螨害方面的应用,由此开发出对螨卵高效的杀螨剂品种“四螨嗪”[3,6-双(2-氯苯基)-1,2,4,5-四嗪],在螨害治理方面已发挥了重要作用。氟螨嗪(flufenzine)属于四螨嗪的衍生物,由匈牙利的Chinion公司于20世纪90年代初开发出来的四嗪类杀螨剂,杀螨活性比四螨嗪高4倍。氟螨嗪由于其作用机理独特,具有较强的触杀作用,击倒力强,对成螨、若螨、幼螨及卵均有效,而且低毒、低残留、安全性好。氟螨嗪对柑橘全爪螨、锈礕虱、茶黄螨、朱砂叶螨和二斑叶螨等害螨均有很好防效,可用于柑桔、葡萄等果树和茄子、辣椒、番茄等茄科作物的螨害治理。虽然氟螨嗪具有很好的触杀性,但是内吸性比较弱,只有中度的内吸性,所以喷雾要均匀;而且在长期的使用过程中也产生了抗药性问题。由于害螨极易产生抗药性,众多杀螨剂品种因抗药性已失去原有的高效性,已不能满足现代农业对杀螨剂超高效、长持效及低公害的要求。因此迫切需要开发新型高活性杀螨剂。本发明是对氟螨嗪的结构进行改造,以氯代吡啶环替代氯苯环,设计筛选得到的新型杀螨剂。在现有技术中,如本发明所示的式I化合物用作杀螨剂未见公开。
发明内容本发明的目的是提供一种结构新颖、生产及使用安全、杀螨效果好、防治成本低的含氟四嗪吡唑类化合物,可用于农业或林业害螨的防治。
本发明的技术方案如下:
一种含氟四嗪吡唑类杀螨剂,结构如式I所示:
式I化合物可通过如下反应步骤制备:
(1)2-氯-3-吡啶甲酸和甲醇反应生成2-氯-3-吡啶甲酸甲酯(化合物Ⅱ):
(2)化合物Ⅱ和水合肼反应生成2-氯-3-吡啶甲酰肼(化合物Ⅲ):
(3)2,6-二氟苯甲酰胺和NaOH反应,然后酸化得到2,6-二氟苯甲酸,2,6-二氟苯甲酸和氯化亚砜反应生成2,6-二氟苯甲酰氯(化合物Ⅳ):
(4)化合物Ⅲ和化合物Ⅳ反应生成双酰基肼化合物Ⅴ:
(5)化合物Ⅴ和五氯化磷反应生成氯甲叉基肼化合物VI;
(6)化合物Ⅵ和水合肼成环生成1,2-二氢-1,2,4,5-四嗪类化合物Ⅶ:
(7)化合物Ⅷ用亚硝酸氧化生成化合物I:
本发明的优点和积极效果:
本发明化合物(式I)将氯代吡啶环引入氟螨嗪杀螨剂结构中,当用吡啶环取代苯环时,由于吡啶环有较好的内吸性,极大地提高了对螨卵的抑杀效果;同时大幅度降低了毒性,减少了对有益生物的危害。式I化合物在10ppm达78%,而同浓度下氟螨嗪的杀卵活性只有52%;在1ppm下本发明化合物仍有42%的抑杀率,而氟螨嗪在该浓度下基本无杀卵作用。本发明化合物的杀螨卵活性是氟螨嗪(KC)的5~8倍,表现出超高效性的显著优点。式I化合物对螨卵、成螨、若螨、幼螨均有效,而且本发明化合物为氮环类化合物,具有对有益生物低毒性、易降解、安全性好的特点,具有作为创制性杀螨剂新品种产业化的巨大潜力。
本发明式I化合物在防治有害螨时,可单独使用,也可与其它活性物质组合使用,以提高产品的综合性能。
具体实施方式
下列合成实例、生测试验结果可用来进一步说明本发明,但不意味着限制本发明。
合成实例
实例1、式Ⅰ化合物的制备:
(1)化合物Ⅱ的制备:
向250mL三口烧瓶中加入15.76g(0.1mol)2-氯-3-吡啶甲酸,100mL甲醇,冰浴下滴加17.85g(0.15mol)氯化亚砜,搅拌升温至回流,搅拌反应8h。薄层色谱跟踪反应,待原料点消失后,停止反应。减压蒸馏除去溶剂得浅黄色15.95g,产率93%。
(2)化合物Ⅲ的制备:
向100mL三口烧瓶中加入10.0g水合肼,40mL二氯乙烷,冰浴下滴加17.16g(0.1mol)化合物Ⅱ,搅拌升温至回流,搅拌反应5h。薄层色谱跟踪反应,待原料点消失后,停止反应。减压蒸馏除去低沸物,冷却结晶,抽滤得粗品15.44g,产率90%。
(3)化合物Ⅳ的制备:
向250mL三口烧瓶中加入17.2g(0.1mol)2,6-二氟苯甲酰胺,常温下滴加20%NaOH(0.2mol)水溶液氯化亚砜,搅拌升温至回流,搅拌反应1-2h。薄层色谱跟踪反应,待原料点消失后,停止反应。加盐酸酸化,抽滤烘干得白色固体15g。将上述产物15g加入到250mL三口烧瓶中,常温下滴加0.15mol氯化亚枫,搅拌升温至回流,搅拌反应2-3h。薄层色谱跟踪反应,待原料点消失后,停止反应。减压蒸馏除去溶剂,得产品16.75g,产率100%。
(4)化合物Ⅴ的制备:
向250mL三口烧瓶中加入13.7g(0.08mol)化合物Ⅲ,8.9g(0.088mol)三乙胺,100mL乙酸乙酯,常温下下滴加15.53g(0.088mol)化合物Ⅳ,搅拌升温至回流,搅拌反应4h。薄层色谱跟踪反应,待原料点消失后,停止反应。抽滤去除三乙胺盐酸盐,减压蒸馏除去溶剂得粗品20.18g,产率81%。
