CN105008395B - 长效单链胰岛素类似物 - Google Patents

长效单链胰岛素类似物 Download PDF

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Publication number
CN105008395B
CN105008395B CN201380069346.0A CN201380069346A CN105008395B CN 105008395 B CN105008395 B CN 105008395B CN 201380069346 A CN201380069346 A CN 201380069346A CN 105008395 B CN105008395 B CN 105008395B
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China
Prior art keywords
insulin
chain
domain
analogs
residues
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Expired - Fee Related
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CN201380069346.0A
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English (en)
Chinese (zh)
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CN105008395A (zh
Inventor
M.维斯
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Case Western Reserve University
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Case Western Reserve University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
CN201380069346.0A 2012-11-05 2013-11-05 长效单链胰岛素类似物 Expired - Fee Related CN105008395B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010947063.3A CN112266414A (zh) 2012-11-05 2013-11-05 长效单链胰岛素类似物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261722350P 2012-11-05 2012-11-05
US61/722350 2012-11-05
PCT/US2013/068585 WO2014071405A2 (en) 2012-11-05 2013-11-05 Long-acting single-chain insulin analogues

Related Child Applications (1)

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CN202010947063.3A Division CN112266414A (zh) 2012-11-05 2013-11-05 长效单链胰岛素类似物

Publications (2)

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CN105008395A CN105008395A (zh) 2015-10-28
CN105008395B true CN105008395B (zh) 2020-12-29

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CN201380069346.0A Expired - Fee Related CN105008395B (zh) 2012-11-05 2013-11-05 长效单链胰岛素类似物
CN202010947063.3A Pending CN112266414A (zh) 2012-11-05 2013-11-05 长效单链胰岛素类似物

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US (2) US9499600B2 (enExample)
EP (1) EP2914620B1 (enExample)
JP (1) JP6584953B2 (enExample)
KR (1) KR102163936B1 (enExample)
CN (2) CN105008395B (enExample)
AU (1) AU2013337250B2 (enExample)
BR (1) BR112015010194B1 (enExample)
CA (1) CA2890719C (enExample)
EA (1) EA201590882A1 (enExample)
ES (1) ES2694418T3 (enExample)
IL (1) IL238651B (enExample)
MX (1) MX2015005662A (enExample)
PH (1) PH12015500989A1 (enExample)
SG (1) SG11201503522RA (enExample)
WO (1) WO2014071405A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9624287B2 (en) 2012-07-17 2017-04-18 Case Western Reserve University O-linked carbohydrate-modified insulin analogues
DK2877200T3 (da) * 2012-07-17 2019-08-12 Univ Case Western Reserve O-bundne carbonhydratmodificerede insulinanaloger
CA2936563A1 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
CZ308383B6 (cs) * 2014-06-30 2020-07-15 Ústav Organické Chemie A Biochemie Akademie Věd Čr, V.V.I. Derivát inzulinu s cyklickou strukturou v C-konci B-řetězce
AU2015328222B9 (en) * 2014-10-06 2020-12-24 Case Western Reserve University Biphasic single-chain insulin analogues
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
US20220002373A1 (en) * 2018-11-19 2022-01-06 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
TW202039437A (zh) 2018-12-11 2020-11-01 法商賽諾菲公司 肽黏合劑
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
KR20220112817A (ko) * 2019-12-10 2022-08-11 사노피 설폰아미드 및 폴리펩티드의 콘주게이트를 형성하는 방법
WO2022173807A2 (en) 2021-02-09 2022-08-18 The Trustees Of Indiana University Conformationally constrained glucagon analogues and their use in glucagon-single chain insulin fusion proteins
WO2023041758A1 (en) 2021-09-20 2023-03-23 Kyon Biotech Ag Arginase-insulin fusion protein

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1902226A (zh) * 2003-12-03 2007-01-24 诺和诺德公司 单链胰岛素
CN102065885A (zh) * 2008-04-22 2011-05-18 卡斯西部储备大学 同种型特异性的胰岛素类似物
US8192957B2 (en) * 2006-10-04 2012-06-05 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60104069T2 (de) * 2000-10-02 2005-08-25 Yonsei University Einkettige Insulinanaloge
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
WO2004096854A2 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
KR100508616B1 (ko) * 2003-06-20 2005-08-17 신항철 염기성 아미노산 첨가를 통한 활성이 증가된 단일사슬 인슐린 아날로그
PH12011502708B1 (en) * 2009-07-06 2017-11-10 Sanofi Aventis Deutschland Insulin preparations containing methionine
WO2011003820A1 (de) * 2009-07-06 2011-01-13 Sanofi-Aventis Deutschland Gmbh Hitze- und schüttelstabile insulinzubereitungen
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
EP2771026A4 (en) * 2011-10-27 2015-08-05 Univ Case Western Reserve ULTRA-CONCENTRATED AND FAST-ACTING INSULIN ANALOG FORMULATIONS
CN104168911A (zh) * 2012-01-20 2014-11-26 卡斯西部储备大学 谷氨酸-稳定的胰岛素类似物
CN108383902A (zh) * 2012-09-26 2018-08-10 印第安纳大学研究及科技有限公司 胰岛素类似物二聚体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1902226A (zh) * 2003-12-03 2007-01-24 诺和诺德公司 单链胰岛素
US8192957B2 (en) * 2006-10-04 2012-06-05 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
CN102065885A (zh) * 2008-04-22 2011-05-18 卡斯西部储备大学 同种型特异性的胰岛素类似物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Design of an Active Ultrastable Single-chain Insulin Analog;Qing-xin Hua 等;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;20080523;第283卷(第21期);第14703–14716页 *

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Publication number Publication date
SG11201503522RA (en) 2015-06-29
IL238651B (en) 2020-03-31
AU2013337250B2 (en) 2017-06-22
WO2014071405A2 (en) 2014-05-08
EP2914620A2 (en) 2015-09-09
JP2016506366A (ja) 2016-03-03
CA2890719A1 (en) 2014-05-08
EP2914620A4 (en) 2016-05-25
EA201590882A1 (ru) 2015-09-30
IL238651A0 (en) 2015-06-30
JP6584953B2 (ja) 2019-10-02
ES2694418T3 (es) 2018-12-20
EP2914620B1 (en) 2018-08-08
CN105008395A (zh) 2015-10-28
MX2015005662A (es) 2015-08-20
US9499600B2 (en) 2016-11-22
BR112015010194A2 (pt) 2017-12-12
PH12015500989A1 (en) 2015-07-13
CN112266414A (zh) 2021-01-26
US9975940B2 (en) 2018-05-22
CA2890719C (en) 2023-02-14
KR20150096387A (ko) 2015-08-24
US20150274803A1 (en) 2015-10-01
BR112015010194B1 (pt) 2022-03-22
WO2014071405A3 (en) 2014-08-21
KR102163936B1 (ko) 2020-10-13
US20170137488A1 (en) 2017-05-18

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