CN105008395B - 长效单链胰岛素类似物 - Google Patents

长效单链胰岛素类似物 Download PDF

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Publication number
CN105008395B
CN105008395B CN201380069346.0A CN201380069346A CN105008395B CN 105008395 B CN105008395 B CN 105008395B CN 201380069346 A CN201380069346 A CN 201380069346A CN 105008395 B CN105008395 B CN 105008395B
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China
Prior art keywords
insulin
chain
domain
analogs
residues
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Expired - Fee Related
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CN201380069346.0A
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Chinese (zh)
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CN105008395A (zh
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M.维斯
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Case Western Reserve University
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Case Western Reserve University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
CN201380069346.0A 2012-11-05 2013-11-05 长效单链胰岛素类似物 Expired - Fee Related CN105008395B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010947063.3A CN112266414A (zh) 2012-11-05 2013-11-05 长效单链胰岛素类似物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722350P 2012-11-05 2012-11-05
US61/722350 2012-11-05
PCT/US2013/068585 WO2014071405A2 (en) 2012-11-05 2013-11-05 Long-acting single-chain insulin analogues

Related Child Applications (1)

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CN202010947063.3A Division CN112266414A (zh) 2012-11-05 2013-11-05 长效单链胰岛素类似物

Publications (2)

Publication Number Publication Date
CN105008395A CN105008395A (zh) 2015-10-28
CN105008395B true CN105008395B (zh) 2020-12-29

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CN201380069346.0A Expired - Fee Related CN105008395B (zh) 2012-11-05 2013-11-05 长效单链胰岛素类似物
CN202010947063.3A Pending CN112266414A (zh) 2012-11-05 2013-11-05 长效单链胰岛素类似物

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US (2) US9499600B2 (enExample)
EP (1) EP2914620B1 (enExample)
JP (1) JP6584953B2 (enExample)
KR (1) KR102163936B1 (enExample)
CN (2) CN105008395B (enExample)
AU (1) AU2013337250B2 (enExample)
BR (1) BR112015010194B1 (enExample)
CA (1) CA2890719C (enExample)
EA (1) EA201590882A1 (enExample)
ES (1) ES2694418T3 (enExample)
IL (1) IL238651B (enExample)
MX (1) MX2015005662A (enExample)
PH (1) PH12015500989A1 (enExample)
SG (1) SG11201503522RA (enExample)
WO (1) WO2014071405A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014015078A1 (en) * 2012-07-17 2014-01-23 Michael Weiss O-linked carbohydrate-modified insulin analogues
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
CZ308383B6 (cs) * 2014-06-30 2020-07-15 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Derivát inzulinu s cyklickou strukturou v C-konci B-řetězce
JP6829928B2 (ja) * 2014-10-06 2021-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 二相性単鎖インスリン類似体
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
US20220002373A1 (en) * 2018-11-19 2022-01-06 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
CA3122636A1 (en) 2018-12-11 2020-06-18 Sanofi Insulin analogs having reduced insulin receptor binding affinity
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
CN114867743A (zh) * 2019-12-10 2022-08-05 赛诺菲 形成磺酰胺与多肽的缀合物的方法
JP2024531773A (ja) 2021-09-20 2024-08-29 キュオン バイオテック アー・ゲー アルギナーゼ－インスリン融合タンパク質

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1902226A (zh) * 2003-12-03 2007-01-24 诺和诺德公司 单链胰岛素
CN102065885A (zh) * 2008-04-22 2011-05-18 卡斯西部储备大学 同种型特异性的胰岛素类似物
US8192957B2 (en) * 2006-10-04 2012-06-05 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE270306T1 (de) * 2000-10-02 2004-07-15 Univ Yonsei Seoul Einkettige insulinanaloge
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
KR100508616B1 (ko) * 2003-06-20 2005-08-17 신항철 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그
WO2011003822A2 (de) * 2009-07-06 2011-01-13 Sanofi-Aventis Deutschland Gmbh Insulinzubereitungen enthaltend methionin
JP2012532177A (ja) * 2009-07-06 2012-12-13 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 熱及び振動安定性インスリン製剤
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
CN104010652A (zh) * 2011-10-27 2014-08-27 卡斯西部储备大学 超浓缩的速效胰岛素类似物制剂
JP2015507916A (ja) * 2012-01-20 2015-03-16 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ グルタミン酸安定化インスリン類似体
CN108383902A (zh) * 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 胰岛素类似物二聚体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1902226A (zh) * 2003-12-03 2007-01-24 诺和诺德公司 单链胰岛素
US8192957B2 (en) * 2006-10-04 2012-06-05 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
CN102065885A (zh) * 2008-04-22 2011-05-18 卡斯西部储备大学 同种型特异性的胰岛素类似物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Design of an Active Ultrastable Single-chain Insulin Analog;Qing-xin Hua 等;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;20080523;第283卷(第21期);第14703–14716页 *

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Publication number Publication date
WO2014071405A2 (en) 2014-05-08
JP2016506366A (ja) 2016-03-03
BR112015010194A2 (pt) 2017-12-12
MX2015005662A (es) 2015-08-20
PH12015500989A1 (en) 2015-07-13
WO2014071405A3 (en) 2014-08-21
CN112266414A (zh) 2021-01-26
KR102163936B1 (ko) 2020-10-13
JP6584953B2 (ja) 2019-10-02
CN105008395A (zh) 2015-10-28
IL238651A0 (en) 2015-06-30
BR112015010194B1 (pt) 2022-03-22
US9499600B2 (en) 2016-11-22
EP2914620B1 (en) 2018-08-08
CA2890719C (en) 2023-02-14
EP2914620A4 (en) 2016-05-25
ES2694418T3 (es) 2018-12-20
EP2914620A2 (en) 2015-09-09
AU2013337250B2 (en) 2017-06-22
IL238651B (en) 2020-03-31
US9975940B2 (en) 2018-05-22
US20170137488A1 (en) 2017-05-18
US20150274803A1 (en) 2015-10-01
EA201590882A1 (ru) 2015-09-30
CA2890719A1 (en) 2014-05-08
SG11201503522RA (en) 2015-06-29
KR20150096387A (ko) 2015-08-24

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