(5)化合物Ⅵ的制备:
向250mL三口烧瓶中加入15.6g(0.05mol)化合物Ⅴ,80mL甲苯,分批加入20.85g(0.1mol)PCl5,搅拌升温至40℃,搅拌反应10h。薄层色谱跟踪反应,待原料点消失后,停止反应。冷却后蒸去溶剂,残留物在冰水浴中,用稀的氢氧化钠水溶液调节pH至中性,用乙酸乙酯萃取。有机层依次用水、饱和食盐水洗涤,用无水硫酸钠干燥,脱溶后得到紫红色固体13.42g,收率77%。
(6)化合物Ⅶ的制备:
250mL三口烧瓶中加入10.46g(0.03mol)化合物Ⅵ,甲苯60mL,在40℃下将2.81g(0.045mol)水合肼滴加到反应液中,滴加完后再保温反应4h。冷却后,加入40ml水,过滤析出的固体,得到产品7.31g,收率80%。
(7)化合物I的制备反应式:
在100mL三口烧瓶中加入6.09g(0.02mol)化合物Ⅶ,乙酸20mL,搅拌下将0.026mol亚硝酸钠的水溶液(20%)在室温下滴加入反应液中,搅拌过夜。过滤析出的固体,并且用水洗至中性,干燥,得到粗产品。粗产品过层析柱(石油醚:乙酸乙酯=5:1),得到紫红色粉末状目标产品5.55g,收率91.7%。熔点189℃-191℃,1HNMR(500MHz,DMSO),δ/ppm:8.82(1H,Ar-H),8.3(2H,Ar-H),7.8(1H,Ar-H),7.6(1H,Ph-H),7.0(2H,Ph-H).
生物活性测试
实例2、采用浸渍法和统计校正害虫死亡率的方法测定杀螨卵活性。具体过程是:将供试药剂按有效成分分别稀释至所需浓度,在无菌条件下各取50mL药液注入培养皿内,再分别浸入有朱砂螨卵(螨卵按室内标准化方法正常饲养的群体)的叶片,以添加50mL灭菌水的平板做空白对照。将培养皿放在24±1℃恒温培养箱内。48h后调查统计死亡率。
表1本发明化合物(式I)杀朱砂叶螨螨卵试验结果
根据测试结果可知,本发明化合物I对朱砂叶螨螨卵抑杀效果显著优于氟螨嗪(KC)。
Claims (3)
1.一种含氟四嗪吡啶类化合物,结构如式I所示:
2.根据权利要求1所述的一种含氟四嗪吡啶类化合物的用途,其特征在于式I化合物用作杀螨剂防治农业害螨。
3.一种杀螨组合物,含有权利要求1所述的式I化合物为活性组分和农业上可接受的载体。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4237127A (en) * | 1978-05-25 | 1980-12-02 | Fisons Limited | 1,2,4,5-Tetrazines |
CN1063016A (zh) * | 1991-01-09 | 1992-07-29 | 希巴-盖吉股份公司 | 杀螨剂组合物 |
CN1105025A (zh) * | 1993-07-21 | 1995-07-12 | 奇诺英药物化学工厂有限公司 | 新的杀螨活性的四嗪衍生物 |
WO2000078739A1 (en) * | 1999-06-21 | 2000-12-28 | Syngenta Participations Ag | Pesticidally active tetrazine derivatives |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4237127A (en) * | 1978-05-25 | 1980-12-02 | Fisons Limited | 1,2,4,5-Tetrazines |
CN1063016A (zh) * | 1991-01-09 | 1992-07-29 | 希巴-盖吉股份公司 | 杀螨剂组合物 |
CN1105025A (zh) * | 1993-07-21 | 1995-07-12 | 奇诺英药物化学工厂有限公司 | 新的杀螨活性的四嗪衍生物 |
WO2000078739A1 (en) * | 1999-06-21 | 2000-12-28 | Syngenta Participations Ag | Pesticidally active tetrazine derivatives |
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